Published in J Cardiovasc Pharmacol on June 01, 2004
Endothelium-mediated control of vascular tone: COX-1 and COX-2 products. Br J Pharmacol (2011) 1.51
Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclin. Br J Pharmacol (2005) 1.21
Endothelial dysfunction: a strategic target in the treatment of hypertension? Pflugers Arch (2010) 1.14
Calcium and reactive oxygen species increase in endothelial cells in response to releasers of endothelium-derived contracting factor. Br J Pharmacol (2007) 1.04
COX-mediated endothelium-dependent contractions: from the past to recent discoveries. Acta Pharmacol Sin (2010) 0.99
Hypertension and the absence of EDHF-mediated responses favour endothelium-dependent contractions in renal arteries of the rat. Br J Pharmacol (2008) 0.93
Oxygen-derived free radicals mediate endothelium-dependent contractions in femoral arteries of rats with streptozotocin-induced diabetes. Br J Pharmacol (2007) 0.88
The calcium ionophore A23187 induces endothelium-dependent contractions in femoral arteries from rats with streptozotocin-induced diabetes. Br J Pharmacol (2007) 0.87
Constrictor prostanoids and uridine adenosine tetraphosphate: vascular mediators and therapeutic targets in hypertension and diabetes. Br J Pharmacol (2015) 0.82
EDHF: bringing the concepts together. Trends Pharmacol Sci (2002) 3.69
Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture). Am J Physiol Heart Circ Physiol (2006) 2.97
Endothelium-derived hyperpolarizing factor: where are we now? Arterioscler Thromb Vasc Biol (2006) 2.69
Endothelium-derived hyperpolarising factors and associated pathways: a synopsis. Pflugers Arch (2010) 2.29
SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells. Circ Res (2010) 2.20
Acetaminophen increases blood pressure in patients with coronary artery disease. Circulation (2010) 1.85
Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res (2008) 1.78
Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention. Clin Sci (Lond) (2008) 1.77
Role of potassium in regulating blood flow and blood pressure. Am J Physiol Regul Integr Comp Physiol (2006) 1.74
Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. Diabetes (2010) 1.71
EDHF: an update. Clin Sci (Lond) (2009) 1.67
Activation of A(2) adenosine receptors dilates cortical efferent arterioles in mouse. Kidney Int (2009) 1.60
Endothelium-mediated control of vascular tone: COX-1 and COX-2 products. Br J Pharmacol (2011) 1.51
Endothelium-dependent hyperpolarizations: past beliefs and present facts. Ann Med (2007) 1.47
Repolarization abnormalities and their arrhythmogenic consequences in porcine tachycardia-induced cardiomyopathy. Cardiovasc Res (2002) 1.46
Upregulation of heme oxygenase 1 by hemin impairs endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Hypertension (2011) 1.45
Adiponectin and cardiovascular health: an update. Br J Pharmacol (2012) 1.42
Cellular signaling and NO production. Pflugers Arch (2010) 1.38
APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice. Cell Metab (2009) 1.36
Characterization of a charybdotoxin-sensitive intermediate conductance Ca2+-activated K+ channel in porcine coronary endothelium: relevance to EDHF. Br J Pharmacol (2002) 1.34
Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension. Circ Res (2010) 1.33
Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins. Proteomics (2009) 1.31
Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1. J Biol Chem (2010) 1.28
Oxygen-derived free radicals mediate endothelium-dependent contractions to acetylcholine in aortas from spontaneously hypertensive rats. Br J Pharmacol (2002) 1.28
Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids. Br J Pharmacol (2005) 1.28
Gene expression changes of prostanoid synthases in endothelial cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension. Physiol Genomics (2007) 1.27
Endothelium-derived vasoactive factors and hypertension: possible roles in pathogenesis and as treatment targets. Curr Hypertens Rep (2010) 1.25
Vitamin D derivatives acutely reduce endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol (2008) 1.23
Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclin. Br J Pharmacol (2005) 1.21
EDHF: new therapeutic targets? Pharmacol Res (2004) 1.21
Endothelium-dependent contractions occur in the aorta of wild-type and COX2-/- knockout but not COX1-/- knockout mice. J Cardiovasc Pharmacol (2005) 1.19
Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase. Cardiovasc Res (2009) 1.17
SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model. FEBS Lett (2010) 1.15
Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress. Eur Heart J (2012) 1.15
Endothelial dysfunction: a strategic target in the treatment of hypertension? Pflugers Arch (2010) 1.14
Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease. Am J Physiol Heart Circ Physiol (2011) 1.13
Nitric oxide: orchestrator of endothelium-dependent responses. Ann Med (2011) 1.13
A diffusible substance(s) mediates endothelium-dependent contractions in the aorta of SHR. Hypertension (2003) 1.12
Prostanoids and reactive oxygen species: team players in endothelium-dependent contractions. Pharmacol Ther (2009) 1.09
Vasoconstrictor prostanoids. Pflugers Arch (2010) 1.09
Endothelium-dependent contractions in SHR: a tale of prostanoid TP and IP receptors. Br J Pharmacol (2009) 1.07
Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs. Circulation (2008) 1.07
N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes. Free Radic Biol Med (2013) 1.07
Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells. Br J Pharmacol (2011) 1.07
Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice. Cell Metab (2011) 1.07
MMP-7 and cardiovascular disease: not so surprising! Basic Clin Pharmacol Toxicol (2012) 1.06
Oxidized low-density lipoprotein activates p66Shc via lectin-like oxidized low-density lipoprotein receptor-1, protein kinase C-beta, and c-Jun N-terminal kinase kinase in human endothelial cells. Arterioscler Thromb Vasc Biol (2011) 1.04
Augmented endothelium-derived hyperpolarizing factor-mediated relaxations attenuate endothelial dysfunction in femoral and mesenteric, but not in carotid arteries from type I diabetic rats. J Pharmacol Exp Ther (2006) 1.03
Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin f(2α) impairs endothelial function in renovascular hypertensive rats. Antioxid Redox Signal (2011) 1.01
Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway. Diabetes (2010) 1.01
Genomic changes in regenerated porcine coronary arterial endothelial cells. Arterioscler Thromb Vasc Biol (2007) 1.01
N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1α/HO-1 signaling in diabetic rats. PLoS One (2013) 1.00
Acetylcholine and sodium nitroprusside cause long-term inhibition of EDCF-mediated contractions. Am J Physiol Heart Circ Physiol (2005) 0.99
Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4. Arterioscler Thromb Vasc Biol (2013) 0.98
Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis. Circulation (2012) 0.98
Role of SK(Ca) and IK(Ca) in endothelium-dependent hyperpolarizations of the guinea-pig isolated carotid artery. Br J Pharmacol (2005) 0.98
PKCβ inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Clin Sci (Lond) (2012) 0.98
The role of prostaglandin E and thromboxane-prostanoid receptors in the response to prostaglandin E2 in the aorta of Wistar Kyoto rats and spontaneously hypertensive rats. Cardiovasc Res (2007) 0.98
The role of pharmacology in drug discovery. Nat Rev Drug Discov (2002) 0.97
Anti-inflammation therapy by activation of prostaglandin EP4 receptor in cardiovascular and other inflammatory diseases. J Cardiovasc Pharmacol (2012) 0.96
Chronic treatment with vitamin D lowers arterial blood pressure and reduces endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol (2010) 0.96
APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice. Diabetes (2011) 0.96
Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice. Endocrinology (2008) 0.95
Endothelium-dependent contractions to acetylcholine, ATP and the calcium ionophore A 23187 in aortas from spontaneously hypertensive and normotensive rats. Fundam Clin Pharmacol (2004) 0.95
Puerarin, an isoflavonoid derived from Radix puerariae, potentiates endothelium-independent relaxation via the cyclic AMP pathway in porcine coronary artery. Eur J Pharmacol (2006) 0.94
Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat. J Pharmacol Exp Ther (2010) 0.93
Blockade of beta 1- and desensitization of beta 2-adrenoceptors reduce isoprenaline-induced cardiac fibrosis. Eur J Pharmacol (2004) 0.91
Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop β-cell dysfunction and metabolic syndrome. FASEB J (2013) 0.91
Endothelial mediators of the acetylcholine-induced relaxation of the rat femoral artery. Vascul Pharmacol (2006) 0.91
In SHR aorta, calcium ionophore A-23187 releases prostacyclin and thromboxane A2 as endothelium-derived contracting factors. Am J Physiol Heart Circ Physiol (2006) 0.91
The thromboxane/endoperoxide receptor (TP): the common villain. J Cardiovasc Pharmacol (2010) 0.91
Oxidative stress and pathological changes after coronary artery interventions. J Am Coll Cardiol (2013) 0.91
Non-genomic activation of adenylyl cyclase and protein kinase G by 17β-estradiol in vascular smooth muscle of the rat superior mesenteric artery. Pharmacol Res (2011) 0.90
Acute impairment of contractile responses by 17beta-estradiol is cAMP and protein kinase G dependent in vascular smooth muscle cells of the porcine coronary arteries. Br J Pharmacol (2005) 0.90
Specific potentiation of endothelium-dependent contractions in SHR by tetrahydrobiopterin. Hypertension (2003) 0.90
Vascular actions of adipokines molecular mechanisms and therapeutic implications. Adv Pharmacol (2010) 0.90
Endothelium-derived NO, but not cyclic GMP, is required for hypoxic augmentation in isolated porcine coronary arteries. Am J Physiol Heart Circ Physiol (2011) 0.89
High binding capacity of cyclophilin B to chondrocyte heparan sulfate proteoglycans and its release from the cell surface by matrix metalloproteinases: possible role as a proinflammatory mediator in arthritis. Arthritis Rheum (2003) 0.89
Tissues cIMPly do not lie. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.88
Two isoforms of cyclooxygenase contribute to augmented endothelium-dependent contractions in femoral arteries of 1-year-old rats. Acta Pharmacol Sin (2008) 0.88
Calcium-independent phospholipase A(2) plays a key role in the endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol (2010) 0.88
Acidosis prevents and alkalosis augments endothelium-dependent contractions in mouse arteries. Pflugers Arch (2013) 0.88
Serum retinol-binding protein 4 as a marker for cardiovascular disease in women. PLoS One (2012) 0.88
Gap junction inhibitors reduce endothelium-dependent contractions in the aorta of spontaneously hypertensive rats. J Pharmacol Exp Ther (2008) 0.87
Senescence of cultured porcine coronary arterial endothelial cells is associated with accelerated oxidative stress and activation of NFkB. J Vasc Res (2009) 0.87
MicroRNA 299-3p modulates replicative senescence in endothelial cells. Physiol Genomics (2013) 0.87
L-arginine enhances nitrative stress and exacerbates tumor necrosis factor-alpha toxicity to human endothelial cells in culture: prevention by propofol. J Cardiovasc Pharmacol (2010) 0.87