Published in Proc Natl Acad Sci U S A on December 09, 2013
The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases. Annu Rev Med (2015) 1.33
Nucleotide-binding oligomerization domain 2 receptor is expressed in platelets and enhances platelet activation and thrombosis. Circulation (2015) 1.12
Microbial diversity similarities in periodontal pockets and atheromatous plaques of cardiovascular disease patients. PLoS One (2014) 0.95
Aggregatibacter actinomycetemcomitans outer membrane vesicles are internalized in human host cells and trigger NOD1- and NOD2-dependent NF-κB activation. Infect Immun (2014) 0.92
Mini but mighty: microRNAs in the pathobiology of periodontal disease. Periodontol 2000 (2015) 0.80
Modulation of unloading-induced bone loss in mice with altered ERK signaling. Mamm Genome (2015) 0.78
Periodontal innate immune mechanisms relevant to atherosclerosis. Mol Oral Microbiol (2014) 0.76
HIV-associated changes in the enteric microbial community: potential role in loss of homeostasis and development of systemic inflammation. Curr Opin Infect Dis (2016) 0.76
Prevention of alveolar bone loss in an osteoporotic animal model via interference of semaphorin 4d. J Dent Res (2014) 0.75
Role of Nucleotide-binding and Oligomerization Domain 2 Protein (NOD2) in the Development of Atherosclerosis. Korean J Physiol Pharmacol (2015) 0.75
Immuno-pathogenesis of Periodontal Disease: Current and Emerging Paradigms. Curr Oral Health Rep (2014) 0.75
Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach. PLoS Med (2017) 0.75
Kava-241 Reduced Periodontal Destruction in a Collagen Antibody Primed Porphyromonas gingivalis Model of Periodontitis. J Clin Periodontol (2017) 0.75
Toll-like receptor signalling. Nat Rev Immunol (2004) 34.74
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature (2001) 33.12
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature (2001) 28.24
Inflammatory bowel disease. N Engl J Med (2009) 8.62
NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu Rev Biochem (2005) 6.18
Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol (2009) 6.11
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol (2009) 5.83
CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells. Gastroenterology (2003) 3.70
Nod2 is required for the regulation of commensal microbiota in the intestine. Proc Natl Acad Sci U S A (2009) 3.58
Crohn's disease and the NOD2 gene: a role for paneth cells. Gastroenterology (2003) 2.72
Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation (2004) 2.46
Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. J Biol Chem (2004) 2.18
Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity (2006) 2.06
Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2. Circ Res (2010) 2.04
Microbiology of odontogenic bacteremia: beyond endocarditis. Clin Microbiol Rev (2009) 1.71
Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect Immun (2009) 1.49
CXC chemokine ligand 4 induces a unique transcriptome in monocyte-derived macrophages. J Immunol (2010) 1.41
Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A (1996) 1.35
Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP. J Biol Chem (2012) 1.26
Innate sensors of pathogen and stress: linking inflammation to obesity. J Allergy Clin Immunol (2013) 1.25
Transient bacteremia induced by toothbrushing a comparison of the Sonicare toothbrush with a conventional toothbrush. Pediatr Dent (2002) 1.22
Toll-like receptors, NOD1, and NOD2 in oral epithelial cells. J Dent Res (2006) 1.19
Toll-like receptor-2 mediates diet and/or pathogen associated atherosclerosis: proteomic findings. PLoS One (2008) 1.15
Molecular detection of Treponema denticola and Porphyromonas gingivalis in carotid and aortic atheromatous plaques by FISH: report of two cases. J Med Microbiol (2005) 1.11
Roles of TLR2, TLR4, NOD2, and NOD1 in pulp fibroblasts. J Dent Res (2009) 1.10
Is inflammatory bowel disease a risk factor for early atherosclerosis? Angiology (2009) 1.06
Expression of TRAF6 and pro-inflammatory cytokines through activation of TLR2, TLR4, NOD1, and NOD2 in human periodontal ligament fibroblasts. Arch Oral Biol (2011) 0.98
Periodontal innate immune mechanisms relevant to atherosclerosis and obesity. Periodontol 2000 (2010) 0.95
Induction and localization of NOD2 protein in human endothelial cells. Cell Immunol (2005) 0.95
Toll-like receptors and immune response in allergic disease. Clin Rev Allergy Immunol (2004) 0.94
Receptor activator of nuclear factor kappa B ligand antagonists inhibit tissue inflammation and bone loss in experimental periodontitis. J Clin Periodontol (2011) 0.94
Atherosclerosis: a classic inflammatory disease. Int J Immunopathol Pharmacol (2012) 0.93
Is Porphyromonas gingivalis cell invasion required for atherogenesis? Pharmacotherapeutic implications. J Immunol (2009) 0.93
Nucleotide oligomerization domains 1 and 2: regulation of expression and function in preadipocytes. J Immunol (2008) 0.92
Evaluation of early atherosclerosis in patients with inflammatory bowel disease. Dig Dis Sci (2012) 0.91
Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology. J Clin Periodontol (2013) 0.91
The association between inflammatory bowel disease and periodontitis among Jordanians: a case-control study. J Periodontal Res (2011) 0.90
The effect of NOD2 activation on TLR2-mediated cytokine responses is dependent on activation dose and NOD2 genotype. Genes Immun (2008) 0.89
Beneficial dysregulation of the time course of inflammatory mediators in lipopolysaccharide-induced tumor necrosis factor alpha factor-deficient mice. Clin Vaccine Immunol (2010) 0.89
Mast cells squeeze the heart and stretch the gird: their role in atherosclerosis and obesity. Trends Pharmacol Sci (2011) 0.88
MDP-NOD2 stimulation induces HNP-1 secretion, which contributes to NOD2 antibacterial function. Inflamm Bowel Dis (2010) 0.86
NF-κB1 inhibits NOD2-induced cytokine secretion through ATF3-dependent mechanisms. Mol Cell Biol (2013) 0.85
Direct bacterial killing in vitro by recombinant Nod2 is compromised by Crohn's disease-associated mutations. PLoS One (2010) 0.85
Subgingival microflora in inflammatory bowel disease patients with untreated periodontitis. Eur J Gastroenterol Hepatol (2013) 0.84
How do elevated triglycerides and low HDL-cholesterol affect inflammation and atherothrombosis? Curr Cardiol Rep (2013) 0.84
Proinflammatory effects of muramyldipeptide on human gingival fibroblasts. J Periodontal Res (2010) 0.84
A quantitative measurement of bacteremia and its relationship to plaque control. J Periodontol (1976) 0.82
Nucleotide-binding oligomerization domain protein 2 deficiency enhances neointimal formation in response to vascular injury. Arterioscler Thromb Vasc Biol (2011) 0.79
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci U S A (2007) 3.13
Porphyromonas gingivalis infection accelerates the progression of atherosclerosis in a heterozygous apolipoprotein E-deficient murine model. Circulation (2002) 2.16
Deep sequencing of the oral microbiome reveals signatures of periodontal disease. PLoS One (2012) 1.96
Interleukin-1 receptor signaling mediates atherosclerosis associated with bacterial exposure and/or a high-fat diet in a murine apolipoprotein E heterozygote model: pharmacotherapeutic implications. Circulation (2004) 1.82
Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine. Biomaterials (2012) 1.81
Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein. Infect Immun (2005) 1.77
Statins (HMG-CoA reductase inhibitors) decrease postoperative adhesions by increasing peritoneal fibrinolytic activity. Ann Surg (2007) 1.75
A new transcription factor that regulates TNF-alpha gene expression, LITAF, is increased in intestinal tissues from patients with CD and UC. Inflamm Bowel Dis (2006) 1.69
Periodontal disease and systemic conditions: a bidirectional relationship. Odontology (2006) 1.52
LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways. Proc Natl Acad Sci U S A (2006) 1.40
A role for advanced glycation end products in diminished bone healing in type 1 diabetes. Diabetes (2003) 1.34
LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines. Proc Natl Acad Sci U S A (2005) 1.29
Identification and functional characterization of a novel binding site on TNF-alpha promoter. Proc Natl Acad Sci U S A (2003) 1.28
Metabolic network model of a human oral pathogen. J Bacteriol (2008) 1.26
Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses. Proc Natl Acad Sci U S A (2009) 1.25
Identification of signaling pathways in macrophage exposed to Porphyromonas gingivalis or to its purified cell wall components. J Immunol (2007) 1.22
Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. Proc Natl Acad Sci U S A (2006) 1.22
Toll-like receptor-2 mediates diet and/or pathogen associated atherosclerosis: proteomic findings. PLoS One (2008) 1.15
Morphometric, histomorphometric, and microcomputed tomographic analysis of periodontal inflammatory lesions in a murine model. J Periodontol (2007) 1.15
Differences in the length of the carboxyl terminus mediate functional properties of neurokinin-1 receptor. Proc Natl Acad Sci U S A (2008) 1.14
Neurokinin-1 receptor and substance P messenger RNA levels increase during intraabdominal adhesion formation. J Surg Res (2002) 1.11
A neurokinin 1 receptor antagonist decreases postoperative peritoneal adhesion formation and increases peritoneal fibrinolytic activity. Proc Natl Acad Sci U S A (2004) 1.11
Inflammation and tissue loss caused by periodontal pathogens is reduced by interleukin-1 antagonists. J Infect Dis (2002) 1.10
Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages. J Clin Invest (2009) 1.09
Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation. Ann N Y Acad Sci (2010) 1.09
A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis. Proc Natl Acad Sci U S A (2007) 1.08
Chitosan acetate bandage as a topical antimicrobial dressing for infected burns. Antimicrob Agents Chemother (2008) 1.07
Functional consequences of alteration of N-linked glycosylation sites on the neurokinin 1 receptor. Proc Natl Acad Sci U S A (2007) 1.02
Identification of proteins differentially expressed in human monocytes exposed to Porphyromonas gingivalis and its purified components by high-throughput immunoblotting. Infect Immun (2006) 1.02
Human mast cell degranulation and preformed TNF secretion require mitochondrial translocation to exocytosis sites: relevance to atopic dermatitis. J Allergy Clin Immunol (2011) 1.02
Atheroprotective role of interleukin-6 in diet- and/or pathogen-associated atherosclerosis using an ApoE heterozygote murine model. Atherosclerosis (2007) 1.02
Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice. Brain (2003) 1.02
Signaling mechanisms in the restoration of impaired immune function due to diet-induced obesity. Proc Natl Acad Sci U S A (2011) 0.98
Practical limitations of bioresorbable membranes in the prevention of intra-abdominal adhesions. J Gastrointest Surg (2008) 0.97
Influence of diabetes on the exacerbation of an inflammatory response in cardiovascular tissue. Endocrinology (2004) 0.97
Periodontal innate immune mechanisms relevant to atherosclerosis and obesity. Periodontol 2000 (2010) 0.95
Short- and long-term effects of IL-1 and TNF antagonists on periodontal wound healing. J Immunol (2004) 0.95
Doxycycline affects diet- and bacteria-associated atherosclerosis in an ApoE heterozygote murine model: cytokine profiling implications. Atherosclerosis (2006) 0.94
Secreted frizzled-related protein 1 (SFRP1) protects fibroblasts from ceramide-induced apoptosis. J Biol Chem (2003) 0.94
A neurokinin 1 receptor antagonist reduces an ongoing ileal pouch inflammation and the response to a subsequent inflammatory stimulus. Am J Physiol Gastrointest Liver Physiol (2003) 0.94
Receptor activator of nuclear factor kappa B ligand antagonists inhibit tissue inflammation and bone loss in experimental periodontitis. J Clin Periodontol (2011) 0.94
Contribution of interleukin-11 and prostaglandin(s) in lipopolysaccharide-induced bone resorption in vivo. Infect Immun (2002) 0.93
Porphyromonas gingivalis fimbriae are pro-inflammatory but do not play a prominent role in the innate immune response to P. gingivalis. J Endotoxin Res (2005) 0.92
Substance P induces rapid and transient membrane blebbing in U373MG cells in a p21-activated kinase-dependent manner. PLoS One (2011) 0.91
Molecular cloning and characterization of mouse LITAF cDNA: role in the regulation of tumor necrosis factor-alpha (TNF-alpha) gene expression. J Endotoxin Res (2004) 0.90
p53 short peptide (p53pep164) regulates lipopolysaccharide-induced tumor necrosis factor-alpha factor/cytokine expression. Cancer Res (2007) 0.90
Truncated neurokinin-1 receptor is increased in colonic epithelial cells from patients with colitis-associated cancer. Proc Natl Acad Sci U S A (2011) 0.89
Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action. Endocrinology (2011) 0.89
Beneficial dysregulation of the time course of inflammatory mediators in lipopolysaccharide-induced tumor necrosis factor alpha factor-deficient mice. Clin Vaccine Immunol (2010) 0.89
Whole-body deletion of LPS-induced TNF-α factor (LITAF) markedly improves experimental endotoxic shock and inflammatory arthritis. Proc Natl Acad Sci U S A (2011) 0.88
Functional disturbances in the striatum by region-specific ablation of NMDA receptors. Proc Natl Acad Sci U S A (2008) 0.88
Metabolic proximity in the order of colonization of a microbial community. PLoS One (2013) 0.87
LITAF, a BCL6 target gene, regulates autophagy in mature B-cell lymphomas. Br J Haematol (2013) 0.86
BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2013) 0.86
Identification and characterization of kava-derived compounds mediating TNF-alpha suppression. Chem Biol Drug Des (2009) 0.84
Localized ridge augmentation with allogenic block grafts prior to implant placement: case reports and histologic evaluations. Implant Dent (2005) 0.84
Immunization enhances inflammation and tissue destruction in response to Porphyromonas gingivalis. Infect Immun (2006) 0.84
LITAF mediation of increased TNF-α secretion from inflamed colonic lamina propria macrophages. PLoS One (2011) 0.84
Stem cells of the lamina propria of human oral mucosa and gingiva develop into mineralized tissues in vivo. J Clin Periodontol (2012) 0.83
Inhibitory effects of a neurokinin-1 receptor antagonist on postoperative peritoneal adhesion formation. Ann N Y Acad Sci (2008) 0.83
Proteomic mapping of stimulus-specific signaling pathways involved in THP-1 cells exposed to Porphyromonas gingivalis or its purified components. J Proteome Res (2007) 0.82
A neurokinin-1 receptor antagonist that reduces intraabdominal adhesion formation increases peritoneal matrix metalloproteinase activity. Wound Repair Regen (2007) 0.81
Role for moesin in lipopolysaccharide-stimulated signal transduction. Infect Immun (2004) 0.81
Bioinformatics analysis of macrophages exposed to Porphyromonas gingivalis: implications in acute vs. chronic infections. PLoS One (2010) 0.80
Controlling the outcome of the Toll-like receptor signaling pathways. PLoS One (2012) 0.79
Local injection of dsRNA targeting calcitonin receptor-like receptor (CLR) ameliorates Clostridium difficile toxin A-induced ileitis. Proc Natl Acad Sci U S A (2012) 0.78
Role of interleukin-1 in bacterial atherogenesis. Drugs Today (Barc) (2006) 0.78
Novel transcriptional regulation of VEGF in inflammatory processes. J Cell Mol Med (2013) 0.78
A PTP4A3 peptide PIMAP39 modulates TNF-alpha levels and endotoxic shock. J Innate Immun (2009) 0.78
Partial restoration of macrophage alteration from diet-induced obesity in response to Porphyromonas gingivalis infection. PLoS One (2013) 0.77
Novel regulation of CCL2 gene expression by murine LITAF and STAT6B. PLoS One (2011) 0.77
The effectiveness of a single intraperitoneal infusion of a neurokinin-1 receptor antagonist in reducing postoperative adhesion formation is time dependent. Surgery (2007) 0.77
Cloning and characterization of lipopolysaccharide-induced tumor necrosis factor alpha factor promoter. FEMS Immunol Med Microbiol (2006) 0.77
An FDA approved neurokinin-1 receptor antagonist is effective in reducing intraabdominal adhesions when administered intraperitoneally, but not orally. J Gastrointest Surg (2008) 0.77
Role of insulin-like growth factor-1 signaling in dental fibroblast apoptosis. J Periodontol (2003) 0.76
p53 suppresses CCL2-induced subcutaneous tumor xenograft. Tumour Biol (2014) 0.75
Plasminogen activator inhibitor-1 is increased in colonic epithelial cells from patients with colitis-associated cancer. J Crohns Colitis (2012) 0.75
Role of interleukin-1 in bacterial atherogenesis. Timely Top Med Cardiovasc Dis (2007) 0.75