Published in Lancet on May 08, 2004
Stenting versus endarterectomy for treatment of carotid-artery stenosis. N Engl J Med (2010) 17.57
10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicentre randomised trial. Lancet (2010) 4.73
Asymptomatic embolisation for prediction of stroke in the Asymptomatic Carotid Emboli Study (ACES): a prospective observational study. Lancet Neurol (2010) 4.01
Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2014) 3.48
Design of the Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST). Int J Stroke (2010) 2.71
Optimal selection of asymptomatic patients for carotid endarterectomy based on predicted 5-year survival. J Vasc Surg (2013) 2.16
Influence of sex on outcomes of stenting versus endarterectomy: a subgroup analysis of the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST). Lancet Neurol (2011) 2.15
Carotid plaque, a subclinical precursor of vascular events: the Northern Manhattan Study. Neurology (2008) 2.09
Controversies in neurology: asymptomatic carotid stenosis--intervention or just stick to medical therapy. The argument for carotid endarterectomy. J Neural Transm (Vienna) (2011) 2.01
Prevalence of asymptomatic carotid artery stenosis in the general population: an individual participant data meta-analysis. Stroke (2010) 1.97
The Carotid Revascularization Endarterectomy versus Stenting Trial (CREST): stenting versus carotid endarterectomy for carotid disease. Stroke (2010) 1.69
Plaque echolucency and stroke risk in asymptomatic carotid stenosis: a systematic review and meta-analysis. Stroke (2014) 1.56
Carotid endarterectomy in asymptomatic patients with limited life expectancy. Stroke (2012) 1.54
Does preoperative carotid stenosis screening reduce perioperative stroke in patients undergoing coronary artery bypass grafting? J Thorac Cardiovasc Surg (2015) 1.52
Predictors of neurocognitive decline after carotid endarterectomy. Neurosurgery (2006) 1.49
Cerebrovascular reserve and stroke risk in patients with carotid stenosis or occlusion: a systematic review and meta-analysis. Stroke (2012) 1.47
Safety of stenting and endarterectomy by symptomatic status in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST). Stroke (2011) 1.45
Gender-specific 30-day outcomes after carotid endarterectomy and carotid artery stenting in the Society for Vascular Surgery Vascular Registry. J Vasc Surg (2013) 1.44
The need for treatment of hemodynamic instability following carotid endarterectomy is associated with increased perioperative and 1-year morbidity and mortality. J Vasc Surg (2013) 1.42
Carotid endarterectomy versus carotid artery stenting: findings in regard to neuroclinical outcomes and diffusion-weighted imaging. Tex Heart Inst J (2008) 1.40
Carotid stenting done exclusively by vascular surgeons: first 175 cases. Ann Surg (2005) 1.38
Waiting times for carotid endarterectomy in UK: observational study. BMJ (2009) 1.34
Carotid plaque surface irregularity predicts ischemic stroke: the northern Manhattan study. Stroke (2006) 1.25
Athero-express: differential atherosclerotic plaque expression of mRNA and protein in relation to cardiovascular events and patient characteristics. Rationale and design. Eur J Epidemiol (2004) 1.23
Risk factors for perioperative death and stroke after carotid endarterectomy: results of the new york carotid artery surgery study. Stroke (2008) 1.16
Carotid endarterectomy. Lancet (2004) 1.10
Predicting risk of perioperative death and stroke after carotid endarterectomy in asymptomatic patients: derivation and validation of a clinical risk score. Stroke (2010) 1.08
Racial and ethnic disparities in outcomes and appropriateness of carotid endarterectomy: impact of patient and provider factors. Stroke (2009) 1.08
Asymptomatic carotid stenosis: intervention or just stick to medical therapy--the case for medical therapy. J Neural Transm (Vienna) (2011) 1.08
Surgery for carotid artery stenosis. BMJ (2004) 1.06
GALA: an international multicentre randomised trial comparing general anaesthesia versus local anaesthesia for carotid surgery. Trials (2008) 1.06
Time to rethink management strategies in asymptomatic carotid artery disease. Nat Rev Cardiol (2011) 1.03
Interventions to increase enrollment in a large multicenter phase 3 trial of carotid stenting vs. endarterectomy. Int J Stroke (2012) 1.02
Symptomatic and asymptomatic carotid artery plaque. Expert Rev Cardiovasc Ther (2011) 1.01
Comparison of the inflammatory burden of truly asymptomatic carotid atheroma with atherosclerotic plaques contralateral to symptomatic carotid stenosis: an ultra small superparamagnetic iron oxide enhanced magnetic resonance study. J Neurol Neurosurg Psychiatry (2007) 1.00
Ultrasonographic markers of vascular risk in patients with asymptomatic carotid stenosis. J Cereb Blood Flow Metab (2013) 0.99
Carotid stenting vs endarterectomy: new results in perspective. Mayo Clin Proc (2010) 0.98
Magnetic resonance angiography detection of abnormal carotid artery plaque in patients with cryptogenic stroke. J Am Heart Assoc (2015) 0.96
Carotid endarterectomy and carotid artery stenting utilization trends over time. BMC Neurol (2012) 0.95
Treatment of carotid artery stenosis: medical therapy, surgery, or stenting? Mayo Clin Proc (2009) 0.94
Caveolin-1 influences vascular protease activity and is a potential stabilizing factor in human atherosclerotic disease. PLoS One (2008) 0.94
Gender differences in treatment of severe carotid stenosis after transient ischemic attack. Stroke (2010) 0.94
Risk index for predicting perioperative stroke, myocardial infarction, or death risk in asymptomatic patients undergoing carotid endarterectomy. J Vasc Surg (2012) 0.93
Plea of the defence-critical comments on the interpretation of EVA3S, SPACE and ICSS. Neuroradiology (2010) 0.93
ACST: which subgroups will benefit most from carotid endarterectomy? Lancet (2004) 0.93
Risk factor management to prevent first stroke. Neurol Clin (2008) 0.92
Cerebrovascular reactivity predicts stroke in high-grade carotid artery disease. Neurology (2014) 0.92
Differential outcomes of carotid stenting and endarterectomy performed exclusively by vascular surgeons in the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST). J Vasc Surg (2012) 0.91
MR plaque imaging of the carotid artery. Neuroradiology (2010) 0.91
"Imaging Evaluation of Collaterals in the Brain: Physiology and Clinical Translation" Curr Radiol Rep (2014) 0.90
The role and importance of gene polymorphisms in the development of atherosclerosis. Interv Med Appl Sci (2013) 0.89
Carotid artery stenting: a single-centre experience with up to 8 years' follow-up. Eur Radiol (2008) 0.89
Prevalence of asymptomatic critical carotid artery stenosis in Korean patients with chronic atherosclerotic lower extremity ischemia: is a screening carotid duplex ultrasonography worthwhile? J Korean Med Sci (2010) 0.88
Society for Vascular Surgery (SVS) Vascular Registry evaluation of comparative effectiveness of carotid revascularization procedures stratified by Medicare age. J Vasc Surg (2012) 0.88
Vessel Wall Imaging of the Intracranial and Cervical Carotid Arteries. J Stroke (2015) 0.88
Carotid revascularization: risks and benefits. Vasc Health Risk Manag (2014) 0.87
The effects of autologous bone marrow mesenchymal stem cell arterial perfusion on vascular repair and angiogenesis in osteonecrosis of the femoral head in dogs. Int Orthop (2012) 0.87
Recommendations for management of patients with carotid stenosis. Stroke Res Treat (2012) 0.87
Composition of the stable carotid plaque: insights from a multidetector computed tomography study of plaque volume. Stroke (2007) 0.87
Nonenhanced ECG-gated time-resolved 4D steady-state free precession (SSFP) MR angiography (MRA) for assessment of cerebral collateral flow: comparison with digital subtraction angiography (DSA). Eur Radiol (2011) 0.86
Middle cerebral artery pulsatility index and cognitive improvement after carotid endarterectomy for symptomatic stenosis. J Neurosurg (2013) 0.86
Risk prediction for adverse events after carotid artery stenting in higher surgical risk patients. Stroke (2012) 0.86
Hyperperfusion syndrome after MCA embolectomy - a rare complication? Am J Case Rep (2013) 0.86
Asymptomatic carotid stenosis: What we can learn from the next generation of randomized clinical trials. JRSM Cardiovasc Dis (2014) 0.85
Current strategies for ischemic stroke prevention: role of multimodal combination therapies. J Neurol (2007) 0.84
Outcomes and risk factors in 1,609 carotid endarterectomies. Tex Heart Inst J (2008) 0.84
Post-carotid endarterectomy neurocognitive decline is associated with cerebral blood flow asymmetry on post-operative magnetic resonance perfusion brain scans. Neurol Res (2007) 0.84
Multimodality imaging of carotid atherosclerotic plaque: Going beyond stenosis. Indian J Radiol Imaging (2013) 0.83
Preoperative magnetic resonance angiography as a predictive test for cerebral ischemia during carotid endarterectomy. World J Surg (2013) 0.83
A risk factor-based predictive model of outcomes in carotid endarterectomy: the National Surgical Quality Improvement Program 2005-2010. Stroke (2013) 0.83
Repeatability of in vivo quantification of atherosclerotic carotid artery plaque components by supervised multispectral classification. MAGMA (2015) 0.83
Grading of carotid artery stenosis with multidetector-row CT angiography: visual estimation or caliper measurements? Eur Radiol (2009) 0.83
MRI plaque imaging detects carotid plaques with a high risk for future cerebrovascular events in asymptomatic patients. PLoS One (2013) 0.82
Carotid artery stenting in asymptomatic and surgically high-risk patients: single-centre, single-operator results. Int J Angiol (2008) 0.82
Management of asymptomatic carotid stenosis in patients undergoing general and vascular surgical procedures. J Neurol Neurosurg Psychiatry (2005) 0.82
The urgent need for contemporary clinical trials in patients with asymptomatic carotid stenosis. Neurology (2016) 0.82
Carotid plaque hemodynamics. Interv Neurol (2012) 0.81
Management of carotid stenosis in women: consensus document. Neurology (2013) 0.81
Management of carotid artery stenosis. Update for family physicians. Can Fam Physician (2005) 0.81
Molecular imaging in atherosclerosis. Eur J Nucl Med Mol Imaging (2010) 0.81
Does managed care affect quality? Appropriateness, referral patterns, and outcomes of carotid endarterectomy. Am J Med Qual (2008) 0.81
Multimodality management of carotid artery stenosis: reviewing the class-I evidence. J Natl Med Assoc (2007) 0.81
Carotid artery stenting versus endarterectomy: a systematic review. Tex Heart Inst J (2012) 0.81
Mediterranean diet and carotid atherosclerosis in the Northern Manhattan Study. Atherosclerosis (2014) 0.81
Asymptomatic and symptomatic carotid stenosis: an obsolete classification? Stroke Res Treat (2012) 0.81
Effect of patching on reducing restenosis in the carotid revascularization endarterectomy versus stenting trial. Stroke (2015) 0.81
Comparative results of conventional and eversion carotid endarterectomy. Ann Surg Treat Res (2014) 0.80
Circulating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis. PLoS One (2014) 0.80
Users' guide to the surgical literature: how to use a decision analysis. Can J Surg (2007) 0.80
Meta- analysis and meta-regression analysis of the associations between sex and the operative outcomes of carotid endarterectomy. BMC Cardiovasc Disord (2015) 0.79
Determinants of left atrial appendage volume in stroke patients without chronic atrial fibrillation. PLoS One (2014) 0.79
Age and gender disparities in the risk of carotid revascularization procedures. Neurol Sci (2013) 0.79
Antiplatelet therapy for carotid artery stenting. Interv Neurol (2013) 0.79
[Position paper on the indication for and implementation of interventional treatment of extracranial carotid stenosis]. Clin Res Cardiol (2006) 0.79
Refinement of Imaging Predictors of Recurrent Events following Transient Ischemic Attack and Minor Stroke. PLoS One (2013) 0.79
Secondary stroke prevention: challenges and solutions. Vasc Health Risk Manag (2015) 0.79
Stroke prevention-surgical and interventional approaches to carotid stenosis. Neurotherapeutics (2011) 0.79
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer (1977) 53.23
Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet (2005) 32.41
Mortality in relation to smoking: 20 years' observations on male British doctors. Br Med J (1976) 28.28
The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst (1981) 25.60
Blood pressure, stroke, and coronary heart disease. Part 1, Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet (1990) 25.12
Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet (1990) 24.72
Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet (2005) 24.57
Mortality in relation to smoking: 40 years' observations on male British doctors. BMJ (1994) 23.80
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design. Br J Cancer (1976) 22.55
Beta blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis (1985) 19.03
Conservatism of the approximation sigma (O-E)2-E in the logrank test for survival data or tumor incidence data. Biometrics (1973) 18.14
Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet (2010) 18.09
A long-term follow-up study of women using different methods of contraception--an interim report. J Biosoc Sci (1976) 13.09
The natural history of chronic airflow obstruction. Br Med J (1977) 13.04
Emerging tobacco hazards in China: 1. Retrospective proportional mortality study of one million deaths. BMJ (1998) 10.71
Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet (2011) 10.62
Exposure measurement error in time-series studies of air pollution: concepts and consequences. Environ Health Perspect (2000) 9.30
Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction: overview of results on mortality, reinfarction and side-effects from 33 randomized controlled trials. Eur Heart J (1985) 9.28
Arabidopsis thaliana mutant that develops as a light-grown plant in the absence of light. Cell (1989) 8.97
Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med (1996) 8.57
Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis. Lancet (2008) 8.53
Alcohol consumption and mortality among middle-aged and elderly U.S. adults. N Engl J Med (1997) 8.25
Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials. Lancet (2011) 8.24
Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. Science (1986) 8.23
Should paediatric intensive care be centralised? Trent versus Victoria. Lancet (1997) 8.08
Cigarette smoking and bronchial carcinoma: dose and time relationships among regular smokers and lifelong non-smokers. J Epidemiol Community Health (1978) 7.80
Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA (1998) 7.67
Why do we need some large, simple randomized trials? Stat Med (1985) 7.67
Dissection of Mycobacterium tuberculosis antigens using recombinant DNA. Proc Natl Acad Sci U S A (1985) 7.46
Menopausal hormone use and ovarian cancer risk: individual participant meta-analysis of 52 epidemiological studies. Lancet (2015) 7.29
UK and USA breast cancer deaths down 25% in year 2000 at ages 20-69 years. Lancet (2000) 7.19
Chronic infections and coronary heart disease: is there a link? Lancet (1997) 7.18
Guidelines for management of hypertension: report of the third working party of the British Hypertension Society. J Hum Hypertens (1999) 6.74
Mortality in relation to consumption of alcohol: 13 years' observations on male British doctors. BMJ (1994) 6.74
Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23,257 women with ovarian cancer and 87,303 controls. Lancet (2008) 6.67
Underestimation of risk associations due to regression dilution in long-term follow-up of prospective studies. Am J Epidemiol (1999) 6.42
Trials: the next 50 years. Large scale randomised evidence of moderate benefits. BMJ (1998) 6.13
Prevalence of patent foramen ovale in patients with stroke. N Engl J Med (1988) 5.94
Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell (1998) 5.92
A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. Mol Cell (1998) 5.89
Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet (2005) 5.86
Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br J Cancer (2002) 5.83
Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin. Overview of results of randomized trials in general, orthopedic, and urologic surgery. N Engl J Med (1988) 5.81
Early intravenous then oral metoprolol in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet (2005) 5.50
Serum cholesterol concentration and coronary heart disease in population with low cholesterol concentrations. BMJ (1991) 5.45
Mortality in relation to smoking: 22 years' observations on female British doctors. Br Med J (1980) 5.21
The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell (1996) 5.10
Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20,536 high-risk individuals: a randomised controlled trial. Lancet (2011) 5.08
The relevance in adults of air-flow obstruction, but not of mucus hypersecretion, to mortality from chronic lung disease. Results from 20 years of prospective observation. Am Rev Respir Dis (1983) 4.90
Tobacco and cancer: recent epidemiological evidence. J Natl Cancer Inst (2004) 4.83
Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse. Nat Genet (2000) 4.66
Mortality among doctors in different occupations. Br Med J (1977) 4.60
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice. Genes Dev (2000) 4.51
Emerging tobacco hazards in China: 2. Early mortality results from a prospective study. BMJ (1998) 4.51
Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy. J Clin Oncol (1994) 4.50
Sudden fall in breast cancer death rates in England and Wales. Lancet (1995) 4.50
Can dietary beta-carotene materially reduce human cancer rates? Nature (1981) 4.43
Associations between cigarette smoking, lifestyle factors, and microsatellite instability in colon tumors. J Natl Cancer Inst (2000) 4.39
Pre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial. Lancet (2008) 4.35
Tobacco--the growing epidemic. Nat Med (1999) 4.31
Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science (1997) 4.23
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature (1998) 4.18
Early health effects of the emerging tobacco epidemic in China. A 16-year prospective study. JAMA (1997) 4.09
CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell (1991) 4.05
Report of the Conference on Low Blood Cholesterol: Mortality Associations. Circulation (1992) 3.98
Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast. Genes Dev (1998) 3.91
Mass and molecular composition of vesicular stomatitis virus: a scanning transmission electron microscopy analysis. J Virol (1985) 3.79
Isolation, characterization and structure of bacterial flagellar motors containing the switch complex. J Mol Biol (1994) 3.71
Fundamental carcinogenic processes and their implications for low dose risk assessment. Cancer Res (1976) 3.58
Sexual health of teenagers in England and Wales: analysis of national data. BMJ (1999) 3.54
The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J Comp Neurol (1992) 3.53
Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant. Br J Haematol (2004) 3.52
Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies. BMJ (1997) 3.51
Why do we need systematic overviews of randomized trials? Stat Med (1987) 3.33
CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci U S A (1997) 3.25
MGDS examination. Br Dent J (1989) 3.21
Energy balance and colon cancer--beyond physical activity. Cancer Res (1997) 3.11
How often does surgery for peptic ulceration eradicate Helicobacter pylori? Systematic review of 36 studies. BMJ (1998) 3.10
Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies. Circulation (2000) 3.05
Postcodes as useful markers of social class: population based study in 26 000 British households. BMJ (1999) 3.01
AREVA: multicenter randomized comparison of low-dose versus standard-dose anticoagulation in patients with mechanical prosthetic heart valves. Circulation (1996) 3.00
Acute lower respiratory tract infections in children: possible criteria for selection of patients for antibiotic therapy and hospital admission. Bull World Health Organ (1984) 2.97
Effect of age and high blood pressure on baroreflex sensitivity in man. Circ Res (1971) 2.95
A carcinogenic potency database of the standardized results of animal bioassays. Environ Health Perspect (1984) 2.92
Adjuvant chemotherapy in oestrogen-receptor-poor breast cancer: patient-level meta-analysis of randomised trials. Lancet (2008) 2.91
Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. J Natl Cancer Inst Monogr (2010) 2.91
Clinical effects of anticoagulant therapy in suspected acute myocardial infarction: systematic overview of randomised trials. BMJ (1996) 2.90
Perivalvular abscesses associated with endocarditis; clinical features and prognostic factors of overall survival in a series of 233 cases. Perivalvular Abscesses French Multicentre Study. Eur Heart J (1999) 2.90
Mortality from cancer in relation to smoking: 50 years observations on British doctors. Br J Cancer (2005) 2.88
An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradation. Oncogene (1999) 2.86
Effect of intravenous nitrates on mortality in acute myocardial infarction: an overview of the randomised trials. Lancet (1988) 2.84
Effects of intravenous magnesium in suspected acute myocardial infarction: overview of randomised trials. BMJ (1991) 2.81
Weibull distributions for continuous-carcinogenesis experiments. Biometrics (1973) 2.80
Health and wages: evidence on men and women in urban Brazil. J Econom (1997) 2.75
Cancer and ageing in mice and men. Br J Cancer (1975) 2.74