PubRank

Jay L Degen

Author PubWeight™ 60.01‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol 2006 3.18
2 Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells. Blood 2004 3.13
3 Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo. J Clin Invest 2004 2.57
4 The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J Exp Med 2007 2.16
5 The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Nat Med 2003 1.98
6 Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nat Commun 2012 1.82
7 Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage. J Neurosci 2010 1.82
8 Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression. Blood 2009 1.79
9 Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway. Genes Dev 2008 1.73
10 The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. Blood 2011 1.71
11 Fibrinogen, acting as a mitogen for tubulointerstitial fibroblasts, promotes renal fibrosis. Kidney Int 2011 1.70
12 Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms. Blood 2007 1.65
13 Spontaneous hematogenous and lymphatic metastasis, but not primary tumor growth or angiogenesis, is diminished in fibrinogen-deficient mice. Cancer Res 2002 1.64
14 Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif. J Clin Invest 2007 1.52
15 Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals. J Am Soc Nephrol 2007 1.25
16 Fibrin(ogen)-alpha M beta 2 interactions regulate leukocyte function and innate immunity in vivo. Exp Biol Med (Maywood) 2004 1.20
17 Platelet TGF-β1 contributions to plasma TGF-β1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload. Blood 2011 1.20
18 Factor XIII activity mediates red blood cell retention in venous thrombi. J Clin Invest 2014 1.18
19 Antithrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in platelets. Blood 2003 1.18
20 Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo. Blood 2010 1.12
21 Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner. PLoS One 2013 1.11
22 Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain. Blood 2008 1.11
23 Reduced thrombin generation increases host susceptibility to group A streptococcal infection. Blood 2008 1.10
24 Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia. Blood 2013 1.03
25 Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia. Am J Pathol 2008 1.01
26 Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain. Blood 2011 1.00
27 Binding of Efb from Staphylococcus aureus to fibrinogen blocks neutrophil adherence. J Biol Chem 2011 0.99
28 Antibody blockade or mutation of the fibrinogen gamma-chain C-terminus is more effective in inhibiting murine arterial thrombus formation than complete absence of fibrinogen. Blood 2003 0.99
29 Plasminogen supports tumor growth through a fibrinogen-dependent mechanism linked to vascular patency. Blood 2003 0.97
30 Control of thrombus embolization and fibronectin internalization by integrin alpha IIb beta 3 engagement of the fibrinogen gamma chain. Blood 2003 0.97
31 Fibrin but not adsorbed fibrinogen supports fibronectin assembly by spread platelets. Effects of the interaction of alphaIIb beta3 with the C terminus of the fibrinogen gamma-chain. J Biol Chem 2005 0.93
32 Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification. J Clin Invest 2015 0.91
33 Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor. BMC Gastroenterol 2006 0.91
34 Plasminogen directs the pleiotropic effects of uPA in liver injury and repair. Am J Physiol Gastrointest Liver Physiol 2002 0.90
35 Administration of factor XIII B subunit increased plasma factor XIII A subunit levels in factor XIII B subunit knock-out mice. Int J Hematol 2007 0.90
36 Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the αMβ2 leukocyte integrin receptor. Hum Mol Genet 2012 0.89
37 Mechanisms coupling the hemostatic system to colitis-associated cancer. Thromb Res 2010 0.89
38 Mechanisms linking tumor cell-associated procoagulant function to tumor metastasis. Thromb Res 2007 0.89
39 Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair. J Biol Chem 2009 0.88
40 Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice. Neurosci Lett 2004 0.88
41 Early detection of thrombin activity in neuroinflammatory disease. Ann Neurol 2014 0.87
42 Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice. Proc Natl Acad Sci U S A 2005 0.85
43 Male-specific cardiac pathologies in mice lacking either the A or B subunit of factor XIII. Thromb Haemost 2008 0.82
44 Fibrin accumulation secondary to loss of plasmin-mediated fibrinolysis drives inflammatory osteoporosis in mice. Arthritis Rheumatol 2014 0.82
45 Plasminogen is a joint-specific positive or negative determinant of arthritis pathogenesis in mice. Arthritis Rheumatol 2014 0.81
46 Fibrinogen deficiency, but not plasminogen deficiency, increases mortality synergistically in combination with sickle hemoglobin SAD in transgenic mice. Am J Hematol 2007 0.79
47 Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression. J Biol Chem 2002 0.79
48 Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification. J Clin Invest 2015 0.76