Published in Dev Cell on June 01, 2004
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Mice deficient in Ext2 lack heparan sulfate and develop exostoses. Development (2005) 1.84
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Proximal tibial osteochondromas in patients with fibrodysplasia ossificans progressiva. J Bone Joint Surg Am (2008) 1.59
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JAWS coordinates chondrogenesis and synovial joint positioning. Development (2008) 0.99
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Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bones. Bone (2011) 0.98
Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects. J Biol Chem (2010) 0.97
Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins. Development (2009) 0.96
Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine. Dev Biol (2010) 0.96
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UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton. Dev Biol (2010) 0.94
Implications of hedgehog signaling antagonists for cancer therapy. Acta Biochim Biophys Sin (Shanghai) (2008) 0.92
Mutation in the heparan sulfate biosynthesis enzyme EXT1 influences growth factor signaling and fibroblast interactions with the extracellular matrix. J Biol Chem (2009) 0.92
Osteopoikilosis and multiple exostoses caused by novel mutations in LEMD3 and EXT1 genes respectively--coincidence within one family. BMC Med Genet (2010) 0.92
EXTra hit for mouse osteochondroma. Proc Natl Acad Sci U S A (2010) 0.91
Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses. Dev Biol (2013) 0.91
Transglutaminase 2 regulates early chondrogenesis and glycosaminoglycan synthesis. Mech Dev (2010) 0.90
Syndecans in cartilage breakdown and synovial inflammation. Nat Rev Rheumatol (2012) 0.90
Sulfotransferase Ndst1 is needed for mandibular and TMJ development. J Dent Res (2010) 0.90
Growth of limb muscle is dependent on skeletal-derived Indian hedgehog. Dev Biol (2011) 0.90
Heparan sulfate proteoglycans containing a glypican 5 core and 2-O-sulfo-iduronic acid function as Sonic Hedgehog co-receptors to promote proliferation. J Biol Chem (2013) 0.88
Extracellular distribution of diffusible growth factors controlled by heparan sulfate proteoglycans during mammalian embryogenesis. Philos Trans R Soc Lond B Biol Sci (2014) 0.88
Clinical implications of hedgehog signaling pathway inhibitors. Chin J Cancer (2011) 0.88
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Solute transport in growth plate cartilage: in vitro and in vivo. Biophys J (2007) 0.87
Hedgehog signaling in skin cancers. Cell Signal (2011) 0.87
Site-1 protease is essential to growth plate maintenance and is a critical regulator of chondrocyte hypertrophic differentiation in postnatal mice. J Biol Chem (2011) 0.86
Forward genetics defines Xylt1 as a key, conserved regulator of early chondrocyte maturation and skeletal length. Dev Biol (2013) 0.85
Unique mutation portraits and frequent COL2A1 gene alteration in chondrosarcoma. Genome Res (2014) 0.85
Human genetic disorders and knockout mice deficient in glycosaminoglycan. Biomed Res Int (2014) 0.85
Heparan sulfate on intestinal epithelial cells plays a critical role in intestinal crypt homeostasis via Wnt/β-catenin signaling. Am J Physiol Gastrointest Liver Physiol (2013) 0.84
An emerging role of Sonic hedgehog shedding as a modulator of heparan sulfate interactions. J Biol Chem (2012) 0.84
Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels. Cell Res (2011) 0.84
Peripheral chondrosarcoma progression is associated with increased type X collagen and vascularisation. Virchows Arch (2011) 0.83
Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation. BMC Dev Biol (2009) 0.83
Matrix disruptions, growth, and degradation of cartilage with impaired sulfation. J Biol Chem (2012) 0.82
Exome sequencing and functional analysis identifies a novel mutation in EXT1 gene that causes multiple osteochondromas. PLoS One (2013) 0.82
Planar cell polarity signaling in craniofacial development. Organogenesis (2011) 0.82
Skeletal maturity of children with multiple osteochondromas: is diminished stature due to a systemic influence? J Child Orthop (2015) 0.81
HSPG-deficient zebrafish uncovers dental aspect of multiple osteochondromas. PLoS One (2012) 0.80
delta-EF1 is a negative regulator of Ihh in the developing growth plate. J Cell Biol (2009) 0.80
FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth. Development (2016) 0.80
Interactions of signaling proteins, growth factors and other proteins with heparan sulfate: mechanisms and mysteries. Connect Tissue Res (2015) 0.79
Detection of exostosin glycosyltransferase gene mutations in patients with non-hereditary osteochondromas of the mandibular condyle. Mol Clin Oncol (2016) 0.78
Zebrafish Ext2 is necessary for Fgf and Wnt signaling, but not for Hh signaling. BMC Dev Biol (2011) 0.78
Presphenoidal synchondrosis fusion in DBA/2J mice. Mamm Genome (2012) 0.77
Multiple roles of the SO4(2-)/Cl-/OH- exchanger protein Slc26a2 in chondrocyte functions. J Biol Chem (2013) 0.77
Disp1 regulates growth of mammalian long bones through the control of Ihh distribution. Dev Biol (2008) 0.77
Functional conservation of the human EXT1 tumor suppressor gene and its Drosophila homolog tout velu. Dev Genes Evol (2007) 0.77
Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis. J Clin Invest (2016) 0.76
Signaling domain of Sonic Hedgehog as cannibalistic calcium-regulated zinc-peptidase. PLoS Comput Biol (2014) 0.76
Novel Genetic Loci Control Calcium Absorption and Femur Bone Mass as Well as Their Response to Low Calcium Intake in Male BXD Recombinant Inbred Mice. J Bone Miner Res (2016) 0.76
Identification of a novel frameshift mutation of the EXT2 gene in a family with multiple osteochondroma. Oncol Lett (2015) 0.75
Osteochondroma of the Hyoid Bone: A Previously Unrecognized Location and Review of the Literature. Head Neck Pathol (2015) 0.75
Glycan Engineering for Cell and Developmental Biology. Cell Chem Biol (2016) 0.75
Pathogenesis and treatment of spine disease in the mucopolysaccharidoses. Mol Genet Metab (2016) 0.75
The Good the Bad and the Ugly of Glycosaminoglycans in Tissue Engineering Applications. Pharmaceuticals (Basel) (2017) 0.75
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Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol (2006) 10.95
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol (2008) 10.60
Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol (2005) 9.58
Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation. Dev Cell (2002) 2.37
A scalable system for production of functional pancreatic progenitors from human embryonic stem cells. PLoS One (2012) 2.24
Role of Runx genes in chondrocyte differentiation. Dev Biol (2002) 2.12
Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. Cell Stem Cell (2013) 1.79
Using a histone yellow fluorescent protein fusion for tagging and tracking endothelial cells in ES cells and mice. Genesis (2005) 1.69
A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes. Proc Natl Acad Sci U S A (2009) 1.47
A membrane associated mCherry fluorescent reporter line for studying vascular remodeling and cardiac function during murine embryonic development. Anat Rec (Hoboken) (2009) 1.33
Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation. Development (2005) 1.32
Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development. Dev Dyn (2008) 1.30
Essential role for ADAM19 in cardiovascular morphogenesis. Mol Cell Biol (2004) 1.27
Transcriptional networks controlling chondrocyte proliferation and differentiation during endochondral ossification. Pediatr Nephrol (2009) 1.19
Hedgehog signaling in skeletal development. Birth Defects Res C Embryo Today (2006) 1.10
Targeted expression of SHH affects chondrocyte differentiation, growth plate organization, and Sox9 expression. J Bone Miner Res (2004) 1.10
Chondrocyte proliferation and differentiation. Endocr Dev (2011) 1.09
Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone. PLoS Genet (2012) 1.09
Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues. J Bone Miner Res (2013) 1.02
Ucma--A novel secreted factor represents a highly specific marker for distal chondrocytes. Matrix Biol (2007) 1.01
Active transport of the ubiquitin ligase MID1 along the microtubules is regulated by protein phosphatase 2A. PLoS One (2008) 0.99
Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3. Dev Biol (2009) 0.97
Embryonic fibroblasts with a gene trap mutation in Ext1 produce short heparan sulfate chains. J Biol Chem (2004) 0.96
Sonic hedgehog signaling during adrenal development. Mol Cell Endocrinol (2011) 0.95
Expression of Trps1 during mouse embryonic development. Mech Dev (2002) 0.93
BMP signaling balances proliferation and differentiation of muscle satellite cell descendants. BMC Cell Biol (2011) 0.92
Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells. PLoS One (2012) 0.91
The rodent Four-jointed ortholog Fjx1 regulates dendrite extension. Dev Biol (2007) 0.89
Follistatin antagonizes transforming growth factor-beta3-induced epithelial-mesenchymal transition in vitro: implications for murine palatal development supported by microarray analysis. Differentiation (2007) 0.89
Alternative polyadenylation signals and promoters act in concert to control tissue-specific expression of the Opitz Syndrome gene MID1. BMC Mol Biol (2007) 0.88
Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice. PLoS One (2012) 0.88
Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification. Gene Expr Patterns (2005) 0.87
Point mutations in GLI3 lead to misregulation of its subcellular localization. PLoS One (2009) 0.86
The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosis. Cell Cycle (2013) 0.81
Expression patterns of sulfatase genes in the developing mouse embryo. Dev Dyn (2010) 0.80
Loss-of-Function of Gli3 in Mice Causes Abnormal Frontal Bone Morphology and Premature Synostosis of the Interfrontal Suture. Front Physiol (2012) 0.79
Inactivation of patched1 in murine chondrocytes causes spinal fusion without inflammation. Arthritis Rheumatol (2014) 0.79
Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60. Chromosoma (2009) 0.78
Diagnosis of a terminal deletion of 4p with duplication of Xp22.31 in a patient with findings of Opitz G/BBB syndrome and Wolf-Hirschhorn syndrome. Am J Med Genet A (2008) 0.77
Expression of Trps1 during mouse embryonic development. Gene Expr Patterns (2002) 0.77
Sweet on Hedgehogs: regulatory roles of heparan sulfate proteoglycans in Hedgehog-dependent cell proliferation and differentiation. Curr Protein Pept Sci (2015) 0.76
Involvement of Ca2+ Activated Cl- Channel Ano6 in Platelet Activation and Apoptosis. Cell Physiol Biochem (2015) 0.76
Cartilage explant cultures. Methods Mol Biol (2014) 0.75