Published in Nature on July 20, 2011
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Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA. Nature (2014) 3.24
A fine-scale chimpanzee genetic map from population sequencing. Science (2012) 2.83
Genetic recombination is directed away from functional genomic elements in mice. Nature (2012) 2.46
A general approach for haplotype phasing across the full spectrum of relatedness. PLoS Genet (2014) 2.38
A direct characterization of human mutation based on microsatellites. Nat Genet (2012) 2.38
Fast and accurate inference of local ancestry in Latino populations. Bioinformatics (2012) 2.30
Probing meiotic recombination and aneuploidy of single sperm cells by whole-genome sequencing. Science (2012) 2.14
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Recombination modulates how selection affects linked sites in Drosophila. PLoS Biol (2012) 1.77
Ethiopian genetic diversity reveals linguistic stratification and complex influences on the Ethiopian gene pool. Am J Hum Genet (2012) 1.60
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RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. Nat Genet (2013) 1.38
Stable recombination hotspots in birds. Science (2015) 1.36
Using population admixture to help complete maps of the human genome. Nat Genet (2013) 1.35
Genetic recombination is targeted towards gene promoter regions in dogs. PLoS Genet (2013) 1.35
Arabidopsis meiotic crossover hot spots overlap with H2A.Z nucleosomes at gene promoters. Nat Genet (2013) 1.29
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A haplotype at STAT2 Introgressed from neanderthals and serves as a candidate of positive selection in Papua New Guinea. Am J Hum Genet (2012) 1.15
The case of the fickle fingers: how the PRDM9 zinc finger protein specifies meiotic recombination hotspots in humans. PLoS Biol (2011) 1.15
Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS Genet (2013) 1.14
Mechanism and regulation of meiotic recombination initiation. Cold Spring Harb Perspect Biol (2014) 1.13
The timing of pigmentation lightening in Europeans. Mol Biol Evol (2012) 1.13
Complex patterns of genomic admixture within southern Africa. PLoS Genet (2013) 1.12
Analysis of Latino populations from GALA and MEC studies reveals genomic loci with biased local ancestry estimation. Bioinformatics (2013) 1.11
Genome-wide scan of 29,141 African Americans finds no evidence of directional selection since admixture. Am J Hum Genet (2014) 1.10
Rare allelic forms of PRDM9 associated with childhood leukemogenesis. Genome Res (2012) 1.09
Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33. Hum Mol Genet (2014) 1.09
Scale matters: the spatial correlation of yeast meiotic DNA breaks with histone H3 trimethylation is driven largely by independent colocalization at promoters. Cell Cycle (2012) 1.02
Recombination regulator PRDM9 influences the instability of its own coding sequence in humans. Proc Natl Acad Sci U S A (2012) 1.02
Population Genomics of Human Adaptation. Annu Rev Ecol Evol Syst (2013) 1.01
A Whole-Chromosome Analysis of Meiotic Recombination in Drosophila melanogaster. G3 (Bethesda) (2012) 1.01
Efficient inference of recombination hot regions in bacterial genomes. Mol Biol Evol (2014) 0.99
High diversity at PRDM9 in chimpanzees and bonobos. PLoS One (2012) 0.98
High-resolution sex-specific linkage maps of the mouse reveal polarized distribution of crossovers in male germline. Genetics (2014) 0.97
Transmission distortion affecting human noncrossover but not crossover recombination: a hidden source of meiotic drive. PLoS Genet (2014) 0.96
Visualizing spatial population structure with estimated effective migration surfaces. Nat Genet (2015) 0.96
Diversity of Prdm9 zinc finger array in wild mice unravels new facets of the evolutionary turnover of this coding minisatellite. PLoS One (2014) 0.95
Deep conservation of human protein tandem repeats within the eukaryotes. Mol Biol Evol (2014) 0.91
Enhanced methods for local ancestry assignment in sequenced admixed individuals. PLoS Comput Biol (2014) 0.91
Evaluation of PRDM9 variation as a risk factor for recurrent genomic disorders and chromosomal non-disjunction. Hum Genet (2012) 0.91
Escape from crossover interference increases with maternal age. Nat Commun (2015) 0.90
Enhanced localization of genetic samples through linkage-disequilibrium correction. Am J Hum Genet (2013) 0.89
Recombination in the human Pseudoautosomal region PAR1. PLoS Genet (2014) 0.89
Overview of admixture mapping. Curr Protoc Hum Genet (2013) 0.88
NRE: a tool for exploring neutral loci in the human genome. BMC Bioinformatics (2012) 0.88
Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes. PLoS Genet (2015) 0.88
Population-specific common SNPs reflect demographic histories and highlight regions of genomic plasticity with functional relevance. BMC Genomics (2014) 0.88
Population demographic history can cause the appearance of recombination hotspots. Am J Hum Genet (2012) 0.87
Quantification of GC-biased gene conversion in the human genome. Genome Res (2015) 0.87
Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots. PLoS Genet (2015) 0.87
Unexpected relationships and inbreeding in HapMap phase III populations. PLoS One (2012) 0.86
Non-crossover gene conversions show strong GC bias and unexpected clustering in humans. Elife (2015) 0.86
Structural basis for human PRDM9 action at recombination hot spots. Genes Dev (2016) 0.85
A fine-scale recombination map of the human-chimpanzee ancestor reveals faster change in humans than in chimpanzees and a strong impact of GC-biased gene conversion. Genome Res (2013) 0.85
Haplotype estimation for biobank-scale data sets. Nat Genet (2016) 0.85
The red queen model of recombination hotspots evolution in the light of archaic and modern human genomes. PLoS Genet (2014) 0.84
Variation in genome-wide levels of meiotic recombination is established at the onset of prophase in mammalian males. PLoS Genet (2014) 0.84
Replication of breast cancer susceptibility loci in whites and African Americans using a Bayesian approach. Am J Epidemiol (2013) 0.84
Ancestry inference in complex admixtures via variable-length Markov chain linkage models. J Comput Biol (2013) 0.84
Zinc finger binding motifs do not explain recombination rate variation within or between species of Drosophila. PLoS One (2012) 0.83
Fine-scale mapping of meiotic recombination in Asians. BMC Genet (2013) 0.83
Spatial localization of recent ancestors for admixed individuals. G3 (Bethesda) (2014) 0.83
Differences in meiotic recombination rates in childhood acute lymphoblastic leukemia at an MHC class II hotspot close to disease associated haplotypes. PLoS One (2014) 0.82
A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years. Proc Natl Acad Sci U S A (2016) 0.82
An examination of the relationship between hotspots and recombination associated with chromosome 21 nondisjunction. PLoS One (2014) 0.81
The Genetic Architecture of Natural Variation in Recombination Rate in Drosophila melanogaster. PLoS Genet (2016) 0.81
Balancing selection on a regulatory region exhibiting ancient variation that predates human-neandertal divergence. PLoS Genet (2013) 0.81
Recombining without Hotspots: A Comprehensive Evolutionary Portrait of Recombination in Two Closely Related Species of Drosophila. Genome Biol Evol (2015) 0.81
Admixture mapping of prostate cancer in African Americans participating in the North Carolina-Louisiana Prostate Cancer Project (PCaP). Prostate (2013) 0.81
Variants of estrogen-related genes and breast cancer risk in European and African American women. Endocr Relat Cancer (2014) 0.81
How to make a sex chromosome. Nat Commun (2016) 0.81
Topological Data Analysis Generates High-Resolution, Genome-wide Maps of Human Recombination. Cell Syst (2016) 0.80
Model-based analyses of whole-genome data reveal a complex evolutionary history involving archaic introgression in Central African Pygmies. Genome Res (2016) 0.80
Meiotic recombinations within major histocompatibility complex of human embryos. Immunogenetics (2012) 0.80
Inference of Ancestral Recombination Graphs through Topological Data Analysis. PLoS Comput Biol (2016) 0.80
New paradigms for conserved, multifactorial, cis-acting regulation of meiotic recombination. Nucleic Acids Res (2012) 0.79
Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage. Epigenetics Chromatin (2015) 0.79
Whole-genome sequence analyses of Western Central African Pygmy hunter-gatherers reveal a complex demographic history and identify candidate genes under positive natural selection. Genome Res (2016) 0.79
Natural variation and dosage of the HEI10 meiotic E3 ligase control Arabidopsis crossover recombination. Genes Dev (2017) 0.78
High-resolution linkage map for two honeybee chromosomes: the hotspot quest. Mol Genet Genomics (2013) 0.78
Testing for Ancient Selection Using Cross-population Allele Frequency Differentiation. Genetics (2015) 0.78
The complex binding of PRDM9. Genome Biol (2013) 0.77
Admixture into and within sub-Saharan Africa. Elife (2016) 0.77
Distribution of recombination hotspots in the human genome--a comparison of computer simulations with real data. PLoS One (2013) 0.76
Inferring ancestry from population genomic data and its applications. Front Genet (2014) 0.76
Joint Prediction of the Effective Population Size and the Rate of Fixation of Deleterious Mutations. Genetics (2016) 0.75
Evolutionary dynamics of meiotic recombination hotspots regulator PRDM9 in bovids. Mol Genet Genomics (2016) 0.75
Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans. Hum Mol Genet (2016) 0.75
Whole-exome sequencing reveals genetic variability among lung cancer cases subphenotyped for emphysema. Carcinogenesis (2015) 0.75
PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis. Mol Biol Cell (2016) 0.75
Variable autosomal and X divergence near and far from genes affects estimates of male mutation bias in great apes. Genome Biol Evol (2016) 0.75
Role of genomics in eliminating health disparities. J Carcinog (2015) 0.75
Na Li and Matthew Stephens on Modeling Linkage Disequilibrium. Genetics (2016) 0.75
Unraveling recombination rate evolution using ancestral recombination maps. Bioessays (2014) 0.75
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Putative linkage signals identified for breast cancer in African American families. Cancer Epidemiol Biomarkers Prev (2014) 0.75
Genome-Wide Association Study of Meiotic Recombination Phenotypes. G3 (Bethesda) (2016) 0.75
Predictive Models of Recombination Rate Variation across the Drosophila melanogaster Genome. Genome Biol Evol (2016) 0.75
A map of human genome variation from population-scale sequencing. Nature (2010) 121.13
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
A high-resolution recombination map of the human genome. Nat Genet (2002) 28.66
A fine-scale map of recombination rates and hotspots across the human genome. Science (2005) 26.82
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol (2010) 26.41
Linkage disequilibrium in the human genome. Nature (2001) 17.24
The fine-scale structure of recombination rate variation in the human genome. Science (2004) 17.05
Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex. Nat Genet (2001) 15.53
Methods for high-density admixture mapping of disease genes. Am J Hum Genet (2004) 12.02
A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet (2004) 10.87
Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proc Natl Acad Sci U S A (2006) 10.32
PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice. Science (2009) 8.72
A common sequence motif associated with recombination hot spots and genome instability in humans. Nat Genet (2008) 8.64
Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination. Science (2009) 7.35
Prdm9 controls activation of mammalian recombination hotspots. Science (2009) 7.02
Sensitive detection of chromosomal segments of distinct ancestry in admixed populations. PLoS Genet (2009) 6.36
Estimating local ancestry in admixed populations. Am J Hum Genet (2008) 5.90
High-resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans. Science (2008) 5.02
Fine-scale recombination rate differences between sexes, populations and individuals. Nature (2010) 4.74
A second-generation combined linkage physical map of the human genome. Genome Res (2007) 3.60
PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans. Nat Genet (2010) 3.33
Sequence variants in the RNF212 gene associate with genome-wide recombination rate. Science (2008) 3.00
Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion. Nat Genet (2006) 2.11
Ethnicity and human genetic linkage maps. Am J Hum Genet (2004) 1.50
Proceedings: Population differences in meiotic recombination frequency between loci on chromosome 1. Cytogenet Cell Genet (1974) 1.41
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
Cancer statistics, 2008. CA Cancer J Clin (2008) 86.74
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Cancer statistics, 2009. CA Cancer J Clin (2009) 83.57
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
Cancer statistics, 2007. CA Cancer J Clin (2007) 53.49
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res (2010) 43.51
A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A (2006) 40.09
Population structure and eigenanalysis. PLoS Genet (2006) 37.21
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med (2003) 35.39
Large-scale copy number polymorphism in the human genome. Science (2004) 34.64
Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94
Cancer statistics, 2006. CA Cancer J Clin (2006) 30.71
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature (2003) 29.16
Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA (2002) 28.72
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49
Cancer statistics, 2005. CA Cancer J Clin (2005) 25.65
American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol (2006) 25.12
Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA (2006) 24.01
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med (2006) 23.83
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell (2006) 23.59
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
A common allele on chromosome 9 associated with coronary heart disease. Science (2007) 20.37
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data. Genome Res (2007) 19.07
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet (2008) 17.65
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (2012) 17.12
The fine-scale structure of recombination rate variation in the human genome. Science (2004) 17.05
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet (2003) 16.51
Assessing the impact of population stratification on genetic association studies. Nat Genet (2004) 16.28
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet (2008) 16.17
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Replicating genotype-phenotype associations. Nature (2007) 16.11
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Cancer statistics, 2004. CA Cancer J Clin (2004) 15.72
Calibrating a coalescent simulation of human genome sequence variation. Genome Res (2005) 15.04
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
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Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Rare variants create synthetic genome-wide associations. PLoS Biol (2010) 14.43
Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet (2007) 14.37