Published in Mol Cell on May 21, 2004
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell (2007) 5.78
The role of Rat1 in coupling mRNA 3'-end processing to transcription termination: implications for a unified allosteric-torpedo model. Genes Dev (2006) 3.36
Identification of protein binding sites on U3 snoRNA and pre-rRNA by UV cross-linking and high-throughput analysis of cDNAs. Proc Natl Acad Sci U S A (2009) 3.04
Antisense transcripts are targets for activating small RNAs. Nat Struct Mol Biol (2008) 3.02
An early step in wobble uridine tRNA modification requires the Elongator complex. RNA (2005) 3.01
Single-molecule mRNA decay measurements reveal promoter- regulated mRNA stability in yeast. Cell (2011) 2.92
Histone modifications defining active genes persist after transcriptional and mitotic inactivation. EMBO J (2004) 2.86
Evidence for distinct mechanisms facilitating transcript elongation through chromatin in vivo. EMBO J (2004) 2.63
HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms. Mol Cell (2008) 2.28
PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element. Genes Dev (2008) 1.90
Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis. J Clin Invest (2010) 1.87
Excess histone levels mediate cytotoxicity via multiple mechanisms. Cell Cycle (2010) 1.83
The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites. Mol Cell (2014) 1.68
The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation. PLoS Genet (2010) 1.45
The histone acetyltransferase PCAF associates with actin and hnRNP U for RNA polymerase II transcription. Mol Cell Biol (2008) 1.33
Elongator function in tRNA wobble uridine modification is conserved between yeast and plants. Mol Microbiol (2010) 1.27
Transcriptional regulation by small RNAs at sequences downstream from 3' gene termini. Nat Chem Biol (2010) 1.25
Preferential repair of oxidized base damage in the transcribed genes of mammalian cells. J Biol Chem (2010) 1.22
Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development. Mol Cell Biol (2006) 1.16
Mutations in ABO1/ELO2, a subunit of holo-Elongator, increase abscisic acid sensitivity and drought tolerance in Arabidopsis thaliana. Mol Cell Biol (2006) 1.11
The growing pre-mRNA recruits actin and chromatin-modifying factors to transcriptionally active genes. Genes Dev (2005) 1.10
ATPase/helicase activities of p68 RNA helicase are required for pre-mRNA splicing but not for assembly of the spliceosome. Mol Cell Biol (2005) 1.10
Translational regulation of glutathione peroxidase 4 expression through guanine-rich sequence-binding factor 1 is essential for embryonic brain development. Genes Dev (2008) 1.09
DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1alpha gene locus. Nucleic Acids Res (2009) 1.09
Co-transcriptional regulation of alternative pre-mRNA splicing. Biochim Biophys Acta (2012) 1.08
The Snf1 protein kinase and Sit4 protein phosphatase have opposing functions in regulating TATA-binding protein association with the Saccharomyces cerevisiae INO1 promoter. Genetics (2005) 1.07
Splice-site mutations cause Rrp6-mediated nuclear retention of the unspliced RNAs and transcriptional down-regulation of the splicing-defective genes. PLoS One (2010) 1.01
Role of elongator subunit Elp3 in Drosophila melanogaster larval development and immunity. Genetics (2011) 1.01
Assembly of an export-competent mRNP is needed for efficient release of the 3'-end processing complex after polyadenylation. Mol Cell Biol (2009) 1.01
Dual functions of yeast tRNA ligase in the unfolded protein response: unconventional cytoplasmic splicing of HAC1 pre-mRNA is not sufficient to release translational attenuation. Mol Biol Cell (2010) 0.98
Histone variant H2A.Z and RNA polymerase II transcription elongation. Mol Cell Biol (2011) 0.97
CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs. J Biol Chem (2008) 0.96
The poly A polymerase Star-PAP controls 3'-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA. EMBO J (2010) 0.93
A coordinated codon-dependent regulation of translation by Elongator. Cell Cycle (2012) 0.92
Ikbkap/Elp1 deficiency causes male infertility by disrupting meiotic progression. PLoS Genet (2013) 0.90
The 68 kDa subunit of mammalian cleavage factor I interacts with the U7 small nuclear ribonucleoprotein and participates in 3'-end processing of animal histone mRNAs. Nucleic Acids Res (2010) 0.89
The tRNA modification complex elongator regulates the Cdc42-dependent mitogen-activated protein kinase pathway that controls filamentous growth in yeast. Eukaryot Cell (2009) 0.88
DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator. J Biol Chem (2012) 0.88
Elongator: transcriptional or translational regulator? Transcription (2012) 0.85
Elongator: an ancestral complex driving transcription and migration through protein acetylation. J Biomed Biotechnol (2011) 0.83
Dimerization of elongator protein 1 is essential for Elongator complex assembly. Proc Natl Acad Sci U S A (2015) 0.83
A novel gene expression pathway regulated by nuclear phosphoinositides. Adv Enzyme Regul (2009) 0.82
TFIID and Spt-Ada-Gcn5-acetyltransferase functions probed by genome-wide synthetic genetic array analysis using a Saccharomyces cerevisiae taf9-ts allele. Genetics (2005) 0.81
Allele-specific suppressors of lin-1(R175Opal) identify functions of MOC-3 and DPH-3 in tRNA modification complexes in Caenorhabditis elegans. Genetics (2010) 0.79
Localized co-transcriptional recruitment of the multifunctional RNA-binding protein CELF1 by lampbrush chromosome transcription units. Chromosome Res (2007) 0.79
Local potentiation of stress-responsive genes by upstream noncoding transcription. Nucleic Acids Res (2016) 0.78
RapMap: a rapid, sensitive and accurate tool for mapping RNA-seq reads to transcriptomes. Bioinformatics (2016) 0.78
Cytological investigations of the Arabidopsis thaliana elo1 mutant give new insights into leaf lateral growth and Elongator function. Ann Bot (2007) 0.78
Global protein-RNA interaction mapping at single nucleotide resolution by iCLIP-seq. Methods Mol Biol (2014) 0.77
Phosphorylation regulates the Star-PAP-PIPKIα interaction and directs specificity toward mRNA targets. Nucleic Acids Res (2015) 0.77
hElp3 directly modulates the expression of HSP70 gene in HeLa cells via HAT activity. PLoS One (2011) 0.76
Developing and mature human granulocytes express ELP 6 in the cytoplasm. Hum Antibodies (2013) 0.75
Elongator and its epigenetic role in plant development and responses to abiotic and biotic stresses. Front Plant Sci (2015) 0.75
Identification of a plant-specific Zn2+-sensitive ribonuclease activity. Planta (2009) 0.75
Evidence for distinct mechanisms facilitating transcript elongation through chromatin in vivo. EMBO J (2004) 2.63
Isolation and mass spectrometry of transcription factor complexes. Methods (2002) 2.46
A role for noncoding transcription in activation of the yeast PHO5 gene. Proc Natl Acad Sci U S A (2007) 2.33
Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo. Proc Natl Acad Sci U S A (2002) 2.27
Transcription impairment and cell migration defects in elongator-depleted cells: implication for familial dysautonomia. Mol Cell (2006) 2.02
Transcript Elongation by RNA Polymerase II. Annu Rev Biochem (2010) 1.97
Purification and characterization of the human elongator complex. J Biol Chem (2001) 1.97
Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1. Mol Cell (2007) 1.95
Multiple mechanisms confining RNA polymerase II ubiquitylation to polymerases undergoing transcriptional arrest. Cell (2005) 1.93
Transcriptional inhibition of genes with severe histone h3 hypoacetylation in the coding region. Mol Cell (2002) 1.91
Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches. Structure (2004) 1.84
Menin links estrogen receptor activation to histone H3K4 trimethylation. Cancer Res (2006) 1.83
A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage. Nature (2002) 1.80
A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair. Mol Cell (2010) 1.79
Stability, flexibility, and dynamic interactions of colliding RNA polymerase II elongation complexes. Mol Cell (2009) 1.65
Evidence that transcript cleavage is essential for RNA polymerase II transcription and cell viability. Mol Cell (2010) 1.55
Proteasome-mediated processing of Def1, a critical step in the cellular response to transcription stress. Cell (2013) 1.46
Vps75, a new yeast member of the NAP histone chaperone family. J Biol Chem (2007) 1.40
RNA immunoprecipitation for determining RNA-protein associations in vivo. Curr Protoc Mol Biol (2006) 1.39
Extraction of genomic DNA from yeasts for PCR-based applications. Biotechniques (2011) 1.38
Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation. Proc Natl Acad Sci U S A (2009) 1.35
Hyperphosphorylation of the C-terminal repeat domain of RNA polymerase II facilitates dissociation of its complex with mediator. J Biol Chem (2007) 1.32
Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA. Mol Cancer Ther (2009) 1.32
RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes. Biochim Biophys Acta (2013) 1.31
RNA polymerase II collision interrupts convergent transcription. Mol Cell (2012) 1.28
Direct inhibition of RNA polymerase II transcription by RECQL5. J Biol Chem (2009) 1.22
DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex. Nucleic Acids Res (2005) 1.17
E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity. J Mol Biol (2008) 1.16
The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation. Mol Biol Cell (2009) 1.14
Spreading of Sir3 protein in cells with severe histone H3 hypoacetylation. Proc Natl Acad Sci U S A (2003) 1.13
Communication between distant sites in RNA polymerase II through ubiquitylation factors and the polymerase CTD. Cell (2007) 1.13
Mechanistic interpretation of promoter-proximal peaks and RNAPII density maps. Cell (2013) 1.13
Ubiquitylation and degradation of elongating RNA polymerase II: the last resort. Biochim Biophys Acta (2012) 1.13
The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence. Mol Biol Cell (2011) 1.11
DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. Nature (2012) 1.11
An iron-sulfur cluster domain in Elp3 important for the structural integrity of elongator. J Biol Chem (2008) 1.08
Reversal of RNA polymerase II ubiquitylation by the ubiquitin protease Ubp3. Mol Cell (2008) 1.08
The NC2 alpha and beta subunits play different roles in vivo. Genes Dev (2002) 1.07
Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae. Genetics (2007) 1.05
The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. PLoS One (2012) 1.03
Role of elongator subunit Elp3 in Drosophila melanogaster larval development and immunity. Genetics (2011) 1.01
DNA damage-induced Def1-RNA polymerase II interaction and Def1 requirement for polymerase ubiquitylation in vitro. J Biol Chem (2004) 1.01
ARF and ATM/ATR cooperate in p53-mediated apoptosis upon oncogenic stress. Biochem Biophys Res Commun (2005) 0.97
Molecular architecture, structure-function relationship, and importance of the Elp3 subunit for the RNA binding of holo-elongator. J Biol Chem (2004) 0.95
Deadenylation of cytoplasmic mRNA by the mammalian Ccr4-Not complex. Biochem Soc Trans (2012) 0.95
RNA immunoprecipitation to determine RNA-protein associations in vivo. Cold Spring Harb Protoc (2009) 0.94
Interaction of Fcp1 phosphatase with elongating RNA polymerase II holoenzyme, enzymatic mechanism of action, and genetic interaction with elongator. J Biol Chem (2004) 0.94
An rtt109-independent role for vps75 in transcription-associated nucleosome dynamics. Mol Cell Biol (2009) 0.93
Acetylation of H3 K56 is required for RNA polymerase II transcript elongation through heterochromatin in yeast. Mol Cell Biol (2010) 0.91
GTP-dependent binding and nuclear transport of RNA polymerase II by Npa3 protein. J Biol Chem (2011) 0.89
Incision of a 1,3-intrastrand d(GpTpG)-cisplatin adduct by nucleotide excision repair proteins from yeast. DNA Repair (Amst) (2002) 0.88
RECQL5 helicase: connections to DNA recombination and RNA polymerase II transcription. DNA Repair (Amst) (2010) 0.87
Studying RNA-protein interactions in vivo by RNA immunoprecipitation. Methods Mol Biol (2011) 0.87
Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells. BMC Cancer (2013) 0.86
Physical and functional interaction between Elongator and the chromatin-associated Kti12 protein. J Biol Chem (2005) 0.86
Relicensing of transcriptionally inactivated replication origins in budding yeast. J Biol Chem (2010) 0.86
A role for checkpoint kinase-dependent Rad26 phosphorylation in transcription-coupled DNA repair in Saccharomyces cerevisiae. Mol Cell Biol (2009) 0.85
In vitro reconstitution of PHO5 promoter chromatin remodeling points to a role for activator-nucleosome competition in vivo. Mol Cell Biol (2010) 0.85
Chromatin-dependent and -independent regulation of DNA replication origin activation in budding yeast. EMBO Rep (2012) 0.85
RNA polymerase II determines the area of nucleosome loss in transcribed gene loci. Biochem Biophys Res Commun (2007) 0.83
A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity. Nucleic Acids Res (2013) 0.83
Interacting partners of the Tfb2 subunit from yeast TFIIH. DNA Repair (Amst) (2009) 0.81
MultiDsk: a ubiquitin-specific affinity resin. PLoS One (2012) 0.80
RNA polymerase II transcript elongation. Biochim Biophys Acta (2013) 0.79
An assay for studying ubiquitylation of RNA polymerase II and other proteins in crude yeast extracts. Methods Enzymol (2006) 0.78
Uniform distribution of elongating RNA polymerase II complexes in transcribed gene locus. J Biol Chem (2011) 0.76
Correction: Retention of the Native Epigenome in Purified Mammalian Chromatin. PLoS One (2015) 0.75
Hereditary dysautonomias: current knowledge and collaborations for the future. Clin Auton Res (2003) 0.75
Transcriptional repression of the Ahr gene by LHCGR signaling in preovulatory granulosa cells is controlled by chromatin accessibility. Mol Cell Endocrinol (2013) 0.75