Published in Cancer Res on June 01, 2004
H2AX: functional roles and potential applications. Chromosoma (2009) 2.27
Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res (2008) 1.58
Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence. Epigenetics Chromatin (2008) 1.50
Adiponectin Suppresses UVB-Induced Premature Senescence and hBD2 Overexpression in Human Keratinocytes. PLoS One (2016) 1.38
ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation. Mol Cell Biol (2005) 1.31
Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through the DNA damage response and the p53/p21 pathway. PLoS One (2011) 1.19
Fanconi anemia proteins and endogenous stresses. Mutat Res (2009) 1.11
Cellular Senescence - its role in cancer and the response to ionizing radiation. Genome Integr (2011) 0.98
Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence. Nat Commun (2015) 0.95
The tumor suppressor PML specifically accumulates at RPA/Rad51-containing DNA damage repair foci but is nonessential for DNA damage-induced fibroblast senescence. Mol Cell Biol (2014) 0.90
Beta-catenin is a mediator of the response of fibroblasts to irradiation. Am J Pathol (2008) 0.89
Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells. Cancer Prev Res (Phila) (2011) 0.88
Stable cellular senescence is associated with persistent DDR activation. PLoS One (2014) 0.87
Modification of the ATM/ATR directed DNA damage response state with aging and long after hepatocyte senescence induction in vivo. Mech Ageing Dev (2008) 0.84
Senescence and life span. Pflugers Arch (2009) 0.84
Inactivation of ATM/ATR DNA damage checkpoint promotes androgen induced chromosomal instability in prostate epithelial cells. PLoS One (2012) 0.82
Single extreme low dose/low dose rate irradiation causes alteration in lifespan and genome instability in primary human cells. Br J Cancer (2007) 0.80
The HSP90 inhibitor alvespimycin enhances the potency of telomerase inhibition by imetelstat in human osteosarcoma. Cancer Biol Ther (2015) 0.78
Transcriptional profiling of the age-related response to genotoxic stress points to differential DNA damage response with age. Mech Ageing Dev (2009) 0.76
Different expression of alternative lengthening of telomere (ALT)-associated proteins/mRNAs in osteosarcoma cell lines. Oncol Lett (2011) 0.76
Beryllium sulfate induces p21 CDKN1A expression and a senescence-like cell cycle arrest in susceptible cancer cell types. Biometals (2010) 0.76
GSK3β activity is essential for senescence-associated heterochromatin foci (SAHF) formation induced by HMGA2 in WI38 cells. Am J Transl Res (2017) 0.75
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (2003) 20.13
Widespread transcription at neuronal activity-regulated enhancers. Nature (2010) 16.52
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell (2012) 6.71
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol (2006) 6.52
Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. Neuron (2006) 5.48
The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity (2010) 5.12
Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet (2010) 4.65
Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol (2002) 4.27
Initiating cellular stress responses. Cell (2004) 4.18
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell (2005) 4.16
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat Cell Biol (2007) 4.14
Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev (2002) 4.12
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev (2004) 3.76
Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell (2002) 3.71
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nat Genet (2009) 3.65
Host-derived nitrate boosts growth of E. coli in the inflamed gut. Science (2013) 3.54
ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab (2006) 3.38
GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc Natl Acad Sci U S A (2003) 3.32
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A (2010) 3.03
Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J Clin Invest (2008) 2.83
Human gut microbiome and risk for colorectal cancer. J Natl Cancer Inst (2013) 2.76
The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification. Cell (2004) 2.59
Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. Mol Cell (2008) 2.46
China's health system performance. Lancet (2008) 2.36
Gain of 1q is associated with inferior event-free and overall survival in patients with favorable histology Wilms tumor: a report from the Children's Oncology Group. Cancer (2013) 2.32
Wilms tumour: prognostic factors, staging, therapy and late effects. Pediatr Radiol (2007) 2.31
ATM activation in normal human tissues and testicular cancer. Cell Cycle (2005) 2.25
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol (2004) 2.23
Phase studies of model biomembranes: complex behavior of DSPC/DOPC/cholesterol. Biochim Biophys Acta (2007) 2.22
The feasibility and outcome of nephron-sparing surgery for children with bilateral Wilms tumor. The St Jude Children's Research Hospital experience: 1999-2006. Cancer (2008) 2.08
Autophagy links inflammasomes to atherosclerotic progression. Cell Metab (2012) 2.08
Resting-state functional connectivity of subgenual anterior cingulate cortex in depressed adolescents. Biol Psychiatry (2013) 2.07
A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis. Nat Genet (2011) 2.05
Multiple roles of ATM in monitoring and maintaining DNA integrity. FEBS Lett (2010) 1.99
Klotho is a target gene of PPAR-gamma. Kidney Int (2008) 1.96
Interaction of FANCD2 and NBS1 in the DNA damage response. Nat Cell Biol (2002) 1.96
A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nat Cell Biol (2013) 1.96
Mitochondrial dysfunction in ataxia-telangiectasia. Blood (2011) 1.93
Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation. J Clin Invest (2015) 1.89
Local lymph node involvement does not predict poor outcome in pediatric renal cell carcinoma. Cancer (2004) 1.89
Comparison of three ternary lipid bilayer mixtures: FRET and ESR reveal nanodomains. Biophys J (2010) 1.88
Measurement of protein-DNA interactions in vivo by chromatin immunoprecipitation. Methods Mol Biol (2004) 1.85
Escherichia coli noncoding RNAs can affect gene expression and physiology of Caenorhabditis elegans. Nat Commun (2012) 1.78
Current therapy for Wilms' tumor. Oncologist (2005) 1.73
Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. Cancer Res (2002) 1.71
Adolescents with major depression demonstrate increased amygdala activation. J Am Acad Child Adolesc Psychiatry (2010) 1.69
5'-3'-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage. Genes Dev (2010) 1.64
Effect of limb ischemic preconditioning on myocardial injury in patients undergoing mitral valve replacement surgery. -A randomized controlled trial-. Circ J (2011) 1.62
Phase studies of model biomembranes: macroscopic coexistence of Lalpha+Lbeta, with light-induced coexistence of Lalpha+Lo Phases. Biochim Biophys Acta (2007) 1.61
Breast cancer in Wilms tumor survivors: new insights into primary and secondary prevention. Cancer (2014) 1.60
Hypomethylation and hypermethylation of DNA in Wilms tumors. Oncogene (2002) 1.59
DC isoketal-modified proteins activate T cells and promote hypertension. J Clin Invest (2014) 1.59
Effect of celecoxib on E-cadherin, VEGF, Microvessel density and apoptosis in gastric cancer. Cancer Biol Ther (2007) 1.59
Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. Oncogene (2004) 1.58
Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res (2008) 1.58
Immune activation caused by vascular oxidation promotes fibrosis and hypertension. J Clin Invest (2015) 1.55
WT1 mutation and 11P15 loss of heterozygosity predict relapse in very low-risk wilms tumors treated with surgery alone: a children's oncology group study. J Clin Oncol (2010) 1.55
Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: meeting summary. Clin Cancer Res (2003) 1.52
Calcium-calmodulin-dependent protein kinase II contributes to spinal cord central sensitization. J Neurosci (2002) 1.51
Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. Neuron (2011) 1.49
Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites. Nat Protoc (2008) 1.49
Aberrant activation, nuclear localization, and phosphorylation of Yes-associated protein-1 in the embryonic kidney and Wilms tumor. Pediatr Blood Cancer (2013) 1.46
O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability. Cell Metab (2012) 1.46
Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting. J Clin Invest (2007) 1.45
BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function. Mol Cell Biol (2004) 1.45
Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: a multi-center study. J Neurooncol (2012) 1.42
LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling. Proc Natl Acad Sci U S A (2010) 1.40
gamma-Cyclodextrin: a review on enzymatic production and applications. Appl Microbiol Biotechnol (2007) 1.39
GUV preparation and imaging: minimizing artifacts. Biochim Biophys Acta (2010) 1.39
The effects of midday nap duration on the risk of hypertension in a middle-aged and older Chinese population: a preliminary evidence from the Tongji-Dongfeng Cohort Study, China. J Hypertens (2014) 1.39
The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev (2005) 1.37
Application of multivariate statistical techniques in the assessment of water quality in the Southwest New Territories and Kowloon, Hong Kong. Environ Monit Assess (2010) 1.34
Development and functional characterization of human bone marrow mesenchymal cells immortalized by enforced expression of telomerase. Br J Haematol (2003) 1.33
Interferon-gamma release assay performance in pulmonary and extrapulmonary tuberculosis. PLoS One (2012) 1.29
Control of a nanoscopic-to-macroscopic transition: modulated phases in four-component DSPC/DOPC/POPC/Chol giant unilamellar vesicles. Biophys J (2011) 1.28
Management of Wilms' tumour: current practice and future goals. Lancet Oncol (2004) 1.28
Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. J Biol Chem (2008) 1.26
Strategies for optimizing the response of cancer and normal tissues to radiation. Nat Rev Drug Discov (2013) 1.25
Amygdala response and functional connectivity during emotion regulation: a study of 14 depressed adolescents. J Affect Disord (2012) 1.24
Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors. Cancer (2008) 1.24
Novel biomarkers distinguishing active tuberculosis from latent infection identified by gene expression profile of peripheral blood mononuclear cells. PLoS One (2011) 1.22
Blastemal expression of type I insulin-like growth factor receptor in Wilms' tumors is driven by increased copy number and correlates with relapse. Cancer Res (2006) 1.21
Cracking the O-GlcNAc code in metabolism. Trends Endocrinol Metab (2013) 1.21
Liquid-liquid domains in bilayers detected by wide angle X-ray scattering. Biophys J (2008) 1.21
Clinically relevant subsets identified by gene expression patterns support a revised ontogenic model of Wilms tumor: a Children's Oncology Group Study. Neoplasia (2012) 1.19
Alterations of metabolic genes and metabolites in cancer. Semin Cell Dev Biol (2012) 1.18
Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis. Cancer Res (2007) 1.18
Telomerase expression predicts unfavorable outcome in osteosarcoma. J Clin Oncol (2004) 1.18
Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics. PLoS One (2008) 1.18
Toward an understanding of the molecular mechanism for successful blood feeding by coupling proteomics analysis with pharmacological testing of horsefly salivary glands. Mol Cell Proteomics (2007) 1.17
Evaluation of Kato-Katz examination method in three areas with low-level endemicity of schistosomiasis japonica in China: A Bayesian modeling approach. Acta Trop (2009) 1.17
Comparison of methods for fecal microbiome biospecimen collection. BMC Microbiol (2014) 1.17
Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis. Mol Cancer Res (2007) 1.16
Anti-infection peptidomics of amphibian skin. Mol Cell Proteomics (2007) 1.16
Use of zoledronate to treat osteoblastic versus osteolytic lesions in a severe-combined-immunodeficient mouse model. Cancer Res (2002) 1.16
Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. Mol Cancer Res (2003) 1.15
Molecular characterization of the genome of duck enteritis virus. Virology (2009) 1.15
The DNA damage response: implications for tumor responses to radiation and chemotherapy. Annu Rev Med (2014) 1.13