Published in Nat Immunol on February 15, 2004
Physiological functions of the HECT family of ubiquitin ligases. Nat Rev Mol Cell Biol (2009) 5.43
Ubiquitylation in innate and adaptive immunity. Nature (2009) 4.60
NFAT, immunity and cancer: a transcription factor comes of age. Nat Rev Immunol (2010) 2.77
Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells. J Exp Med (2010) 2.17
c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses. Biochem J (2005) 2.16
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. Nat Immunol (2009) 2.07
The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice. J Clin Invest (2009) 2.02
The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells. Immunity (2015) 1.94
T-cell tolerance or function is determined by combinatorial costimulatory signals. EMBO J (2006) 1.92
The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1. Nat Immunol (2008) 1.91
A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways. EMBO Rep (2005) 1.79
Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions. Cell Death Differ (2010) 1.77
Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity (2006) 1.71
Calcineurin: a central controller of signalling in eukaryotes. EMBO Rep (2004) 1.65
Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target. Immunology (2008) 1.59
TLR7 induces anergy in human CD4(+) T cells. Nat Immunol (2014) 1.56
CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2. Proc Natl Acad Sci U S A (2009) 1.52
c-Cbl-mediated regulation of LAT-nucleated signaling complexes. Mol Cell Biol (2007) 1.46
Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells. Blood (2007) 1.43
A signal-switch hypothesis for cross-regulation of cytokine and TLR signalling pathways. Nat Rev Immunol (2008) 1.41
Yin-Yang of costimulation: crucial controls of immune tolerance and function. Immunol Rev (2009) 1.39
Molecular mechanisms for adaptive tolerance and other T cell anergy models. Semin Immunol (2007) 1.38
Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3. Eur J Immunol (2008) 1.35
The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells. Nat Immunol (2014) 1.35
Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1. Proc Natl Acad Sci U S A (2009) 1.34
Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery. Proc Natl Acad Sci U S A (2010) 1.33
Diversity in CD8(+) T cell differentiation. Curr Opin Immunol (2009) 1.32
The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity (2010) 1.31
T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b. Mol Cell Biol (2008) 1.30
K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling. Immunity (2010) 1.30
Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells. J Exp Med (2007) 1.28
Diacylglycerol kinases in immune cell function and self-tolerance. Immunol Rev (2008) 1.28
Induction of T cell anergy: integration of environmental cues and infectious tolerance. Curr Opin Immunol (2010) 1.28
Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells. J Exp Med (2005) 1.25
Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL. J Immunol (2008) 1.24
Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance. J Exp Med (2009) 1.24
Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat Immunol (2008) 1.23
mTOR at the crossroads of T cell proliferation and tolerance. Semin Immunol (2007) 1.22
Innate signals compensate for the absence of PKC-{theta} during in vivo CD8(+) T cell effector and memory responses. Proc Natl Acad Sci U S A (2005) 1.21
Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation. J Clin Invest (2006) 1.21
CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse. J Immunol (2005) 1.20
HECT E3s and human disease. BMC Biochem (2007) 1.19
Molecular regulation of T-cell anergy. EMBO Rep (2008) 1.16
Endothelial protein kinase C isoform identity and differential activity of PKCzeta in an athero-susceptible region of porcine aorta. Circ Res (2005) 1.15
E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance. Proc Natl Acad Sci U S A (2009) 1.14
The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation. Nat Immunol (2011) 1.14
Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy. J Immunol (2008) 1.13
The quantal theory of how the immune system discriminates between "self and non-self" Med Immunol (2004) 1.13
The E3 ubiquitin ligase Itch in T cell activation, differentiation, and tolerance. Semin Immunol (2007) 1.13
The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination. Mol Cell Biol (2009) 1.12
High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy. Cell Death Dis (2014) 1.12
Targeted cleavage of signaling proteins by caspase 3 inhibits T cell receptor signaling in anergic T cells. Immunity (2008) 1.12
Tumor suppressor TSC1 is critical for T-cell anergy. Proc Natl Acad Sci U S A (2012) 1.11
The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells. Nat Immunol (2008) 1.10
Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation. Nat Immunol (2014) 1.10
E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity. Cell Rep (2012) 1.09
The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane. J Biol Chem (2008) 1.09
Phosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-kappaB activation. Mol Cell Biol (2007) 1.06
Ubiquitin in the immune system. EMBO Rep (2013) 1.06
Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells. Proc Natl Acad Sci U S A (2009) 1.06
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders: an evolving web of heritable autoimmune diseases. Curr Opin Pediatr (2013) 1.06
T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain. Biochem J (2008) 1.05
Negative regulators in homeostasis of naïve peripheral T cells. Immunol Res (2008) 1.05
Molecular regulation of CRAC channels and their role in lymphocyte function. Cell Mol Life Sci (2012) 1.03
Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2-mediated reversal of T-cell tolerance. Proc Natl Acad Sci U S A (2012) 1.02
Abrogating Cbl-b in effector CD8(+) T cells improves the efficacy of adoptive therapy of leukemia in mice. J Clin Invest (2010) 1.02
T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation. J Cell Biol (2004) 1.01
Transcriptional regulation of T cell tolerance. Semin Immunol (2007) 1.00
Receptor signaling in immune cell development and function. Immunol Res (2011) 0.98
Axotrophin and leukaemia inhibitory factor (LIF) in transplantation tolerance. Philos Trans R Soc Lond B Biol Sci (2005) 0.98
NFATc1/αA: The other Face of NFAT Factors in Lymphocytes. Cell Commun Signal (2012) 0.98
A new look at T cell receptor signaling to nuclear factor-κB. Trends Immunol (2013) 0.97
T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells. J Immunol (2013) 0.96
Endocytic events in TCR signaling: focus on adapters in microclusters. Immunol Rev (2009) 0.96
The transmembrane E3 ligase GRAIL ubiquitinates and degrades CD83 on CD4 T cells. J Immunol (2009) 0.94
IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes. Mol Immunol (2008) 0.94
Modular design of immunological synapses and kinapses. Cold Spring Harb Perspect Biol (2009) 0.94
Itch-/- alphabeta and gammadelta T cells independently contribute to autoimmunity in Itchy mice. Blood (2008) 0.93
Diversity in immunological synapse structure. Immunology (2010) 0.92
Transcriptional modulation of TCR, Notch and Wnt signaling pathways in SEB-anergized CD4+ T cells. Genes Immun (2005) 0.92
PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes. Mol Cell Biol (2007) 0.92
Control of virus-specific CD8+ T-cell exhaustion and immune-mediated pathology by E3 ubiquitin ligase Cbl-b during chronic viral infection. J Virol (2008) 0.91
E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation. Cell Rep (2014) 0.91
Tuberous sclerosis 1 promotes invariant NKT cell anergy and inhibits invariant NKT cell-mediated antitumor immunity. J Immunol (2014) 0.91
NFAT1 supports tumor-induced anergy of CD4(+) T cells. Cancer Res (2012) 0.91
GRAIL: a unique mediator of CD4 T-lymphocyte unresponsiveness. FEBS J (2010) 0.89
microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells. J Exp Med (2014) 0.89
Regulation of peripheral T cell activation by calreticulin. J Exp Med (2006) 0.89
Upregulation of GRAIL is associated with impaired CD4 T cell proliferation in sepsis. J Immunol (2014) 0.88
T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency. Proc Natl Acad Sci U S A (2010) 0.88
Cbl-b in T-cell activation. Semin Immunopathol (2010) 0.88
Cbl-b and itch: key regulators of peripheral T-cell tolerance. Cancer Res (2010) 0.88
Induction and stability of the anergic phenotype in T cells. Semin Immunol (2013) 0.87
The yin and yang of protein kinase C-theta (PKCθ): a novel drug target for selective immunosuppression. Adv Pharmacol (2013) 0.87
Involvement of distinct PKC gene products in T cell functions. Front Immunol (2012) 0.87
p85beta phosphoinositide 3-kinase regulates CD28 coreceptor function. Blood (2009) 0.87
The Role of the Transmembrane RING Finger Proteins in Cellular and Organelle Function. Membranes (Basel) (2011) 0.87
Silencing of the Il2 gene transcription is regulated by epigenetic changes in anergic T cells. Eur J Immunol (2012) 0.87
Genomic expression profiling of TNF-alpha-treated BDC2.5 diabetogenic CD4+ T cells. Proc Natl Acad Sci U S A (2008) 0.86
E3 ubiquitin ligase Cbl-b in innate and adaptive immunity. Cell Cycle (2014) 0.86
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature (2006) 14.78
Regulation of the germinal center response by microRNA-155. Science (2007) 12.25
ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci (2005) 11.55
Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev (2003) 9.39
FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell (2006) 9.24
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature (2010) 8.87
Orai1 is an essential pore subunit of the CRAC channel. Nature (2006) 8.60
The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. PLoS One (2010) 8.10
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature (2011) 7.43
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell (2011) 7.41
Visualizing dendritic cell networks in vivo. Nat Immunol (2004) 7.13
T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity (2006) 6.93
Aberrant T cell differentiation in the absence of Dicer. J Exp Med (2005) 6.58
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nat Immunol (2005) 6.48
Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol (2006) 6.10
Nanoscale organization of multiple GPI-anchored proteins in living cell membranes. Cell (2004) 5.61
Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J Exp Med (2005) 5.55
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell (2010) 5.49
The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell (2006) 5.18
Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu Rev Immunol (2010) 5.11
The immunological synapse balances T cell receptor signaling and degradation. Science (2003) 4.94
MicroRNA profiling of the murine hematopoietic system. Genome Biol (2005) 4.94
Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol (2006) 4.81
The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science (2011) 4.76
T cell receptor signaling precedes immunological synapse formation. Science (2002) 4.56
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity (2010) 4.52
T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol (2002) 4.38
Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle (2009) 4.14
Transcriptional mechanisms underlying lymphocyte tolerance. Cell (2002) 4.04
Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol (2005) 4.01
Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol (2008) 3.98
Altered TCR signaling from geometrically repatterned immunological synapses. Science (2005) 3.94
Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse. Cell (2007) 3.92
An epigenetic view of helper T cell differentiation. Nat Immunol (2003) 3.87
Biochemical and functional characterization of Orai proteins. J Biol Chem (2007) 3.87
In vivo imaging of germinal centres reveals a dynamic open structure. Nature (2007) 3.83
Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science (2004) 3.66
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature (2006) 3.61
MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. Cancer Res (2010) 3.57
Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J Exp Med (2006) 3.57
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature (2007) 3.55
Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science (2009) 3.47
Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. Nat Immunol (2002) 3.32
Protein kinase C-theta mediates negative feedback on regulatory T cell function. Science (2010) 3.31
Dynamic imaging of the immune system: progress, pitfalls and promise. Nat Rev Immunol (2006) 3.31
Lrp4 is a receptor for Agrin and forms a complex with MuSK. Cell (2008) 3.29
Costimulation and endogenous MHC ligands contribute to T cell recognition. Nat Immunol (2001) 3.24
Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol (2006) 3.19
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription. Nat Rev Mol Cell Biol (2013) 3.18
Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. Science (2008) 3.17
Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J Exp Med (2009) 3.13
Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells. Proc Natl Acad Sci U S A (2007) 3.11
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc Natl Acad Sci U S A (2011) 3.07
The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nat Cell Biol (2002) 3.05
Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs. J Exp Med (2009) 3.01
Functional anatomy of T cell activation and synapse formation. Annu Rev Immunol (2010) 3.01
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97
Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo. Nat Immunol (2005) 2.89
Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature (2008) 2.87
NFAT, immunity and cancer: a transcription factor comes of age. Nat Rev Immunol (2010) 2.77
Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity (2004) 2.76
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature (2013) 2.76
Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Mol Cell (2005) 2.75
Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol (2005) 2.75
STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity. N Engl J Med (2009) 2.72
Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma. J Exp Med (2010) 2.70
microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia. J Exp Med (2010) 2.68
c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation. Nat Immunol (2002) 2.64
Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol (2008) 2.61
A distal enhancer in the interferon-gamma (IFN-gamma) locus revealed by genome sequence comparison. J Biol Chem (2003) 2.59
Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol Cell Biol (2008) 2.50
Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. Proc Natl Acad Sci U S A (2006) 2.49
Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity (2002) 2.47
LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation. Immunity (2004) 2.47
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood (2011) 2.47
Development and migration of plasma cells in the mouse lymph node. Immunity (2010) 2.44
Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation. Immunity (2008) 2.42
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol (2004) 2.38
The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J (2005) 2.38
Calcium signaling in lymphocytes. Curr Opin Immunol (2008) 2.38
Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. J Clin Invest (2004) 2.31
An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry. Nature (2013) 2.31
A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels. Biochem Biophys Res Commun (2009) 2.28
Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis. J Biol Chem (2003) 2.23
Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium (2007) 2.23