Published in Biochemistry on June 01, 2004
Mutations in iron-sulfur cluster scaffold genes NFU1 and BOLA3 cause a fatal deficiency of multiple respiratory chain and 2-oxoacid dehydrogenase enzymes. Am J Hum Genet (2011) 1.70
Radical S-adenosylmethionine enzymes. Chem Rev (2014) 1.64
RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA. J Am Chem Soc (2010) 1.60
Self-sacrifice in radical S-adenosylmethionine proteins. Curr Opin Chem Biol (2007) 1.55
In vitro characterization of AtsB, a radical SAM formylglycine-generating enzyme that contains three [4Fe-4S] clusters. Biochemistry (2008) 1.46
The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A. Nat Chem Biol (2012) 1.39
Control of radical chemistry in the AdoMet radical enzymes. Curr Opin Chem Biol (2009) 1.34
Pyrroloquinoline quinone biogenesis: demonstration that PqqE from Klebsiella pneumoniae is a radical S-adenosyl-L-methionine enzyme. Biochemistry (2009) 1.34
Characterization of RimO, a new member of the methylthiotransferase subclass of the radical SAM superfamily. Biochemistry (2009) 1.33
RimO, a MiaB-like enzyme, methylthiolates the universally conserved Asp88 residue of ribosomal protein S12 in Escherichia coli. Proc Natl Acad Sci U S A (2008) 1.27
Identification of a cyclic nucleotide as a cryptic intermediate in molybdenum cofactor biosynthesis. J Am Chem Soc (2013) 1.24
Variant non ketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5. Brain (2013) 1.22
Adenosyl radical: reagent and catalyst in enzyme reactions. Chembiochem (2010) 1.19
Characterization and mechanistic studies of DesII: a radical S-adenosyl-L-methionine enzyme involved in the biosynthesis of TDP-D-desosamine. J Am Chem Soc (2009) 1.15
Scavenging of the cofactor lipoate is essential for the survival of the malaria parasite Plasmodium falciparum. Mol Microbiol (2007) 1.14
Tyrosine, cysteine, and S-adenosyl methionine stimulate in vitro [FeFe] hydrogenase activation. PLoS One (2009) 1.11
Comparative metaproteomic analysis on consecutively Rehmannia glutinosa-monocultured rhizosphere soil. PLoS One (2011) 1.11
The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase. Proc Natl Acad Sci U S A (2006) 1.11
α-Ketoglutarate dehydrogenase: a mitochondrial redox sensor. Free Radic Res (2010) 1.10
Post-translational modification of ribosomal proteins: structural and functional characterization of RimO from Thermotoga maritima, a radical S-adenosylmethionine methylthiotransferase. J Biol Chem (2009) 1.09
Stoichiometry of the redox neutral deamination and oxidative dehydrogenation reactions catalyzed by the radical SAM enzyme DesII. J Am Chem Soc (2010) 1.09
Structural diversity in the AdoMet radical enzyme superfamily. Biochim Biophys Acta (2012) 1.06
Spectroscopic, steady-state kinetic, and mechanistic characterization of the radical SAM enzyme QueE, which catalyzes a complex cyclization reaction in the biosynthesis of 7-deazapurines. Biochemistry (2012) 1.05
Identification of an intermediate methyl carrier in the radical S-adenosylmethionine methylthiotransferases RimO and MiaB. J Am Chem Soc (2013) 0.95
Further characterization of Cys-type and Ser-type anaerobic sulfatase maturating enzymes suggests a commonality in the mechanism of catalysis. Biochemistry (2013) 0.95
9-Mercaptodethiobiotin is formed as a competent catalytic intermediate by Escherichia coli biotin synthase. Biochemistry (2008) 0.95
Probing the reaction mechanism of spore photoproduct lyase (SPL) via diastereoselectively labeled dinucleotide SP TpT substrates. J Am Chem Soc (2011) 0.95
The biosynthesis of thiol- and thioether-containing cofactors and secondary metabolites catalyzed by radical S-adenosylmethionine enzymes. J Biol Chem (2014) 0.93
Biochemical and Spectroscopic Characterization of a Radical S-Adenosyl-l-methionine Enzyme Involved in the Formation of a Peptide Thioether Cross-Link. Biochemistry (2016) 0.92
Dph3 is an electron donor for Dph1-Dph2 in the first step of eukaryotic diphthamide biosynthesis. J Am Chem Soc (2014) 0.92
Radical SAM enzymes in the biosynthesis of sugar-containing natural products. Biochim Biophys Acta (2011) 0.90
Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine. Curr Opin Chem Biol (2013) 0.88
Chemical and Biological Reduction of the Radical SAM Enzyme CPH4 Synthase. Biochemistry (2015) 0.88
The Radical S-Adenosyl-L-methionine Enzyme QhpD Catalyzes Sequential Formation of Intra-protein Sulfur-to-Methylene Carbon Thioether Bonds. J Biol Chem (2015) 0.87
Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis. J Am Chem Soc (2012) 0.87
Characterization of quinolinate synthases from Escherichia coli, Mycobacterium tuberculosis, and Pyrococcus horikoshii indicates that [4Fe-4S] clusters are common cofactors throughout this class of enzymes. Biochemistry (2008) 0.87
Biotin and Lipoic Acid: Synthesis, Attachment, and Regulation. Ecosal Plus (2014) 0.86
Reduction of the [2Fe-2S] cluster accompanies formation of the intermediate 9-mercaptodethiobiotin in Escherichia coli biotin synthase. Biochemistry (2011) 0.85
Evidence for a catalytically and kinetically competent enzyme-substrate cross-linked intermediate in catalysis by lipoyl synthase. Biochemistry (2014) 0.85
Protein-protein interactions in assembly of lipoic acid on the 2-oxoacid dehydrogenases of aerobic metabolism. J Biol Chem (2011) 0.84
Spectroscopic characterization and mechanistic investigation of P-methyl transfer by a radical SAM enzyme from the marine bacterium Shewanella denitrificans OS217. Biochim Biophys Acta (2014) 0.81
Physical and functional interactions of a monothiol glutaredoxin and an iron sulfur cluster carrier protein with the sulfur-donating radical S-adenosyl-L-methionine enzyme MiaB. J Biol Chem (2013) 0.80
4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppresses the mitochondrial fatty acid synthesis pathway and impairs mitochondrial function. J Biol Chem (2014) 0.79
Metabolic evolution of a deep-branching hyperthermophilic chemoautotrophic bacterium. PLoS One (2014) 0.78
Assembly of Lipoic Acid on Its Cognate Enzymes: an Extraordinary and Essential Biosynthetic Pathway. Microbiol Mol Biol Rev (2016) 0.78
The enzyme-mediated direct reversal of a dithymine photoproduct in germinating endospores. Int J Mol Sci (2013) 0.78
Crystallographic snapshots of sulfur insertion by lipoyl synthase. Proc Natl Acad Sci U S A (2016) 0.77
Kinetic Isotope Effects and Hydrogen/Deuterium Exchange Reveal Large Conformational Changes During the Catalysis of the Clostridium acetobutylicum Spore Photoproduct Lyase. Photochem Photobiol (2016) 0.76
Overproduction of α-Lipoic Acid by Gene Manipulated Escherichia coli. PLoS One (2017) 0.75
Synthesis and characterization of a series of structurally and electronically diverse Fe(II) complexes featuring a family of triphenylamido-amine ligands. Inorg Chem (2010) 0.75
Radical Reaction Control in the AdoMet Radical Enzyme CDG Synthase (QueE): Consolidate, Destabilize, Accelerate. Chemistry (2016) 0.75
On the Role of Additional [4Fe-4S] Clusters with a Free Coordination Site in Radical-SAM Enzymes. Front Chem (2017) 0.75
Regulation and function of Arabidopsis JASMONATE ZIM-domain genes in response to wounding and herbivory. Plant Physiol (2008) 2.94
A radically different mechanism for S-adenosylmethionine-dependent methyltransferases. Science (2011) 2.55
Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily. Nat Chem Biol (2008) 1.96
A rapid wound signal activates the systemic synthesis of bioactive jasmonates in Arabidopsis. Plant J (2009) 1.95
CsrA regulates translation of the Escherichia coli carbon starvation gene, cstA, by blocking ribosome access to the cstA transcript. J Bacteriol (2003) 1.82
Detection of formate, rather than carbon monoxide, as the stoichiometric coproduct in conversion of fatty aldehydes to alkanes by a cyanobacterial aldehyde decarbonylase. J Am Chem Soc (2011) 1.62
Structural basis for methyl transfer by a radical SAM enzyme. Science (2011) 1.61
Evidence for only oxygenative cleavage of aldehydes to alk(a/e)nes and formate by cyanobacterial aldehyde decarbonylases. Biochemistry (2012) 1.60
Conversion of fatty aldehydes to alka(e)nes and formate by a cyanobacterial aldehyde decarbonylase: cryptic redox by an unusual dimetal oxygenase. J Am Chem Soc (2011) 1.54
Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2. Proc Natl Acad Sci U S A (2009) 1.47
In vitro characterization of AtsB, a radical SAM formylglycine-generating enzyme that contains three [4Fe-4S] clusters. Biochemistry (2008) 1.46
Cholesterol metabolism increases the metabolic pool of propionate in Mycobacterium tuberculosis. Biochemistry (2009) 1.45
Multifaceted characterization of cell wall decomposition products formed during ammonia fiber expansion (AFEX) and dilute acid based pretreatments. Bioresour Technol (2010) 1.41
Insight into the polar reactivity of the onium chalcogen analogues of S-adenosyl-L-methionine. Biochemistry (2004) 1.36
Mechanistic investigations of lipoic acid biosynthesis in Escherichia coli: both sulfur atoms in lipoic acid are contributed by the same lipoyl synthase polypeptide. J Am Chem Soc (2005) 1.36
Escherichia coli lipoyl synthase binds two distinct [4Fe-4S] clusters per polypeptide. Biochemistry (2004) 1.35
Characterization of RimO, a new member of the methylthiotransferase subclass of the radical SAM superfamily. Biochemistry (2009) 1.33
Purification and characterization of four beta-expansins (Zea m 1 isoforms) from maize pollen. Plant Physiol (2003) 1.28
Broad connections in the Arabidopsis seed metabolic network revealed by metabolite profiling of an amino acid catabolism mutant. Plant J (2009) 1.21
Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1. Chem Biol (2007) 1.21
Cyanobacterial alkane biosynthesis further expands the catalytic repertoire of the ferritin-like 'di-iron-carboxylate' proteins. Curr Opin Chem Biol (2011) 1.19
A genetic screen reveals Arabidopsis stomatal and/or apoplastic defenses against Pseudomonas syringae pv. tomato DC3000. PLoS Pathog (2011) 1.19
Comparative functional genomic analysis of Solanum glandular trichome types. Plant Physiol (2010) 1.18
Two-component signaling in the AAA + ATPase DctD: binding Mg2+ and BeF3- selects between alternate dimeric states of the receiver domain. FASEB J (2002) 1.17
Distortion of trichome morphology by the hairless mutation of tomato affects leaf surface chemistry. J Exp Bot (2009) 1.15
Plastochromanol-8 and tocopherols are essential lipid-soluble antioxidants during seed desiccation and quiescence in Arabidopsis. Proc Natl Acad Sci U S A (2010) 1.15
Bioengineering and Bioinformatics Summer Institutes: meeting modern challenges in undergraduate summer research. CBE Life Sci Educ (2008) 1.14
The tomato odorless-2 mutant is defective in trichome-based production of diverse specialized metabolites and broad-spectrum resistance to insect herbivores. Plant Physiol (2010) 1.14
Genetic manipulation of carotenoid biosynthesis in the green sulfur bacterium Chlorobium tepidum. J Bacteriol (2004) 1.14
A consensus mechanism for Radical SAM-dependent dehydrogenation? BtrN contains two [4Fe-4S] clusters. Biochemistry (2010) 1.13
Constitutive activation of the jasmonate signaling pathway enhances the production of secondary metabolites in tomato. FEBS Lett (2006) 1.12
LC-MS/MS assay for protein amino acids and metabolically related compounds for large-scale screening of metabolic phenotypes. Anal Chem (2007) 1.10
X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification. Proc Natl Acad Sci U S A (2013) 1.08
A small ATPase protein of Arabidopsis, TGD3, involved in chloroplast lipid import. J Biol Chem (2007) 1.08
Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2. Mol Pharmacol (2009) 1.08
Towards the plant metabolome and beyond. Nat Rev Mol Cell Biol (2007) 1.08
Cfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation. J Am Chem Soc (2011) 1.07
RlmN and AtsB as models for the overproduction and characterization of radical SAM proteins. Methods Enzymol (2012) 1.03
Identification and function of auxiliary iron-sulfur clusters in radical SAM enzymes. Biochim Biophys Acta (2012) 1.02
Isotope and elemental effects indicate a rate-limiting methyl transfer as the initial step in the reaction catalyzed by Escherichia coli cyclopropane fatty acid synthase. Biochemistry (2004) 1.01
Atmospheric pressure femtosecond laser imaging mass spectrometry. Anal Chem (2010) 0.98
Mechanistic and functional versatility of radical SAM enzymes. F1000 Biol Rep (2010) 0.98
Protein targets of 1,4-benzoquinone and 1,4-naphthoquinone in human bronchial epithelial cells. Proteomics (2003) 0.96
Further characterization of Cys-type and Ser-type anaerobic sulfatase maturating enzymes suggests a commonality in the mechanism of catalysis. Biochemistry (2013) 0.95
Triacylglycerol profiling of microalgae Chlamydomonas reinhardtii and Nannochloropsis oceanica. Bioresour Technol (2013) 0.95
Monocrotaline pyrrole targets proteins with and without cysteine residues in the cytosol and membranes of human pulmonary artery endothelial cells. Proteomics (2005) 0.95
The low resolution structure of ApoA1 in spherical high density lipoprotein revealed by small angle neutron scattering. J Biol Chem (2011) 0.95
Use of ab initio calculations to predict the biological potency of carboxylesterase inhibitors. J Med Chem (2002) 0.94
Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism. Biochem J (2004) 0.93
A substrate radical intermediate in catalysis by the antibiotic resistance protein Cfr. Nat Chem Biol (2013) 0.93
Escherichia coli quinolinate synthetase does indeed harbor a [4Fe-4S] cluster. J Am Chem Soc (2005) 0.93
The flavonoid biosynthetic enzyme chalcone isomerase modulates terpenoid production in glandular trichomes of tomato. Plant Physiol (2014) 0.93
A point mutation converts dihydroneopterin aldolase to a cofactor-independent oxygenase. J Am Chem Soc (2006) 0.93
X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry. Proc Natl Acad Sci U S A (2013) 0.93
Sulindac metabolism and synergy with tumor necrosis factor-alpha in a drug-inflammation interaction model of idiosyncratic liver injury. J Pharmacol Exp Ther (2009) 0.92
Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase. Protein Expr Purif (2005) 0.91
Facile electron transfer during formation of cluster X and kinetic competence of X for tyrosyl radical production in protein R2 of ribonucleotide reductase from mouse. Biochemistry (2002) 0.91
Escherichia coli L-serine deaminase requires a [4Fe-4S] cluster in catalysis. J Biol Chem (2004) 0.91
Functional identification of valerena-1,10-diene synthase, a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in Valeriana officinalis. J Biol Chem (2012) 0.90
Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha. Toxicol Sci (2011) 0.89
Human breath analysis: methods for sample collection and reduction of localized background effects. Anal Bioanal Chem (2009) 0.89
Striking natural diversity in glandular trichome acylsugar composition is shaped by variation at the Acyltransferase2 locus in the wild tomato Solanum habrochaites. Plant Physiol (2012) 0.88
Novel histidine-heme covalent linkage in a hemoglobin. J Am Chem Soc (2002) 0.88
Cardiolipin-mediated mitochondrial dynamics and stress response in Arabidopsis. Plant Cell (2014) 0.88
Comparative metabolic profiling revealed limitations in xylose-fermenting yeast during co-fermentation of glucose and xylose in the presence of inhibitors. Biotechnol Bioeng (2014) 0.88
Femtosecond laser-induced ionization/dissociation of protonated peptides. J Am Chem Soc (2009) 0.88
Characterization of quinolinate synthases from Escherichia coli, Mycobacterium tuberculosis, and Pyrococcus horikoshii indicates that [4Fe-4S] clusters are common cofactors throughout this class of enzymes. Biochemistry (2008) 0.87
Spectroscopic and Electrochemical Characterization of the Iron-Sulfur and Cobalamin Cofactors of TsrM, an Unusual Radical S-Adenosylmethionine Methylase. J Am Chem Soc (2016) 0.86
A high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases. Proc Natl Acad Sci U S A (2013) 0.85
Evidence for a catalytically and kinetically competent enzyme-substrate cross-linked intermediate in catalysis by lipoyl synthase. Biochemistry (2014) 0.85
Nuclear factor-kappaB mediated inhibition of cytokine production by imidazoline scaffolds. J Med Chem (2009) 0.85
Protease domain glycans affect oligomerization, disulfide bond formation, and stability of the meprin A metalloprotease homo-oligomer. J Biol Chem (2006) 0.84
Polymethylated myricetin in trichomes of the wild tomato species Solanum habrochaites and characterization of trichome-specific 3'/5'- and 7/4'-myricetin O-methyltransferases. Plant Physiol (2011) 0.84
Characterization of a cross-linked protein-nucleic acid substrate radical in the reaction catalyzed by RlmN. J Am Chem Soc (2014) 0.83
Bioassay-directed fractionation for discovery of bioactive neutral lipids guided by relative mass defect filtering and multiplexed collision-induced dissociation. Rapid Commun Mass Spectrom (2010) 0.82
Chemical imaging of trichome specialized metabolites using contact printing and laser desorption/ionization mass spectrometry. Anal Bioanal Chem (2013) 0.82
Biochemical evidence for multiple dimeric states of the Sinorhizobium meliloti DctD receiver domain. Biochemistry (2002) 0.82
Biochemistry: The ylide has landed. Nature (2013) 0.82
Metabolic Profiles Distinguish Non-Dampness-Phlegm and Dampness-Phlegm Patterns among Korean Patients with Acute Cerebral Infarction. Evid Based Complement Alternat Med (2013) 0.82
Rapid LC-MS/MS profiling of protein amino acids and metabolically related compounds for large-scale assessment of metabolic phenotypes. Methods Mol Biol (2012) 0.82
Glutathione reverses early effects of glycation on myosin function. Am J Physiol Cell Physiol (2003) 0.81
The activity of Escherichia coli cyclopropane fatty acid synthase depends on the presence of bicarbonate. J Am Chem Soc (2005) 0.81
Analysis of the stability of amino acids derivatized with naphthalene-2,3-dicarboxaldehyde using high-performance liquid chromatography and mass spectrometry. Anal Biochem (2003) 0.81
Profiling of soluble neutral oligosaccharides from treated biomass using solid phase extraction and LC-TOF MS. Carbohydr Polym (2013) 0.81
Solute attributes and molecular interactions contributing to "U-shape" retention on a fluorinated high-performance liquid chromatography stationary phase. J Chromatogr A (2005) 0.81
Regulation of the activity of Escherichia coli quinolinate synthase by reversible disulfide-bond formation. Biochemistry (2008) 0.80
Metastatic Breast Carcinoma Presenting as Perforated Appendicitis. Breast Care (Basel) (2010) 0.80
Rapid quantification of major reaction products formed during thermochemical pretreatment of lignocellulosic biomass using GC-MS. J Chromatogr B Analyt Technol Biomed Life Sci (2011) 0.80
Structure elucidation and characterization of polychlorinated biphenyl carboxylic acids as major constituents of chromophoric dissolved organic matter in seawater. Environ Sci Technol (2004) 0.79
Determination of betaine metabolites and dimethylsulfoniopropionate in coral tissues using liquid chromatography-time-of-flight mass spectrometry and stable isotope-labeled internal standards. J Chromatogr B Analyt Technol Biomed Life Sci (2010) 0.79