Published in Proc Natl Acad Sci U S A on February 02, 2010
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. Nat Genet (2011) 2.74
Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. Nat Rev Cancer (2010) 1.63
Chondrosarcoma: with updates on molecular genetics. Sarcoma (2011) 1.01
Rearrangement of chromosome bands 12q14~15 causing HMGA2-SOX5 gene fusion and HMGA2 expression in extraskeletal osteochondroma. Oncol Rep (2015) 0.94
A broad spectrum of genomic changes in latinamerican patients with EXT1/EXT2-CDG. Sci Rep (2014) 0.81
Near universal detection of alterations in CTNNB1 and Wnt pathway regulators in desmoid-type fibromatosis by whole-exome sequencing and genomic analysis. Genes Chromosomes Cancer (2015) 0.78
A"Proteoglycan targeting strategy" for the scintigraphic imaging and monitoring of the swarm rat chondrosarcoma orthotopic model. Sarcoma (2011) 0.75
From an orphan disease to a generalized molecular mechanism: PTPN11 loss-of-function mutations in the pathogenesis of metachondromatosis. Rare Dis (2013) 0.75
NFAT restricts osteochondroma formation from entheseal progenitors. JCI Insight (2016) 0.75
Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A (1971) 31.05
The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate. Nat Genet (1998) 3.14
Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification. Dev Cell (2004) 2.06
Mice deficient in Ext2 lack heparan sulfate and develop exostoses. Development (2005) 1.84
EXT-mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomas. Am J Hum Genet (1999) 1.70
Regulation of zebrafish skeletogenesis by ext2/dackel and papst1/pinscher. PLoS Genet (2008) 1.59
A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes. Proc Natl Acad Sci U S A (2009) 1.47
The role of EXT1 in nonhereditary osteochondroma: identification of homozygous deletions. J Natl Cancer Inst (2007) 1.37
Fibrous dysplasia as a stem cell disease. J Bone Miner Res (2006) 1.25
Reevaluation of a genetic model for the development of exostosis in hereditary multiple exostosis. Am J Med Genet (2002) 1.07
Targeting EXT1 reveals a crucial role for heparan sulfate in the growth of multiple myeloma. Blood (2009) 0.90