Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor.

PubWeight™: 2.12‹?› | Rank: Top 2%

🔗 View Article (PMID 15895091)

Published in Nat Struct Mol Biol on May 15, 2005

Authors

Georgios Skiniotis1, Martin J Boulanger, K Christopher Garcia, Thomas Walz

Author Affiliations

1: Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.

Articles citing this

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. Nature (2008) 5.38

Structural biology of shared cytokine receptors. Annu Rev Immunol (2009) 2.27

The constant region of the membrane immunoglobulin mediates B cell-receptor clustering and signaling in response to membrane antigens. Immunity (2009) 2.25

IL-6 as a keystone cytokine in health and disease. Nat Immunol (2015) 2.14

Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells. Cancer Res (2009) 1.77

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease. Blood (2009) 1.63

Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex. Structure (2011) 1.63

Molecular electron microscopy: state of the art and current challenges. ACS Chem Biol (2008) 1.41

A short receptor downregulates JAK/STAT signalling to control the Drosophila cellular immune response. PLoS Biol (2010) 1.20

Molecular interactions within the IL-6/IL-12 cytokine/receptor superfamily. Immunol Res (2011) 1.19

Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex. Mol Cell (2008) 1.17

An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor. Proc Natl Acad Sci U S A (2007) 1.01

Signal transduction by human herpesvirus 8 viral interleukin-6 (vIL-6) is modulated by the nonsignaling gp80 subunit of the IL-6 receptor complex and is distinct from signaling induced by human IL-6. J Virol (2006) 1.00

Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells. Mol Biol Cell (2006) 1.00

Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes. J Biol Chem (2010) 0.99

The EM structure of a type I interferon-receptor complex reveals a novel mechanism for cytokine signaling. J Mol Biol (2007) 0.99

N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130. J Biol Chem (2009) 0.98

A ligand peptide motif selected from a cancer patient is a receptor-interacting site within human interleukin-11. PLoS One (2008) 0.96

Regulation of a lymphocyte-endothelial-IL-6 trans-signaling axis by fever-range thermal stress: hot spot of immune surveillance. Cytokine (2007) 0.94

Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth. Mol Biol Cell (2010) 0.93

Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling. J Biol Chem (2012) 0.91

Inflammatory cytokines: potential biomarkers of immunologic dysfunction in autism spectrum disorders. Mediators Inflamm (2015) 0.91

The dynamics of signal triggering in a gp130-receptor complex. Structure (2007) 0.91

Viral interleukin-6: role in Kaposi's sarcoma-associated herpesvirus: associated malignancies. J Interferon Cytokine Res (2011) 0.89

Insights into cytokine-receptor interactions from cytokine engineering. Annu Rev Immunol (2014) 0.87

JAK2 activation by growth hormone and other cytokines. Biochem J (2015) 0.85

Ligand-induced architecture of the leptin receptor signaling complex. Mol Cell (2012) 0.84

Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention. J Biol Chem (2012) 0.82

Selected cytokine pathways in rheumatoid arthritis. Semin Immunopathol (2017) 0.80

Bow to your partner for signaling. Nat Struct Mol Biol (2005) 0.77

Development of a membrane-anchored ligand and receptor yeast two-hybrid system for ligand-receptor interaction identification. Sci Rep (2016) 0.75

Growth control of hybridoma cells with an artificially induced EpoR-gp130 heterodimer. Cytotechnology (2006) 0.75

Non-core region modulates interleukin-11 signaling activity: generation of agonist and antagonist variants. J Biol Chem (2010) 0.75

Synthetic Deletion of the Interleukin 23 Receptor (IL-23R) Stalk Region Led to Autonomous IL-23R Homodimerization and Activation. Mol Cell Biol (2017) 0.75

Bazedoxifene enhances the anti-tumor effects of cisplatin and radiation treatment by blocking IL-6 signaling in head and neck cancer. Oncotarget (2016) 0.75

Articles by these authors

A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science (2006) 7.84

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling. Cell (2002) 7.03

STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell (2009) 6.92

Negative Staining and Image Classification - Powerful Tools in Modern Electron Microscopy. Biol Proced Online (2004) 6.14

Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature (2005) 5.44

Neurodegenerative disease: amyloid pores from pathogenic mutations. Nature (2002) 5.32

Multiple associated proteins regulate proteasome structure and function. Mol Cell (2002) 4.97

Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature (2004) 4.48

Structural basis of Wnt recognition by Frizzled. Science (2012) 4.31

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell (2012) 4.29

Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell (2008) 3.72

Structure of the human transferrin receptor-transferrin complex. Cell (2004) 3.64

Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science (2013) 3.59

Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell (2009) 3.46

Latent TGF-β structure and activation. Nature (2011) 3.42

Structure of the human mTOR complex I and its implications for rapamycin inhibition. Mol Cell (2010) 3.33

Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies. Science (2013) 3.25

How a single T cell receptor recognizes both self and foreign MHC. Cell (2007) 3.20

Activation of leukocyte beta2 integrins by conversion from bent to extended conformations. Immunity (2006) 3.11

Structure of integrin alpha5beta1 in complex with fibronectin. EMBO J (2003) 2.99

Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature (2004) 2.94

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. J Mol Biol (2002) 2.92

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science (2003) 2.87

ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins. Mol Cell (2005) 2.82

Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'. Nat Immunol (2007) 2.78

Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science (2005) 2.64

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. Mol Cell (2003) 2.61

Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Neuron (2007) 2.54

Implications of the aquaporin-4 structure on array formation and cell adhesion. J Mol Biol (2005) 2.50

Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature (2013) 2.49

Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions. Neuron (2004) 2.49

Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell (2007) 2.48

Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-dependent histone deacetylation. Cell (2005) 2.47

Two-step binding mechanism for T-cell receptor recognition of peptide MHC. Nature (2002) 2.45

Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell (2011) 2.39

An extracellular interactome of immunoglobulin and LRR proteins reveals receptor-ligand networks. Cell (2013) 2.36

Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5. Cell (2012) 2.34

Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide. Science (2011) 2.32

Structure of nerve growth factor complexed with the shared neurotrophin receptor p75. Science (2004) 2.32

Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22. Science (2005) 2.32

Structural biology of shared cytokine receptors. Annu Rev Immunol (2009) 2.27

Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci U S A (2005) 2.27

A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1. Cell (2009) 2.24

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat Struct Mol Biol (2011) 2.23

Structure and different conformational states of native AMPA receptor complexes. Nature (2005) 2.22

Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly. J Mol Biol (2006) 2.17

Antigen recognition determinants of gammadelta T cell receptors. Science (2005) 2.14

Structure of the measles virus hemagglutinin. Nat Struct Mol Biol (2007) 2.11

Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design. FASEB J (2008) 2.10

The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering. Cell (2006) 2.10

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. Nature (2012) 2.08

The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat Struct Mol Biol (2010) 2.08

Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. Neuron (2003) 2.06

A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron (2005) 2.03

Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity. Immunity (2005) 2.03

Structural basis of Dscam isoform specificity. Nature (2007) 2.02

Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition. Proc Natl Acad Sci U S A (2011) 1.99

The structure of aquaporins. Q Rev Biophys (2006) 1.90

Role of the conserved Sir3-BAH domain in nucleosome binding and silent chromatin assembly. Mol Cell (2007) 1.89

T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex. Immunity (2011) 1.86

The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites. PLoS Pathog (2011) 1.84

Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores. J Mol Biol (2003) 1.81

Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature (2004) 1.81

Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. Structure (2010) 1.79

The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle. Nat Struct Mol Biol (2005) 1.78

The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes. PLoS Pathog (2011) 1.78

Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection neurons. Cell (2007) 1.77

Specificity and degeneracy of T cells. Mol Immunol (2004) 1.71

Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes. EMBO J (2002) 1.68

Polyspecificity of T cell and B cell receptor recognition. Semin Immunol (2007) 1.68

Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain. Science (2008) 1.67

Deconstructing the form and function of the TCR/CD3 complex. Immunity (2006) 1.64

Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex. Structure (2011) 1.63

Aquaporin-0 membrane junctions form upon proteolytic cleavage. J Mol Biol (2004) 1.63

The composition and signaling of the IL-35 receptor are unconventional. Nat Immunol (2012) 1.63

Structural basis of receptor sharing by interleukin 17 cytokines. Nat Immunol (2009) 1.60

Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain. J Biol Chem (2004) 1.60

Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB. Chem Biol (2010) 1.60

RIG-I forms signaling-competent filaments in an ATP-dependent, ubiquitin-independent manner. Mol Cell (2013) 1.57

Structural transitions of complement component C3 and its activation products. Proc Natl Acad Sci U S A (2006) 1.57

Structural and functional characterization of the integral membrane protein VDAC-1 in lipid bilayer nanodiscs. J Am Chem Soc (2009) 1.55

BacMam system for high-level expression of recombinant soluble and membrane glycoproteins for structural studies. Protein Expr Purif (2008) 1.53

Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1. Mol Cell (2007) 1.53

The structure of interleukin-2 complexed with its alpha receptor. Science (2005) 1.53

Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2. J Exp Med (2013) 1.53

The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments. Cell (2010) 1.48

Functional and structural stability of the epidermal growth factor receptor in detergent micelles and phospholipid nanodiscs. Biochemistry (2008) 1.48

Structure of a VEGF-VEGF receptor complex determined by electron microscopy. Nat Struct Mol Biol (2007) 1.48

Structural snapshot of aberrant antigen presentation linked to autoimmunity: the immunodominant epitope of MBP complexed with I-Au. Immunity (2002) 1.47

Cytokine therapy reverses NK cell anergy in MHC-deficient tumors. J Clin Invest (2014) 1.45

Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor. Nat Struct Mol Biol (2011) 1.45

Structural and functional insights into the malaria parasite moving junction complex. PLoS Pathog (2012) 1.44

An intersubunit disulfide bond prevents in vitro aggregation of a superoxide dismutase-1 mutant linked to familial amytrophic lateral sclerosis. Biochemistry (2004) 1.43

Structural and functional analysis of essential pre-mRNA splicing factor Prp19p. Mol Cell Biol (2005) 1.42

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nat Immunol (2012) 1.41

Molecular electron microscopy: state of the art and current challenges. ACS Chem Biol (2008) 1.41

Mutations in WNT1 cause different forms of bone fragility. Am J Hum Genet (2013) 1.39