Published in Mamm Genome on November 21, 2012
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Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med (2010) 4.88
Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. Nat Med (2008) 3.98
The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. J Clin Invest (2005) 3.56
Somatic mosaic activating mutations in PIK3CA cause CLOVES syndrome. Am J Hum Genet (2012) 3.13
The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. J Biol Chem (2006) 3.04
Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density. Am J Hum Genet (2003) 2.86
Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. Nat Cell Biol (2008) 2.85
Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3. Mol Biol Cell (2008) 2.78
Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc Natl Acad Sci U S A (2005) 2.67
Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. J Clin Invest (2012) 2.58
Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis. Development (2002) 2.57
Association between friction and wear in diarthrodial joints lacking lubricin. Arthritis Rheum (2007) 2.56
Neuronal loss and brain atrophy in mice lacking cathepsins B and L. Proc Natl Acad Sci U S A (2002) 2.54
VEGFA is necessary for chondrocyte survival during bone development. Development (2004) 2.54
Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J Bone Miner Res (2004) 2.46
Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function. Am J Pathol (2005) 2.38
NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest (2008) 2.29
Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice. Cell (2007) 2.18
Lack of collagen XVIII/endostatin results in eye abnormalities. EMBO J (2002) 2.13
Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation. Curr Biol (2010) 2.08
Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis. Arthritis Rheum (2007) 2.07
Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling. Mol Cell Biol (2005) 2.00
Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling. Exp Cell Res (2005) 1.92
The genetic basis for skeletal diseases. Nature (2003) 1.92
Sclerostin inhibition reverses skeletal fragility in an Lrp5-deficient mouse model of OPPG syndrome. Sci Transl Med (2013) 1.90
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Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210. N Engl J Med (2010) 1.81
Multiple roles of vascular endothelial growth factor (VEGF) in skeletal development, growth, and repair. Curr Top Dev Biol (2005) 1.75
Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations ("glomangiomas"). Am J Hum Genet (2002) 1.66
Knobloch syndrome: novel mutations in COL18A1, evidence for genetic heterogeneity, and a functionally impaired polymorphism in endostatin. Hum Mutat (2004) 1.61
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Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development (2004) 1.58
Localization of collagen XVIII and the endostatin portion of collagen XVIII in aged human control eyes and eyes with age-related macular degeneration. Invest Ophthalmol Vis Sci (2004) 1.56
Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice. J Biol Chem (2004) 1.53
FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis. J Cell Biol (2008) 1.53
Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney. EMBO J (2003) 1.53
The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations. Calcif Tissue Int (2008) 1.52
Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2. Am J Hum Genet (2009) 1.47
Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux. Am J Hum Genet (2004) 1.45
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Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4. Arthritis Rheum (2010) 1.36
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Loss-of-function mutations in PTPN11 cause metachondromatosis, but not Ollier disease or Maffucci syndrome. PLoS Genet (2011) 1.34
Genome scans provide evidence for keloid susceptibility loci on chromosomes 2q23 and 7p11. J Invest Dermatol (2004) 1.34
Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function. EMBO J (2003) 1.34
Loss of collagen XVIII enhances neovascularization and vascular permeability in atherosclerosis. Circulation (2004) 1.30
Intravenous bisphosphonate therapy in children with osteogenesis imperfecta. Pediatrics (2003) 1.28
Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nat Commun (2011) 1.27
WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice. Mol Cell Biol (2005) 1.27
Molecular interplay between endostatin, integrins, and heparan sulfate. J Biol Chem (2009) 1.25
Efficient mapping and cloning of mutations in zebrafish by low-coverage whole-genome sequencing. Genetics (2011) 1.23
Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4. Dev Biol (2003) 1.23
The diagnostic challenge of progressive pseudorheumatoid dysplasia (PPRD): a review of clinical features, radiographic features, and WISP3 mutations in 63 affected individuals. Am J Med Genet C Semin Med Genet (2012) 1.23
The mutational spectrum of brachydactyly type C. Am J Med Genet (2002) 1.22
The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling. J Clin Invest (2007) 1.19
Targeted disruption of Col8a1 and Col8a2 genes in mice leads to anterior segment abnormalities in the eye. FASEB J (2005) 1.18
Broad phenotypic spectrum caused by an identical heterozygous CDMP-1 mutation in three unrelated families. Am J Med Genet A (2003) 1.15
Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms. Dev Biol (2007) 1.15
FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. Hum Mol Genet (2008) 1.15
Identification of a Prg4-expressing articular cartilage progenitor cell population in mice. Arthritis Rheumatol (2015) 1.13
Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Proc Natl Acad Sci U S A (2013) 1.13
Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing. J Biol Chem (2005) 1.08
Characterization of endostatin binding to heparin and heparan sulfate by surface plasmon resonance and molecular modeling: role of divalent cations. J Biol Chem (2003) 1.07
Growth of cranial synchondroses and sutures requires polycystin-1. Dev Biol (2008) 1.06
Commitment to the osteoblast lineage is not required for RANKL gene expression. J Biol Chem (2009) 1.05
High-bone-mass-producing mutations in the Wnt signaling pathway result in distinct skeletal phenotypes. Bone (2011) 1.05
Infantile hemangioma: challenges, new insights, and therapeutic promise. J Craniofac Surg (2009) 1.04
Endogenous endostatin inhibits choroidal neovascularization. FASEB J (2007) 1.03
Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity. Am J Hum Genet (2011) 1.02
Two-dimensional nanoscale structural and functional imaging in individual collagen type I fibrils. Biophys J (2010) 1.02
Rapamycin inhibits proliferation of hemangioma endothelial cells by reducing HIF-1-dependent expression of VEGF. PLoS One (2012) 1.01
Second harmonic generation imaging of fascia within thick tissue block. Opt Express (2007) 1.01
Cyclic loading increases friction and changes cartilage surface integrity in lubricin-mutant mouse knees. Arthritis Rheum (2012) 1.00
Multimodal nonlinear optical imaging of collagen arrays. J Struct Biol (2008) 1.00
Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity. BMC Med Genet (2012) 1.00
Signaling mechanisms in infantile hemangioma. Curr Opin Hematol (2009) 1.00
Risk of vascular anomalies with Down syndrome. Pediatrics (2008) 1.00
Mechanical force-induced midpalatal suture remodeling in mice. Bone (2007) 1.00
Endothelial Cells from Capillary Malformations Are Enriched for Somatic GNAQ Mutations. Plast Reconstr Surg (2016) 1.00
Wnt/beta-catenin--a canonical tale of cell-fate choice in the vertebrate skeleton. Dev Cell (2005) 0.99
A novel missense mutation in the paired domain of PAX9 causes non-syndromic oligodontia. Hum Genet (2003) 0.98
The first draft of the endostatin interaction network. J Biol Chem (2009) 0.98
The role of structural genes in the pathogenesis of osteoarthritic disorders. Arthritis Res (2002) 0.97
An RNA-seq protocol to identify mRNA expression changes in mouse diaphyseal bone: applications in mice with bone property altering Lrp5 mutations. J Bone Miner Res (2013) 0.97
PIK3CA activating mutations in facial infiltrating lipomatosis. Plast Reconstr Surg (2014) 0.96
Age-dependent iris abnormalities in collagen XVIII/endostatin deficient mice with similarities to human pigment dispersion syndrome. Invest Ophthalmol Vis Sci (2003) 0.96
The polycystic kidney disease 1 (Pkd1) gene is required for the responses of osteochondroprogenitor cells to midpalatal suture expansion in mice. Bone (2009) 0.96
A novel mutation in the IHH gene causes brachydactyly type A1: a 95-year-old mystery resolved. Hum Genet (2002) 0.96
The role of endothelial-mesenchymal transition in heterotopic ossification. J Bone Miner Res (2012) 0.95
Collagen XI sequence variations in nonsyndromic cleft palate, Robin sequence and micrognathia. Eur J Hum Genet (2003) 0.95
The role of SH3BP2 in the pathophysiology of cherubism. Orphanet J Rare Dis (2012) 0.95
Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in mice. Dev Biol (2004) 0.94