What is the importance of the immunological synapse?

Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLoS Biol (2005) 4.26

Formation and function of the lytic NK-cell immunological synapse. Nat Rev Immunol (2008) 3.17

Dangerous liaisons at the virological synapse. J Clin Invest (2004) 2.23

Spatial organization and signal transduction at intercellular junctions. Nat Rev Mol Cell Biol (2010) 1.72

Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse. J Exp Med (2007) 1.70

Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy. PLoS Biol (2011) 1.70

Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse. Blood (2010) 1.56

Understanding the structure and function of the immunological synapse. Cold Spring Harb Perspect Biol (2010) 1.54

In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain. J Exp Med (2006) 1.52

Natural killer cells in infection and inflammation of the lung. Immunology (2009) 1.46

ADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugation. J Exp Med (2004) 1.44

T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells. Proc Natl Acad Sci U S A (2005) 1.44

Microclusters of inhibitory killer immunoglobulin-like receptor signaling at natural killer cell immunological synapses. J Cell Biol (2006) 1.42

Noncytotoxic functions of NK cells: direct pathogen restriction and assistance to adaptive immunity. J Immunol (2008) 1.42

Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse. J Immunol (2009) 1.36

Dendritic cells control T cell tonic signaling required for responsiveness to foreign antigen. Proc Natl Acad Sci U S A (2010) 1.27

Natural killer cell signal integration balances synapse symmetry and migration. PLoS Biol (2009) 1.22

The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells. J Cell Biol (2009) 1.20

Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse. Mol Cell Biol (2007) 1.18

An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R. J Exp Med (2005) 1.18

Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion. Mol Cell Biol (2007) 1.13

Human and murine inhibitory natural killer cell receptors transfer from natural killer cells to target cells. Proc Natl Acad Sci U S A (2004) 1.11

The biological basis of severe outcomes in Anaplasma phagocytophilum infection. FEMS Immunol Med Microbiol (2011) 1.09

Engulfment-regulated proteolysis of SpoIIQ: evidence that dual checkpoints control sigma activity. Mol Microbiol (2005) 1.08

Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse. J Exp Med (2009) 1.08

Coronin-1A links cytoskeleton dynamics to TCR alpha beta-induced cell signaling. PLoS One (2008) 1.07

Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells. PLoS One (2010) 1.01

Immunological synapse formation inhibits, via NF-kappaB and FOXO1, the apoptosis of dendritic cells. Nat Immunol (2009) 1.01

Axotrophin and leukaemia inhibitory factor (LIF) in transplantation tolerance. Philos Trans R Soc Lond B Biol Sci (2005) 0.98

The immunological synapse: a cause or consequence of T-cell receptor triggering? Immunology (2011) 0.97

Close encounters of the first and second kind: T-DC and T-B interactions in the lymph node. Semin Immunol (2005) 0.97

HIV-1 fusion peptide targets the TCR and inhibits antigen-specific T cell activation. J Clin Invest (2005) 0.96

Super-resolution imaging of remodeled synaptic actin reveals different synergies between NK cell receptors and integrins. Blood (2012) 0.94

LFA-1 and CD2 synergize for the Erk1/2 activation in the Natural Killer (NK) cell immunological synapse. J Biol Chem (2009) 0.91

SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering. Proc Natl Acad Sci U S A (2010) 0.90

Quantitative measurement of F-actin accumulation at the NK cell immunological synapse. J Immunol Methods (2010) 0.89

Mechanisms for size-dependent protein segregation at immune synapses assessed with molecular rulers. Biophys J (2011) 0.89

Monte Carlo study of single molecule diffusion can elucidate the mechanism of B cell synapse formation. Biophys J (2008) 0.88

Lck, Membrane Microdomains, and TCR Triggering Machinery: Defining the New Rules of Engagement. Front Immunol (2012) 0.85

Effects of the geometry of the immunological synapse on the delivery of effector molecules. Biophys J (2004) 0.84

Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability. Immunol Cell Biol (2016) 0.84

Functional imaging of microdomains in cell membranes. Eur Biophys J (2008) 0.84

Cutting edge: phosphatidylinositol 4,5-bisphosphate concentration at the APC side of the immunological synapse is required for effector T cell function. J Immunol (2009) 0.84

Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation. PLoS One (2011) 0.83

Exosomes and nanotubes: Control of immune cell communication. Int J Biochem Cell Biol (2015) 0.82

Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages. J Cell Biol (2017) 0.82

Modeling of B cell Synapse Formation by Monte Carlo Simulation Shows That Directed Transport of Receptor Molecules Is a Potential Formation Mechanism. Cell Mol Bioeng (2010) 0.82

Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells. Invest Ophthalmol Vis Sci (2009) 0.81

Cell-cell nanotubes: Tunneling through several types of synapses. Commun Integr Biol (2009) 0.81

The immune synapse clears and excludes molecules above a size threshold. Nat Commun (2014) 0.81

Bifunctional nanoarrays for probing the immune response at the single-molecule level. J Vac Sci Technol B Nanotechnol Microelectron (2013) 0.80

The endothelin-integrin axis is involved in macrophage-induced breast cancer cell chemotactic interactions with endothelial cells. J Biol Chem (2014) 0.79

Sepsis-induced potentiation of peritoneal macrophage migration is mitigated by programmed cell death receptor-1 gene deficiency. J Innate Immun (2013) 0.79

The Size of Activating and Inhibitory Killer Ig-like Receptor Nanoclusters Is Controlled by the Transmembrane Sequence and Affects Signaling. Cell Rep (2016) 0.79

Essential role of the Ly49A stalk region for immunological synapse formation and signaling. Proc Natl Acad Sci U S A (2009) 0.79

Nanostructures of designed geometry and functionality enable regulation of cellular signaling processes. Biochemistry (2012) 0.78

Integrative network analysis of signaling in human CD34(+) hematopoietic progenitor cells by global phosphoproteomic profiling using TiO2 enrichment combined with 2D LC-MS/MS and pathway mapping. Proteomics (2013) 0.78

Downregulation of RhoA and changes in T cell cytoskeleton correlate with the abrogation of allograft rejection. Transpl Immunol (2010) 0.77

Dendritic cells enhance the antigen sensitivity of T cells. Front Immunol (2012) 0.77

Imaging of Cell-Cell Communication in a Vertical Orientation Reveals High-Resolution Structure of Immunological Synapse and Novel PD-1 Dynamics. J Immunol (2015) 0.77

Identification of the tetraspanin CD82 as a new barrier to xenotransplantation. J Immunol (2013) 0.77

Modulation of tumor immunity by soluble and membrane-bound molecules at the immunological synapse. Clin Dev Immunol (2013) 0.76

Down regulation of genes involved in T cell polarity and motility during the induction of heart allograft tolerance by allochimeric MHC I. PLoS One (2009) 0.76

Solution structure of a novel T-cell adhesion inhibitor derived from the fragment of ICAM-1 receptor: cyclo(1,8)-Cys-Pro-Arg-Gly-Gly-Ser-Val-Cys. Biopolymers (2009) 0.75

High throughput method to quantify anterior-posterior polarity of T-cells and epithelial cells. Viruses (2011) 0.75

LFA-1/ICAM-1 Interaction as a Therapeutic Target in Dry Eye Disease. J Ocul Pharmacol Ther (2016) 0.75

A Role For Mitochondria In Antigen Processing And Presentation. Immunology (2014) 0.75

Investigative and clinical applications of synthetic immune synapses. Wiley Interdiscip Rev Nanomed Nanobiotechnol (2012) 0.75

The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis. Sci Rep (2017) 0.75

Myristoylation: An Important Protein Modification in the Immune Response. Front Immunol (2017) 0.75

ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci (2005) 11.55

Visualizing dendritic cell networks in vivo. Nat Immunol (2004) 7.13

T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity (2006) 6.93

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nat Immunol (2005) 6.48

Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J Exp Med (2005) 5.55

Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell (2010) 5.49

The immunological synapse balances T cell receptor signaling and degradation. Science (2003) 4.94

The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science (2011) 4.76

T cell receptor signaling precedes immunological synapse formation. Science (2002) 4.56

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol (2004) 4.21

Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol (2005) 4.01

Altered TCR signaling from geometrically repatterned immunological synapses. Science (2005) 3.94

Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse. Cell (2007) 3.92

In vivo imaging of germinal centres reveals a dynamic open structure. Nature (2007) 3.83

Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J Exp Med (2006) 3.57

Protein kinase C-theta mediates negative feedback on regulatory T cell function. Science (2010) 3.31

Dynamic imaging of the immune system: progress, pitfalls and promise. Nat Rev Immunol (2006) 3.31

Lrp4 is a receptor for Agrin and forms a complex with MuSK. Cell (2008) 3.29

Costimulation and endogenous MHC ligands contribute to T cell recognition. Nat Immunol (2001) 3.24

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J Exp Med (2009) 3.13

Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells. Proc Natl Acad Sci U S A (2007) 3.11

Functional anatomy of T cell activation and synapse formation. Annu Rev Immunol (2010) 3.01

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97

Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo. Nat Immunol (2005) 2.89

Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature (2008) 2.87

Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol (2008) 2.61

LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation. Immunity (2004) 2.47

Development and migration of plasma cells in the mouse lymph node. Immunity (2010) 2.44

Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation. Immunity (2008) 2.42

Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells. Immunity (2007) 2.19

T cell antigen receptor signaling and immunological synapse stability require myosin IIA. Nat Immunol (2009) 2.17

Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain. Immunity (2009) 1.98

A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center. J Exp Med (2011) 1.97

Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation. Nat Immunol (2013) 1.96

Supported planar bilayers in studies on immune cell adhesion and communication. J Immunol Methods (2003) 1.95

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia. Nature (2009) 1.94

T cell receptor microcluster transport through molecular mazes reveals mechanism of translocation. Biophys J (2008) 1.92

Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes. Nat Immunol (2007) 1.90

Integrin inside-out signaling and the immunological synapse. Curr Opin Cell Biol (2011) 1.89

Lateral membrane waves constitute a universal dynamic pattern of motile cells. Phys Rev Lett (2006) 1.85

Identification of transcriptional regulators in the mouse immune system. Nat Immunol (2013) 1.79

Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses. Immunity (2009) 1.74

Cytotoxic T lymphocytes form an antigen-independent ring junction. J Clin Invest (2004) 1.72

The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2. Nat Cell Biol (2007) 1.72

T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters. Proc Natl Acad Sci U S A (2011) 1.61

The transcriptional landscape of αβ T cell differentiation. Nat Immunol (2013) 1.61

Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response. Proc Natl Acad Sci U S A (2006) 1.58

Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster. Immunity (2010) 1.56

Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects. J Clin Invest (2012) 1.55

ICAM-1 co-stimulates target cells to facilitate antigen presentation. Curr Opin Immunol (2005) 1.55

Micropatterning of costimulatory ligands enhances CD4+ T cell function. Proc Natl Acad Sci U S A (2008) 1.55

The critical role of agrin in the hematopoietic stem cell niche. Blood (2011) 1.54

Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes. Proc Natl Acad Sci U S A (2005) 1.51

Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation. Immunity (2002) 1.50

PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis. J Exp Med (2013) 1.48

Requirements for T lymphocyte migration in explanted lymph nodes. J Immunol (2007) 1.48

The immunological synapse: integrins take the stage. Immunol Rev (2002) 1.47

Visualization of mucosal homeostasis via single- and multiphoton intravital fluorescence microscopy. J Leukoc Biol (2012) 1.47

Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain. J Exp Med (2011) 1.43

Small GTPases and LFA-1 reciprocally modulate adhesion and signaling. Immunol Rev (2007) 1.42

WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation. Immunity (2002) 1.41

T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta. J Immunol (2008) 1.41

Self-reactive human CD4 T cell clones form unusual immunological synapses. J Exp Med (2012) 1.38

Cutting edge: activation by innate cytokines or microbial antigens can cause arrest of natural killer T cell patrolling of liver sinusoids. J Immunol (2008) 1.38

Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression. J Immunol (2010) 1.38

Innate response to focal necrotic injury inside the blood-brain barrier. J Immunol (2006) 1.31

Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites. J Immunol Methods (2009) 1.29

Measuring diffusion and binding kinetics by contact area FRAP. Biophys J (2008) 1.26

Analysis of two-dimensional dissociation constant of laterally mobile cell adhesion molecules. Biophys J (2006) 1.25

Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL. J Immunol (2008) 1.24

Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation. Trends Immunol (2002) 1.24

In silico models for cellular and molecular immunology: successes, promises and challenges. Nat Immunol (2003) 1.21

Mechanosensing in T lymphocyte activation. Biophys J (2012) 1.21

CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse. J Immunol (2005) 1.20

The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells. J Cell Biol (2009) 1.20

Cutting edge: quantitative imaging of raft accumulation in the immunological synapse. J Immunol (2002) 1.18

Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cells. J Virol (2008) 1.16

Dynamic imaging of the effector immune response to listeria infection in vivo. PLoS Pathog (2011) 1.16

Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses. Proc Natl Acad Sci U S A (2012) 1.16

Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse. Proc Natl Acad Sci U S A (2009) 1.16

Human immunodeficiency virus type 1 envelope gp120-induced partial T-cell receptor signaling creates an F-actin-depleted zone in the virological synapse. J Virol (2009) 1.14

Pillars article: The immunological synapse: a molecular machine controlling T cell activation. Science. 1999. 285: 221-227. J Immunol (2015) 1.13

Nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse. J Biol Chem (2008) 1.09

Th1 and Th2 cells form morphologically distinct immunological synapses. J Immunol (2008) 1.08

Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane. Mol Cell Biol (2009) 1.08

PKC-θ function at the immunological synapse: prospects for therapeutic targeting. Trends Immunol (2011) 1.06

High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells. Mol Membr Biol (2010) 1.04

Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection. J Exp Med (2011) 1.03

The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells. Mol Biol Cell (2009) 1.03

T-cell activation: a multidimensional signaling network. Curr Opin Cell Biol (2002) 1.02

T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation. J Cell Biol (2004) 1.01

Stimulation of naïve T-cell adhesion and immunological synapse formation by chemokine-dependent and -independent mechanisms. Immunology (2002) 1.00

Signaling microdomains in T cells. FEBS Lett (2010) 0.97

A coupled diffusion-kinetics model for analysis of contact-area FRAP experiment. Biophys J (2008) 0.97

A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling. Novartis Found Symp (2005) 0.96

T Lymphocyte Myosin IIA is Required for Maturation of the Immunological Synapse. Front Immunol (2012) 0.96

Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function. Proc Natl Acad Sci U S A (2012) 0.95

Cell:cell interactions in the immune system. Immunol Rev (2013) 0.95

HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse. Viruses (2010) 0.94

Intravital two-photon microscopy of host-pathogen interactions in a mouse model of Staphylococcus aureus skin abscess formation. Cell Microbiol (2012) 0.92