Published in Diabetes on May 01, 2004
Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes (2010) 2.80
Gap junction coupling and calcium waves in the pancreatic islet. Biophys J (2008) 1.65
Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. Biochem J (2009) 1.64
Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets. Diabetologia (2011) 1.52
Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice. PLoS One (2012) 1.50
Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus. J Clin Invest (2004) 1.50
Immune rejection after pancreatic islet cell transplantation: in vivo dual contrast-enhanced MR imaging in a mouse model. Radiology (2012) 1.41
Molecular imaging of vascular endothelial growth factor receptor 2 expression using targeted contrast-enhanced high-frequency ultrasonography. J Ultrasound Med (2007) 1.38
Extracellular matrix in pancreatic islets: relevance to scaffold design and transplantation. Cell Transplant (2009) 1.35
Polymer scaffolds as synthetic microenvironments for extrahepatic islet transplantation. Transplantation (2006) 1.23
Bioluminescence imaging in mouse models quantifies beta cell mass in the pancreas and after islet transplantation. Mol Imaging Biol (2009) 1.23
Growth factor delivery from self-assembling nanofibers to facilitate islet transplantation. Transplantation (2008) 1.20
MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic β-cells. J Biol Chem (2012) 1.19
Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets. Diabetes (2008) 1.17
Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor. Diabetes (2012) 1.17
MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells. J Biol Chem (2009) 1.15
Revascularization of transplanted islets: can it be improved? Diabetes (2008) 1.15
Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation. Endocr Rev (2008) 1.12
The role of blood vessels, endothelial cells, and vascular pericytes in insulin secretion and peripheral insulin action. Endocr Rev (2010) 1.11
The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background. PLoS One (2012) 1.11
A multiwalled carbon nanotube/dihydropyran composite film electrode for insulin detection in a microphysiometer chamber. Anal Chim Acta (2008) 1.11
Phosphoenolpyruvate carboxykinase (Pck1) helps regulate the triglyceride/fatty acid cycle and development of insulin resistance in mice. J Lipid Res (2010) 1.11
Self-assembling nanostructures to deliver angiogenic factors to pancreatic islets. Biomaterials (2010) 1.09
Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes β cell regeneration. Cell Metab (2014) 1.08
Ischaemia is linked to inflammation and induction of angiogenesis in pancreatic islets. Clin Exp Immunol (2006) 1.07
Hypoglycemia reduces vascular endothelial growth factor A production by pancreatic beta cells as a regulator of beta cell mass. J Biol Chem (2013) 1.06
Donor islet endothelial cells in pancreatic islet revascularization. Diabetes (2011) 1.05
Revascularization of transplanted pancreatic islets and role of the transplantation site. Clin Dev Immunol (2013) 1.04
In vivo non-viral gene delivery of human vascular endothelial growth factor improves revascularisation and restoration of euglycaemia after human islet transplantation into mouse liver. Diabetologia (2010) 1.04
Pancreatic duct cells as a source of VEGF in mice. Diabetologia (2014) 1.03
Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation. Dev Biol (2012) 1.01
Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain. Mol Cell Biol (2010) 0.99
Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets. Diabetes (2013) 0.99
In vivo magnetic resonance imaging of vascularization in islet transplantation. Transpl Int (2007) 0.97
Markedly decreased blood perfusion of pancreatic islets transplanted intraportally into the liver: disruption of islet integrity necessary for islet revascularization. Diabetes (2012) 0.95
Current status of clinical islet transplantation. World J Transplant (2013) 0.91
Young capillary vessels rejuvenate aged pancreatic islets. Proc Natl Acad Sci U S A (2014) 0.90
Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes. Diabetologia (2012) 0.90
Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligands. Proc Natl Acad Sci U S A (2011) 0.90
Contribution of subcutaneous connective tissues to the epithelialization and cyst formation by the skin transplanted subcutaneously. Organogenesis (2004) 0.90
Enhanced rat islet function and survival in vitro using a biomimetic self-assembled nanomatrix gel. Tissue Eng Part A (2010) 0.89
Elevation of vascular endothelial growth factor production and its effect on revascularization and function of graft islets in diabetic rats. World J Gastroenterol (2007) 0.88
Angiopoietin 2 alters pancreatic vascularization in diabetic conditions. PLoS One (2012) 0.87
Loss of Foxd3 results in decreased β-cell proliferation and glucose intolerance during pregnancy. Endocrinology (2011) 0.87
Application of an endothelialized modular construct for islet transplantation in syngeneic and allogeneic immunosuppressed rat models. Tissue Eng Part A (2011) 0.86
Dimensionality and size scaling of coordinated Ca(2+) dynamics in MIN6 β-cell clusters. Biophys J (2014) 0.86
Switching-on survival and repair response programs in islet transplants by bone marrow-derived vasculogenic cells. Diabetes (2008) 0.86
Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding. Development (2014) 0.84
An isolated venous sac as a novel site for cell therapy in diabetes mellitus. Transplantation (2012) 0.84
Stress-impaired transcription factor expression and insulin secretion in transplanted human islets. J Clin Invest (2016) 0.84
Co-transplantation of endothelial progenitor cells and pancreatic islets to induce long-lasting normoglycemia in streptozotocin-treated diabetic rats. PLoS One (2014) 0.83
Dipeptidyl peptidase IV inhibition activates CREB and improves islet vascularization through VEGF-A/VEGFR-2 signaling pathway. PLoS One (2013) 0.83
Autoimmune-mediated glucose intolerance in a mouse model of systemic lupus erythematosus. Am J Physiol Endocrinol Metab (2012) 0.83
Angiotensin-Converting Enzyme 2 Deficiency Aggravates Glucose Intolerance via Impairment of Islet Microvascular Density in Mice with High-Fat Diet. J Diabetes Res (2013) 0.80
Adipose stem cell-based regenerative medicine for reversal of diabetic hyperglycemia. World J Diabetes (2014) 0.79
Incorporation of bone marrow cells in pancreatic pseudoislets improves posttransplant vascularization and endocrine function. PLoS One (2013) 0.78
Improving islet engraftment by gene therapy. J Transplant (2011) 0.78
Differentially Expressed MicroRNA-483 Confers Distinct Functions in Pancreatic β- and α-Cells. J Biol Chem (2015) 0.78
Non-invasive bioluminescence imaging of β-cell function in obese-hyperglycemic [ob/ob] mice. PLoS One (2014) 0.77
Lymphangiogenesis and angiogenesis during human fetal pancreas development. Vasc Cell (2014) 0.77
Glucose-regulated insulin production in the liver improves glycemic control in type 1 diabetic mice. Mol Metab (2014) 0.77
Genetically modified human bone marrow derived mesenchymal stem cells for improving the outcome of human islet transplantation. PLoS One (2013) 0.77
Endothelium-derived essential signals involved in pancreas organogenesis. World J Exp Med (2015) 0.76
Mesenchymal stromal cells support endothelial cell interactions in an intramuscular islet transplantation model. Regen Med Res (2015) 0.76
The role of endothelial cells on islet function and revascularization after islet transplantation. Organogenesis (2016) 0.75
CD8+ Effector T Cell Migration to Pancreatic Islet Grafts Is Dependent on Cognate Antigen Presentation by Donor Graft Cells. J Immunol (2016) 0.75
Fibroblasts accelerate islet revascularization and improve long-term graft survival in a mouse model of subcutaneous islet transplantation. PLoS One (2017) 0.75
Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. J Clin Invest (2017) 0.75
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet (2002) 8.28
Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell (2004) 7.61
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell (2008) 6.78
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol (2002) 5.36
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat Med (2004) 5.04
Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy. J Histochem Cytochem (2005) 4.40
Impact of medical student research in the development of physician-scientists. J Investig Med (2003) 3.72
Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem (2002) 2.87
Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes (2010) 2.80
Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A (2005) 2.60
Quantitative pharmacokinetic analysis of DCE-MRI data without an arterial input function: a reference region model. Magn Reson Imaging (2005) 2.54
Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes (2006) 2.53
Glucose metabolism in vivo in four commonly used inbred mouse strains. Diabetes (2008) 2.38
Inactivation of specific β cell transcription factors in type 2 diabetes. J Clin Invest (2013) 2.18
Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev (2006) 2.15
Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. J Mol Endocrinol (2007) 2.12
Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. Science (2006) 2.02
VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue. Blood (2012) 1.94
Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase. Genesis (2005) 1.90
Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. J Biol Chem (2002) 1.85
Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance. J Biol Chem (2007) 1.73
The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass. Mol Endocrinol (2006) 1.70
Gene therapy targeting the Tie2 function ameliorates collagen-induced arthritis and protects against bone destruction. Arthritis Rheum (2005) 1.67
Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. Circulation (2003) 1.66
A defect in glucose-induced dissociation of glucokinase from the regulatory protein in Zucker diabetic fatty rats in the early stage of diabetes. Am J Physiol Regul Integr Comp Physiol (2007) 1.58
Endothelial cell adhesion molecules and cancer progression. Curr Med Chem (2007) 1.55
Real-time, multidimensional in vivo imaging used to investigate blood flow in mouse pancreatic islets. J Clin Invest (2008) 1.53
Physical activity patterns and exercise performance in cardiac transplant recipients. J Cardiopulm Rehabil (2003) 1.52
Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice. PLoS One (2012) 1.50
Functional significance of Tie2 signaling in the adult vasculature. Recent Prog Horm Res (2004) 1.50
Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen. Diabetes (2009) 1.47
Repeatability of a reference region model for analysis of murine DCE-MRI data at 7T. J Magn Reson Imaging (2006) 1.47
SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival. Clin Cancer Res (2012) 1.46
Beta-cell proliferation, but not neogenesis, following 60% partial pancreatectomy is impaired in the absence of FoxM1. Diabetes (2008) 1.46
Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene. Genesis (2005) 1.42
Type 2 diabetes and the aging pancreatic beta cell. Aging (Albany NY) (2011) 1.39
Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation. Diabetes (2003) 1.36
Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression. Mol Cell Biol (2007) 1.31
Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis. Am J Physiol Endocrinol Metab (2004) 1.31
Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice. Diabetes (2010) 1.30
Individual mice can be distinguished by the period of their islet calcium oscillations: is there an intrinsic islet period that is imprinted in vivo? Diabetes (2005) 1.30
Incorporating the effects of transcytolemmal water exchange in a reference region model for DCE-MRI analysis: theory, simulations, and experimental results. Magn Reson Med (2008) 1.30
Validation of luminescent source reconstruction using single-view spectrally resolved bioluminescence images. Appl Opt (2007) 1.27
A versatile valve-enabled microfluidic cell co-culture platform and demonstration of its applications to neurobiology and cancer biology. Biomed Microdevices (2011) 1.27
Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. Mol Endocrinol (2009) 1.24
Pancreatic islet vasculature adapts to insulin resistance through dilation and not angiogenesis. Diabetes (2013) 1.24
Polymer scaffolds as synthetic microenvironments for extrahepatic islet transplantation. Transplantation (2006) 1.23
Bioluminescence imaging in mouse models quantifies beta cell mass in the pancreas and after islet transplantation. Mol Imaging Biol (2009) 1.23
Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev (2009) 1.23
Regulation of pancreas plasticity and malignant transformation by Akt signaling. Gastroenterology (2008) 1.22
PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression. Cell Metab (2009) 1.21
Factors influencing quantification of in vivo bioluminescence imaging: application to assessment of pancreatic islet transplants. Mol Imaging (2004) 1.21
Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats. Diabetes (2008) 1.20
Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6. Mol Cell Biol (2002) 1.18
Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor. Diabetes (2012) 1.17
Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. Proc Natl Acad Sci U S A (2010) 1.16
Revascularization of transplanted islets: can it be improved? Diabetes (2008) 1.15
Assessment of pancreatic islet mass after islet transplantation using in vivo bioluminescence imaging. Transplantation (2005) 1.15
Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats. Am J Physiol Gastrointest Liver Physiol (2003) 1.15
The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background. PLoS One (2012) 1.11
In vivo monitoring of pancreatic beta-cells in a transgenic mouse model. Mol Imaging (2006) 1.11
Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells. Proc Natl Acad Sci U S A (2011) 1.06
Pancreatic islet beta-cells transiently metabolize pyruvate. J Biol Chem (2002) 1.04
Impaired glucagon secretory responses in mice lacking the type 1 sulfonylurea receptor. Am J Physiol Endocrinol Metab (2005) 1.04
Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation. Dev Biol (2012) 1.01
Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Dev Biol (2006) 1.01
Glucose toxicity is responsible for the development of impaired regulation of endogenous glucose production and hepatic glucokinase in Zucker diabetic fatty rats. Diabetes (2006) 1.00
Glucose-dependent blood flow dynamics in murine pancreatic islets in vivo. Am J Physiol Endocrinol Metab (2010) 0.99
Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets. Diabetes (2013) 0.99
Defect in glucokinase translocation in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab (2004) 0.98
OASIS/CREB3L1 induces expression of genes involved in extracellular matrix production but not classical endoplasmic reticulum stress response genes in pancreatic beta-cells. Endocrinology (2010) 0.97
Effect of intraportal glucagon-like peptide-1 on glucose metabolism in conscious dogs. Am J Physiol Endocrinol Metab (2003) 0.96
Interleukin-32beta propagates vascular inflammation and exacerbates sepsis in a mouse model. PLoS One (2010) 0.96
Onecut1 is essential for horizontal cell genesis and retinal integrity. J Neurosci (2013) 0.95
A physiological role for connective tissue growth factor in early wound healing. Lab Invest (2012) 0.95
Identifying children with dental care needs: evaluation of a targeted school-based dental screening program. J Public Health Dent (2004) 0.95
Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cells. Diabetes (2006) 0.95