Published in Diabetes on August 26, 2008
Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. Diabetes (2010) 2.12
Beta-cell growth and regeneration: replication is only part of the story. Diabetes (2010) 1.92
The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality. Diabetologia (2009) 1.83
Expansion of beta-cell mass in response to pregnancy. Trends Endocrinol Metab (2009) 1.81
Multiple faces of FoxM1 transcription factor: lessons from transgenic mouse models. Cell Cycle (2011) 1.74
Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT. Dev Cell (2012) 1.72
Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen. Diabetes (2009) 1.47
Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas. BMC Dev Biol (2010) 1.45
Type 2 diabetes and the aging pancreatic beta cell. Aging (Albany NY) (2011) 1.39
Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size. Diabetes (2011) 1.37
FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation. Mol Endocrinol (2010) 1.23
Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling. Development (2010) 1.21
Cellular origins of beta-cell regeneration: a legacy view of historical controversies. J Intern Med (2009) 1.16
Forkhead box M1 transcriptional factor is required for smooth muscle cells during embryonic development of blood vessels and esophagus. Dev Biol (2009) 1.14
Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells. Proc Natl Acad Sci U S A (2011) 1.06
High Fat Diet Regulation of β-Cell Proliferation and β-Cell Mass. Open Endocrinol J (2010) 0.99
Pancreatic beta-cells: from generation to regeneration. Semin Cell Dev Biol (2010) 0.97
Neurogenin3 activation is not sufficient to direct duct-to-beta cell transdifferentiation in the adult pancreas. J Biol Chem (2013) 0.94
Differential regulation of embryonic and adult β cell replication. Cell Cycle (2012) 0.93
Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains. Am J Physiol Endocrinol Metab (2013) 0.91
Epidermal growth factor receptor signaling promotes pancreatic β-cell proliferation in response to nutrient excess in rats through mTOR and FOXM1. Diabetes (2013) 0.91
Pancreas cell fate. Birth Defects Res C Embryo Today (2009) 0.91
Heterogeneity in mitotic activity and telomere length implies an important role of young islets in the maintenance of islet mass in the adult pancreas. Endocrinology (2009) 0.91
CENP-A, a protein required for chromosome segregation in mitosis, declines with age in islet but not exocrine cells. Aging (Albany NY) (2010) 0.89
Precursor cells in mouse islets generate new beta-cells in vivo during aging and after islet injury. Endocrinology (2010) 0.89
Postnatal development, maturation and aging in the mouse cochlea and their effects on hair cell regeneration. Hear Res (2012) 0.89
mRNA expression analysis of cell cycle genes in islets of pregnant mice. Diabetologia (2010) 0.88
Loss of Foxd3 results in decreased β-cell proliferation and glucose intolerance during pregnancy. Endocrinology (2011) 0.87
High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice. Am J Physiol Endocrinol Metab (2015) 0.87
The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice. Diabetologia (2015) 0.86
The transcription factor Foxm1 is essential for the quiescence and maintenance of hematopoietic stem cells. Nat Immunol (2015) 0.83
Activated FoxM1 attenuates streptozotocin-mediated β-cell death. Mol Endocrinol (2014) 0.83
Islet neogenesis: a possible pathway for beta-cell replenishment. Rev Diabet Stud (2012) 0.83
Diet-induced impaired glucose tolerance and gestational diabetes in the dog. J Appl Physiol (1985) (2010) 0.81
ALDH expression characterizes G1-phase proliferating beta cells during pregnancy. PLoS One (2014) 0.81
Survivin is required for beta-cell mass expansion in the pancreatic duct-ligated mouse model. PLoS One (2012) 0.78
Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation. Cell Metab (2017) 0.77
Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion. Diabetes (2015) 0.76
Proproliferative and antiapoptotic action of exogenously introduced YAP in pancreatic β cells. JCI Insight (2016) 0.75
Parathyroid Hormone-Related Peptide (1-36) Enhances Beta Cell Regeneration and Increases Beta Cell Mass in a Mouse Model of Partial Pancreatectomy. PLoS One (2016) 0.75
Swertisin an Anti-Diabetic Compound Facilitate Islet Neogenesis from Pancreatic Stem/Progenitor Cells via p-38 MAP Kinase-SMAD Pathway: An In-Vitro and In-Vivo Study. PLoS One (2015) 0.75
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature (2004) 16.56
International trial of the Edmonton protocol for islet transplantation. N Engl J Med (2006) 13.43
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development (2002) 12.21
Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell (2008) 8.57
Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet (1999) 8.53
neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A (2000) 8.34
FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat Cell Biol (2005) 7.02
Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell (2007) 4.90
Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol Cell Biol (2005) 4.80
Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? Diabetologia (2005) 4.61
Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest (2004) 4.12
Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Mol Cell Biol (2005) 3.50
Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes (1995) 3.47
FoxM1: at the crossroads of ageing and cancer. Biochim Biophys Acta (2006) 2.98
The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration. Proc Natl Acad Sci U S A (2002) 2.93
Characterization of the abnormal pancreatic development, reduced growth and infertility in Cdk4 mutant mice. Oncogene (2003) 2.64
Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes. Diabetologia (2006) 2.53
The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes (1999) 2.44
Molecular control of cell cycle progression in the pancreatic beta-cell. Endocr Rev (2006) 2.30
The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis. Dev Biol (2004) 2.19
Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. J Mol Endocrinol (2007) 2.12
Premature expression of the winged helix transcription factor HFH-11B in regenerating mouse liver accelerates hepatocyte entry into S phase. Mol Cell Biol (1999) 2.11
Over-expression of FoxM1 stimulates cyclin B1 expression. FEBS Lett (2001) 1.99
FoxM1 dances with mitosis. Nat Cell Biol (2005) 1.85
The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass. Mol Endocrinol (2006) 1.70
Ubiquitous expression of the forkhead box M1B transgene accelerates proliferation of distinct pulmonary cell types following lung injury. J Biol Chem (2003) 1.63
Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1. Dev Biol (2001) 1.47
Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/lacZ transcriptional reporter. Endocrinology (1999) 1.41
Regeneration of pancreatic islets after partial pancreatectomy in mice does not involve the reactivation of neurogenin-3. Diabetes (2005) 1.38
Regulation of pancreatic beta-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse. Diabetes (2006) 1.36
FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression. J Biol Chem (2007) 1.25
The development of the dorsal and ventral mammalian pancreas in vivo and in vitro. J Cell Biol (1970) 1.08
Induced ICER Igamma down-regulates cyclin A expression and cell proliferation in insulin-producing beta cells. Biochem Biophys Res Commun (2005) 0.84
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet (2002) 8.28
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol (2002) 5.36
Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol Cell Biol (2005) 4.80
Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. Genes Dev (2004) 3.91
The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration. Proc Natl Acad Sci U S A (2002) 2.93
Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice. Cancer Res (2006) 2.92
Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem (2002) 2.87
The Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer. Cancer Res (2006) 2.84
Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes (2010) 2.80
Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators. Mol Cell Biol (2004) 2.72
Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1. Cancer Res (2006) 2.58
Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes (2006) 2.53
Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets. Diabetes (2004) 2.26
The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis. Dev Biol (2004) 2.19
Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev (2006) 2.15
Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. J Mol Endocrinol (2007) 2.12
FoxM1, a critical regulator of oxidative stress during oncogenesis. EMBO J (2009) 2.11
Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. Mol Cell Biol (2006) 2.11
A cell-penetrating ARF peptide inhibitor of FoxM1 in mouse hepatocellular carcinoma treatment. J Clin Invest (2006) 2.02
The forkhead box M1 transcription factor contributes to the development and growth of mouse colorectal cancer. Gastroenterology (2007) 1.99
Growth hormone stimulates proliferation of old-aged regenerating liver through forkhead box m1b. Hepatology (2003) 1.94
Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase. Genesis (2005) 1.90
FoxM1 dances with mitosis. Nat Cell Biol (2005) 1.85
The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature. J Biol Chem (2005) 1.83
Endothelial cell-restricted disruption of FoxM1 impairs endothelial repair following LPS-induced vascular injury. J Clin Invest (2006) 1.71
The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass. Mol Endocrinol (2006) 1.70
On the epigenetic regulation of the human reelin promoter. Nucleic Acids Res (2002) 1.69
Ubiquitous expression of the forkhead box M1B transgene accelerates proliferation of distinct pulmonary cell types following lung injury. J Biol Chem (2003) 1.63
Increased hepatic Forkhead Box M1B (FoxM1B) levels in old-aged mice stimulated liver regeneration through diminished p27Kip1 protein levels and increased Cdc25B expression. J Biol Chem (2002) 1.63
Foxf1 +/- mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury. Hepatology (2003) 1.59
FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. J Biol Chem (2008) 1.58
Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice. PLoS One (2012) 1.50
Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen. Diabetes (2009) 1.47
Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding. Mol Cell Biol (2003) 1.47
Deregulation of FoxM1b leads to tumour metastasis. EMBO Mol Med (2010) 1.43
Anaphase-promoting complex/cyclosome-CDH1-mediated proteolysis of the forkhead box M1 transcription factor is critical for regulated entry into S phase. Mol Cell Biol (2008) 1.42
Type 2 diabetes and the aging pancreatic beta cell. Aging (Albany NY) (2011) 1.39
Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression. Mol Cell Biol (2007) 1.31
Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder development. J Biol Chem (2002) 1.30
FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression. J Biol Chem (2007) 1.25
Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. Mol Endocrinol (2009) 1.24
Bioluminescence imaging in mouse models quantifies beta cell mass in the pancreas and after islet transplantation. Mol Imaging Biol (2009) 1.23
Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev (2009) 1.23
Regulation of pancreas plasticity and malignant transformation by Akt signaling. Gastroenterology (2008) 1.22
Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development. Am J Physiol Lung Cell Mol Physiol (2003) 1.22
Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box M1 transcription factor. Dev Dyn (2007) 1.18
Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6. Mol Cell Biol (2002) 1.18
A conserved phosphorylation site within the forkhead domain of FoxM1B is required for its activation by cyclin-CDK1. J Biol Chem (2009) 1.17
FoxM1 in tumorigenicity of the neuroblastoma cells and renewal of the neural progenitors. Cancer Res (2011) 1.15
Increased expression of hepatocyte nuclear factor 6 stimulates hepatocyte proliferation during mouse liver regeneration. Gastroenterology (2006) 1.07
Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells. Proc Natl Acad Sci U S A (2011) 1.06
Functional characterization of evolutionarily conserved DNA regions in forkhead box f1 gene locus. J Biol Chem (2005) 1.05
Fusion of lung lobes and vessels in mouse embryos heterozygous for the forkhead box f1 targeted allele. Am J Physiol Lung Cell Mol Physiol (2002) 1.05
Stability of the hepatocyte nuclear factor 6 transcription factor requires acetylation by the CREB-binding protein coactivator. J Biol Chem (2004) 1.03
Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Dev Biol (2006) 1.01
ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARF. Mol Cell Biol (2005) 0.99
C/EBPalpha and HNF6 protein complex formation stimulates HNF6-dependent transcription by CBP coactivator recruitment in HepG2 cells. Hepatology (2006) 0.97
OASIS/CREB3L1 induces expression of genes involved in extracellular matrix production but not classical endoplasmic reticulum stress response genes in pancreatic beta-cells. Endocrinology (2010) 0.97
Wild-type levels of the mouse Forkhead Box f1 gene are essential for lung repair. Am J Physiol Lung Cell Mol Physiol (2002) 0.96
Onecut1 is essential for horizontal cell genesis and retinal integrity. J Neurosci (2013) 0.95
Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cells. Diabetes (2006) 0.95
A physiological role for connective tissue growth factor in early wound healing. Lab Invest (2012) 0.95
Inactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function. Am J Physiol Endocrinol Metab (2012) 0.93
Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo. Hepatology (2012) 0.93
Diminished hepatic expression of the HNF-6 transcription factor during bile duct obstruction. Hepatology (2002) 0.93
Differential regulation of embryonic and adult β cell replication. Cell Cycle (2012) 0.93
Advancements and challenges in generating accurate animal models of gestational diabetes mellitus. Am J Physiol Endocrinol Metab (2013) 0.92
Maintaining HNF6 expression prevents AdHNF3beta-mediated decrease in hepatic levels of Glut-2 and glycogen. Hepatology (2002) 0.92
Gene expression profiling of a mouse model of pancreatic islet dysmorphogenesis. PLoS One (2008) 0.92
Hepatocyte nuclear factor 3beta inhibits hepatitis B virus replication in vivo. J Virol (2002) 0.92
Pancreas cell fate. Birth Defects Res C Embryo Today (2009) 0.91
The forkhead box F1 transcription factor is expressed in brain and head mesenchyme during mouse embryonic development. Gene Expr Patterns (2003) 0.88
In vivo regulation of murine CYP7A1 by HNF-6: a novel mechanism for diminished CYP7A1 expression in biliary obstruction. Hepatology (2004) 0.88
Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin. Cancer Biol Ther (2010) 0.88
Rapid hepatocyte nuclear translocation of the Forkhead Box M1B (FoxM1B) transcription factor caused a transient increase in size of regenerating transgenic hepatocytes. Gene Expr (2003) 0.88
Adenovirus-mediated increase in HNF-3beta or HNF-3alpha shows differences in levels of liver glycogen and gene expression. Hepatology (2002) 0.86
Structure of the hepatocyte nuclear factor 6alpha and its interaction with DNA. J Biol Chem (2004) 0.86
Connective tissue growth factor (CTGF/CCN2) negatively regulates BMP-2 induced osteoblast differentiation and signaling. J Cell Physiol (2014) 0.85
Functional polymorphism of the Anpep gene increases promoter activity in the Dahl salt-resistant rat. Hypertension (2007) 0.84
The role of pdx1 and HNF6 in proliferation and differentiation of endocrine precursors. Diabetes Metab Res Rev (2004) 0.84
Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage. Hepatology (2003) 0.82
Diet-induced impaired glucose tolerance and gestational diabetes in the dog. J Appl Physiol (1985) (2010) 0.81
The skeletal site-specific role of connective tissue growth factor in prenatal osteogenesis. Dev Dyn (2012) 0.80
The CAR nuclear receptor and hepatocyte proliferation. Hepatology (2005) 0.80
Transplanted hepatocytes over-expressing FoxM1B efficiently repopulate chronically injured mouse liver independent of donor age. Mol Ther (2007) 0.78
Retraction. Am J Physiol Endocrinol Metab (2017) 0.75