Published in Clin Exp Immunol on January 01, 2008
Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis. Lancet (2010) 3.74
The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Prog Retin Eye Res (2009) 3.40
Atypical hemolytic uremic syndrome. Orphanet J Rare Dis (2011) 3.35
Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies. Nat Rev Nephrol (2012) 2.62
Structure of complement fragment C3b-factor H and implications for host protection by complement regulators. Nat Immunol (2009) 2.54
Structural basis for engagement by complement factor H of C3b on a self surface. Nat Struct Mol Biol (2011) 2.32
Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation. J Clin Invest (2010) 2.18
Complement and the atypical hemolytic uremic syndrome in children. Pediatr Nephrol (2008) 1.99
Translational mini-review series on complement factor H: renal diseases associated with complement factor H: novel insights from humans and animals. Clin Exp Immunol (2008) 1.89
The development of atypical hemolytic uremic syndrome depends on complement C5. J Am Soc Nephrol (2010) 1.88
Complement control protein factor H: the good, the bad, and the inadequate. Mol Immunol (2010) 1.68
The alternative complement pathway revisited. J Cell Mol Med (2008) 1.62
Clinical practice. Today's understanding of the haemolytic uraemic syndrome. Eur J Pediatr (2009) 1.61
A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration. Invest Ophthalmol Vis Sci (2009) 1.54
The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity. Hum Mol Genet (2009) 1.52
A hybrid CFHR3-1 gene causes familial C3 glomerulopathy. J Am Soc Nephrol (2012) 1.52
Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. PLoS Genet (2011) 1.49
Complement, age-related macular degeneration and a vision of the future. Arch Ophthalmol (2010) 1.42
Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis. J Am Soc Nephrol (2012) 1.40
A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function. Blood (2012) 1.28
Disease-causing mutations in genes of the complement system. Am J Hum Genet (2011) 1.24
Complement factor H is expressed in adipose tissue in association with insulin resistance. Diabetes (2009) 1.19
Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities. J Biol Chem (2011) 1.15
Update on hemolytic uremic syndrome: Diagnostic and therapeutic recommendations. World J Nephrol (2013) 1.14
Inflammatory mediators and angiogenic factors in choroidal neovascularization: pathogenetic interactions and therapeutic implications. Mediators Inflamm (2010) 1.11
Rapid evolution of disease resistance is accompanied by functional changes in gene expression in a wild bird. Proc Natl Acad Sci U S A (2011) 1.11
Discrimination between host and pathogens by the complement system. Vaccine (2008) 1.11
The role of complement in tumor growth. Adv Exp Med Biol (2014) 1.11
Common genetic variants in complement genes other than CFH, CD46 and the CFHRs are not associated with aHUS. Mol Immunol (2011) 1.06
The complotype: dictating risk for inflammation and infection. Trends Immunol (2012) 1.03
Factor h: a complement regulator in health and disease, and a mediator of cellular interactions. Biomolecules (2012) 0.99
Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tactic. PLoS One (2012) 0.97
Complement activation pathways in murine immune complex-induced arthritis and in C3a and C5a generation in vitro. Clin Exp Immunol (2009) 0.97
Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration. Hum Mol Genet (2013) 0.97
The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module. J Mol Biol (2009) 0.96
Properdin in complement activation and tissue injury. Mol Immunol (2013) 0.95
Nonfunctional variant 3 factor H binding proteins as meningococcal vaccine candidates. Infect Immun (2013) 0.95
Complement mutations in diacylglycerol kinase-ε-associated atypical hemolytic uremic syndrome. Clin J Am Soc Nephrol (2014) 0.94
Complement factor H: a biomarker for progression of cutaneous squamous cell carcinoma. J Invest Dermatol (2013) 0.89
The Effect of Acute and Chronic Social Stress on the Hippocampal Transcriptome in Mice. PLoS One (2015) 0.89
Severe atypical HUS caused by CFH S1191L--case presentation and review of treatment options. Pediatr Nephrol (2009) 0.88
Structural basis for complement evasion by Lyme disease pathogen Borrelia burgdorferi. J Biol Chem (2013) 0.86
Solution structure of CCP modules 10-12 illuminates functional architecture of the complement regulator, factor H. J Mol Biol (2012) 0.86
A novel atypical hemolytic uremic syndrome-associated hybrid CFHR1/CFH gene encoding a fusion protein that antagonizes factor H-dependent complement regulation. J Am Soc Nephrol (2014) 0.85
The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation. J Immunol (2011) 0.85
Properdin: a tightly regulated critical inflammatory modulator. Immunol Rev (2016) 0.85
Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH). PLoS One (2012) 0.83
Zebrafish complement factor H and its related genes: identification, evolution, and expression. Funct Integr Genomics (2010) 0.82
Review: Complement and its regulatory proteins in kidney diseases. Nephrology (Carlton) (2010) 0.82
Complement regulator CD46: genetic variants and disease associations. Hum Genomics (2015) 0.82
Molecular Basis of Factor H R1210C Association with Ocular and Renal Diseases. J Am Soc Nephrol (2015) 0.82
Maternal serum proteome changes between the first and third trimester of pregnancy in rural southern Nepal. Placenta (2012) 0.82
Complement Evasion Mediated by Enhancement of Captured Factor H: Implications for Protection of Self-Surfaces from Complement. J Immunol (2015) 0.80
AprioriGWAS, a new pattern mining strategy for detecting genetic variants associated with disease through interaction effects. PLoS Comput Biol (2014) 0.80
Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia. PLoS One (2012) 0.80
Dynamic control of the complement system by modulated expression of regulatory proteins. Lab Invest (2010) 0.80
Factor H in porcine seminal plasma protects sperm against complement attack in genital tracts. J Biol Chem (2009) 0.80
Recruitment of Factor H to the Streptococcus suis Cell Surface is Multifactorial. Pathogens (2016) 0.80
Affinity purification of human factor H on polypeptides derived from streptococcal m protein: enrichment of the Y402 variant. PLoS One (2013) 0.79
Advances and challenges in the management of complement-mediated thrombotic microangiopathies. Ther Adv Hematol (2015) 0.79
Complement factor H gene (CFH) polymorphisms C-257T, G257A and haplotypes are associated with protection against severe dengue phenotype, possible related with high CFH expression. Hum Immunol (2013) 0.79
Complement factor H: using atomic resolution structure to illuminate disease mechanisms. Adv Exp Med Biol (2008) 0.79
Partial Complement Factor H Deficiency Associates with C3 Glomerulopathy and Thrombotic Microangiopathy. J Am Soc Nephrol (2015) 0.78
Lack of association between polymorphisms in C4b-binding protein and atypical haemolytic uraemic syndrome in the Spanish population. Clin Exp Immunol (2009) 0.77
IgA nephropathy associated with a novel N-terminal mutation in factor H. Eur J Pediatr (2010) 0.77
Principles of separation: indications and therapeutic targets for plasma exchange. Clin J Am Soc Nephrol (2013) 0.77
Regulator of complement activation (RCA) group 2 gene cluster in zebrafish: identification, expression, and evolution. Funct Integr Genomics (2012) 0.77
Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in Vitro. J Biol Chem (2016) 0.76
Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury. Kidney Int (2016) 0.76
From Normal Skin to Squamous Cell Carcinoma: A Quest for Novel Biomarkers. Dis Markers (2016) 0.76
Effects of Benzo(e)pyrene on Reactive Oxygen/Nitrogen Species and Inflammatory Cytokines Induction in Human RPE Cells and Attenuation by Mitochondrial-involved Mechanism. J Ophthalmic Vis Res (2016) 0.75
Therapeutic regulation of complement in patients with renal disease - where is the promise? Clin Nephrol (2012) 0.75
Utilizing complement evasion strategies to design complement-based antibacterial immunotherapeutics: Lessons from the pathogenic Neisseriae. Immunobiology (2016) 0.75
Modulation of miR-146a/ complement factor H mediated inflammatory responses in a rat model of temporal lobe epilepsy. Biosci Rep (2016) 0.75
Complement's hidden arsenal: New insights and novel functions inside the cell. Mol Immunol (2017) 0.75
Annexin A2 Enhances Complement Activation by Inhibiting Factor H. J Immunol (2016) 0.75
Analysis of Linear Antibody Epitopes on Factor H and CFHR1 Using Sera of Patients with Autoimmune Atypical Hemolytic Uremic Syndrome. Front Immunol (2017) 0.75
Complexity of Complement Resistance Factors Expressed by Acinetobacter baumannii Needed for Survival in Human Serum. J Immunol (2017) 0.75
Systemic complement activation in central serous chorioretinopathy. PLoS One (2017) 0.75
Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self surface-selective regulation of complement activation. J Biol Chem (2017) 0.75
Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet (1998) 40.97
Complement factor H polymorphism in age-related macular degeneration. Science (2005) 31.10
Complement factor H variant increases the risk of age-related macular degeneration. Science (2005) 17.95
Complement factor H polymorphism and age-related macular degeneration. Science (2005) 17.79
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A (2005) 13.44
Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat Genet (2006) 8.33
Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution. J Exp Med (1977) 7.89
Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. Nat Genet (2006) 7.49
Modulation of the alternative complement pathways by beta 1 H globulin. J Exp Med (1976) 7.00
Control of the amplification convertase of complement by the plasma protein beta1H. Proc Natl Acad Sci U S A (1976) 6.65
Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk. Hum Mol Genet (2005) 6.36
A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol (2002) 5.57
CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration. Nat Genet (2006) 4.51
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Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H. Nat Genet (2002) 4.22
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Genetic studies into inherited and sporadic hemolytic uremic syndrome. Kidney Int (1998) 4.03
A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration. Nat Genet (2006) 3.96
Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome. Proc Natl Acad Sci U S A (2006) 3.80
Membranoproliferative glomerulonephritis type II (dense deposit disease): an update. J Am Soc Nephrol (2005) 3.57
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A novel sialic acid binding site on factor H mediates serum resistance of sialylated Neisseria gonorrhoeae. J Exp Med (1998) 3.03
Anti-Factor H autoantibodies associated with atypical hemolytic uremic syndrome. J Am Soc Nephrol (2004) 2.97
Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome. J Clin Invest (2003) 2.96
Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease). J Med Genet (2005) 2.92
Factor H mutations in hemolytic uremic syndrome cluster in exons 18-20, a domain important for host cell recognition. Am J Hum Genet (2001) 2.92
Structure and composition of drusen associated with glomerulonephritis: implications for the role of complement activation in drusen biogenesis. Eye (Lond) (2001) 2.85
Familial haemolytic uraemic syndrome and an MCP mutation. Lancet (2003) 2.79
Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome. PLoS Genet (2007) 2.79
Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome. Proc Natl Acad Sci U S A (2003) 2.79
Clustering of missense mutations in the C-terminal region of factor H in atypical hemolytic uremic syndrome. Am J Hum Genet (2001) 2.75
Complement factor H mutations and gene polymorphisms in haemolytic uraemic syndrome: the C-257T, the A2089G and the G2881T polymorphisms are strongly associated with the disease. Hum Mol Genet (2003) 2.71
Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II). Kidney Int (2006) 2.64
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The molecular basis of familial hemolytic uremic syndrome: mutation analysis of factor H gene reveals a hot spot in short consensus repeat 20. J Am Soc Nephrol (2001) 2.56
Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains. J Exp Med (2007) 2.55
Complement factor I: a susceptibility gene for atypical haemolytic uraemic syndrome. J Med Genet (2004) 2.55
Heterozygous and homozygous factor h deficiencies associated with hemolytic uremic syndrome or membranoproliferative glomerulonephritis: report and genetic analysis of 16 cases. J Am Soc Nephrol (2004) 2.46
Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency. Blood (2007) 2.46
Genetic and environmental factors influencing the human factor H plasma levels. Immunogenetics (2004) 2.43
Structural and functional characterization of factor H mutations associated with atypical hemolytic uremic syndrome. Am J Hum Genet (2002) 2.29
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Human genes for three complement components that regulate the activation of C3 are tightly linked. J Exp Med (1985) 2.12
Atypical haemolytic uraemic syndrome associated with a hybrid complement gene. PLoS Med (2006) 2.07
Predisposition to atypical hemolytic uremic syndrome involves the concurrence of different susceptibility alleles in the regulators of complement activation gene cluster in 1q32. Hum Mol Genet (2005) 2.06
Structural basis for complement factor H linked age-related macular degeneration. J Exp Med (2007) 2.02
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