Published in Am J Physiol Gastrointest Liver Physiol on December 04, 2003
Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats. Diabetes (2008) 1.20
Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population. Diabetologia (2009) 1.15
Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion. Diabetes (2008) 1.07
Exenatide sensitizes insulin-mediated whole-body glucose disposal and promotes uptake of exogenous glucose by the liver. Diabetes (2008) 1.03
Fructose in perspective. Nutr Metab (Lond) (2013) 0.96
Evidence against a physiologic role for acute changes in CNS insulin action in the rapid regulation of hepatic glucose production. Cell Metab (2012) 0.95
Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease. Hepatology (2012) 0.94
A physiological increase in the hepatic glycogen level does not affect the response of net hepatic glucose uptake to insulin. Am J Physiol Endocrinol Metab (2009) 0.93
Brought to life: targeted activation of enzyme function with small molecules. J Chem Biol (2008) 0.88
Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study. BMC Med Genet (2011) 0.86
Portal vein glucose entry triggers a coordinated cellular response that potentiates hepatic glucose uptake and storage in normal but not high-fat/high-fructose-fed dogs. Diabetes (2012) 0.86
Evidence for heightened hexokinase II immunoexpression in hepatocyte dysplasia and hepatocellular carcinoma. Dig Dis Sci (2014) 0.83
Normal glucose metabolism in carnivores overlaps with diabetes pathology in non-carnivores. Front Endocrinol (Lausanne) (2013) 0.82
A panel of diverse assays to interrogate the interaction between glucokinase and glucokinase regulatory protein, two vital proteins in human disease. PLoS One (2014) 0.82
Changes in glucose and fat metabolism in response to the administration of a hepato-preferential insulin analog. Diabetes (2014) 0.82
Comparison of the physiological relevance of systemic vs. portal insulin delivery to evaluate whole body glucose flux during an insulin clamp. Am J Physiol Endocrinol Metab (2014) 0.81
Liver glycogen loading dampens glycogen synthesis seen in response to either hyperinsulinemia or intraportal glucose infusion. Diabetes (2012) 0.80
Present status of clinical deployment of glucokinase activators. J Diabetes Investig (2014) 0.80
Glucotoxicity targets hepatic glucokinase in Zucker diabetic fatty rats, a model of type 2 diabetes associated with obesity. Am J Physiol Endocrinol Metab (2014) 0.79
Dynamic localization of glucokinase and its regulatory protein in hypothalamic tanycytes. PLoS One (2014) 0.77
A hepatic protein modulates glucokinase activity in fish and avian liver: a comparative study. J Comp Physiol B (2009) 0.77
The role of CCK8 in the inhibition of glucose production. Cellscience (2009) 0.75
Time-dependent mechanisms in beta-cell glucose sensing. J Biol Phys (2006) 0.75
Portal glucose delivery stimulates muscle but not liver protein metabolism. Am J Physiol Endocrinol Metab (2012) 0.75
Correcting Postprandial Hyperglycemia in Zucker Diabetic Fatty Rats with a SGLT2 Inhibitor Restores Glucose Effectiveness in Liver and Reduces Insulin Resistance in Skeletal Muscle. Diabetes (2017) 0.75
Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med (2010) 36.57
Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell (2006) 5.19
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat Med (2004) 5.04
RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models. Cancer Res (2010) 4.70
Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells. Am J Physiol Endocrinol Metab (2002) 4.45
Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat Med (2005) 4.14
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity (2010) 4.06
Allosteric activators of glucokinase: potential role in diabetes therapy. Science (2003) 3.97
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell (2009) 3.78
Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A (2004) 3.40
Control of pancreatic β cell regeneration by glucose metabolism. Cell Metab (2011) 3.35
Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis (2002) 3.21
Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J Biol Chem (2004) 3.17
Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J (2007) 3.08
Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover. J Clin Invest (2012) 2.98
Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem (2002) 2.87
Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A (2005) 2.60
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature (2002) 2.59
Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes (2006) 2.53
Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab (2007) 2.47
Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity. Mol Cell Biol (2007) 2.32
RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J Biol Chem (2005) 2.32
Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes (2010) 2.30
Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets. Diabetes (2004) 2.26
Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev (2006) 2.15
Of mice and MEN1: Insulinomas in a conditional mouse knockout. Mol Cell Biol (2003) 2.12
Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development (2006) 2.09
Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A (2009) 2.09
Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. J Biol Chem (2003) 2.07
Piragliatin (RO4389620), a novel glucokinase activator, lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus: a mechanistic study. J Clin Endocrinol Metab (2010) 2.05
Novel PEGylated basal insulin LY2605541 has a preferential hepatic effect on glucose metabolism. Diabetes (2013) 2.03
Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. Science (2006) 2.02
MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes (2010) 2.01
Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1. Circ Res (2008) 1.98
Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. J Biol Chem (2004) 1.86
Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. J Biol Chem (2002) 1.85
Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development (2013) 1.83
The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. Diabetes (2006) 1.80
Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Genes Dev (2007) 1.79
Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance. J Biol Chem (2007) 1.73
pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol (2007) 1.68
Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol (2008) 1.67
Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene (2003) 1.62
Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol (2006) 1.61
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol (2003) 1.60
A defect in glucose-induced dissociation of glucokinase from the regulatory protein in Zucker diabetic fatty rats in the early stage of diabetes. Am J Physiol Regul Integr Comp Physiol (2007) 1.58
A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. Genes Dev (2008) 1.54
Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells. J Biol Chem (2005) 1.54
Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice. EMBO J (2003) 1.51
Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol (2005) 1.50
Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming. Genes Dev (2011) 1.48
SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival. Clin Cancer Res (2012) 1.46
The effects of a high-fat meal on single-dose vemurafenib pharmacokinetics. J Clin Pharmacol (2014) 1.45
Regulation of hepatic glucose uptake and storage in vivo. Adv Nutr (2012) 1.44
Insulin's direct effects on the liver dominate the control of hepatic glucose production. J Clin Invest (2006) 1.43
Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene. Genesis (2005) 1.42
Analysis of dermatologic events in vemurafenib-treated patients with melanoma. Oncologist (2013) 1.41
Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Hum Mol Genet (2005) 1.40
Hepatic energy state is regulated by glucagon receptor signaling in mice. J Clin Invest (2009) 1.39
Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Circulation (2011) 1.38
Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass. J Clin Invest (2003) 1.37
Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. PLoS Genet (2013) 1.37
Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size. Diabetes (2011) 1.37
Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation. Diabetes (2003) 1.36
Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo. Diabetes (2010) 1.35
The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy. Diabetes (2002) 1.35
Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations. Diabetes (2003) 1.33
Targeting glucokinase activation for the treatment of type 2 diabetes--a status review. Curr Opin Drug Discov Devel (2005) 1.32
Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis. Am J Physiol Endocrinol Metab (2004) 1.31
Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues. Mol Cell Biol (2004) 1.29
Pancreatic islet vasculature adapts to insulin resistance through dilation and not angiogenesis. Diabetes (2013) 1.24
Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism caused by glucokinase activating mutations. Diabetes (2009) 1.23
Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev (2009) 1.23
Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo. Diabetes (2009) 1.23
Generation of a conditional allele of the mouse prostaglandin EP4 receptor. Genesis (2004) 1.22
Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev (2007) 1.20
From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation. Diabetes (2006) 1.20
Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats. Diabetes (2008) 1.20
Glucose and aging control the quiescence period that follows pancreatic beta cell replication. Development (2010) 1.19
Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver. J Clin Invest (2015) 1.19
Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs. J Clin Invest (2011) 1.18
Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice. PLoS Biol (2010) 1.16
Quantification of factors influencing fluorescent protein expression using RMCE to generate an allelic series in the ROSA26 locus in mice. Dis Model Mech (2011) 1.16
A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes. Mol Cell Biol (2008) 1.15
Assessment of pancreatic islet mass after islet transplantation using in vivo bioluminescence imaging. Transplantation (2005) 1.15
Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2. Mol Cancer Res (2010) 1.15
Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass. Diabetes (2005) 1.14
Direct and indirect effects of insulin on glucose uptake and storage by the liver. Diabetes (2002) 1.14