Periodontal innate immune mechanisms relevant to atherosclerosis and obesity.

PubWeight™: 0.95‹?› | Rank: Top 15%

🔗 View Article (PMC 2928057)

Published in Periodontol 2000 on October 01, 2010

Authors

Sami A Zelkha, Robert W Freilich, Salomon Amar

Articles citing this

Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol (2015) 2.44

Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine. Biomaterials (2012) 1.81

Breaking bad: manipulation of the host response by Porphyromonas gingivalis. Eur J Immunol (2014) 1.47

Polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic ApoE(null) mice. PLoS One (2013) 1.06

The Impact of Vitamin D Levels on Inflammatory Status: A Systematic Review of Immune Cell Studies. PLoS One (2015) 0.89

Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss. Proc Natl Acad Sci U S A (2013) 0.88

Chronic oral infection with major periodontal bacteria Tannerella forsythia modulates systemic atherosclerosis risk factors and inflammatory markers. Pathog Dis (2015) 0.84

Immune and regulatory functions of neutrophils in inflammatory bone loss. Semin Immunol (2016) 0.82

Porphyromonas gingivalis promotes neointimal formation after arterial injury through toll-like receptor 2 signaling. Heart Vessels (2013) 0.79

Immune cells link obesity-associated type 2 diabetes and periodontitis. J Dent Res (2014) 0.78

Polybacterial Periodontal Pathogens Alter Vascular and Gut BH4/nNOS/NRF2-Phase II Enzyme Expression. PLoS One (2015) 0.77

Advances in immune-modulating therapies to treat atherosclerotic cardiovascular diseases. Ther Adv Vaccines (2014) 0.76

Porphyromonas gingivalis Differentially Modulates Cell Death Profile in Ox-LDL and TNF-α Pre-Treated Endothelial Cells. PLoS One (2016) 0.75

Associations of Toll-Like Receptor and β-Defensin Polymorphisms with Measures of Periodontal Disease (PD) in HIV+ North American Adults: An Exploratory Study. PLoS One (2016) 0.75

Serum Amyloid A Promotes E-Selectin Expression via Toll-Like Receptor 2 in Human Aortic Endothelial Cells. Mediators Inflamm (2016) 0.75

Role of Nucleotide-binding and Oligomerization Domain 2 Protein (NOD2) in the Development of Atherosclerosis. Korean J Physiol Pharmacol (2015) 0.75

Transcriptome Analysis of B Cell Immune Functions in Periodontitis: Mucosal Tissue Responses to the Oral Microbiome in Aging. Front Immunol (2016) 0.75

Oral application of a periodontal pathogen impacts SerpinE1 expression and pancreatic islet architecture in prediabetes. J Periodontal Res (2017) 0.75

Articles cited by this

(truncated to the top 100)

Pathogen recognition and innate immunity. Cell (2006) 44.14

Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature (2001) 33.12

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature (2001) 28.24

TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest (2006) 17.49

Toll-like receptors and innate immunity. Nat Rev Immunol (2001) 16.50

The immunopathogenesis of sepsis. Nature (2002) 11.83

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem (2003) 10.79

CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest (2005) 10.44

Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol (2005) 8.39

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science (2003) 7.49

Biochemistry of endotoxins. Annu Rev Biochem (1990) 6.75

A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem (2007) 6.58

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol (2003) 6.46

NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu Rev Biochem (2005) 6.18

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol (2004) 5.59

Endotoxin tolerance: new mechanisms, molecules and clinical significance. Trends Immunol (2009) 5.37

Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu Rev Immunol (2006) 5.35

CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet (2002) 5.31

Black-pigmented Bacteroides species, Capnocytophaga species, and Actinobacillus actinomycetemcomitans in human periodontal disease: virulence factors in colonization, survival, and tissue destruction. J Dent Res (1984) 5.29

Innate immune recognition: mechanisms and pathways. Immunol Rev (2000) 5.15

Treatment of periodontitis and endothelial function. N Engl J Med (2007) 4.83

Dental disease and risk of coronary heart disease and mortality. BMJ (1993) 3.97

CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri. EMBO Rep (2001) 3.55

Identification of periodontal pathogens in atheromatous plaques. J Periodontol (2000) 3.45

The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis. Am Heart J (2007) 3.40

Human Nod1 confers responsiveness to bacterial lipopolysaccharides. J Biol Chem (2000) 3.23

Inflammatory bio-markers and cardiovascular risk prediction. J Intern Med (2002) 2.70

The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity (2008) 2.53

Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation (2004) 2.46

Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: effects of TLR "homotolerance" versus "heterotolerance" on NF-kappa B signaling pathway components. J Immunol (2003) 2.44

A proposed model linking inflammation to obesity, diabetes, and periodontal infections. J Periodontol (2005) 2.36

Tolerance to the action of endotoxins of enteric bacilli in patients convalescent from typhoid and paratyphoid fevers. J Lab Clin Med (1950) 2.32

Barrett esophagus: prevalence of central adiposity, metabolic syndrome, and a proinflammatory state. Ann Surg (2008) 2.30

Diet-induced obese mice have increased mortality and altered immune responses when infected with influenza virus. J Nutr (2007) 2.28

Cutting Edge: TLR2 is required for the innate response to Porphyromonas gingivalis: activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone resorption. J Immunol (2006) 2.28

Invasion of aortic and heart endothelial cells by Porphyromonas gingivalis. Infect Immun (1998) 2.27

Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J Immunol (2002) 2.27

Infection and atherosclerosis: emerging mechanistic paradigms. Circulation (1999) 2.23

Relationship between obesity, glucose tolerance, and periodontal disease in Japanese women: the Hisayama study. J Periodontal Res (2005) 2.01

Poor oral health and coronary heart disease. J Dent Res (1996) 1.92

A role for fimbriae in Porphyromonas gingivalis invasion of oral epithelial cells. Infect Immun (1997) 1.84

Interleukin-1 receptor signaling mediates atherosclerosis associated with bacterial exposure and/or a high-fat diet in a murine apolipoprotein E heterozygote model: pharmacotherapeutic implications. Circulation (2004) 1.82

Prior stressor exposure sensitizes LPS-induced cytokine production. Brain Behav Immun (2002) 1.82

Impaired immunity in obesity: suppressed but reversible lymphocyte responsiveness. Int J Obes Relat Metab Disord (1993) 1.82

Obesity and immune function relationships. Obes Rev (2001) 1.80

Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. Cell Microbiol (2003) 1.79

Sexual reproduction and the evolution of microbial pathogens. Curr Biol (2006) 1.78

Toll-like receptors as potential therapeutic targets for multiple diseases. Nat Rev Drug Discov (2002) 1.75

Structural biology of the LPS recognition. Int J Med Microbiol (2007) 1.73

Diabetes and periodontal disease: a case-control study. J Periodontol (2005) 1.72

Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation. Arterioscler Thromb Vasc Biol (2003) 1.69

Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge. Proc Natl Acad Sci U S A (2007) 1.67

Risk factors for periodontitis. J Int Acad Periodontol (2005) 1.63

Evidence of a substantial genetic basis for risk of adult periodontitis. J Periodontol (2000) 1.62

TLR signaling: an emerging bridge from innate immunity to atherogenesis. J Immunol (2004) 1.62

Association between extent of periodontal attachment loss and self-reported history of heart attack: an analysis of NHANES III data. J Dent Res (1999) 1.61

Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells. J Immunol (2007) 1.60

Periodontal disease and systemic conditions: a bidirectional relationship. Odontology (2006) 1.52

Toll like receptor 4 in atherosclerosis and plaque destabilization. Atherosclerosis (2009) 1.51

Relationship between upper body obesity and periodontitis. J Dent Res (2001) 1.49

Dental infection and the risk of new coronary events: prospective study of patients with documented coronary artery disease. Clin Infect Dis (1995) 1.48

Porphyromonas gingivalis lipopolysaccharide signaling in gingival fibroblasts-CD14 and Toll-like receptors. Crit Rev Oral Biol Med (2002) 1.48

Interleukin-1 and tumor necrosis factor activities partially account for calvarial bone resorption induced by local injection of lipopolysaccharide. Infect Immun (1999) 1.47

Mycobacterial interaction with innate receptors: TLRs, C-type lectins, and NLRs. Curr Opin Infect Dis (2008) 1.41

Oral mucosal endotoxin tolerance induction in chronic periodontitis. Infect Immun (2005) 1.39

Nosocomial infections and obesity in surgical patients. Obes Res (2003) 1.37

Lipopolysaccharide stimulation of ERK1/2 increases TNF-alpha production via Egr-1. Am J Physiol Cell Physiol (2002) 1.37

Viral and bacterial infections in patients with acute myocardial infarction. J Intern Med (1989) 1.36

Phagocytosis and the inflammatory response. J Infect Dis (2003) 1.35

Obesity is the major determinant of elevated C-reactive protein in subjects with the metabolic syndrome. Int J Obes Relat Metab Disord (2004) 1.34

Phenotypic abnormalities in macrophages from leptin-deficient, obese mice. Am J Physiol (1999) 1.32

Levels of interleukin-1 beta and interleukin-8 in gingival crevicular fluids in adult periodontitis. J Periodontol (1995) 1.32

C-reactive protein levels in patients with aggressive periodontitis. J Periodontol (2006) 1.31

Impairment of cell-mediated immunity in mutation diabetic mice (db/db). J Immunol (1978) 1.26

Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses. Proc Natl Acad Sci U S A (2009) 1.25

Atherosclerotic lesion development and Toll like receptor 2 and 4 responsiveness. Atherosclerosis (2007) 1.25

Cytomegalovirus in the pathogenesis of atherosclerosis: the role of inflammation as reflected by elevated C-reactive protein levels. J Am Coll Cardiol (1999) 1.25

Atherogenesis: the role of inflammation and infection. Histopathology (2007) 1.24

Leptin and wound inflammation in diabetic ob/ob mice: differential regulation of neutrophil and macrophage influx and a potential role for the scab as a sink for inflammatory cells and mediators. Diabetes (2003) 1.22

Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing. Trends Immunol (2003) 1.22

Bacterial fimbriae and their peptides activate human gingival epithelial cells through Toll-like receptor 2. Infect Immun (2001) 1.21

Severe periodontitis enhances macrophage activation via increased serum lipopolysaccharide. Arterioscler Thromb Vasc Biol (2004) 1.20

Deficient humoral responses underlie susceptibility to Toxoplasma gondii in CD4-deficient mice. Infect Immun (2002) 1.19

Toll-like receptor 4-deficient mice have reduced bone destruction following mixed anaerobic infection. Infect Immun (2000) 1.18

Toll-like receptor-2 mediates diet and/or pathogen associated atherosclerosis: proteomic findings. PLoS One (2008) 1.15

Metabolic disorders related to obesity and periodontal disease. Periodontol 2000 (2007) 1.15

Peptidoglycans as promoters of slow-wave sleep. I. Structure of the sleep-promoting factor isolated from human urine. J Biol Chem (1984) 1.13

Change of cytokine balance in diet-induced obese mice. Metabolism (2000) 1.13

Obesity and periodontitis. N Engl J Med (1998) 1.13

Measurements of interleukin-6 in gingival crevicular fluid from adults with destructive periodontal disease. J Periodontol (1993) 1.13

Vascular cells contribute to atherosclerosis by cytokine- and innate-immunity-related inflammatory mechanisms. Innate Immun (2008) 1.13

Porphyromonas gingivalis virulence factors and invasion of cells of the cardiovascular system. J Periodontal Res (1999) 1.12

Molecular detection of Treponema denticola and Porphyromonas gingivalis in carotid and aortic atheromatous plaques by FISH: report of two cases. J Med Microbiol (2005) 1.11

Processing of Bacillus subtilis peptidoglycan by a mouse macrophage cell line. Infect Immun (1984) 1.11

Pattern recognition receptors and their role in innate immunity: focus on microbial protein ligands. Contrib Microbiol (2008) 1.09

The expression profile of lipopolysaccharide-binding protein, membrane-bound CD14, and toll-like receptors 2 and 4 in chronic periodontitis. J Periodontol (2005) 1.08

Fimbria-dependent activation of cell adhesion molecule expression in Porphyromonas gingivalis-infected endothelial cells. Infect Immun (2002) 1.08

Prevalence of medical problems in periodontal patients obtained from three different populations. J Periodontol (1987) 1.07

Severity of periodontal disease correlates to inflammatory systemic status and independently predicts the presence and angiographic extent of stable coronary artery disease. J Intern Med (2008) 1.06

Articles by these authors

Porphyromonas gingivalis infection accelerates the progression of atherosclerosis in a heterozygous apolipoprotein E-deficient murine model. Circulation (2002) 2.16

Deep sequencing of the oral microbiome reveals signatures of periodontal disease. PLoS One (2012) 1.96

Interleukin-1 receptor signaling mediates atherosclerosis associated with bacterial exposure and/or a high-fat diet in a murine apolipoprotein E heterozygote model: pharmacotherapeutic implications. Circulation (2004) 1.82

Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine. Biomaterials (2012) 1.81

Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein. Infect Immun (2005) 1.77

A new transcription factor that regulates TNF-alpha gene expression, LITAF, is increased in intestinal tissues from patients with CD and UC. Inflamm Bowel Dis (2006) 1.69

Periodontal disease and systemic conditions: a bidirectional relationship. Odontology (2006) 1.52

LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways. Proc Natl Acad Sci U S A (2006) 1.40

A role for advanced glycation end products in diminished bone healing in type 1 diabetes. Diabetes (2003) 1.34

LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines. Proc Natl Acad Sci U S A (2005) 1.29

Identification and functional characterization of a novel binding site on TNF-alpha promoter. Proc Natl Acad Sci U S A (2003) 1.28

Metabolic network model of a human oral pathogen. J Bacteriol (2008) 1.26

Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses. Proc Natl Acad Sci U S A (2009) 1.25

Identification of signaling pathways in macrophage exposed to Porphyromonas gingivalis or to its purified cell wall components. J Immunol (2007) 1.22

Morphometric, histomorphometric, and microcomputed tomographic analysis of periodontal inflammatory lesions in a murine model. J Periodontol (2007) 1.15

Toll-like receptor-2 mediates diet and/or pathogen associated atherosclerosis: proteomic findings. PLoS One (2008) 1.15

Inflammation and tissue loss caused by periodontal pathogens is reduced by interleukin-1 antagonists. J Infect Dis (2002) 1.10

Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages. J Clin Invest (2009) 1.09

Identification of proteins differentially expressed in human monocytes exposed to Porphyromonas gingivalis and its purified components by high-throughput immunoblotting. Infect Immun (2006) 1.02

Atheroprotective role of interleukin-6 in diet- and/or pathogen-associated atherosclerosis using an ApoE heterozygote murine model. Atherosclerosis (2007) 1.02

Signaling mechanisms in the restoration of impaired immune function due to diet-induced obesity. Proc Natl Acad Sci U S A (2011) 0.98

Influence of diabetes on the exacerbation of an inflammatory response in cardiovascular tissue. Endocrinology (2004) 0.97

Short- and long-term effects of IL-1 and TNF antagonists on periodontal wound healing. J Immunol (2004) 0.95

Doxycycline affects diet- and bacteria-associated atherosclerosis in an ApoE heterozygote murine model: cytokine profiling implications. Atherosclerosis (2006) 0.94

Secreted frizzled-related protein 1 (SFRP1) protects fibroblasts from ceramide-induced apoptosis. J Biol Chem (2003) 0.94

Receptor activator of nuclear factor kappa B ligand antagonists inhibit tissue inflammation and bone loss in experimental periodontitis. J Clin Periodontol (2011) 0.94

Contribution of interleukin-11 and prostaglandin(s) in lipopolysaccharide-induced bone resorption in vivo. Infect Immun (2002) 0.93

Porphyromonas gingivalis fimbriae are pro-inflammatory but do not play a prominent role in the innate immune response to P. gingivalis. J Endotoxin Res (2005) 0.92

Molecular cloning and characterization of mouse LITAF cDNA: role in the regulation of tumor necrosis factor-alpha (TNF-alpha) gene expression. J Endotoxin Res (2004) 0.90

p53 short peptide (p53pep164) regulates lipopolysaccharide-induced tumor necrosis factor-alpha factor/cytokine expression. Cancer Res (2007) 0.90

Beneficial dysregulation of the time course of inflammatory mediators in lipopolysaccharide-induced tumor necrosis factor alpha factor-deficient mice. Clin Vaccine Immunol (2010) 0.89

Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss. Proc Natl Acad Sci U S A (2013) 0.88

Whole-body deletion of LPS-induced TNF-α factor (LITAF) markedly improves experimental endotoxic shock and inflammatory arthritis. Proc Natl Acad Sci U S A (2011) 0.88

Metabolic proximity in the order of colonization of a microbial community. PLoS One (2013) 0.87

LITAF, a BCL6 target gene, regulates autophagy in mature B-cell lymphomas. Br J Haematol (2013) 0.86

Identification and characterization of kava-derived compounds mediating TNF-alpha suppression. Chem Biol Drug Des (2009) 0.84

Immunization enhances inflammation and tissue destruction in response to Porphyromonas gingivalis. Infect Immun (2006) 0.84

LITAF mediation of increased TNF-α secretion from inflamed colonic lamina propria macrophages. PLoS One (2011) 0.84

Localized ridge augmentation with allogenic block grafts prior to implant placement: case reports and histologic evaluations. Implant Dent (2005) 0.84

Stem cells of the lamina propria of human oral mucosa and gingiva develop into mineralized tissues in vivo. J Clin Periodontol (2012) 0.83

Proteomic mapping of stimulus-specific signaling pathways involved in THP-1 cells exposed to Porphyromonas gingivalis or its purified components. J Proteome Res (2007) 0.82

Role for moesin in lipopolysaccharide-stimulated signal transduction. Infect Immun (2004) 0.81

Bioinformatics analysis of macrophages exposed to Porphyromonas gingivalis: implications in acute vs. chronic infections. PLoS One (2010) 0.80

Controlling the outcome of the Toll-like receptor signaling pathways. PLoS One (2012) 0.79

Novel transcriptional regulation of VEGF in inflammatory processes. J Cell Mol Med (2013) 0.78

A PTP4A3 peptide PIMAP39 modulates TNF-alpha levels and endotoxic shock. J Innate Immun (2009) 0.78

Role of interleukin-1 in bacterial atherogenesis. Drugs Today (Barc) (2006) 0.78

Partial restoration of macrophage alteration from diet-induced obesity in response to Porphyromonas gingivalis infection. PLoS One (2013) 0.77

Novel regulation of CCL2 gene expression by murine LITAF and STAT6B. PLoS One (2011) 0.77

Cloning and characterization of lipopolysaccharide-induced tumor necrosis factor alpha factor promoter. FEMS Immunol Med Microbiol (2006) 0.77

Role of insulin-like growth factor-1 signaling in dental fibroblast apoptosis. J Periodontol (2003) 0.76

p53 suppresses CCL2-induced subcutaneous tumor xenograft. Tumour Biol (2014) 0.75

Role of interleukin-1 in bacterial atherogenesis. Timely Top Med Cardiovasc Dis (2007) 0.75