Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice.

PubWeight™: 2.46‹?› | Rank: Top 2%

🔗 View Article (PMID 15123526)

Published in Circulation on May 03, 2004

Authors

Frank C Gibson1, Charlie Hong, Hsin-Hua Chou, Hiromichi Yumoto, Jiqiu Chen, Egil Lien, Jodie Wong, Caroline Attardo Genco

Author Affiliations

1: Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass, USA.

Articles citing this

Modulation of atherosclerosis in mice by Toll-like receptor 2. J Clin Invest (2005) 3.91

Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol (2015) 2.44

Insulin resistance and atherosclerosis. J Clin Invest (2006) 2.27

The use of rodent models to investigate host-bacteria interactions related to periodontal diseases. J Clin Periodontol (2008) 2.21

Microbial hijacking of complement-toll-like receptor crosstalk. Sci Signal (2010) 1.91

Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function. Proc Natl Acad Sci U S A (2008) 1.77

Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint. Mol Cell (2009) 1.64

"Gum bug, leave my heart alone!"--epidemiologic and mechanistic evidence linking periodontal infections and atherosclerosis. J Dent Res (2010) 1.61

Does the importance of the C-terminal residues in the maturation of RgpB from Porphyromonas gingivalis reveal a novel mechanism for protein export in a subgroup of Gram-Negative bacteria? J Bacteriol (2006) 1.56

Periodontal disease and systemic conditions: a bidirectional relationship. Odontology (2006) 1.52

Review: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways. Mol Oral Microbiol (2010) 1.44

CD36/SR-B2-TLR2 Dependent Pathways Enhance Porphyromonas gingivalis Mediated Atherosclerosis in the Ldlr KO Mouse Model. PLoS One (2015) 1.39

Porphyromonas gingivalis fimbriae proactively modulate beta2 integrin adhesive activity and promote binding to and internalization by macrophages. Infect Immun (2006) 1.28

Gingipains from Porphyromonas gingivalis W83 induce cell adhesion molecule cleavage and apoptosis in endothelial cells. Infect Immun (2005) 1.21

Pathogen-mediated inflammatory atherosclerosis is mediated in part via Toll-like receptor 2-induced inflammatory responses. J Innate Immun (2010) 1.21

Complement and periodontitis. Biochem Pharmacol (2010) 1.20

Polymicrobial infection with periodontal pathogens specifically enhances microRNA miR-146a in ApoE-/- mice during experimental periodontal disease. Infect Immun (2011) 1.20

Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss. J Immunol (2012) 1.18

Oral infection, hyperglycemia, and endothelial dysfunction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2007) 1.18

Induction of distinct TLR2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriae. J Immunol (2009) 1.17

Toll-like receptor-2 mediates diet and/or pathogen associated atherosclerosis: proteomic findings. PLoS One (2008) 1.15

Why are sex and gender important to basic physiology and translational and individualized medicine? Am J Physiol Heart Circ Physiol (2014) 1.15

Bacteria present in carotid arterial plaques are found as biofilm deposits which may contribute to enhanced risk of plaque rupture. MBio (2014) 1.14

Serum amyloid A directly accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Mol Med (2011) 1.13

Increased atherogenesis during Streptococcus mutans infection in ApoE-null mice. J Dent Res (2012) 1.12

Active invasion of oral and aortic tissues by Porphyromonas gingivalis in mice causally links periodontitis and atherosclerosis. PLoS One (2014) 1.12

Animal models to study host-bacteria interactions involved in periodontitis. Front Oral Biol (2011) 1.12

Sensitization of human aortic endothelial cells to lipopolysaccharide via regulation of Toll-like receptor 4 by bacterial fimbria-dependent invasion. Infect Immun (2005) 1.10

Porphyromonas gingivalis fimbria-dependent activation of inflammatory genes in human aortic endothelial cells. Infect Immun (2005) 1.08

The expression and functions of toll-like receptors in atherosclerosis. Mediators Inflamm (2010) 1.07

Polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic ApoE(null) mice. PLoS One (2013) 1.06

Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile. PLoS One (2011) 1.04

Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation. J Immunol (2008) 1.02

Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen. J Immunol (2012) 1.02

Porphyromonas gingivalis accelerates inflammatory atherosclerosis in the innominate artery of ApoE deficient mice. Atherosclerosis (2010) 1.02

Pathogen-accelerated atherosclerosis occurs early after exposure and can be prevented via immunization. Infect Immun (2006) 0.99

Lipid raft-dependent uptake, signalling and intracellular fate of Porphyromonas gingivalis in mouse macrophages. Cell Microbiol (2008) 0.99

Porphyromonas gingivalis strain specific interactions with human coronary artery endothelial cells: a comparative study. PLoS One (2012) 0.98

Porphyromonas gingivalis lipids inhibit osteoblastic differentiation and function. Infect Immun (2010) 0.97

Hemagglutinin B is involved in the adherence of Porphyromonas gingivalis to human coronary artery endothelial cells. Infect Immun (2005) 0.97

Periodontal innate immune mechanisms relevant to atherosclerosis and obesity. Periodontol 2000 (2010) 0.95

Host adhesive activities and virulence of novel fimbrial proteins of Porphyromonas gingivalis. Infect Immun (2009) 0.95

Gene expression profile analysis of Porphyromonas gingivalis during invasion of human coronary artery endothelial cells. Infect Immun (2005) 0.94

Sequence-independent processing site of the C-terminal domain (CTD) influences maturation of the RgpB protease from Porphyromonas gingivalis. Mol Microbiol (2013) 0.94

Invasion of oral and aortic tissues by oral spirochete Treponema denticola in ApoE(-/-) mice causally links periodontal disease and atherosclerosis. Infect Immun (2014) 0.94

Lipoxin A₄ inhibits porphyromonas gingivalis-induced aggregation and reactive oxygen species production by modulating neutrophil-platelet interaction and CD11b expression. Infect Immun (2011) 0.93

Serine lipids of Porphyromonas gingivalis are human and mouse Toll-like receptor 2 ligands. Infect Immun (2013) 0.93

Porphyromonas gingivalis fimbriae. J Oral Microbiol (2013) 0.92

Immune response of macrophages from young and aged mice to the oral pathogenic bacterium Porphyromonas gingivalis. Immun Ageing (2010) 0.90

Distinct lipid a moieties contribute to pathogen-induced site-specific vascular inflammation. PLoS Pathog (2014) 0.90

Fusobacterium nucleatum Alters Atherosclerosis Risk Factors and Enhances Inflammatory Markers with an Atheroprotective Immune Response in ApoE(null) Mice. PLoS One (2015) 0.90

Periodontal disease and risk of atherosclerotic coronary heart disease. Odontology (2009) 0.89

Differential virulence and innate immune interactions of Type I and II fimbrial genotypes of Porphyromonas gingivalis. Oral Microbiol Immunol (2009) 0.89

Nasal vaccination with the 40-kilodalton outer membrane protein of Porphyromonas gingivalis and a nontoxic chimeric enterotoxin adjuvant induces long-term protective immunity with reduced levels of immunoglobulin E antibodies. Infect Immun (2008) 0.88

Gingival vascular functions are altered in type 2 diabetes mellitus model and/or periodontitis model. J Clin Biochem Nutr (2012) 0.88

Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss. Proc Natl Acad Sci U S A (2013) 0.88

Genomic comparison of invasive and rare non-invasive strains reveals Porphyromonas gingivalis genetic polymorphisms. J Oral Microbiol (2011) 0.86

Pathogen-mediated proteolysis of the cell death regulator RIPK1 and the host defense modulator RIPK2 in human aortic endothelial cells. PLoS Pathog (2012) 0.86

Recognition of Porphyromonas gingivalis gingipain epitopes by natural IgM binding to malondialdehyde modified low-density lipoprotein. PLoS One (2012) 0.86

Exome capture from saliva produces high quality genomic and metagenomic data. BMC Genomics (2014) 0.86

P. gingivalis and E. coli lipopolysaccharides exhibit different systemic but similar local induction of inflammatory markers. J Periodontol (2008) 0.85

Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice. J Gastroenterol (2013) 0.85

Receptor for advanced glycation endproducts mediates pro-atherogenic responses to periodontal infection in vascular endothelial cells. Atherosclerosis (2010) 0.85

Disruption of immune regulation by microbial pathogens and resulting chronic inflammation. J Cell Physiol (2013) 0.85

Free lipid A isolated from Porphyromonas gingivalis lipopolysaccharide is contaminated with phosphorylated dihydroceramide lipids: recovery in diseased dental samples. Infect Immun (2011) 0.85

Apolipoprotein A-I inhibits LPS-induced atherosclerosis in ApoE(-/-) mice possibly via activated STAT3-mediated upregulation of tristetraprolin. Acta Pharmacol Sin (2013) 0.84

Chronic oral infection with major periodontal bacteria Tannerella forsythia modulates systemic atherosclerosis risk factors and inflammatory markers. Pathog Dis (2015) 0.84

A prospective cohort study of periodontal disease measures and cardiovascular disease markers in HIV-infected adults. AIDS Res Hum Retroviruses (2011) 0.83

Porphyromonas gingivalis infection and prothrombotic effects in human aortic smooth muscle cells. Thromb Res (2008) 0.83

Porphyromonas gingivalis-dendritic cell interactions: consequences for coronary artery disease. J Oral Microbiol (2010) 0.82

Oxidized LDLs inhibit TLR-induced IL-10 production by monocytes: a new aspect of pathogen-accelerated atherosclerosis. Inflammation (2012) 0.82

Bacterial invasion of vascular cell types: vascular infectology and atherogenesis. Future Cardiol (2012) 0.81

What fans the fire: insights into mechanisms of inflammation in atherosclerosis and diabetes mellitus. Circulation (2011) 0.81

Polymicrobial Oral Infection with Four Periodontal Bacteria Orchestrates a Distinct Inflammatory Response and Atherosclerosis in ApoEnull Mice. PLoS One (2015) 0.81

Oral P. gingivalis infection alters the vascular reactivity in healthy and spontaneously atherosclerotic mice. Lipids Health Dis (2011) 0.80

Porphyromonas gingivalis in periodontal pockets and heart valves. Virulence (2014) 0.80

Effects of Intravenous Injection of Porphyromonas gingivalis on Rabbit Inflammatory Immune Response and Atherosclerosis. Mediators Inflamm (2015) 0.79

Porphyromonas gingivalis promotes neointimal formation after arterial injury through toll-like receptor 2 signaling. Heart Vessels (2013) 0.79

The Interaction between Enterobacteriaceae and Calcium Oxalate Deposits. PLoS One (2015) 0.79

Periodontal Pathogens Invade Gingiva and Aortic Adventitia and Elicit Inflammasome Activation in αvβ6 Integrin-Deficient Mice. Infect Immun (2015) 0.79

Linking the Microbiota, Chronic Disease, and the Immune System. Trends Endocrinol Metab (2016) 0.79

The role of heme binding by DNA-protective protein from starved cells (Dps) in the Tolerance of Porphyromonas gingivalis to heme toxicity. J Biol Chem (2012) 0.78

A mouse model for pathogen-induced chronic inflammation at local and systemic sites. J Vis Exp (2014) 0.78

Propionibacterium acnes Recovered from Atherosclerotic Human Carotid Arteries Undergoes Biofilm Dispersion and Releases Lipolytic and Proteolytic Enzymes in Response to Norepinephrine Challenge In Vitro. Infect Immun (2015) 0.78

Periodontal pathogens and atherosclerosis: implications of inflammation and oxidative modification of LDL. Biomed Res Int (2014) 0.78

Nasal immunization with a fusion protein consisting of the hemagglutinin A antigenic region and the maltose-binding protein elicits CD11c(+) CD8(+) dendritic cells for induced long-term protective immunity. Infect Immun (2010) 0.77

Distinct gene signatures in aortic tissue from ApoE-/- mice exposed to pathogens or Western diet. BMC Genomics (2014) 0.77

Global TLR2 and 4 deficiency in mice impacts bone resorption, inflammatory markers and atherosclerosis to polymicrobial infection. Mol Oral Microbiol (2016) 0.77

Unraveling the link between periodontitis and cardiovascular disease. J Am Heart Assoc (2013) 0.77

Periodontal innate immune mechanisms relevant to atherosclerosis. Mol Oral Microbiol (2014) 0.76

Dendritic cells: microbial clearance via autophagy and potential immunobiological consequences for periodontal disease. Periodontol 2000 (2015) 0.75

Liver X receptors contribute to periodontal pathogen-elicited inflammation and oral bone loss. Mol Oral Microbiol (2015) 0.75

Myxomavirus anti-inflammatory chemokine binding protein reduces the increased plaque growth induced by chronic Porphyromonas gingivalis oral infection after balloon angioplasty aortic injury in mice. PLoS One (2014) 0.75

Evaluation of the effect of andrographolide on atherosclerotic rabbits induced by Porphyromonas gingivalis. Biomed Res Int (2014) 0.75

Specific Inflammatory Stimuli Lead to Distinct Platelet Responses in Mice and Humans. PLoS One (2015) 0.75

Articles by these authors

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature (2010) 10.60

TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol (2004) 8.06

The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury. Cardiovasc Res (2013) 3.92

Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response. Nat Immunol (2006) 3.89

Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction. J Biol Chem (2002) 3.58

Hemagglutinin protein of wild-type measles virus activates toll-like receptor 2 signaling. J Virol (2002) 2.86

Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4. Circulation (2002) 2.44

The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes. Immunity (2010) 2.29

Identification of iron-activated and -repressed Fur-dependent genes by transcriptome analysis of Neisseria meningitidis group B. Proc Natl Acad Sci U S A (2003) 2.17

Clinical predictors of long-term outcomes in patients with critical limb ischemia who have undergone endovascular therapy. Angiology (2013) 2.08

Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling. J Immunol (2002) 1.88

A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia. J Immunol (2006) 1.76

Injury primes the innate immune system for enhanced Toll-like receptor reactivity. J Immunol (2003) 1.76

Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. EMBO J (2006) 1.72

Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy. Circulation (2009) 1.71

The NLRP12 inflammasome recognizes Yersinia pestis. Immunity (2012) 1.70

Stem cell factor gene transfer promotes cardiac repair after myocardial infarction via in situ recruitment and expansion of c-kit+ cells. Circ Res (2012) 1.68

Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids. Atherosclerosis (2007) 1.67

Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. J Immunol (2002) 1.63

Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling: role of CD14 and CD36. J Leukoc Biol (2008) 1.61

Mediation analysis reveals a sex-dependent association between ABO gene variants and TG/HDL-C ratio that is suppressed by sE-selectin level. Atherosclerosis (2013) 1.50

Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome. J Immunol (2010) 1.42

Dual vascular access for critical limb ischemia: immediate and follow-up results. Catheter Cardiovasc Interv (2011) 1.39

Iron and heme utilization in Porphyromonas gingivalis. FEMS Microbiol Rev (2005) 1.36

Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection. PLoS Pathog (2006) 1.35

MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation. J Biol Chem (2009) 1.35

TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats. J Immunol (2005) 1.29

The gonococcal fur regulon: identification of additional genes involved in major catabolic, recombination, and secretory pathways. J Bacteriol (2002) 1.26

UNC93B1 mediates host resistance to infection with Toxoplasma gondii. PLoS Pathog (2010) 1.22

TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat. J Immunol (2007) 1.21

Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection. Proc Natl Acad Sci U S A (2005) 1.20

Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers. J Biol Chem (2002) 1.16

Macrophage-elicited osteoclastogenesis in response to bacterial stimulation requires Toll-like receptor 2-dependent tumor necrosis factor-alpha production. Infect Immun (2007) 1.12

Role for fimbriae and lysine-specific cysteine proteinase gingipain K in expression of interleukin-8 and monocyte chemoattractant protein in Porphyromonas gingivalis-infected endothelial cells. Infect Immun (2002) 1.12

Increased expression of toll-like receptor 2 on monocytes in HIV infection: possible roles in inflammation and viral replication. Clin Infect Dis (2004) 1.11

Fimbria-dependent activation of pro-inflammatory molecules in Porphyromonas gingivalis infected human aortic endothelial cells. Cell Microbiol (2006) 1.11

Inflammasomes and host defenses against bacterial infections. Curr Opin Microbiol (2013) 1.11

Sensitization of human aortic endothelial cells to lipopolysaccharide via regulation of Toll-like receptor 4 by bacterial fimbria-dependent invasion. Infect Immun (2005) 1.10

MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses. J Immunol (2007) 1.09

Toll-like receptors and their function in innate and adaptive immunity. Int Arch Allergy Immunol (2003) 1.08

Fimbria-dependent activation of cell adhesion molecule expression in Porphyromonas gingivalis-infected endothelial cells. Infect Immun (2002) 1.08

Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration. J Immunol (2008) 1.08

Porphyromonas gingivalis fimbria-dependent activation of inflammatory genes in human aortic endothelial cells. Infect Immun (2005) 1.08

Identification of amino acid residues involved in heme binding and hemoprotein utilization in the Porphyromonas gingivalis heme receptor HmuR. Infect Immun (2006) 1.06

Evaluation of the role of LcrV-Toll-like receptor 2-mediated immunomodulation in the virulence of Yersinia pestis. Infect Immun (2007) 1.05

Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi. J Immunol (2008) 1.03

High-throughput FRET assay yields allosteric SERCA activators. J Biomol Screen (2012) 1.01

MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4). J Leukoc Biol (2006) 1.01

Lipopolysaccharide and double-stranded RNA up-regulate toll-like receptor 2 independently of myeloid differentiation factor 88. J Biol Chem (2004) 0.99

Pathogen-accelerated atherosclerosis occurs early after exposure and can be prevented via immunization. Infect Immun (2006) 0.99

The LPS receptor generates inflammatory signals from the cell surface. J Endotoxin Res (2003) 0.99

A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif. Proc Natl Acad Sci U S A (2003) 0.98

Three-dimensional quantification of alveolar bone loss in Porphyromonas gingivalis-infected mice using micro-computed tomography. J Periodontol (2005) 0.97

D27-pLpxL, an avirulent strain of Yersinia pestis, primes T cells that protect against pneumonic plague. Infect Immun (2009) 0.96

Long-term in vivo resistin overexpression induces myocardial dysfunction and remodeling in rats. J Mol Cell Cardiol (2011) 0.95

Comparison of tongue functions between mature and tongue-thrust swallowing--an ultrasound investigation. Am J Orthod Dentofacial Orthop (2004) 0.95

Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling. Blood (2008) 0.94

Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: interaction with obesity. Atherosclerosis (2008) 0.93

Fur-mediated activation of gene transcription in the human pathogen Neisseria gonorrhoeae. J Bacteriol (2012) 0.93

Cell distributions and functions of Toll-like receptor 4 studied by fluorescent gene constructs. Scand J Infect Dis (2003) 0.92

CXCR4 gene transfer prevents pressure overload induced heart failure. J Mol Cell Cardiol (2012) 0.91

Association between functional variants of the ICAM1 and CRP genes and metabolic syndrome in Taiwanese subjects. Metabolism (2010) 0.91

Soluble toll-like receptor 2 in HIV infection: association with disease progression. AIDS (2004) 0.91

Induction of diabetes in the RIP-B7.1 mouse model is critically dependent on TLR3 and MyD88 pathways and is associated with alterations in the intestinal microbiome. Diabetes (2013) 0.91

TLR4 is a negative regulator in noninfectious lung inflammation. J Immunol (2010) 0.90

Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus. Infect Immun (2009) 0.90

Tea catechins reduce inflammatory reactions via mitogen-activated protein kinase pathways in toll-like receptor 2 ligand-stimulated dental pulp cells. Life Sci (2010) 0.89

Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. J Infect (2008) 0.88

Anti-inflammatory effect of catechin on cultured human dental pulp cells affected by bacteria-derived factors. Eur J Oral Sci (2010) 0.88

Growth-differentiation factor-15 and major cardiac events. Am J Med Sci (2014) 0.87

The essentiality and involvement of Streptococcus intermedius histone-like DNA-binding protein in bacterial viability and normal growth. Mol Microbiol (2008) 0.87

Draft Genome Sequence of Porphyromonas gingivalis Strain SJD2, Isolated from the Periodontal Pocket of a Patient with Periodontitis in China. Genome Announc (2014) 0.87

Gingipain-specific IgG in the sera of patients with periodontal disease is necessary for opsonophagocytosis of Porphyromonas gingivalis. J Periodontol (2005) 0.87

Pathogen-mediated proteolysis of the cell death regulator RIPK1 and the host defense modulator RIPK2 in human aortic endothelial cells. PLoS Pathog (2012) 0.86

An immunohistological study of the localization of bacteria invading root pulpal walls of teeth with periapical lesions. J Endod (2003) 0.85

Adjuvants and their signaling pathways: beyond TLRs. Nat Immunol (2003) 0.85

Coordinate expression of the Porphyromonas gingivalis lysine-specific gingipain proteinase, Kgp, arginine-specific gingipain proteinase, RgpA, and the heme/hemoglobin receptor, HmuR. Biol Chem (2004) 0.85

Correlates of impaired global right ventricular function in patients with a reperfused acute myocardial infarction and without right ventricular infarction. J Investig Med (2013) 0.84

Association of soluble intercellular adhesion molecule-1 with insulin resistance and metabolic syndrome in Taiwanese. Metabolism (2009) 0.84

Ectopic and atretic ostium of left main coronary artery: from interleaflet triangle between left and noncoronary cusps. Tex Heart Inst J (2012) 0.83

Effect of obesity on the association between common variations in the HNF1A gene region and C-reactive protein level in Taiwanese. Clin Chim Acta (2010) 0.83

Porphyromonas gingivalis-specific immunoglobulin G prevents P. gingivalis-elicited oral bone loss in a murine model. Infect Immun (2004) 0.83

Differential gene expression downstream of Toll-like receptors (TLRs): role of c-Src and activating transcription factor 3 (ATF3). J Biol Chem (2010) 0.83

Oxidative stress and compartment of gene expression determine proatherosclerotic effects of inducible nitric oxide synthase. Am J Pathol (2009) 0.83

Fur-mediated global regulatory circuits in pathogenic Neisseria species. J Bacteriol (2012) 0.83

Biofilm formation of Candida albicans on implant overdenture materials and its removal. J Dent (2012) 0.82

Comparison of echocardiographic measurements of left ventricular volumes to full volume magnetic resonance imaging in normal and diseased rats. J Am Soc Echocardiogr (2013) 0.82

Toll-like receptor 2 deficiency results in impaired antibody responses and septic shock during Borrelia hermsii infection. Infect Immun (2010) 0.82

Development of a preclinical model of ischemic cardiomyopathy in swine. Am J Physiol Heart Circ Physiol (2011) 0.82

Synergistic role of protein phosphatase inhibitor 1 and sarco/endoplasmic reticulum Ca2+ -ATPase in the acquisition of the contractile phenotype of arterial smooth muscle cells. Circulation (2013) 0.81

Histone-like DNA binding protein of Streptococcus intermedius induces the expression of pro-inflammatory cytokines in human monocytes via activation of ERK1/2 and JNK pathways. Cell Microbiol (2007) 0.81

Serum cytokine profiles associated with specific adjuvants used in a DNA prime-protein boost vaccination strategy. PLoS One (2013) 0.81

Toll-like receptor 3-elicited MAPK activation induces stabilization of interferon-β mRNA. Cytokine (2011) 0.80