Published in Biomolecules on February 07, 2012
Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation. Blood (2017) 1.39
Human factor H (FH) impairs protective meningococcal anti-FHbp antibody responses and the antibodies enhance FH binding. MBio (2014) 1.13
Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein. J Biol Chem (2012) 1.06
Regulation of complement and modulation of its activity in monoclonal antibody therapy of cancer. MAbs (2014) 0.91
Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis. J Immunol (2013) 0.87
The phosphocholine-binding pocket on C-reactive protein is necessary for initial protection of mice against pneumococcal infection. J Biol Chem (2012) 0.81
The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling. J Hepatol (2016) 0.80
Structural and functional influences of coagulation factor XIII subunit B heterozygous missense mutants. Mol Genet Genomic Med (2015) 0.78
Complement factor H in host defense and immune evasion. Cell Mol Life Sci (2016) 0.78
Transcriptome markers of viral persistence in naturally-infected andes virus (bunyaviridae) seropositive long-tailed pygmy rice rats. PLoS One (2015) 0.77
Factor H Family Proteins in Complement Evasion of Microorganisms. Front Immunol (2017) 0.76
The Borrelia afzelii outer membrane protein BAPKO_0422 binds human factor-H and is predicted to form a membrane-spanning β-barrel. Biosci Rep (2015) 0.76
Transcriptomics of liver and muscle in Holstein cows genetically divergent for fertility highlight differences in nutrient partitioning and inflammation processes. BMC Genomics (2016) 0.75
Fibulin-1 purification from human plasma using affinity chromatography on Factor H-Sepharose. Protein Expr Purif (2016) 0.75
Transcriptomic Analysis of Persistent Infection with Foot-and-Mouth Disease Virus in Cattle Suggests Impairment of Apoptosis and Cell-Mediated Immunity in the Nasopharynx. PLoS One (2016) 0.75
IL‑6 and IL‑8 enhance factor H binding to the cell membranes. Mol Med Rep (2016) 0.75
The Murine Factor H-Related Protein FHR-B Promotes Complement Activation. Front Immunol (2017) 0.75
Complement factor H polymorphism in age-related macular degeneration. Science (2005) 31.10
Complement factor H variant increases the risk of age-related macular degeneration. Science (2005) 17.95
Complement factor H polymorphism and age-related macular degeneration. Science (2005) 17.79
ISOLATION OF BETA IF-GLOBULIN FROM HUMAN SERUM AND ITS CHARACTERIZATION AS THE FIFTH COMPONENT OF COMPLEMENT. J Exp Med (1965) 15.47
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A (2005) 13.44
Recognition of microorganisms and activation of the immune response. Nature (2007) 12.99
C-reactive protein: a critical update. J Clin Invest (2003) 11.77
Complement. First of two parts. N Engl J Med (2001) 11.16
Complement: a key system for immune surveillance and homeostasis. Nat Immunol (2010) 10.37
Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution. J Exp Med (1977) 7.89
Modulation of the alternative complement pathways by beta 1 H globulin. J Exp Med (1976) 7.00
Control of the amplification convertase of complement by the plasma protein beta1H. Proc Natl Acad Sci U S A (1976) 6.65
Complement. Second of two parts. N Engl J Med (2001) 6.32
Atypical hemolytic-uremic syndrome. N Engl J Med (2009) 5.66
C-reactive Protein. J Biol Chem (2004) 4.39
Complement evasion by human pathogens. Nat Rev Microbiol (2008) 4.24
The human complement factor H: functional roles, genetic variations and disease associations. Mol Immunol (2004) 4.16
A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration. Nat Genet (2006) 3.96
A rare penetrant mutation in CFH confers high risk of age-related macular degeneration. Nat Genet (2011) 3.55
Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human peripheral blood monocytes. J Exp Med (1980) 3.50
Atypical hemolytic uremic syndrome. Orphanet J Rare Dis (2011) 3.35
New approaches to the treatment of dense deposit disease. J Am Soc Nephrol (2007) 3.02
Anti-Factor H autoantibodies associated with atypical hemolytic uremic syndrome. J Am Soc Nephrol (2004) 2.97
Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation. Blood (2009) 2.97
Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome. J Clin Invest (2003) 2.96
Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates. Nature (2009) 2.81
Discrimination between activators and nonactivators of the alternative pathway of complement: regulation via a sialic acid/polyanion binding site on factor H. Proc Natl Acad Sci U S A (1990) 2.79
An integrated view of humoral innate immunity: pentraxins as a paradigm. Annu Rev Immunol (2010) 2.71
Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature (2011) 2.64
Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II). Kidney Int (2006) 2.64
The complete amino acid sequence of human complement factor H. Biochem J (1988) 2.63
Structure of complement fragment C3b-factor H and implications for host protection by complement regulators. Nat Immunol (2009) 2.54
Heterozygous and homozygous factor h deficiencies associated with hemolytic uremic syndrome or membranoproliferative glomerulonephritis: report and genetic analysis of 16 cases. J Am Soc Nephrol (2004) 2.46
Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency. Blood (2007) 2.46
Genetic and environmental factors influencing the human factor H plasma levels. Immunogenetics (2004) 2.43
Structural basis for engagement by complement factor H of C3b on a self surface. Nat Struct Mol Biol (2011) 2.32
Structural and functional characterization of factor H mutations associated with atypical hemolytic uremic syndrome. Am J Hum Genet (2002) 2.29
Complement activation and inhibition: a delicate balance. Trends Immunol (2009) 2.22
Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H. Clin Exp Immunol (2008) 2.19
Atypical haemolytic uraemic syndrome associated with a hybrid complement gene. PLoS Med (2006) 2.07
Structural basis for complement factor H linked age-related macular degeneration. J Exp Med (2007) 2.02
Identification of complement regulatory domains in human factor H. J Immunol (1995) 2.02
Factor H family proteins and human diseases. Trends Immunol (2008) 2.02
Y402H polymorphism of complement factor H affects binding affinity to C-reactive protein. J Immunol (2007) 2.00
Mapping of the complement regulatory domains in the human factor H-like protein 1 and in factor H1. J Immunol (1995) 1.99
Release of endogenous C3b inactivator from lymphocytes in response to triggering membrane receptors for beta 1H globulin. J Exp Med (1980) 1.96
Defective complement control of factor H (Y402H) and FHL-1 in age-related macular degeneration. Mol Immunol (2007) 1.94
Identification of the second heparin-binding domain in human complement factor H. J Immunol (1998) 1.92
Identification of three physically and functionally distinct binding sites for C3b in human complement factor H by deletion mutagenesis. Proc Natl Acad Sci U S A (1996) 1.91
A new map of glycosaminoglycan and C3b binding sites on factor H. J Immunol (2008) 1.89
Structural recognition and functional activation of FcgammaR by innate pentraxins. Nature (2008) 1.88
Each of the three binding sites on complement factor H interacts with a distinct site on C3b. J Biol Chem (2000) 1.82
His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form. J Biol Chem (2006) 1.79
Regulation of complement activation by C-reactive protein. Immunopharmacology (1999) 1.78
Localization of the heparin-binding site on complement factor H. J Biol Chem (1991) 1.77
Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome. Blood (2007) 1.70
Cutting edge: localization of the host recognition functions of complement factor H at the carboxyl-terminal: implications for hemolytic uremic syndrome. J Immunol (2002) 1.69
Interaction of C-reactive protein complexes with the complement system. II. Consumption of guinea pig complement by CRP complexes: requirement for human C1q. J Immunol (1974) 1.68
Identification of a heparin binding domain in the seventh short consensus repeat of complement factor H. J Immunol (1996) 1.68
Biochemical and functional characterization of the interaction between pentraxin 3 and C1q. Eur J Immunol (2003) 1.67
Complement factor H variants I890 and L1007 while commonly associated with atypical hemolytic uremic syndrome are polymorphisms with no functional significance. Kidney Int (2011) 1.64
Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces. J Immunol (2006) 1.63
Factor H and atypical hemolytic uremic syndrome: mutations in the C-terminus cause structural changes and defective recognition functions. J Am Soc Nephrol (2005) 1.62
The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q. J Biol Chem (2005) 1.61
Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk. Proc Natl Acad Sci U S A (2011) 1.60
The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models. Hum Mutat (2007) 1.59
The high frequency of complement factor H related CFHR1 gene deletion is restricted to specific subgroups of patients with atypical haemolytic uraemic syndrome. J Med Genet (2009) 1.59
Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement. Proc Natl Acad Sci U S A (2011) 1.58
Host recognition and target differentiation by factor H, a regulator of the alternative pathway of complement. Immunopharmacology (2000) 1.58
Variant-specific quantification of factor H in plasma identifies null alleles associated with atypical hemolytic uremic syndrome. Kidney Int (2010) 1.56
Activation of the alternative pathway of complement by monoclonal lambda light chains in membranoproliferative glomerulonephritis. J Exp Med (1992) 1.56
Proteomics characterization of extracellular space components in the human aorta. Mol Cell Proteomics (2010) 1.53
Nephritogenic lambda light chain dimer: a unique human miniautoantibody against complement factor H. J Immunol (1999) 1.51
The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cells. J Biol Chem (2007) 1.51
Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partners. J Biol Chem (2000) 1.50
The C-terminus of complement regulator Factor H mediates target recognition: evidence for a compact conformation of the native protein. Clin Exp Immunol (2006) 1.50
Complement resistance of tumor cells: basal and induced mechanisms. Mol Immunol (2000) 1.49
Human factor H deficiency. Mutations in framework cysteine residues and block in H protein secretion and intracellular catabolism. J Biol Chem (1997) 1.48
Factor H binding to bone sialoprotein and osteopontin enables tumor cell evasion of complement-mediated attack. J Biol Chem (2000) 1.46
De novo gene conversion in the RCA gene cluster (1q32) causes mutations in complement factor H associated with atypical hemolytic uremic syndrome. Hum Mutat (2006) 1.46
Regulation of complement activation by C-reactive protein: targeting the complement inhibitory activity of factor H by an interaction with short consensus repeat domains 7 and 8-11. J Immunol (1999) 1.42
Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding site. Am J Pathol (2005) 1.40
Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments. Exp Eye Res (2006) 1.36
Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism. J Biol Chem (2007) 1.36
Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina. J Biol Chem (2010) 1.36
FHL-1/reconectin and factor H: two human complement regulators which are encoded by the same gene are differently expressed and regulated. Mol Immunol (2000) 1.33
Hereditary and acquired complement dysregulation in membranoproliferative glomerulonephritis. Thromb Haemost (2009) 1.33
Measurement of factor H variants in plasma using variant-specific monoclonal antibodies: application to assessing risk of age-related macular degeneration. Invest Ophthalmol Vis Sci (2008) 1.32
C4b-binding protein and factor H compensate for the loss of membrane-bound complement inhibitors to protect apoptotic cells against excessive complement attack. J Biol Chem (2007) 1.30
Exceptional resistance of human H2 glioblastoma cells to complement-mediated killing by expression and utilization of factor H and factor H-like protein 1. J Immunol (2000) 1.30
Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition. J Biol Chem (2009) 1.29
Pentraxins in innate immunity: lessons from PTX3. Cell Tissue Res (2010) 1.26
Binding of the long pentraxin PTX3 to factor H: interacting domains and function in the regulation of complement activation. J Immunol (2008) 1.23
Human polymorphonuclear leukocytes adhere to complement factor H through an interaction that involves alphaMbeta2 (CD11b/CD18). J Immunol (1998) 1.23
Cell membranes and liposomes dissociate C-reactive protein (CRP) to form a new, biologically active structural intermediate: mCRP(m). FASEB J (2006) 1.22
Characterization of the lymphocyte membrane receptor for factor H (beta 1H-globulin) with an antibody to anti-factor H idiotype. J Exp Med (1982) 1.21
Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation. Mol Immunol (2008) 1.21