Published in Circulation on July 23, 2002
Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest (2006) 3.33
Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation. PLoS Comput Biol (2011) 3.21
Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes. Circ Res (2006) 3.03
Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current. J Cardiovasc Electrophysiol (2006) 2.56
A novel computational model of the human ventricular action potential and Ca transient. J Mol Cell Cardiol (2009) 2.36
A computational model of the human left-ventricular epicardial myocyte. Biophys J (2004) 1.88
Excitation-contraction coupling and mitochondrial energetics. Basic Res Cardiol (2007) 1.74
Altered intracellular Ca2+ handling in heart failure. J Clin Invest (2005) 1.70
Elevated cytosolic Na+ increases mitochondrial formation of reactive oxygen species in failing cardiac myocytes. Circulation (2010) 1.61
Deranged sodium to sudden death. J Physiol (2015) 1.51
Chronic heart failure slows late sodium current in human and canine ventricular myocytes: implications for repolarization variability. Eur J Heart Fail (2006) 1.47
Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials. Biophys J (2007) 1.45
Impaired mitochondrial network excitability in failing guinea-pig cardiomyocytes. Cardiovasc Res (2015) 1.39
Mechanisms of altered Ca²⁺ handling in heart failure. Circ Res (2013) 1.37
Modulation of late sodium current by Ca2+, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differences. Am J Physiol Heart Circ Physiol (2008) 1.36
Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts. Circ Res (2003) 1.35
Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout. J Physiol (2009) 1.34
A multi-modal composition of the late Na+ current in human ventricular cardiomyocytes. Cardiovasc Res (2005) 1.29
Phospholemman-mediated activation of Na/K-ATPase limits [Na]i and inotropic state during beta-adrenergic stimulation in mouse ventricular myocytes. Circulation (2008) 1.27
Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart. Heart Fail Rev (2009) 1.19
Late sodium current contributes to diastolic cell Ca2+ accumulation in chronic heart failure. J Physiol Sci (2010) 1.18
There goes the neighborhood: pathological alterations in T-tubule morphology and consequences for cardiomyocyte Ca2+ handling. J Biomed Biotechnol (2010) 1.17
Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species. Am J Physiol Heart Circ Physiol (2011) 1.17
Na⁺ transport in the normal and failing heart - remember the balance. J Mol Cell Cardiol (2013) 1.14
Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice. J Mol Cell Cardiol (2012) 1.13
Cardiac sodium-calcium exchanger is regulated by allosteric calcium and exchanger inhibitory peptide at distinct sites. Circ Res (2004) 1.09
Mitochondrial Ca2+ influx and efflux rates in guinea pig cardiac mitochondria: low and high affinity effects of cyclosporine A. Biochim Biophys Acta (2011) 1.08
Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol (2015) 1.06
Diastolic dysfunction and arrhythmias caused by overexpression of CaMKIIδ(C) can be reversed by inhibition of late Na(+) current. Basic Res Cardiol (2010) 1.06
The arrhythmogenic consequences of increasing late INa in the cardiomyocyte. Cardiovasc Res (2013) 1.03
Redox regulation of sodium and calcium handling. Antioxid Redox Signal (2012) 1.00
Dynamical mechanisms of pacemaker generation in IK1-downregulated human ventricular myocytes: insights from bifurcation analyses of a mathematical model. Biophys J (2005) 0.99
The slow force response to stretch in atrial and ventricular myocardium from human heart: functional relevance and subcellular mechanisms. Prog Biophys Mol Biol (2008) 0.97
The role of Na dysregulation in cardiac disease and how it impacts electrophysiology. Drug Discov Today Dis Models (2007) 0.96
Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease. J Mol Cell Cardiol (2013) 0.96
Overexpression of the Na+/K+ ATPase α2 but not α1 isoform attenuates pathological cardiac hypertrophy and remodeling. Circ Res (2013) 0.95
Simulation and mechanistic investigation of the arrhythmogenic role of the late sodium current in human heart failure. PLoS One (2012) 0.93
Regulation of the cardiac sodium pump. Cell Mol Life Sci (2012) 0.92
Role of sodium and calcium dysregulation in tachyarrhythmias in sudden cardiac death. Circ Res (2015) 0.91
Remodeling of calcium handling in human heart failure. Adv Exp Med Biol (2012) 0.91
Na+ transport in cardiac myocytes; Implications for excitation-contraction coupling. IUBMB Life (2009) 0.89
Mild metabolic acidosis impairs the β-adrenergic response in isolated human failing myocardium. Crit Care (2012) 0.87
MR spectroscopy in heart failure--clinical and experimental findings. Heart Fail Rev (2007) 0.86
Cardiac hypertrophy in mice expressing unphosphorylatable phospholemman. Cardiovasc Res (2014) 0.85
Expert consensus document: Mitochondrial function as a therapeutic target in heart failure. Nat Rev Cardiol (2016) 0.83
An integrated mitochondrial ROS production and scavenging model: implications for heart failure. Biophys J (2013) 0.81
Mechanism of action of the new anti-ischemia drug ranolazine. Clin Res Cardiol (2007) 0.81
[Reverse remodeling of the intracellular Ca(2+)-homeostasis: new concepts of pathophysiology and therapy of heart failure]. Wien Med Wochenschr (2006) 0.79
Metabolic remodeling in moderate synchronous versus dyssynchronous pacing-induced heart failure: integrated metabolomics and proteomics study. PLoS One (2015) 0.79
Na(+)-Ca2+ exchange function underlying contraction frequency inotropy in the cat myocardium. J Physiol (2003) 0.79
Intracellular Na+ Concentration ([Na+]i) Is Elevated in Diabetic Hearts Due to Enhanced Na+-Glucose Cotransport. J Am Heart Assoc (2015) 0.78
Mutation of the calmodulin binding motif IQ of the L-type Ca(v)1.2 Ca2+ channel to EQ induces dilated cardiomyopathy and death. J Biol Chem (2012) 0.77
New treatment options for late Na current, arrhythmias, and diastolic dysfunction. Curr Heart Fail Rep (2012) 0.77
The Electrogenic Na(+)/K(+) Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study. Front Physiol (2017) 0.76
Myocyte repolarization modulates myocardial function in aging dogs. Am J Physiol Heart Circ Physiol (2016) 0.76
Myocardial Na,K-ATPase: Clinical aspects. Exp Clin Cardiol (2003) 0.76
Changes in Intracellular Na+ following Enhancement of Late Na+ Current in Virtual Human Ventricular Myocytes. PLoS One (2016) 0.75
Effect of ion concentration changes in the limited extracellular spaces on sarcolemmal ion transport and Ca2+ turnover in a model of human ventricular cardiomyocyte. Int J Mol Sci (2013) 0.75
Ranolazine versus placebo in patients with ischemic cardiomyopathy and persistent chest pain or dyspnea despite optimal medical and revascularization therapy: randomized, double-blind crossover pilot study. Ther Clin Risk Manag (2015) 0.75
Left ventricular diastolic function associated with common genetic variation in ATP12A in a general population. BMC Med Genet (2014) 0.75
Regulation of Cardiac Remodeling by Cardiac Na(+)/K(+)-ATPase Isoforms. Front Physiol (2016) 0.75
Xanthohumol modulates calcium signaling in rat ventricular myocytes: Possible Antiarrhythmic properties. J Pharmacol Exp Ther (2016) 0.75
Computational modeling for cardiac safety pharmacology analysis: Contribution of fibroblasts. J Pharmacol Toxicol Methods (2017) 0.75
Systolic [Ca(2+) ]i regulates diastolic levels in rat ventricular myocytes. J Physiol (2017) 0.75
Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy. N Engl J Med (2015) 6.00
Pluripotency of spermatogonial stem cells from adult mouse testis. Nature (2006) 4.29
The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res (2003) 4.13
Increased myocardial NADPH oxidase activity in human heart failure. J Am Coll Cardiol (2003) 3.73
Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest (2006) 3.33
Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study. J Am Coll Cardiol (2011) 3.13
Generation of functional murine cardiac myocytes from induced pluripotent stem cells. Circulation (2008) 3.11
Increased neuronal nitric oxide synthase-derived NO production in the failing human heart. Lancet (2004) 3.07
Generation of induced pluripotent stem cells from human cord blood. Cell Stem Cell (2009) 2.78
Low-energy control of electrical turbulence in the heart. Nature (2011) 2.75
The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload. Proc Natl Acad Sci U S A (2009) 2.66
L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices. Circ Res (2002) 2.62
Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes. Circ Res (2005) 2.50
Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation. J Mol Cell Cardiol (2008) 2.49
Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium. Circ Res (2010) 2.38
Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction. J Pharmacol Exp Ther (2006) 2.21
Na(+)-Ca(2+) exchange current and submembrane [Ca(2+)] during the cardiac action potential. Circ Res (2002) 2.21
Differential cardiac remodeling in preload versus afterload. Circulation (2010) 2.20
Altered Na(+) currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium. J Am Coll Cardiol (2010) 2.04
CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation. Circ Res (2010) 2.02
NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. Circulation (2005) 1.87
Frequency-dependent acceleration of relaxation in the heart depends on CaMKII, but not phospholamban. J Mol Cell Cardiol (2002) 1.82
Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium. J Mol Cell Cardiol (2004) 1.81
High precision quantitative proteomics using iTRAQ on an LTQ Orbitrap: a new mass spectrometric method combining the benefits of all. J Proteome Res (2009) 1.75
Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium. Circulation (2002) 1.73
Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circ Res (2011) 1.69
Predictive value of the high-sensitivity troponin T assay and the simplified Pulmonary Embolism Severity Index in hemodynamically stable patients with acute pulmonary embolism: a prospective validation study. Circulation (2011) 1.68
Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes. J Am Coll Cardiol (2013) 1.68
Ca2+/calmodulin-dependent protein kinase II and protein kinase A differentially regulate sarcoplasmic reticulum Ca2+ leak in human cardiac pathology. Circulation (2013) 1.67
Leptin enhances the recruitment of endothelial progenitor cells into neointimal lesions after vascular injury by promoting integrin-mediated adhesion. Circ Res (2008) 1.66
Atrial overdrive pacing in patients with sleep apnea with implanted pacemaker. Am J Respir Crit Care Med (2005) 1.65
Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure. Circ Heart Fail (2009) 1.64
CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses. J Biol Chem (2007) 1.64
Elevated heart-type fatty acid-binding protein levels on admission predict an adverse outcome in normotensive patients with acute pulmonary embolism. J Am Coll Cardiol (2010) 1.59
Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation (2007) 1.57
Acquired von Willebrand syndrome in continuous-flow ventricular assist device recipients. Ann Thorac Surg (2010) 1.57
Differential interaction of clinical characteristics with key functional parameters in heart failure with preserved ejection fraction--results of the Aldo-DHF trial. Int J Cardiol (2013) 1.56
Heart-type fatty acid-binding protein permits early risk stratification of pulmonary embolism. Eur Heart J (2006) 1.55
Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. J Clin Invest (2013) 1.53
Ca(2+) /calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca(2+) leak in human ischaemic and dilated cardiomyopathy. Eur J Heart Fail (2014) 1.52
Plasminogen activator inhibitor-1 from bone marrow-derived cells suppresses neointimal formation after vascular injury in mice. Arterioscler Thromb Vasc Biol (2006) 1.49
Myocardial adaptation of energy metabolism to elevated preload depends on calcineurin activity : a proteomic approach. Basic Res Cardiol (2008) 1.49
2015 ESC Guidelines for the Management of Acute Coronary Syndromes in Patients Presenting Without Persistent ST-segment Elevation. Rev Esp Cardiol (Engl Ed) (2015) 1.49
Biventricular pacing improves the blunted force-frequency relation present during univentricular pacing in patients with heart failure and conduction delay. Circulation (2006) 1.47
Stimulated emission depletion live-cell super-resolution imaging shows proliferative remodeling of T-tubule membrane structures after myocardial infarction. Circ Res (2012) 1.47
Phosphorylation of phospholamban at threonine-17 reduces cardiac adrenergic contractile responsiveness in chronic pressure overload-induced hypertrophy. Am J Physiol Heart Circ Physiol (2006) 1.46
Limitations of FKBP12.6-directed treatment strategies for maladaptive cardiac remodeling and heart failure. J Mol Cell Cardiol (2010) 1.46
Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials. Biophys J (2007) 1.45
Absence of leptin resistance in platelets from morbidly obese individuals may contribute to the increased thrombosis risk in obesity. Thromb Haemost (2008) 1.45
Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo. Cardiovasc Res (2011) 1.44
The German CPU Registry: comparison of troponin positive to troponin negative patients. Int J Cardiol (2013) 1.43
Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy. Cardiovasc Res (2008) 1.42
[Management of stable coronary artery disease]. MMW Fortschr Med (2009) 1.40
Ca/calmodulin kinase II differentially modulates potassium currents. Circ Arrhythm Electrophysiol (2009) 1.37
Enhanced detection of paroxysmal atrial fibrillation by early and prolonged continuous holter monitoring in patients with cerebral ischemia presenting in sinus rhythm. Stroke (2010) 1.35
Generation of functional cardiomyocytes from adult mouse spermatogonial stem cells. Circ Res (2007) 1.32
Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging. J Clin Invest (2010) 1.29
Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation (2013) 1.29
Remote magnetic versus manual catheter navigation for circumferential pulmonary vein ablation in patients with atrial fibrillation. Clin Res Cardiol (2011) 1.25
Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles. Mol Hum Reprod (2008) 1.24
Dynamic regulation of sodium/calcium exchange function in human heart failure. Circulation (2003) 1.24
Phenotypic differences in transient outward K+ current of human and canine ventricular myocytes: insights into molecular composition of ventricular Ito. Am J Physiol Heart Circ Physiol (2003) 1.22
Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation. Cardiovasc Res (2010) 1.22
Periostin and periostin-like factor in the human heart: possible therapeutic targets. Cardiovasc Pathol (2006) 1.22
Evidence for altered interleukin 18 (IL)-18 pathway in human heart failure. FASEB J (2004) 1.22
Effects of large volume, ice-cold intravenous fluid infusion on respiratory function in cardiac arrest survivors. Resuscitation (2009) 1.20
Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation. Circ Res (2013) 1.20
Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart. Heart Fail Rev (2009) 1.19
Calcium entry via Na/Ca exchange during the action potential directly contributes to contraction of failing human ventricular myocytes. Cardiovasc Res (2003) 1.18
Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro. Eur Heart J (2012) 1.16
Myocyte nitric oxide synthase 2 contributes to blunted beta-adrenergic response in failing human hearts by decreasing Ca2+ transients. Circulation (2004) 1.15
Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy. Proc Natl Acad Sci U S A (2013) 1.13
A common MLP (muscle LIM protein) variant is associated with cardiomyopathy. Circ Res (2009) 1.11
Highly sensitive troponin T assay in normotensive patients with acute pulmonary embolism. Eur Heart J (2010) 1.11
Isolation and cultivation of stem cells from adult mouse testes. Nat Protoc (2009) 1.11
Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts. Eur Heart J (2012) 1.10
Conditional neuronal nitric oxide synthase overexpression impairs myocardial contractility. Circ Res (2007) 1.10
Endothelin-1 enhances nuclear Ca2+ transients in atrial myocytes through Ins(1,4,5)P3-dependent Ca2+ release from perinuclear Ca2+ stores. J Cell Sci (2007) 1.10
The risk-to-benefit ratio of transcatheter aortic valve implantation in specific patient cohorts: a single-centre experience. Clin Res Cardiol (2012) 1.09
Mechanical load-dependent regulation of gene expression in monocrotaline-induced right ventricular hypertrophy in the rat. Circ Res (2003) 1.08
Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells. FASEB J (2010) 1.08