Published in Cell on May 17, 2002
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell (2007) 8.71
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell (2007) 6.68
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers. Nature (2008) 5.98
How the fanconi anemia pathway guards the genome. Annu Rev Genet (2009) 4.94
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Mol Cell Proteomics (2011) 4.40
Replication stress induces sister-chromatid bridging at fragile site loci in mitosis. Nat Cell Biol (2009) 4.15
Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc Natl Acad Sci U S A (2005) 3.93
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev (2004) 3.76
Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice. Genes Dev (2003) 3.58
ATR couples FANCD2 monoubiquitination to the DNA-damage response. Genes Dev (2004) 3.44
Pathophysiology and management of inherited bone marrow failure syndromes. Blood Rev (2010) 3.24
Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. Mol Cell Biol (2004) 3.20
Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24. Blood (2008) 2.83
Susceptibility pathways in Fanconi's anemia and breast cancer. N Engl J Med (2010) 2.79
Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. Mol Cell Biol (2004) 2.67
Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes Dev (2004) 2.33
The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways. EMBO J (2004) 2.20
Multiple roles of ATM in monitoring and maintaining DNA integrity. FEBS Lett (2010) 1.99
Saccharomyces cerevisiae chromatin-assembly factors that act during DNA replication function in the maintenance of genome stability. Proc Natl Acad Sci U S A (2003) 1.96
ATR: a master conductor of cellular responses to DNA replication stress. Trends Biochem Sci (2010) 1.96
Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells. Mol Cell Biol (2003) 1.84
Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks. Mol Cell Biol (2006) 1.82
Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J Clin Invest (2007) 1.80
Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights. Mutat Res (2009) 1.80
MRE11/RAD50/NBS1: complex activities. Chromosoma (2004) 1.79
Fanconi anaemia. J Med Genet (2003) 1.70
Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability. EMBO J (2007) 1.65
Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination. Mol Cell Biol (2005) 1.65
Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance. Mol Cell Biol (2006) 1.65
Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res (2008) 1.58
BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks. EMBO J (2004) 1.48
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. PLoS Biol (2014) 1.47
DNA polymerase POLN participates in cross-link repair and homologous recombination. Mol Cell Biol (2009) 1.47
Update of the human and mouse Fanconi anemia genes. Hum Genomics (2015) 1.46
Monoubiquitinated Fanconi anemia D2 (FANCD2-Ub) is required for BCR-ABL1 kinase-induced leukemogenesis. Leukemia (2011) 1.43
UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination. Mol Cell Biol (2007) 1.40
Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence. J Cell Sci (2007) 1.40
Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2. Dev Cell (2016) 1.39
MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression. Mol Cancer Res (2011) 1.33
Radioprotection. In Vivo (2009) 1.33
Active role for nibrin in the kinetics of atm activation. Mol Cell Biol (2006) 1.27
An ATR- and BRCA1-mediated Fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplication. Mol Cell Biol (2006) 1.27
Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer. Cancer Res (2010) 1.26
FAVL elevation in human tumors disrupts Fanconi anemia pathway signaling and promotes genomic instability and tumor growth. J Clin Invest (2010) 1.25
A role for monoubiquitinated FANCD2 at telomeres in ALT cells. Nucleic Acids Res (2009) 1.24
Ubiquitylation and the Fanconi anemia pathway. FEBS Lett (2011) 1.21
BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J (2007) 1.21
Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links. Oncogene (2008) 1.20
Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways. Mol Cell (2008) 1.19
ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function. Blood (2008) 1.19
Convergence of Rad6/Rad18 and Fanconi anemia tumor suppressor pathways upon DNA damage. PLoS One (2010) 1.17
Genetic determinants at the interface of cancer and neurodegenerative disease. Oncogene (2010) 1.17
FANCI protein binds to DNA and interacts with FANCD2 to recognize branched structures. J Biol Chem (2009) 1.15
Therapeutic targeting of C-terminal binding protein in human cancer. Cell Cycle (2010) 1.12
Fanconi anemia proteins and endogenous stresses. Mutat Res (2009) 1.11
The Fanconi anemia pathway and ubiquitin. BMC Biochem (2007) 1.10
Contributions of DNA interstrand cross-links to aging of cells and organisms. Nucleic Acids Res (2007) 1.09
FAVL impairment of the Fanconi anemia pathway promotes the development of human bladder cancer. Cell Cycle (2012) 1.09
Learning from a paradox: recent insights into Fanconi anaemia through studying mouse models. Dis Model Mech (2013) 1.05
A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage. Mol Cell Biol (2008) 1.04
Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms. Breast Cancer Res (2010) 1.03
Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers. Cancer Res (2009) 1.01
Fanconi anemia proteins, DNA interstrand crosslink repair pathways, and cancer therapy. Curr Cancer Drug Targets (2009) 1.00
Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase. Nucleic Acids Res (2012) 1.00
Stress and DNA repair biology of the Fanconi anemia pathway. Blood (2014) 0.99
The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways. J Biol Chem (2009) 0.99
The molecular pathology of primary immunodeficiencies. J Mol Diagn (2004) 0.98
MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair. EMBO J (2009) 0.98
Ataxia-Pancytopenia Syndrome Is Caused by Missense Mutations in SAMD9L. Am J Hum Genet (2016) 0.97
FANCG is phosphorylated at serines 383 and 387 during mitosis. Mol Cell Biol (2004) 0.97
(+)-Larreatricin hydroxylase, an enantio-specific polyphenol oxidase from the creosote bush (Larrea tridentata). Proc Natl Acad Sci U S A (2003) 0.97
The BLM dissolvasome in DNA replication and repair. Cell Mol Life Sci (2013) 0.97
Finding the needle in the hay stack: hematopoietic stem cells in Fanconi anemia. Mutat Res (2009) 0.96
Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility. J Biol Chem (2011) 0.95
Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia. Blood (2010) 0.95
The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma. Mutat Res (2013) 0.95
The ups and downs of DNA repair biomarkers for PARP inhibitor therapies. Am J Cancer Res (2010) 0.95
FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex. Cell Cycle (2015) 0.95
Significance of the Fanconi anemia FANCD2 protein in sporadic and metastatic human breast cancer. Am J Pathol (2010) 0.94
FANCJ/BRIP1 recruitment and regulation of FANCD2 in DNA damage responses. Chromosoma (2010) 0.94
Mammalian Fbh1 is important to restore normal mitotic progression following decatenation stress. DNA Repair (Amst) (2010) 0.91
Haploinsufficiency of DNA Damage Response Genes and their Potential Influence in Human Genomic Disorders. Curr Genomics (2008) 0.91
High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins. PLoS One (2013) 0.90
The Fanconi anemia pathway and ICL repair: implications for cancer therapy. Crit Rev Biochem Mol Biol (2010) 0.90
HPV 5 and 8 E6 expression reduces ATM protein levels and attenuates LINE-1 retrotransposition. Virology (2013) 0.89
Tumor suppressors and cell-cycle proteins in lung cancer. Patholog Res Int (2011) 0.89
Biomarkers and mechanisms of FANCD2 function. J Biomed Biotechnol (2008) 0.89
BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade. Proc Natl Acad Sci U S A (2013) 0.88
DNA polymerase ζ is a major determinant of resistance to platinum-based chemotherapeutic agents. Mol Pharmacol (2012) 0.88
A signaling network stimulated by β2 integrin promotes the polarization of lytic granules in cytotoxic cells. Sci Signal (2014) 0.87
The Fanconi anemia ID2 complex: dueling saxes at the crossroads. Cell Cycle (2014) 0.87
A Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblasts. Nucleic Acids Res (2004) 0.86
Snm1B/Apollo functions in the Fanconi anemia pathway in response to DNA interstrand crosslinks. Hum Mol Genet (2011) 0.86
Erythrocyte disorders in the perinatal period. Semin Perinatol (2007) 0.86
Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase. Cell (2016) 0.85
Genomic instability in mice is greater in Fanconi anemia caused by deficiency of Fancd2 than Fancg. Cancer Res (2010) 0.84
FANCD2-deficient human fibroblasts are hypersensitive to ionising radiation at oxygen concentrations of 0% and 3% but not under normoxic conditions. Int J Radiat Biol (2009) 0.84
A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel. RNA Biol (2013) 0.83
Combining affinity proteomics and network context to identify new phosphatase substrates and adapters in growth pathways. Front Genet (2014) 0.83
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (2003) 20.13
Biallelic inactivation of BRCA2 in Fanconi anemia. Science (2002) 9.31
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell (2007) 6.68
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol (2006) 6.52
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J Biol Chem (2003) 5.86
Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell (2006) 5.40
The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity (2010) 5.12
ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell (2006) 5.01
How the fanconi anemia pathway guards the genome. Annu Rev Genet (2009) 4.94
Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat Cell Biol (2006) 4.67
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. Mol Cell (2005) 4.40
Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol (2004) 4.31
Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol (2002) 4.27
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood (2002) 4.27
Initiating cellular stress responses. Cell (2004) 4.18
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell (2005) 4.16
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat Cell Biol (2007) 4.14
Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev (2002) 4.12
Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors. Nat Med (2003) 4.04
HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell (2007) 3.99
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell (2011) 3.95
Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc Natl Acad Sci U S A (2005) 3.93
The Fanconi Anemia/BRCA pathway: new faces in the crowd. Genes Dev (2005) 3.90
Ordered phosphorylation governs oscillation of a three-protein circadian clock. Science (2007) 3.78
Randomized controlled trial of cetuximab plus chemotherapy for patients with KRAS wild-type unresectable colorectal liver-limited metastases. J Clin Oncol (2013) 3.76
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev (2004) 3.76
Molecular pathogenesis of Fanconi anemia: recent progress. Blood (2006) 3.76
BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. Cancer Cell (2005) 3.44
ATR couples FANCD2 monoubiquitination to the DNA-damage response. Genes Dev (2004) 3.44
Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev (2012) 3.42
ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab (2006) 3.38
Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev (2010) 3.33
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J Biol Chem (2002) 3.33
A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. Mol Cell (2007) 3.27
HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. Nat Struct Biol (2003) 3.22
Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. Mol Cell Biol (2004) 3.20
Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. Nat Genet (2008) 3.14
A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. Mol Cell Biol (2005) 3.04
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A (2010) 3.03
Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell (2008) 3.01
Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24. Blood (2008) 2.83
Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J Clin Invest (2008) 2.83
A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc Natl Acad Sci U S A (2002) 2.78
The human LINE-1 retrotransposon creates DNA double-strand breaks. J Mol Biol (2006) 2.77
AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain. Biochem J (2005) 2.76
Regulation of DNA repair by ubiquitylation. Nat Rev Mol Cell Biol (2006) 2.73
Inhibition of homologous recombination by the PCNA-interacting protein PARI. Mol Cell (2011) 2.61
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. Mol Cell (2006) 2.51
DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes. J Clin Oncol (2006) 2.49
Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science (2009) 2.48
Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. Mol Cell (2008) 2.46
JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. Proc Natl Acad Sci U S A (2007) 2.45
Ultrahard nanotwinned cubic boron nitride. Nature (2013) 2.44
SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell (2007) 2.42
Bacterial glycosidases for the production of universal red blood cells. Nat Biotechnol (2007) 2.41
Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. Nat Med (2011) 2.35
Potential impact of adding genetic markers to clinical parameters in predicting prostate biopsy outcomes in men following an initial negative biopsy: findings from the REDUCE trial. Eur Urol (2012) 2.34
In vivo residue-specific histone methylation dynamics. J Biol Chem (2009) 2.33
Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M. Blood (2009) 2.33
Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin. Genes Dev (2003) 2.30
BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome. Genes Dev (2008) 2.29
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J (2005) 2.29
Sequence variants at 22q13 are associated with prostate cancer risk. Cancer Res (2009) 2.27
Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells. Cell Stem Cell (2012) 2.26
ATM activation in normal human tissues and testicular cancer. Cell Cycle (2005) 2.25
The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability. Hum Mol Genet (2005) 2.23
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol (2004) 2.23
Wheat grain yield on saline soils is improved by an ancestral Na⁺ transporter gene. Nat Biotechnol (2012) 2.22
Registry and survival study in chinese patients with idiopathic and familial pulmonary arterial hypertension. Chest (2007) 2.19
Chromatin remodeling at DNA double-strand breaks. Cell (2013) 2.18
UAF1 is a subunit of multiple deubiquitinating enzyme complexes. J Biol Chem (2008) 2.17
Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications. Genes Dev (2006) 2.15
The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol (2004) 2.13
Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype. Dev Cell (2009) 2.12
Protein arginine methyltransferase 1 regulates hepatic glucose production in a FoxO1-dependent manner. Hepatology (2012) 2.12
The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression. Dev Cell (2003) 2.08
Autophagy links inflammasomes to atherosclerotic progression. Cell Metab (2012) 2.08
Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin. Blood (2004) 2.08
A DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapy. J Natl Cancer Inst (2012) 2.07
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. J Biol Chem (2004) 2.05
PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2. Mol Cancer Res (2009) 2.01
G1 tetraploidy checkpoint and the suppression of tumorigenesis. J Cell Biochem (2003) 2.01
Multiple roles of ATM in monitoring and maintaining DNA integrity. FEBS Lett (2010) 1.99
CtBP represses p300-mediated transcriptional activation by direct association with its bromodomain. Nat Struct Mol Biol (2005) 1.98
System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. Chem Biol (2008) 1.97
Interaction of FANCD2 and NBS1 in the DNA damage response. Nat Cell Biol (2002) 1.96
A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nat Cell Biol (2013) 1.96
TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. Genes Dev (2010) 1.95
Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients. Prostate (2009) 1.95
Mitochondrial dysfunction in ataxia-telangiectasia. Blood (2011) 1.93
Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. J Biol Chem (2005) 1.93