Published in Ann N Y Acad Sci on April 01, 2004
Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity. Proc Natl Acad Sci U S A (2005) 2.08
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities. Physiol Rev (2014) 1.51
Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2. Chem Biol Interact (2012) 1.45
Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction. Cardiovasc Res (2008) 1.43
Evidence that Environmental Heterogeneity Maintains a Detoxifying Enzyme Polymorphism in Drosophila melanogaster. Curr Biol (2015) 1.39
Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications. Curr Pharm Des (2011) 1.29
Alterations in the diabetic myocardial proteome coupled with increased myocardial oxidative stress underlies diabetic cardiomyopathy. J Mol Cell Cardiol (2007) 1.15
Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system. Sci Transl Med (2014) 0.99
Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism. Exp Neurol (2014) 0.87
Association of ADH1B and ALDH2 gene polymorphisms with alcohol dependence: a pilot study from India. Hum Genomics (2009) 0.85
Association of a Missense ALDH2 Single Nucleotide Polymorphism (Glu504Lys) With Benign Prostate Hyperplasia in a Korean Population. Int Neurourol J (2013) 0.84
Drosophila lacking a homologue of mammalian ALDH2 have multiple fitness defects. Chem Biol Interact (2011) 0.80
Remodeling of protein and mRNA expression in Leishmania mexicana induced by deletion of glucose transporter genes. Mol Biochem Parasitol (2010) 0.78
Over-expression of aldehyde dehydrogenase-2 protects against H₂O₂-induced oxidative damage and apoptosis in peripheral blood mononuclear cells. Acta Pharmacol Sin (2011) 0.78
Preventive effects of Chlorella on skeletal muscle atrophy in muscle-specific mitochondrial aldehyde dehydrogenase 2 activity-deficient mice. BMC Complement Altern Med (2014) 0.77
Mitochondrial PKC-ε deficiency promotes I/R-mediated myocardial injury via GSK3β-dependent mitochondrial permeability transition pore opening. J Cell Mol Med (2017) 0.76
Hydrogen Sulfide Ameliorates Homocysteine-Induced Cognitive Dysfunction by Inhibition of Reactive Aldehydes Involving Upregulation of ALDH2. Int J Neuropsychopharmacol (2016) 0.76
Polymorphisms in the aldehyde dehydrogenase 2 and dopamine β hydroxylase genes are not associated with Alzheimer's disease. J Neural Transm (Vienna) (2013) 0.76
Predicting dedifferentiation in liposarcoma: a proteomic approach. Virchows Arch (2013) 0.76
The Pivotal Role of Aldehyde Toxicity in Autism Spectrum Disorder: The Therapeutic Potential of Micronutrient Supplementation. Nutr Metab Insights (2016) 0.76
Relationship Between Alcohol Consumption and Prostatic Hyperplasia According to Facial Flushing After Drinking in Korean Men. Korean J Fam Med (2017) 0.75
Proteomic Analysis of Mitochondria-Enriched Fraction Isolated from the Frontal Cortex and Hippocampus of Apolipoprotein E Knockout Mice Treated with Alda-1, an Activator of Mitochondrial Aldehyde Dehydrogenase (ALDH2). Int J Mol Sci (2017) 0.75
Mitochondrial genome variation in eastern Asia and the peopling of Japan. Genome Res (2004) 3.34
Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun (2007) 2.27
Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun (2008) 2.04
Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology (2008) 1.55
Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol (2009) 1.54
Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neurosci Lett (2009) 1.54
The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease. Hum Mol Genet (2006) 1.50
Association of polymorphisms of the androgen receptor and klotho genes with bone mineral density in Japanese women. J Mol Med (Berl) (2004) 1.50
Prevalence of hyperesthesia detected by current perception threshold test in subjects with glucose metabolic impairments in a community. Intern Med (2002) 1.48
Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia. J Lipid Res (2007) 1.48
Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart. Circ Res (2009) 1.31
Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1. Mol Cell Biol (2007) 1.28
Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am J Physiol Lung Cell Mol Physiol (2011) 1.25
The clock drawing test as a valid screening method for mild cognitive impairment. Dement Geriatr Cogn Disord (2004) 1.20
Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells. J Neurochem (2003) 1.19
Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Obesity (Silver Spring) (2011) 1.17
Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1. J Biol Chem (2009) 1.15
Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury. Invest Ophthalmol Vis Sci (2009) 1.13
Prevention of gastroesophageal reflux using an application of half-solid nutrients in patients with percutaneous endoscopic gastrostomy feeding. J Am Geriatr Soc (2004) 1.12
Protection against ischemic brain injury by protein therapeutics. Proc Natl Acad Sci U S A (2002) 1.11
A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment. PLoS One (2013) 1.10
Prognostic significance of the immunohistochemical index of survivin in glioma: a comparative study with the MIB-1 index. J Neurooncol (2005) 1.09
Refractive errors and factors associated with myopia in an adult Japanese population. Jpn J Ophthalmol (2003) 1.08
The relationship between age and intraocular pressure in a Japanese population: the influence of central corneal thickness. Curr Eye Res (2002) 1.07
SORL1 is genetically associated with Alzheimer disease in a Japanese population. Neurosci Lett (2009) 1.07
Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. J Nutr Biochem (2009) 1.06
MTHFR gene polymorphism as a risk factor for silent brain infarcts and white matter lesions in the Japanese general population: The NILS-LSA Study. Stroke (2003) 1.05
Is there a relevant effect of noise and smoking on hearing? A population-based aging study. Int J Audiol (2005) 1.05
Dietary magnesium intake and the future risk of coronary heart disease (the Honolulu Heart Program). Am J Cardiol (2003) 1.04
Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? FEBS Lett (2009) 1.02
No association between rs7566605 variant and being overweight in Japanese. Obesity (Silver Spring) (2007) 1.01
High prevalence of sarcopenia and reduced leg muscle mass in Japanese patients immediately after a hip fracture. Geriatr Gerontol Int (2012) 0.98
The SIGMAR1 gene is associated with a risk of schizophrenia and activation of the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry (2011) 0.98
Glutathione peroxidase 1 Pro198Leu variant contributes to the metabolic syndrome in men in a large Japanese cohort. Am J Clin Nutr (2008) 0.98
Association of candidate gene polymorphisms with bone mineral density in community-dwelling Japanese women and men. Int J Mol Med (2007) 0.96
Association of polymorphisms of the osteoprotegerin gene with bone mineral density in Japanese women but not men. Mol Genet Metab (2003) 0.96
Prevalence of knee pain, lumbar pain and its coexistence in Japanese men and women: The Longitudinal Cohorts of Motor System Organ (LOCOMO) study. J Bone Miner Metab (2013) 0.95
Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer's disease: on defects in the cytochrome c oxidase complex and aldehyde detoxification. J Alzheimers Dis (2006) 0.95
Prognosis of glioma patients by combined immunostaining for survivin, Ki-67 and epidermal growth factor receptor. J Clin Neurosci (2008) 0.94
The relationship between intraocular pressure and refractive error adjusting for age and central corneal thickness. Ophthalmic Physiol Opt (2004) 0.94
Age-specific change of prevalence of metabolic syndrome: longitudinal observation of large Japanese cohort. Atherosclerosis (2006) 0.94
Effect of aging on serum uric acid levels: longitudinal changes in a large Japanese population group. J Gerontol A Biol Sci Med Sci (2002) 0.93
Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with sudden sensorineural hearing loss. Laryngoscope (2010) 0.93
Identification of hippocampus-related candidate genes for Alzheimer's disease. Ann Neurol (2005) 0.93
Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan. Dement Geriatr Cogn Disord (2006) 0.92
Impact of caregiver burden on adverse health outcomes in community-dwelling dependent older care recipients. Am J Geriatr Psychiatry (2011) 0.92
Association of polymorphisms of interleukin-6, osteocalcin, and vitamin D receptor genes, alone or in combination, with bone mineral density in community-dwelling Japanese women and men. J Clin Endocrinol Metab (2003) 0.92
The impact of health problems on depression and activities in middle-aged and older adults: age and social interactions as moderators. J Gerontol B Psychol Sci Soc Sci (2004) 0.91
Association of the mitochondrial DNA 15497G/A polymorphism with obesity in a middle-aged and elderly Japanese population. Hum Genet (2003) 0.91
Age differences in the effect of physical activity on depressive symptoms. Psychol Aging (2004) 0.91
Polymorphisms in genes involved in inflammatory pathways in patients with sudden sensorineural hearing loss. J Neurogenet (2012) 0.90
Association study of KIBRA gene with memory performance in a Japanese population. World J Biol Psychiatry (2010) 0.90
Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females. J Hum Genet (2003) 0.89
The effects of aging on distortion-product otoacoustic emissions in adults with normal hearing. Ear Hear (2008) 0.89
Down-regulation of a novel gene, DRLM, in human liver malignancy from 4q22 that encodes a NAP-like protein. Gene (2002) 0.89
Hearing impairment risk and interaction of folate metabolism related gene polymorphisms in an aging study. BMC Med Genet (2011) 0.89
Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density of the femoral neck in elderly Japanese women. J Mol Med (Berl) (2002) 0.89
Synergistic interaction of cigarette smoking and alcohol drinking with serum carotenoid concentrations: findings from a middle-aged Japanese population. Br J Nutr (2009) 0.89
Preventive effects of Chlorella on cognitive decline in age-dependent dementia model mice. Neurosci Lett (2009) 0.88
Dietary supplement use by community-living population in Japan: data from the National Institute for Longevity Sciences Longitudinal Study of Aging (NILS-LSA). J Epidemiol (2006) 0.88
Relationship between astigmatism and aging in middle-aged and elderly Japanese. Jpn J Ophthalmol (2005) 0.88
Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis. J Bone Miner Res (2012) 0.87
The association between decline in physical functioning and atrophy of medial temporal areas in community-dwelling older adults with amnestic and nonamnestic mild cognitive impairment. Arch Phys Med Rehabil (2011) 0.87
Relationship between number of metabolic syndrome components and dietary factors in middle-aged and elderly Japanese subjects. Hypertens Res (2010) 0.87
Association of polymorphisms of paraoxonase 1 and 2 genes, alone or in combination, with bone mineral density in community-dwelling Japanese. J Hum Genet (2003) 0.87
The KCNH2 gene is associated with neurocognition and the risk of schizophrenia. World J Biol Psychiatry (2011) 0.87
Six-year longitudinal changes in body composition of middle-aged and elderly Japanese: age and sex differences in appendicular skeletal muscle mass. Geriatr Gerontol Int (2013) 0.87
Prevalence of self-perceived auditory problems and their relation to audiometric thresholds in a middle-aged to elderly population. Acta Otolaryngol (2003) 0.86