Published in N Engl J Med on May 13, 2004
Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest (2005) 5.19
Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus. Osteoporos Int (2010) 2.69
Impact of nutrition on muscle mass, strength, and performance in older adults. Osteoporos Int (2012) 2.48
Proton pump inhibitors and risk of fractures: a meta-analysis of 11 international studies. Am J Med (2011) 2.27
The effect of proton pump inhibitors on fracture risk: report from the Canadian Multicenter Osteoporosis Study. Osteoporos Int (2012) 1.76
Homocysteine and osteoporotic fractures--culprit or bystander? N Engl J Med (2004) 1.74
A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia. Eur J Epidemiol (2006) 1.68
Assessment and management of nutrition in older people and its importance to health. Clin Interv Aging (2010) 1.61
Association of coronary artery and aortic calcium with lumbar bone density: the MESA Abdominal Aortic Calcium Study. Am J Epidemiol (2008) 1.45
The methylenetetrahydrofolate reductase 677C-->T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism. Am J Hum Genet (2007) 1.42
Cardiovascular diseases and future risk of hip fracture in women. Osteoporos Int (2007) 1.38
Cystatin-C, renal function, and incidence of hip fracture in postmenopausal women. J Am Geriatr Soc (2008) 1.24
The treatment of hyperhomocysteinemia. Annu Rev Med (2009) 1.23
Reductions in degree of mineralization and enzymatic collagen cross-links and increases in glycation-induced pentosidine in the femoral neck cortex in cases of femoral neck fracture. Osteoporos Int (2006) 1.23
Do proton pump inhibitors decrease calcium absorption? J Bone Miner Res (2010) 1.21
Bone mineral density and fracture risk in older individuals with CKD. Clin J Am Soc Nephrol (2012) 1.18
A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project. Am J Hum Genet (2005) 1.15
Peripheral arterial disease is associated with higher rates of hip bone loss and increased fracture risk in older men. Circulation (2009) 1.14
Homocysteine suppresses the expression of the collagen cross-linker lysyl oxidase involving IL-6, Fli1, and epigenetic DNA methylation. J Biol Chem (2010) 1.12
The link between osteoporosis and cardiovascular disease. Clin Cases Miner Bone Metab (2008) 1.08
Lathyrism-induced alterations in collagen cross-links influence the mechanical properties of bone material without affecting the mineral. Bone (2011) 1.07
Plasma B vitamins, homocysteine, and their relation with bone loss and hip fracture in elderly men and women. J Clin Endocrinol Metab (2008) 1.05
Hydrogen sulfide maintains mesenchymal stem cell function and bone homeostasis via regulation of Ca(2+) channel sulfhydration. Cell Stem Cell (2014) 1.01
Molecular targeting of proteins by L-homocysteine: mechanistic implications for vascular disease. Antioxid Redox Signal (2007) 1.01
Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12 and folic acid on fracture incidence. BMC Geriatr (2011) 1.00
Raloxifene ameliorates detrimental enzymatic and nonenzymatic collagen cross-links and bone strength in rabbits with hyperhomocysteinemia. Osteoporos Int (2009) 1.00
Accurate assessment and identification of naturally occurring cellular cobalamins. Clin Chem Lab Med (2008) 0.99
Homocysteine levels and risk of hip fracture in postmenopausal women. J Clin Endocrinol Metab (2009) 0.98
1,25-dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine β-synthase. J Bone Miner Res (2011) 0.97
Association of the methylenetetrahydrofolate reductase C677T polymorphism and fracture risk in Chinese postmenopausal women. Bone (2006) 0.96
Homocysteine and fracture risk in postmenopausal women: the OFELY study. Osteoporos Int (2007) 0.94
Relationship of homocysteine levels to quadriceps strength, gait speed, and late-life disability in older adults. J Gerontol A Biol Sci Med Sci (2007) 0.94
Life-course approach to nutrition. Osteoporos Int (2015) 0.94
Vitamin B12, folate, homocysteine, and bone health in adults and elderly people: a systematic review with meta-analyses. J Nutr Metab (2013) 0.93
Skeletal effects of nutrients and nutraceuticals, beyond calcium and vitamin D. Osteoporos Int (2012) 0.93
The contribution of collagen crosslinks to bone strength. Bonekey Rep (2012) 0.92
Involvement of endoplasmic reticulum stress in homocysteine-induced apoptosis of osteoblastic cells. J Bone Miner Metab (2012) 0.91
Contribution of endogenously produced reactive oxygen species to the activation of podocyte NLRP3 inflammasomes in hyperhomocysteinemia. Free Radic Biol Med (2013) 0.90
Biochemical assessment of bone turnover and bone fragility in men. Osteoporos Int (2007) 0.90
Homocysteine and mobility in older adults. J Am Geriatr Soc (2010) 0.88
Homocysteine mediated decrease in bone blood flow and remodeling: role of folic acid. J Orthop Res (2011) 0.88
Urinary pentosidine and plasma homocysteine levels at baseline predict future fractures in osteoporosis patients under bisphosphonate treatment. J Bone Miner Metab (2010) 0.87
Vibrational spectroscopic imaging for the evaluation of matrix and mineral chemistry. Curr Osteoporos Rep (2014) 0.87
Stimulation of osteoblast activity by homocysteine. J Cell Mol Med (2008) 0.87
Variation in risk factors for fractures at different sites. Curr Osteoporos Rep (2009) 0.87
Hyperhomocysteinemia decreases bone blood flow. Vasc Health Risk Manag (2011) 0.86
The synergistic effect of bone mineral density and methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) on fractures. J Bone Miner Metab (2008) 0.85
Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes. PLoS One (2009) 0.85
The effects of homocysteine and MTHFR genotype on hip bone loss and fracture risk in elderly women. Osteoporos Int (2008) 0.85
Effect of ibandronate therapy on serum homocysteine and leptin in postmenopausal osteoporotic females. Osteoporos Int (2014) 0.85
The effect of homocysteine-lowering with B-vitamins on osteoporotic fractures in patients with cerebrovascular disease: substudy of VITATOPS, a randomised placebo-controlled trial. BMC Geriatr (2013) 0.85
The role of homocysteine in bone remodeling. Clin Chem Lab Med (2013) 0.85
Relationship between two sequence variations in the gene for peroxisome proliferator-activated receptor-gamma and plasma homocysteine concentration. Health in men study. Hum Genet (2007) 0.84
The association between high plasma homocysteine levels and lower bone mineral density in Slovak women: the impact of vegetarian diet. Eur J Nutr (2009) 0.84
Effect of Vitamin B12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial. Calcif Tissue Int (2015) 0.83
Bone quality determined by Fourier transform infrared imaging analysis in mild primary hyperparathyroidism. J Clin Endocrinol Metab (2008) 0.83
Relationship of circulating total homocysteine and C-reactive protein to trabecular bone in postmenopausal women. J Clin Densitom (2007) 0.83
Homocysteine transport by human aortic endothelial cells: identification and properties of import systems. Arch Biochem Biophys (2006) 0.83
B vitamins, homocysteine and bone health. Nutrients (2015) 0.83
Associations between methotrexate treatment and methylenetetrahydrofolate reductase gene polymorphisms with incident fractures in Japanese female rheumatoid arthritis patients. J Bone Miner Metab (2009) 0.83
Hydrogen Sulfide Is a Novel Regulator of Bone Formation Implicated in the Bone Loss Induced by Estrogen Deficiency. J Bone Miner Res (2015) 0.82
Metabolomic profiles delineate signature metabolic shifts during estrogen deficiency-induced bone loss in rat by GC-TOF/MS. PLoS One (2013) 0.82
A Proton Pump Inhibitor's Effect on Bone Metabolism Mediated by Osteoclast Action in Old Age: A Prospective Randomized Study. Gut Liver (2015) 0.81
Serum metabolites as potential biomarkers for diagnosis of knee osteoarthritis. Dis Markers (2015) 0.81
Association of red blood cell 5-methyltetrahydrofolate folate with bone mineral density in postmenopausal Iranian women. Osteoporos Int (2005) 0.80
Dietary Approaches for Bone Health: Lessons from the Framingham Osteoporosis Study. Curr Osteoporos Rep (2015) 0.80
Low bone mineral density and bone mineral content are associated with low cobalamin status in adolescents. Eur J Nutr (2004) 0.79
Association between methylenetetrahydrofolate reductase C677T polymorphism and bone mineral density: the Dong-gu Study and the Namwon Study. J Korean Med Sci (2013) 0.79
Design of a randomized clinical trial of concurrent treatment with vitamin K2 and risedronate compared to risedronate alone in osteoporotic patients: Japanese Osteoporosis Intervention Trial-03 (JOINT-03). J Bone Miner Metab (2013) 0.78
Variation in the MC4R gene is associated with bone phenotypes in elderly Swedish women. PLoS One (2014) 0.78
Effect of folic acid on bone metabolism: a randomized double blind clinical trial in postmenopausal osteoporotic women. Daru (2014) 0.77
The ever-expanding conundrum of primary osteoporosis: aetiopathogenesis, diagnosis, and treatment. Ital J Pediatr (2014) 0.77
Mitochondrial epigenetics in bone remodeling during hyperhomocysteinemia. Mol Cell Biochem (2014) 0.77
Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med (2004) 0.77
Poststroke hip fracture: prevalence, clinical characteristics, mineral-bone metabolism, outcomes, and gaps in prevention. Stroke Res Treat (2013) 0.77
The out-of-focus bias in drug surveillance. Eur J Clin Pharmacol (2012) 0.77
Strontium ranelate decreases plasma homocysteine levels in postmenopausal osteoporotic women. Rheumatol Int (2008) 0.77
Tissue-specific relationship of S-adenosylhomocysteine with allele-specific H19/Igf2 methylation and imprinting in mice with hyperhomocysteinemia. Epigenetics (2012) 0.77
The relation of plasma homocysteine to radiographic knee osteoarthritis. Osteoarthritis Cartilage (2008) 0.76
Vertebral fractures on routine chest computed tomography: relation with arterial calcifications and future cardiovascular events. Int J Cardiovasc Imaging (2014) 0.76
Homocysteine as a Pathological Biomarker for Bone Disease. J Cell Physiol (2016) 0.76
Association of the MTHFR C677T polymorphism and bone mineral density in postmenopausal women: a meta-analysis. J Biomed Res (2010) 0.75
Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing. Nutrients (2016) 0.75
Comparison of parameters of bone profile and homocysteine in physically active and non-active postmenopausal females. Pak J Med Sci (2016) 0.75
Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med (2004) 0.75
Impact of the uremic milieu on the osteogenic potential of mesenchymal stem cells. PLoS One (2015) 0.75
Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med (2004) 0.75
Hydrogen Sulfide Regulates Homeostasis of Mesenchymal Stem Cells and Regulatory T Cells. J Dent Res (2016) 0.75
Association between Homocysteine and Bone Mineral Density according to Age and Sex in Healthy Adults. J Bone Metab (2016) 0.75
Plasma homocysteine level is a risk factor for osteoporotic fractures in elderly patients. Clin Interv Aging (2016) 0.75
Protective Action of Anandamide and Its COX-2 Metabolite against l-Homocysteine-Induced NLRP3 Inflammasome Activation and Injury in Podocytes. J Pharmacol Exp Ther (2016) 0.75
Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses. Dis Markers (2016) 0.75
Determinants of homocysteine levels in Ivorian rural population. Int J Vitam Nutr Res (2009) 0.75
Comparison of carbamazepine and oxcarbazepine effects on aminothiol levels. Eur J Clin Pharmacol (2007) 0.75
Low holotranscobalamin and cobalamins predict incident fractures in elderly men: the MrOS Sweden. Osteoporos Int (2013) 0.75
Low calcium intake is associated with high plasma homocysteine levels in postmenopausal women. J Bone Miner Metab (2014) 0.75
Vibrational spectroscopic techniques to assess bone quality. Osteoporos Int (2017) 0.75
Homocysteine, an additional factor, is linked to osteoporosis in postmenopausal women with type 2 diabetes. J Bone Miner Metab (2013) 0.75
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med (2006) 15.60
Vitamin D deficiency and risk of cardiovascular disease. Circulation (2008) 13.39
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation (2007) 12.79
Metabolite profiles and the risk of developing diabetes. Nat Med (2011) 12.22
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med (2002) 11.20
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination. Am J Epidemiol (2007) 9.90
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet (2007) 9.80
Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med (2008) 9.68
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Disclosure of APOE genotype for risk of Alzheimer's disease. N Engl J Med (2009) 6.43
Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation (2007) 6.34
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. BMC Med Genet (2007) 5.64
Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med (2009) 5.63
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet (2009) 5.32
Empirically derived eating patterns using factor or cluster analysis: a review. Nutr Rev (2004) 5.18
The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet (2007) 5.02
Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet (2009) 4.71
Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr (2007) 4.37
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci U S A (2002) 4.22
Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes (2008) 4.20
Chronic musculoskeletal pain and the occurrence of falls in an older population. JAMA (2009) 4.18
Genomewide linkage analysis of body mass index across 28 years of the Framingham Heart Study. Am J Hum Genet (2002) 4.07
Approaching health disparities from a population perspective: the National Institutes of Health Centers for Population Health and Health Disparities. Am J Public Health (2008) 3.98
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet (2010) 3.55
Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study. Am J Med (2003) 3.54
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Carbohydrate nutrition, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham Offspring Cohort. Diabetes Care (2004) 3.37
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet (2009) 3.18
Autoantibodies to folate receptors in the cerebral folate deficiency syndrome. N Engl J Med (2005) 3.17
Risk of dementia among white and African American relatives of patients with Alzheimer disease. JAMA (2002) 3.16
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circ Cardiovasc Genet (2010) 3.15
Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials. Am J Clin Nutr (2007) 3.14
The landscape of recombination in African Americans. Nature (2011) 3.06
Genetic associations with valvular calcification and aortic stenosis. N Engl J Med (2013) 3.02
Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial. J Bone Miner Res (2009) 2.99
Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Arch Neurol (2006) 2.98
Whole-grain intake is inversely associated with the metabolic syndrome and mortality in older adults. Am J Clin Nutr (2006) 2.94
Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes. BMC Med Genet (2007) 2.93
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer. J Natl Cancer Inst (2003) 2.92
A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev (2007) 2.91
Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol (2010) 2.91
Candidate gene association resource (CARe): design, methods, and proof of concept. Circ Cardiovasc Genet (2010) 2.91
A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes Care (2002) 2.91
The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci (2014) 2.84
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Ann Intern Med (2009) 2.80
FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet (2011) 2.73
CUBN is a gene locus for albuminuria. J Am Soc Nephrol (2011) 2.70
Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study. Diabetes (2009) 2.70
Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium. PLoS One (2013) 2.65
Whole-genome sequence-based analysis of high-density lipoprotein cholesterol. Nat Genet (2013) 2.62
Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the Folic Acid for Vascular Outcome Reduction in Transplantation trial. Circulation (2011) 2.62
Value of high-density lipoprotein (HDL) subpopulations in predicting recurrent cardiovascular events in the Veterans Affairs HDL Intervention Trial. Arterioscler Thromb Vasc Biol (2005) 2.61
A 100K genome-wide association scan for diabetes and related traits in the Framingham Heart Study: replication and integration with other genome-wide datasets. Diabetes (2007) 2.60
Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nat Genet (2009) 2.58
Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies. Am J Hum Genet (2010) 2.57
Depression as a risk factor for Alzheimer disease: the MIRAGE Study. Arch Neurol (2003) 2.56
Prospective studies of dairy product and calcium intakes and prostate cancer risk: a meta-analysis. J Natl Cancer Inst (2005) 2.54
Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis. JAMA (2008) 2.52
C-reactive protein and reclassification of cardiovascular risk in the Framingham Heart Study. Circ Cardiovasc Qual Outcomes (2008) 2.50
Who seeks genetic susceptibility testing for Alzheimer's disease? Findings from a multisite, randomized clinical trial. Genet Med (2004) 2.44
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS Genet (2010) 2.43
The MOBILIZE Boston Study: design and methods of a prospective cohort study of novel risk factors for falls in an older population. BMC Geriatr (2008) 2.42
Dietary patterns and adenocarcinoma of the esophagus and distal stomach. Am J Clin Nutr (2002) 2.40
Plasma 25-hydroxyvitamin d is associated with markers of the insulin resistant phenotype in nondiabetic adults. J Nutr (2008) 2.39
Genomewide linkage analysis to serum creatinine, GFR, and creatinine clearance in a community-based population: the Framingham Heart Study. J Am Soc Nephrol (2004) 2.36
Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Circulation (2004) 2.35
Relations of biomarkers of distinct pathophysiological pathways and atrial fibrillation incidence in the community. Circulation (2010) 2.32
Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study. BMJ (2012) 2.32