Published in Mol Immunol on June 01, 2004
Complement factor H polymorphism in age-related macular degeneration. Science (2005) 31.10
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A (2005) 13.44
Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome. Proc Natl Acad Sci U S A (2006) 3.80
The role of inflammation in the pathogenesis of age-related macular degeneration. Surv Ophthalmol (2006) 3.60
Age-related macular degeneration--emerging pathogenetic and therapeutic concepts. Ann Med (2006) 2.99
Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains. J Exp Med (2007) 2.55
Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H. Clin Exp Immunol (2008) 2.19
Systemic complement activation in age-related macular degeneration. PLoS One (2008) 2.18
Atypical haemolytic uraemic syndrome associated with a hybrid complement gene. PLoS Med (2006) 2.07
An update on the genetics of age-related macular degeneration. Mol Vis (2007) 1.95
Translational mini-review series on complement factor H: renal diseases associated with complement factor H: novel insights from humans and animals. Clin Exp Immunol (2008) 1.89
Therapeutic potential of complement modulation. Nat Rev Drug Discov (2009) 1.85
Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome. EMBO J (2006) 1.72
Complement control protein factor H: the good, the bad, and the inadequate. Mol Immunol (2010) 1.68
Genetics and complement in atypical HUS. Pediatr Nephrol (2010) 1.64
Immunopathological aspects of age-related macular degeneration. Semin Immunopathol (2008) 1.63
Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid. Proc Natl Acad Sci U S A (2006) 1.63
Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk. Proc Natl Acad Sci U S A (2011) 1.60
Variant-specific quantification of factor H in plasma identifies null alleles associated with atypical hemolytic uremic syndrome. Kidney Int (2010) 1.56
The potential role of amyloid beta in the pathogenesis of age-related macular degeneration. J Clin Invest (2005) 1.56
No association between complement factor H gene polymorphism and exudative age-related macular degeneration in Japanese. Hum Genet (2006) 1.54
Variation of the factor H-binding protein of Neisseria meningitidis. Microbiology (2009) 1.54
The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity. Hum Mol Genet (2009) 1.52
Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. PLoS Genet (2011) 1.49
Plasma complement factor H is associated with disease activity of patients with ANCA-associated vasculitis. Arthritis Res Ther (2015) 1.49
Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis. J Am Soc Nephrol (2012) 1.40
Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation. Blood (2017) 1.39
The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b. PLoS Pathog (2008) 1.34
Complement-mediated bactericidal activity of anti-factor H binding protein monoclonal antibodies against the meningococcus relies upon blocking factor H binding. Infect Immun (2011) 1.29
Characterization of diverse subvariants of the meningococcal factor H (fH) binding protein for their ability to bind fH, to mediate serum resistance, and to induce bactericidal antibodies. Infect Immun (2010) 1.24
Pneumolysin, PspA, and PspC contribute to pneumococcal evasion of early innate immune responses during bacteremia in mice. Infect Immun (2007) 1.22
Age-related macular degeneration in the aspect of chronic low-grade inflammation (pathophysiological parainflammation). Mediators Inflamm (2014) 1.20
C3 glomerulopathy: clinicopathologic features and predictors of outcome. Clin J Am Soc Nephrol (2013) 1.19
Complement factor H is expressed in adipose tissue in association with insulin resistance. Diabetes (2009) 1.19
Age and disease-related structural changes in the retinal pigment epithelium. Clin Ophthalmol (2008) 1.19
Genetics. Was the Human Genome Project worth the effort? Science (2005) 1.16
Genetic requirement for pneumococcal ear infection. PLoS One (2007) 1.16
Complement factor H binds to denatured rather than to native pentameric C-reactive protein. J Biol Chem (2008) 1.15
Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities. J Biol Chem (2011) 1.15
The membrane attack pathway of complement drives pathology in passively induced experimental autoimmune myasthenia gravis in mice. Clin Exp Immunol (2006) 1.12
Genetic variants of complement factor H gene are not associated with premature coronary heart disease: a family-based study in the Irish population. BMC Med Genet (2007) 1.11
Proteome-based identification of plasma proteins associated with hippocampal metabolism in early Alzheimer's disease. J Neurol (2008) 1.11
Design and evaluation of meningococcal vaccines through structure-based modification of host and pathogen molecules. PLoS Pathog (2012) 1.10
Species-specific interaction of Streptococcus pneumoniae with human complement factor H. J Immunol (2008) 1.08
Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein. J Biol Chem (2012) 1.06
DEAP-HUS: deficiency of CFHR plasma proteins and autoantibody-positive form of hemolytic uremic syndrome. Pediatr Nephrol (2010) 1.05
Role of factor H binding protein in Neisseria meningitidis virulence and its potential as a vaccine candidate to broadly protect against meningococcal disease. Microbiol Mol Biol Rev (2013) 1.05
Regulated secretion of complement factor H by RPE and its role in RPE migration. Graefes Arch Clin Exp Ophthalmol (2009) 1.05
The Plasmodium bottleneck: malaria parasite losses in the mosquito vector. Mem Inst Oswaldo Cruz (2014) 1.04
Initiation of the alternative pathway of murine complement by immune complexes is dependent on N-glycans in IgG antibodies. Arthritis Rheum (2008) 1.02
Progress in defining the molecular biology of age related macular degeneration. Hum Genet (2007) 1.01
Polyanion-induced self-association of complement factor H. J Immunol (2009) 1.01
Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells. Free Radic Biol Med (2012) 1.00
Factor h: a complement regulator in health and disease, and a mediator of cellular interactions. Biomolecules (2012) 0.99
Genetic variants of complement genes ficolin-2, mannose-binding lectin and complement factor H are associated with leprosy in Han Chinese from Southwest China. Hum Genet (2013) 0.99
Recent developments in the treatment of age-related macular degeneration. J Clin Invest (2014) 0.99
An RNA-seq protocol to identify mRNA expression changes in mouse diaphyseal bone: applications in mice with bone property altering Lrp5 mutations. J Bone Miner Res (2013) 0.97
Genome-wide association study for serum complement C3 and C4 levels in healthy Chinese subjects. PLoS Genet (2012) 0.97
New functional and structural insights from updated mutational databases for complement factor H, Factor I, membrane cofactor protein and C3. Biosci Rep (2014) 0.96
Role of ocular complement factor H in a murine model of choroidal neovascularization. Am J Pathol (2010) 0.95
Genetic analysis of complement factor H related 5, CFHR5, in patients with age-related macular degeneration. Mol Vis (2009) 0.94
Annexin-II, DNA, and histones serve as factor H ligands on the surface of apoptotic cells. J Biol Chem (2009) 0.92
That's my story, and I'm sticking to it--an update on B. burgdorferi adhesins. Front Cell Infect Microbiol (2014) 0.91
Renal transplantation in HUS patients with disorders of complement regulation. Pediatr Nephrol (2006) 0.91
C-reactive protein and the incidence of macular degeneration: pooled analysis of 5 cohorts. JAMA Ophthalmol (2013) 0.91
Regulation of complement and modulation of its activity in monoclonal antibody therapy of cancer. MAbs (2014) 0.91
Proteomic analysis of human vitreous humor. Clin Proteomics (2014) 0.90
Copy number variation in the complement factor H-related genes and age-related macular degeneration. Mol Vis (2011) 0.90
Molecular and cellular changes in the lumbar spinal cord following thoracic injury: regulation by treadmill locomotor training. PLoS One (2014) 0.90
Heparan sulfate, including that in Bruch's membrane, inhibits the complement alternative pathway: implications for age-related macular degeneration. J Immunol (2010) 0.89
Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy. Pediatr Nephrol (2010) 0.89
Age-related macular degeneration and changes in the extracellular matrix. Med Sci Monit (2014) 0.88
Interaction of complement factor h and fibulin3 in age-related macular degeneration. PLoS One (2013) 0.86
Human pentraxin 3 binds to the complement regulator c4b-binding protein. PLoS One (2011) 0.86
Complement factor H binding by different Lyme disease and relapsing fever Borrelia in animals and human. BMC Res Notes (2009) 0.86
The role of CRP and inflammation in the pathogenesis of age-related macular degeneration. Biochem Med (Zagreb) (2012) 0.85
Risk factors and biomarkers of age-related macular degeneration. Prog Retin Eye Res (2016) 0.85
Association of the complement factor H Y402H polymorphism with cardiovascular disease is dependent upon hypertension status: The ARIC study. Am J Hypertens (2008) 0.84
Complement factor H autoantibodies are associated with early stage NSCLC. Clin Cancer Res (2010) 0.84
Reduction of complement factor H binding to CLL cells improves the induction of rituximab-mediated complement-dependent cytotoxicity. Leukemia (2013) 0.83
Reference genome of wild goat (capra aegagrus) and sequencing of goat breeds provide insight into genic basis of goat domestication. BMC Genomics (2015) 0.83
Complement factor H-derived short consensus repeat 18-20 enhanced complement-dependent cytotoxicity of ofatumumab on chronic lymphocytic leukemia cells. Haematologica (2013) 0.83
Zebrafish complement factor H and its related genes: identification, evolution, and expression. Funct Integr Genomics (2010) 0.82
Role of heparan sulfate in ocular diseases. Exp Eye Res (2013) 0.82
Loa loa Microfilariae evade complement attack in vivo by acquiring regulatory proteins from host plasma. Infect Immun (2009) 0.82
Molecular Basis of Factor H R1210C Association with Ocular and Renal Diseases. J Am Soc Nephrol (2015) 0.82
Monozygotic twins with polypoidal choroidal vasuculopathy. Clin Ophthalmol (2010) 0.81
Genomics: risk and outcomes in cardiac surgery. Anesthesiol Clin (2008) 0.81
Plasma levels of complement proteins from the alternative pathway in patients with age-related macular degeneration are independent of Complement Factor H Tyr⁴⁰²His polymorphism. Mol Vis (2012) 0.81
Common and rare variants associating with serum levels of creatine kinase and lactate dehydrogenase. Nat Commun (2016) 0.81
Efficacy of plasma therapy in atypical hemolytic uremic syndrome with complement factor H mutations. Pediatr Nephrol (2008) 0.80
Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases factor H-dependent resistance of peripheral platelets to complement attack. J Immunol (2013) 0.80
An extended mini-complement factor H molecule ameliorates experimental C3 glomerulopathy. Kidney Int (2015) 0.80
Flavivirus nonstructural protein NS1: complementary surprises. Proc Natl Acad Sci U S A (2006) 0.80
The rickettsial OmpB β-peptide of Rickettsia conorii is sufficient to facilitate factor H-mediated serum resistance. Infect Immun (2012) 0.80
Recruitment of Factor H to the Streptococcus suis Cell Surface is Multifactorial. Pathogens (2016) 0.80
Mapping genetic variants in the CFH gene for association with leprosy in Han Chinese. Genes Immun (2014) 0.79
Systematic review and meta-analysis of the association between complement factor H I62V polymorphism and risk of polypoidal choroidal vasculopathy in Asian populations. PLoS One (2014) 0.79
Interaction between M-like protein and macrophage thioredoxin facilitates antiphagocytosis for Streptococcus equi ssp. zooepidemicus. PLoS One (2012) 0.79
Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome. Proc Natl Acad Sci U S A (2006) 3.80
Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond. J Allergy Clin Immunol (2004) 3.07
C3 glomerulopathy: consensus report. Kidney Int (2013) 2.85
Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation. J Clin Invest (2010) 2.18
Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march. J Allergy Clin Immunol (2006) 2.09
Predisposition to atypical hemolytic uremic syndrome involves the concurrence of different susceptibility alleles in the regulators of complement activation gene cluster in 1q32. Hum Mol Genet (2005) 2.06
Association screening in the Epidermal Differentiation Complex (EDC) identifies an SPRR3 repeat number variant as a risk factor for eczema. J Invest Dermatol (2011) 1.67
Complement factor H variants I890 and L1007 while commonly associated with atypical hemolytic uremic syndrome are polymorphisms with no functional significance. Kidney Int (2011) 1.64
Insights into hemolytic uremic syndrome: segregation of three independent predisposition factors in a large, multiple affected pedigree. Mol Immunol (2006) 1.64
The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models. Hum Mutat (2007) 1.59
A hybrid CFHR3-1 gene causes familial C3 glomerulopathy. J Am Soc Nephrol (2012) 1.52
C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation. J Clin Invest (2013) 1.52
De novo gene conversion in the RCA gene cluster (1q32) causes mutations in complement factor H associated with atypical hemolytic uremic syndrome. Hum Mutat (2006) 1.46
Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis. PLoS Biol (2007) 1.21
An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma. J Allergy Clin Immunol (2009) 1.19
High prevalence of anti-C1q antibodies in biopsy-proven active lupus nephritis. Nephrol Dial Transplant (2006) 1.17
Genetic deficiency of complement factor H in a patient with age-related macular degeneration and membranoproliferative glomerulonephritis. Mol Immunol (2008) 1.12
High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. Nat Genet (2013) 1.11
Acute presentation and persistent glomerulonephritis following streptococcal infection in a patient with heterozygous complement factor H-related protein 5 deficiency. Am J Kidney Dis (2012) 1.03
The eczema risk variant on chromosome 11q13 (rs7927894) in the population-based ALSPAC cohort: a novel susceptibility factor for asthma and hay fever. Hum Mol Genet (2011) 1.00
A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema. J Allergy Clin Immunol (2007) 1.00
Eculizumab in the treatment of atypical hemolytic uremic syndrome in infants. Am J Kidney Dis (2011) 1.00
Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome. Kidney Int (2011) 0.94
An engineered construct combining complement regulatory and surface-recognition domains represents a minimal-size functional factor H. J Immunol (2013) 0.90
Antinucleosome antibodies as a marker of active proliferative lupus nephritis. Am J Kidney Dis (2008) 0.89
Atypical hemolytic uremic syndrome-associated variants and autoantibodies impair binding of factor h and factor h-related protein 1 to pentraxin 3. J Immunol (2012) 0.88
Functional C1-inhibitor diagnostics in hereditary angioedema: assay evaluation and recommendations. J Immunol Methods (2008) 0.87
Mutations in proteins of the alternative pathway of complement and the pathogenesis of atypical hemolytic uremic syndrome. Am J Kidney Dis (2008) 0.87
Eculizumab long-term therapy for pediatric renal transplant in aHUS with CFH/CFHR1 hybrid gene. Pediatr Nephrol (2013) 0.81
Multi-locus stepwise regression: a haplotype-based algorithm for finding genetic associations applied to atopic dermatitis. BMC Med Genet (2012) 0.80
Molecular characterization of Complement Factor I deficiency in two Spanish families. Mol Immunol (2008) 0.79
The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma. J Allergy Clin Immunol (2012) 0.78
Shared genetic determinants between eczema and other immune-related diseases. Curr Opin Allergy Clin Immunol (2013) 0.76
Atypical hemolytic uremic syndrome in the Tunisian population. Int Urol Nephrol (2010) 0.75
The genetics of the skin barrier in eczema and other allergic disorders. Curr Opin Allergy Clin Immunol (2015) 0.75