Published in Chem Biol on April 01, 2004
Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Proc Natl Acad Sci U S A (2008) 3.62
High-mobility group box 1 and cancer. Biochim Biophys Acta (2010) 3.11
Soluble single-walled carbon nanotubes as longboat delivery systems for platinum(IV) anticancer drug design. J Am Chem Soc (2007) 2.82
Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device. J Am Chem Soc (2008) 2.40
New trends for metal complexes with anticancer activity. Curr Opin Chem Biol (2008) 2.06
Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs. Drug Discov Today (2009) 1.47
Conjugated platinum(IV)-peptide complexes for targeting angiogenic tumor vasculature. Bioconjug Chem (2007) 1.46
Novel organometallic cationic ruthenium(II) pentamethylcyclopentadienyl benzenesulfonamide complexes targeted to inhibit carbonic anhydrase. J Biol Inorg Chem (2009) 1.26
Monofunctional and higher-valent platinum anticancer agents. Inorg Chem (2013) 1.13
Novel metals and metal complexes as platforms for cancer therapy. Curr Pharm Des (2010) 1.13
Synthetic methods for the preparation of platinum anticancer complexes. Chem Rev (2013) 1.11
Redox activation of metal-based prodrugs as a strategy for drug delivery. Adv Drug Deliv Rev (2012) 1.06
Spectrum of cellular responses to pyriplatin, a monofunctional cationic antineoplastic platinum(II) compound, in human cancer cells. Mol Cancer Ther (2011) 1.03
Synthesis, characterization, and cytotoxicity of platinum(IV) carbamate complexes. Inorg Chem (2011) 1.02
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs. Chem Rev (2016) 1.02
Pt(IV) prodrugs designed to bind non-covalently to human serum albumin for drug delivery. J Am Chem Soc (2014) 0.97
Antiproliferative Pt(IV) complexes: synthesis, biological activity, and quantitative structure-activity relationship modeling. J Biol Inorg Chem (2010) 0.93
Exploring the cellular accumulation of metal complexes. Dalton Trans (2009) 0.90
Modulation of Ligand Fluorescence by the Pt(II)/Pt(IV) Redox Couple. Inorganica Chim Acta (2012) 0.89
Nanoparticle encapsulation of mitaplatin and the effect thereof on in vivo properties. ACS Nano (2013) 0.88
Cisplatin-loaded porous Si microparticles capped by electroless deposition of platinum. Small (2011) 0.87
Synthesis, characterization, and photophysical properties of three platinum(II) complexes bearing fluorescent analogues of the Di-2-pyridylmethane ligand. Inorg Chem (2010) 0.87
Design, synthesis, and initial biological evaluation of a steroidal anti-estrogen-doxorubicin bioconjugate for targeting estrogen receptor-positive breast cancer cells. Bioconjug Chem (2012) 0.85
Texaphyrins: tumor localizing redox active expanded porphyrins. Anticancer Agents Med Chem (2011) 0.84
A texaphyrin-oxaliplatin conjugate that overcomes both pharmacologic and molecular mechanisms of cisplatin resistance in cancer cells. Medchemcomm (2012) 0.83
Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery. Chem Commun (Camb) (2013) 0.81
Diamminetetrakis(carboxylato)platinum(IV) complexes--synthesis, characterization, and cytotoxicity. Chem Biodivers (2012) 0.80
Molecular and statistical modeling of reduction peak potential and lipophilicity of platinum(IV) complexes. J Biol Inorg Chem (2010) 0.80
The implication and potential applications of high-mobility group box 1 protein in breast cancer. Ann Transl Med (2016) 0.79
Design of a platinum-acridine-endoxifen conjugate targeted at hormone-dependent breast cancer. Chem Commun (Camb) (2013) 0.79
A new hexapeptide from the leader peptide of rMnSOD enters cells through the oestrogen receptor to deliver therapeutic molecules. Sci Rep (2016) 0.79
Convergent synthesis of a steroidal antiestrogen-mitomycin C hybrid using "click" chemistry. Org Biomol Chem (2012) 0.78
Reinterpretation of the vibrational spectroscopy of the medicinal bioinorganic synthon c,c,t-[Pt(NH3)2Cl2(OH)2]. J Biol Inorg Chem (2014) 0.77
Oxidative Reactivity and Cytotoxic Properties of a Platinum(II) Complex Prepared by Outer-Sphere Amide Bond Coupling. Polyhedron (2013) 0.77
Oxidative Stress Induced by Pt(IV) Pro-drugs Based on the Cisplatin Scaffold and Indole Carboxylic Acids in Axial Position. Sci Rep (2016) 0.75
Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes. Bioinorg Chem Appl (2014) 0.75
Platinum(II) chloride indenyl complexes: electrochemical and biological evaluation. J Biol Inorg Chem (2011) 0.75
Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin. Bioinorg Chem Appl (2017) 0.75
Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov (2005) 9.47
Synthetic models for non-heme carboxylate-bridged diiron metalloproteins: strategies and tactics. Chem Rev (2004) 3.73
Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Proc Natl Acad Sci U S A (2008) 3.62
Direct cellular responses to platinum-induced DNA damage. Chem Rev (2007) 3.42
Objective measures of renal mass anatomic complexity predict rates of major complications following partial nephrectomy. Eur Urol (2011) 2.87
Soluble single-walled carbon nanotubes as longboat delivery systems for platinum(IV) anticancer drug design. J Am Chem Soc (2007) 2.82
Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science (2013) 2.61
Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device. J Am Chem Soc (2008) 2.40
Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res (2006) 2.37
Visualization of nitric oxide in living cells by a copper-based fluorescent probe. Nat Chem Biol (2006) 2.33
Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy. Proc Natl Acad Sci U S A (2010) 2.21
Prevalence of baseline chronic kidney disease in patients presenting with solid renal tumors. Urology (2011) 2.20
Polyvalent oligonucleotide gold nanoparticle conjugates as delivery vehicles for platinum(IV) warheads. J Am Chem Soc (2009) 2.16
Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo. Proc Natl Acad Sci U S A (2011) 2.16
Small-molecule fluorescent sensors for investigating zinc metalloneurochemistry. Acc Chem Res (2009) 2.07
Dioxygen activation in soluble methane monooxygenase. Acc Chem Res (2011) 2.07
Small renal masses progressing to metastases under active surveillance: a systematic review and pooled analysis. Cancer (2011) 1.98
Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Genes Dev (2010) 1.95
Correlating structure with function in bacterial multicomponent monooxygenases and related diiron proteins. Acc Chem Res (2006) 1.93
Mechanistic studies on the hydroxylation of methane by methane monooxygenase. Chem Rev (2003) 1.89
New metal complexes as potential therapeutics. Curr Opin Chem Biol (2003) 1.89
Inhibition of transcription by platinum antitumor compounds. Metallomics (2009) 1.88
A novel imaging approach for early detection of prostate cancer based on endogenous zinc sensing. Cancer Res (2010) 1.79
Baseline renal function status limits patient eligibility to receive perioperative chemotherapy for invasive bladder cancer and is minimally affected by radical cystectomy. Urology (2010) 1.77
Tools and tactics for the optical detection of mercuric ion. Chem Rev (2008) 1.77
Photoaffinity isolation and identification of proteins in cancer cell extracts that bind to platinum-modified DNA. Chembiochem (2009) 1.71
Trends in regionalization of adrenalectomy to higher volume surgical centers. J Urol (2012) 1.64
cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects. Proc Natl Acad Sci U S A (2008) 1.62
Characterization of the arene-oxidizing intermediate in ToMOH as a diiron(III) species. J Am Chem Soc (2007) 1.60
Imaging mobile zinc in biology. Curr Opin Chem Biol (2010) 1.57
Assessing performance trends in laparoscopic nephrectomy and nephron-sparing surgery for localized renal tumors. Urology (2012) 1.54
Water-soluble porphyrins as a dual-function molecular imaging platform for MRI and fluorescence zinc sensing. Proc Natl Acad Sci U S A (2007) 1.53
Consequences of cisplatin binding on nucleosome structure and dynamics. Chem Biol (2010) 1.51
Characterization of the particulate methane monooxygenase metal centers in multiple redox states by X-ray absorption spectroscopy. Inorg Chem (2006) 1.50
Intermediates in dioxygen activation by methane monooxygenase: a QM/MM study. J Am Chem Soc (2007) 1.50
Clinical characteristics associated with treatment type for localized renal tumors: implications for practice pattern assessment. Urology (2013) 1.49
Bacillus anthracis-derived nitric oxide is essential for pathogen virulence and survival in macrophages. Proc Natl Acad Sci U S A (2008) 1.49
Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile. Proc Natl Acad Sci U S A (2012) 1.48
Nephron-sparing management vs radical nephroureterectomy for low- or moderate-grade, low-stage upper tract urothelial carcinoma. BJU Int (2014) 1.47
Conjugated platinum(IV)-peptide complexes for targeting angiogenic tumor vasculature. Bioconjug Chem (2007) 1.46
Utility of the R.E.N.A.L. nephrometry scoring system in objectifying treatment decision-making of the enhancing renal mass. Urology (2011) 1.46
Chemical characterization of the smallest S-nitrosothiol, HSNO; cellular cross-talk of H2S and S-nitrosothiols. J Am Chem Soc (2012) 1.46
Robot-assisted partial nephrectomy: a large single-institutional experience. Urology (2010) 1.45
Role of tumor location in selecting patients for percutaneous versus surgical cryoablation of renal masses. Can J Urol (2012) 1.45
Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro. Proc Natl Acad Sci U S A (2002) 1.45
Substrate trafficking and dioxygen activation in bacterial multicomponent monooxygenases. Acc Chem Res (2007) 1.43
Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate. Proc Natl Acad Sci U S A (2009) 1.43
Bacterial nitric-oxide synthases operate without a dedicated redox partner. J Biol Chem (2008) 1.41
The interface of inorganic chemistry and biology. J Am Chem Soc (2010) 1.41
Comparison of prostate cancer diagnosis in patients receiving unrelated urological and non-urological cancer care. BJU Int (2013) 1.41
Enhancing renal tumors in patients with prior normal abdominal imaging: further insight into the natural history of renal cell carcinoma. J Urol (2012) 1.40
X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct. Proc Natl Acad Sci U S A (2010) 1.39
X-ray structure of a hydroxylase-regulatory protein complex from a hydrocarbon-oxidizing multicomponent monooxygenase, Pseudomonas sp. OX1 phenol hydroxylase. Biochemistry (2006) 1.38
How Hugh Hampton Young's treatment of President Woodrow Wilson's urinary retention and urosepsis affected the resolution of World War I. J Urol (2011) 1.38
Reactions of the peroxo intermediate of soluble methane monooxygenase hydroxylase with ethers. J Am Chem Soc (2005) 1.38
Dioxygen activation in methane monooxygenase: a theoretical study. J Am Chem Soc (2004) 1.38
Modeling the syn disposition of nitrogen donors at the active sites of carboxylate-bridged diiron enzymes. Enforcing dinuclearity and kinetic stability with a 1,2-diethynylbenzene-based ligand. Inorg Chem (2003) 1.35
Membrane-permeable and -impermeable sensors of the Zinpyr family and their application to imaging of hippocampal zinc in vivo. Chem Biol (2004) 1.33
Current challenges of modeling diiron enzyme active sites for dioxygen activation by biomimetic synthetic complexes. Chem Soc Rev (2010) 1.33
Dioxygen activation at non-heme diiron centers: characterization of intermediates in a mutant form of toluene/o-xylene monooxygenase hydroxylase. J Am Chem Soc (2006) 1.32
Clinicopathological outcomes after radical cystectomy for clinical T2 urothelial carcinoma: further evidence to support the use of neoadjuvant chemotherapy. BJU Int (2011) 1.31
Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug. Proc Natl Acad Sci U S A (2013) 1.30
Peripheral heme substituents control the hydrogen-atom abstraction chemistry in cytochromes P450. Proc Natl Acad Sci U S A (2003) 1.30
ZP4, an improved neuronal Zn2+ sensor of the Zinpyr family. J Am Chem Soc (2003) 1.29
Vesicular zinc promotes presynaptic and inhibits postsynaptic long-term potentiation of mossy fiber-CA3 synapse. Neuron (2011) 1.29
New strategy for quantifying biological zinc by a modified zinpyr fluorescence sensor. J Am Chem Soc (2008) 1.28
A tautomeric zinc sensor for ratiometric fluorescence imaging: application to nitric oxide-induced release of intracellular zinc. Proc Natl Acad Sci U S A (2004) 1.27
Nucleotide excision repair from site-specifically platinum-modified nucleosomes. Biochemistry (2003) 1.27
Revisiting the mechanism of dioxygen activation in soluble methane monooxygenase from M. capsulatus (Bath): evidence for a multi-step, proton-dependent reaction pathway. Biochemistry (2009) 1.26
Hydroxylation of methane by non-heme diiron enzymes: molecular orbital analysis of C-H bond activation by reactive intermediate Q. J Am Chem Soc (2002) 1.25
Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesis. Proc Natl Acad Sci U S A (2011) 1.25
Carboxylate as the protonation site in (Peroxo)diiron(III) model complexes of soluble methane monooxygenase and related diiron proteins. J Am Chem Soc (2010) 1.24
Modeling dioxygen-activating centers in non-heme diiron enzymes: carboxylate shifts in diiron(II) complexes supported by sterically hindered carboxylate ligands. Inorg Chem (2002) 1.24
Direct detection of nitroxyl in aqueous solution using a tripodal copper(II) BODIPY complex. J Am Chem Soc (2010) 1.23
Bright fluorescent chemosensor platforms for imaging endogenous pools of neuronal zinc. Chem Biol (2004) 1.22
Biochemistry of mobile zinc and nitric oxide revealed by fluorescent sensors. Annu Rev Biochem (2011) 1.21
Metal-based turn-on fluorescent probes for sensing nitric oxide. Acc Chem Res (2007) 1.20
Product bound structures of the soluble methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath): protein motion in the alpha-subunit. J Am Chem Soc (2005) 1.19
RNA polymerase II blockage by cisplatin-damaged DNA. Stability and polyubiquitylation of stalled polymerase. J Biol Chem (2005) 1.19
Zinspy sensors with enhanced dynamic range for imaging neuronal cell zinc uptake and mobilization. J Am Chem Soc (2006) 1.18
Soluble methane monooxygenase: activation of dioxygen and methane. Curr Opin Chem Biol (2002) 1.18
A "turn-on" fluorescent sensor for the selective detection of mercuric ion in aqueous media. J Am Chem Soc (2003) 1.18
Non-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targeting. Dalton Trans (2009) 1.17
Direct nitric oxide detection in aqueous solution by copper(II) fluorescein complexes. J Am Chem Soc (2006) 1.16
Esterase-activated two-fluorophore system for ratiometric sensing of biological zinc(II). Inorg Chem (2005) 1.15
Solution and fluorescence properties of symmetric dipicolylamine-containing dichlorofluorescein-based Zn2+ sensors. J Am Chem Soc (2009) 1.14
QZ1 and QZ2: rapid, reversible quinoline-derivatized fluoresceins for sensing biological Zn(II). J Am Chem Soc (2005) 1.14
Dirhodium tetracarboxylate scaffolds as reversible fluorescence-based nitric oxide sensors. J Am Chem Soc (2004) 1.14
Organelle-specific zinc detection using zinpyr-labeled fusion proteins in live cells. J Am Chem Soc (2008) 1.14
Meeting of the minds: metalloneurochemistry. Proc Natl Acad Sci U S A (2003) 1.14
Monofunctional and higher-valent platinum anticancer agents. Inorg Chem (2013) 1.13
Redox state-dependent interaction of HMGB1 and cisplatin-modified DNA. Biochemistry (2011) 1.13
Characterization of iron dinitrosyl species formed in the reaction of nitric oxide with a biological Rieske center. J Am Chem Soc (2010) 1.12
Control of substrate access to the active site in methane monooxygenase. Nature (2013) 1.12
Synthetic methods for the preparation of platinum anticancer complexes. Chem Rev (2013) 1.11
Zinc and zinc transporters in prostate carcinogenesis. Nat Rev Urol (2013) 1.11
Selective labeling of extracellular proteins containing polyhistidine sequences by a fluorescein-nitrilotriacetic acid conjugate. J Am Chem Soc (2006) 1.10
Reactions of synthetic [2Fe-2S] and [4Fe-4S] clusters with nitric oxide and nitrosothiols. J Am Chem Soc (2008) 1.10
Substrate hydroxylation in methane monooxygenase: quantitative modeling via mixed quantum mechanics/molecular mechanics techniques. J Am Chem Soc (2005) 1.10