Published in BMJ on January 04, 2011
The Hypertension in the Very Elderly Trial (HYVET) | NCT00122811
Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people. Lancet (2014) 4.11
Can blood pressure be lowered safely in older adults with lacunar stroke? The Secondary Prevention of Small Subcortical Strokes study experience. J Am Geriatr Soc (2015) 1.38
Management of hypertension in the elderly. Nat Rev Cardiol (2012) 0.98
Anti-hypertensive medications and cardiovascular events in older adults with multiple chronic conditions. PLoS One (2014) 0.85
GPs' perspectives on secondary cardiovascular prevention in older age: a focus group study in the Netherlands. Br J Gen Pract (2015) 0.83
Insights into the clinical management of the syndrome of supine hypertension--orthostatic hypotension (SH-OH): the Irish Longitudinal Study on Ageing (TILDA). BMC Geriatr (2013) 0.81
Longitudinal systolic blood pressure characteristics and integrity of white matter tracts in a cohort of very old black and white adults. Am J Hypertens (2014) 0.81
Antihypertensives in octogenarians. BMJ (2012) 0.81
Type 2 diabetes in older people; the importance of blood pressure control. Curr Cardiovasc Risk Rep (2013) 0.79
Angiogenic inhibitors for older patients with advanced colorectal cancer: does the age hold the stage? World J Gastroenterol (2013) 0.78
Comparative review of the blood pressure-lowering and cardiovascular benefits of telmisartan and perindopril. Vasc Health Risk Manag (2014) 0.78
Systematic review of clinical practice guidelines recommendations about primary cardiovascular disease prevention for older adults. BMC Fam Pract (2015) 0.76
The Hypertension in the Very Elderly Trial - latest data. Br J Clin Pharmacol (2013) 0.76
Diuretics in primary hypertension - Reloaded. Indian Heart J (2016) 0.75
Healthcare maintenance in elderly patients with inflammatory bowel disease. Ann Gastroenterol (2017) 0.75
Unanswered clinical questions in the management of cardiometabolic risk in the elderly: a statement of the Spanish Society of Internal Medicine. BMC Cardiovasc Disord (2014) 0.75
Managing hypertension: evidence supporting the 2013/2014 recommendations of the Canadian Hypertension Education Program. CMAJ (2014) 0.75
Approach to preventive care in the elderly. Can Fam Physician (2016) 0.75
[Not Available]. Praxis (Bern 1994) (2012) 0.75
[Aborder les soins préventifs chez les aînés]. Can Fam Physician (2016) 0.75
Comparison of hypertension healthcare outcomes among older people in the USA and England. J Epidemiol Community Health (2015) 0.75
Which thiazide to choose as add-on therapy for hypertension? Integr Blood Press Control (2014) 0.75
Chinese expert consensus on the management of hypertension in the very elderly. J Geriatr Cardiol (2016) 0.75
Hypertension: Does antihypertensive treatment have long-term benefits? Nat Rev Cardiol (2012) 0.75
Targets for body fat, blood pressure, lipids, and glucose-lowering interventions in healthy older people. Diabetes Care (2013) 0.75
Multiprofessional Treatment of High Blood Pressure in Very Elderly Patients. Arq Bras Cardiol (2017) 0.75
Association between Frailty and Hypertension Prevalence, Treatment, and Control in the Elderly Korean Population. Sci Rep (2017) 0.75
The Fifth Edition of the Addiction Severity Index. J Subst Abuse Treat (1992) 29.45
Electrophoretic resolution of the "major outer membrane protein" of Escherichia coli K12 into four bands. FEBS Lett (1975) 26.78
Treatment of hypertension in patients 80 years of age or older. N Engl J Med (2008) 21.04
Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial. Lancet (2004) 12.59
Haplotype tagging for the identification of common disease genes. Nat Genet (2001) 11.27
A microfluorimetric study of translational diffusion in erythrocyte membranes. Biochim Biophys Acta (1974) 9.57
Mortality and morbidity results from the European Working Party on High Blood Pressure in the Elderly trial. Lancet (1985) 8.35
Management guidelines in essential hypertension: report of the second working party of the British Hypertension Society. BMJ (1993) 8.24
High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation (1992) 7.11
Estimation of contribution of changes in classic risk factors to trends in coronary-event rates across the WHO MONICA Project populations. Lancet (2000) 6.94
Guidelines for management of hypertension: report of the third working party of the British Hypertension Society. J Hum Hypertens (1999) 6.74
Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet (1998) 6.20
Preventing non-insulin-dependent diabetes. Diabetes (1995) 6.16
Cardiovascular protection and blood pressure reduction: a meta-analysis. Lancet (2001) 6.05
Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell (1998) 5.92
Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology (2005) 5.51
Influence of cultural conditions and mutations on the composition of the outer membrane proteins of Escherichia coli. Mol Gen Genet (1976) 5.45
Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study. BMJ (2001) 5.40
Prevention of falls in the elderly trial (PROFET): a randomised controlled trial. Lancet (1999) 5.37
Early growth and coronary heart disease in later life: longitudinal study. BMJ (2001) 5.25
Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia (1992) 5.25
Catch-up growth in childhood and death from coronary heart disease: longitudinal study. BMJ (1999) 5.17
Worldwide increase in incidence of Type I diabetes--the analysis of the data on published incidence trends. Diabetologia (1999) 5.11
The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell (1996) 5.10
Management of elderly patients with sustained hypertension. BMJ (1992) 4.92
Imaging and tracking of single GFP molecules in solution. Biophys J (2000) 4.82
Duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer. Oncogene (2007) 4.81
Molecular diversity of K+ channels. Ann N Y Acad Sci (1999) 4.63
Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes Care (2000) 4.62
Quality of life measures in health care. I: Applications and issues in assessment. BMJ (1992) 4.53
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice. Genes Dev (2000) 4.51
Lateral and rotational diffusion of bacteriorhodopsin in lipid bilayers: experimental test of the Saffman-Delbrück equations. Proc Natl Acad Sci U S A (1982) 4.45
Associations between cigarette smoking, lifestyle factors, and microsatellite instability in colon tumors. J Natl Cancer Inst (2000) 4.39
Invasive cervical cancer after conservative therapy for cervical intraepithelial neoplasia. Lancet (1997) 4.38
The community-based strategy to prevent coronary heart disease: conclusions from the ten years of the North Karelia project. Annu Rev Public Health (1985) 4.30
Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science (1997) 4.23
Do cardiovascular risk factors explain the relation between socioeconomic status, risk of all-cause mortality, cardiovascular mortality, and acute myocardial infarction? Am J Epidemiol (1996) 4.23
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature (1998) 4.18
CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell (1991) 4.05
Change in risk factors for coronary heart disease during 10 years of a community intervention programme (North Karelia project). Br Med J (Clin Res Ed) (1983) 4.00
Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. Diabetes Care (1998) 3.99
Report of the Conference on Low Blood Cholesterol: Mortality Associations. Circulation (1992) 3.98
The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study. Working Group on Sepsis related Problems of the ESICM. Intensive Care Med (1999) 3.93
The genetically isolated populations of Finland and sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes. Nat Genet (2000) 3.92
Changes in risk factors explain changes in mortality from ischaemic heart disease in Finland. BMJ (1994) 3.92
Antihypertensive drugs in very old people: a subgroup meta-analysis of randomised controlled trials. INDANA Group. Lancet (1999) 3.81
Changes in coronary risk factors during comprehensive five-year community programme to control cardiovascular diseases (North Karelia project). Br Med J (1979) 3.75
Parental monitoring and peer influences on adolescent substance use. Pediatrics (1994) 3.66
Mother's weight in pregnancy and coronary heart disease in a cohort of Finnish men: follow up study. BMJ (1997) 3.63
Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study. Neurology (2001) 3.56
Molecular mobility and nucleocytoplasmic flux in hepatoma cells. J Cell Biol (1986) 3.48
Effects of calcium-channel blockade in older patients with diabetes and systolic hypertension. Systolic Hypertension in Europe Trial Investigators. N Engl J Med (1999) 3.43
A review of the recent epidemiological data on the worldwide incidence of type 1 (insulin-dependent) diabetes mellitus. World Health Organization DIAMOND Project Group. Diabetologia (1993) 3.35
The rate of nuclear cytoplasmic protein transport is determined by the casein kinase II site flanking the nuclear localization sequence of the SV40 T-antigen. EMBO J (1991) 3.27
Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials. Lancet (2000) 3.25
Iatrogenic Creutzfeldt-Jakob disease at the millennium. Neurology (2000) 3.23
A European evidence-based guideline for the prevention of type 2 diabetes. Horm Metab Res (2010) 3.15
Fluorescence microphotolysis to measure nucleocytoplasmic transport and intracellular mobility. Biochim Biophys Acta (1986) 3.12
Energy balance and colon cancer--beyond physical activity. Cancer Res (1997) 3.11
The fetal and childhood growth of persons who develop type 2 diabetes. Ann Intern Med (2000) 3.10
Educational level, relative body weight, and changes in their association over 10 years: an international perspective from the WHO MONICA Project. Am J Public Health (2000) 3.08
The metabolic syndrome: useful concept or clinical tool? Report of a WHO Expert Consultation. Diabetologia (2009) 3.05
Analysis of EEG and CSF 14-3-3 proteins as aids to the diagnosis of Creutzfeldt-Jakob disease. Neurology (2000) 3.03
Translational diffusion in phospholipid monolayers measured by fluorescence microphotolysis. Proc Natl Acad Sci U S A (1983) 3.03
Symptoms of chronic bronchitis and the risk of coronary disease. Lancet (1996) 3.03
Peptidoglycan-associated outer membrane proteins in gammegatine bacteria. Biochim Biophys Acta (1977) 3.00
Intake of mercury from fish, lipid peroxidation, and the risk of myocardial infarction and coronary, cardiovascular, and any death in eastern Finnish men. Circulation (1995) 2.99
Theory and action for health promotion illustrations from the North Karelia Project. Am J Public Health (1982) 2.95
Twenty-year trends in coronary risk factors in north Karelia and in other areas of Finland. Int J Epidemiol (1994) 2.91
Social class, health behaviour, and mortality among men and women in eastern Finland. BMJ (1995) 2.89
Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease. Neuroepidemiology (1998) 2.83
Prospective observational study to assess value of prostate specific antigen as screening test for prostate cancer. BMJ (1995) 2.80
Decline in mortality from coronary heart disease in Finland from 1969 to 1979. Br Med J (Clin Res Ed) (1983) 2.80
Growth in utero and during childhood among women who develop coronary heart disease: longitudinal study. BMJ (1999) 2.78
Sex, age, cardiovascular risk factors, and coronary heart disease: a prospective follow-up study of 14 786 middle-aged men and women in Finland. Circulation (1999) 2.78
The evaluation of diagnostic and prognostic criteria and the terminology of thin cutaneous malignant melanoma by the CRC Melanoma Pathology Panel. Histopathology (1996) 2.74
Perceived health status and morbidity and mortality: evidence from the Kuopio ischaemic heart disease risk factor study. Int J Epidemiol (1996) 2.73
Changes in smoking, serum cholesterol and blood pressure levels during a community-based cardiovascular disease prevention program--the North Karelia Project. Am J Epidemiol (1981) 2.72
Impact of diabetes on mortality after the first myocardial infarction. The FINMONICA Myocardial Infarction Register Study Group. Diabetes Care (1998) 2.70
A role for hydrophobic residues in the voltage-dependent gating of Shaker K+ channels. Proc Natl Acad Sci U S A (1991) 2.68
Early adiposity rebound in childhood and risk of Type 2 diabetes in adult life. Diabetologia (2003) 2.60
Beta-blockers versus diuretics in hypertensive men: main results from the HAPPHY trial. J Hypertens (1987) 2.59
Translational diffusion in the plasma membrane of single cells as studied by fluorescence microphotolysis. Cell Biol Int Rep (1981) 2.59
Glucose intolerance during diuretic therapy. Results of trial by the European Working Party on Hypertension in the Elderly. Lancet (1978) 2.56