Published in Annu Rev Nutr on January 01, 2004
Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci U S A (2005) 2.60
Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells. Proc Natl Acad Sci U S A (2006) 2.35
Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice. Proc Natl Acad Sci U S A (2009) 1.96
Responsive transporter genes within the murine intestinal-pancreatic axis form a basis of zinc homeostasis. Proc Natl Acad Sci U S A (2004) 1.82
Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression. Proc Natl Acad Sci U S A (2007) 1.81
The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways. PLoS One (2008) 1.76
Ion channels and transporters in lymphocyte function and immunity. Nat Rev Immunol (2012) 1.74
Zinc as an anti-tumor agent in prostate cancer and in other cancers. Arch Biochem Biophys (2007) 1.65
ZIP4 upregulates the expression of neuropilin-1, vascular endothelial growth factor, and matrix metalloproteases in pancreatic cancer cell lines and xenografts. Cancer Biol Ther (2010) 1.63
A mathematical model of zinc absorption in humans as a function of dietary zinc and phytate. J Nutr (2007) 1.59
Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-gamma expression in activated human T cells. J Leukoc Biol (2009) 1.50
Zinc and zinc transporters in normal prostate and the pathogenesis of prostate cancer. Front Biosci (2005) 1.50
A secretory pathway-localized cation diffusion facilitator confers plant manganese tolerance. Proc Natl Acad Sci U S A (2007) 1.45
Zinc bioavailability and homeostasis. Am J Clin Nutr (2010) 1.41
Zinc-induced neurotoxicity mediated by transient receptor potential melastatin 7 channels. J Biol Chem (2010) 1.38
Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. Am J Physiol Cell Physiol (2011) 1.32
Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione. Nucleic Acids Res (2005) 1.30
Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts. Clin Cancer Res (2009) 1.30
Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes. Mol Brain (2010) 1.27
Mechanism and regulation of cellular zinc transport. Mol Med (2007) 1.25
Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. Exp Cell Res (2007) 1.20
Roles of the extraintestinal pathogenic Escherichia coli ZnuACB and ZupT zinc transporters during urinary tract infection. Infect Immun (2008) 1.19
Zinspy sensors with enhanced dynamic range for imaging neuronal cell zinc uptake and mobilization. J Am Chem Soc (2006) 1.18
Zinc and its importance for human health: An integrative review. J Res Med Sci (2013) 1.18
Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc. Nucleic Acids Res (2006) 1.14
QZ1 and QZ2: rapid, reversible quinoline-derivatized fluoresceins for sensing biological Zn(II). J Am Chem Soc (2005) 1.14
Zinc: new clues to diverse roles in brain ischemia. Trends Pharmacol Sci (2011) 1.13
Interleukin-1beta contributes via nitric oxide to the upregulation and functional activity of the zinc transporter Zip14 (Slc39a14) in murine hepatocytes. Am J Physiol Gastrointest Liver Physiol (2009) 1.11
Transport properties of members of the ZIP family in plants and their role in Zn and Mn homeostasis. J Exp Bot (2013) 1.11
Zinc and zinc transporters in prostate carcinogenesis. Nat Rev Urol (2013) 1.11
A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission. Am J Clin Nutr (2011) 1.10
The EVER proteins as a natural barrier against papillomaviruses: a new insight into the pathogenesis of human papillomavirus infections. Microbiol Mol Biol Rev (2009) 1.09
Glucose regulates free cytosolic Zn²⁺ concentration, Slc39 (ZiP), and metallothionein gene expression in primary pancreatic islet β-cells. J Biol Chem (2011) 1.06
Zinc homeostasis and neurodegenerative disorders. Front Aging Neurosci (2013) 1.05
Regulation of ZIP and ZnT zinc transporters in zebrafish gill: zinc repression of ZIP10 transcription by an intronic MRE cluster. Physiol Genomics (2008) 1.04
The immune system and the impact of zinc during aging. Immun Ageing (2009) 1.03
Evidence for operation of the direct zinc ligand exchange mechanism for trafficking, transport, and reactivity of zinc in mammalian cells. J Inorg Biochem (2011) 1.02
Gene expression profiling of immune-competent human cells exposed to engineered zinc oxide or titanium dioxide nanoparticles. PLoS One (2013) 1.02
Sequence similarity and functional relationship among eukaryotic ZIP and CDF transporters. Genomics Proteomics Bioinformatics (2006) 1.00
Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting. BMC Genomics (2007) 0.98
New challenges in studying nutrition-disease interactions in the developing world. J Clin Invest (2008) 0.98
Manganese homeostasis in the nervous system. J Neurochem (2015) 0.98
Trace elements in glucometabolic disorders: an update. Diabetol Metab Syndr (2010) 0.97
Response of Schizosaccharomyces pombe to zinc deficiency. Eukaryot Cell (2008) 0.97
Coupled calcium and zinc dyshomeostasis and oxidative stress in cardiac myocytes and mitochondria of rats with chronic aldosteronism. J Cardiovasc Pharmacol (2009) 0.96
A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth. EMBO Mol Med (2013) 0.96
Generation and characterization of mice lacking the zinc uptake transporter ZIP3. Mol Cell Biol (2005) 0.96
Zn²⁺ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation. Hum Mol Genet (2013) 0.96
Zinc in innate and adaptive tumor immunity. J Transl Med (2010) 0.95
Role of Zn2+ ions in host-virus interactions. J Virol (2008) 0.95
The cation diffusion facilitator gene cdf-2 mediates zinc metabolism in Caenorhabditis elegans. Genetics (2009) 0.94
Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in rats. BMC Cancer (2010) 0.94
Increased inflammatory response in aged mice is associated with age-related zinc deficiency and zinc transporter dysregulation. J Nutr Biochem (2012) 0.94
Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans. PLoS Genet (2011) 0.93
Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals. Diabetologia (2013) 0.93
Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8. Am J Hum Genet (2015) 0.92
Chronic cadmium exposure in vitro induces cancer cell characteristics in human lung cells. Toxicol Appl Pharmacol (2013) 0.92
Zinc transporters in prostate cancer. Mol Aspects Med (2013) 0.92
Association analysis of SLC30A8 rs13266634 and rs16889462 polymorphisms with type 2 diabetes mellitus and repaglinide response in Chinese patients. Eur J Clin Pharmacol (2010) 0.91
Carbonic anhydrase II-based metal ion sensing: Advances and new perspectives. Biochim Biophys Acta (2009) 0.90
Dynamic transcriptomic profiles of zebrafish gills in response to zinc depletion. BMC Genomics (2010) 0.90
Biomarkers of Nutrition for Development (BOND)-Zinc Review. J Nutr (2016) 0.89
Zinc status and vacuolar zinc transporters control alkaline phosphatase accumulation and activity in Saccharomyces cerevisiae. Mol Microbiol (2009) 0.89
Zinc exploitation by pathogenic fungi. PLoS Pathog (2012) 0.88
Redox regulation of intracellular zinc: molecular signaling in the life and death of neurons. Antioxid Redox Signal (2011) 0.88
Impact of zinc metabolism on innate immune function in the setting of sepsis. Int J Vitam Nutr Res (2010) 0.88
Cadmium-mediated toxicity of lung epithelia is enhanced through NF-κB-mediated transcriptional activation of the human zinc transporter ZIP8. Am J Physiol Lung Cell Mol Physiol (2012) 0.88
Dietary zinc deficiency affects blood linoleic acid: dihomo-γ-linolenic acid (LA:DGLA) ratio; a sensitive physiological marker of zinc status in vivo (Gallus gallus). Nutrients (2014) 0.88
Zinc sequestration: arming phagocyte defense against fungal attack. PLoS Pathog (2013) 0.87
A Drosophila model identifies a critical role for zinc in mineralization for kidney stone disease. PLoS One (2015) 0.87
The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia. Nature (2015) 0.86
Cellular mechanisms of zinc dysregulation: a perspective on zinc homeostasis as an etiological factor in the development and progression of breast cancer. Nutrients (2012) 0.86
Accumulation of cadmium in insulin-producing β cells. Islets (2012) 0.85
Profiling of zinc-altered gene expression in human prostate normal vs. cancer cells: a time course study. J Nutr Biochem (2008) 0.85
Gene profile identifies zinc transporters differentially expressed in normal human organs and human pancreatic cancer. Curr Mol Med (2013) 0.84
Nitric oxide and zinc homeostasis in acute lung injury. Proc Am Thorac Soc (2005) 0.84
Zn(II)-coordination modulated ligand photophysical processes - the development of fluorescent indicators for imaging biological Zn(II) ions. RSC Adv (2014) 0.83
Copper chaperone for Cu/Zn superoxide dismutase is a sensitive biomarker of mild copper deficiency induced by moderately high intakes of zinc. Nutr J (2005) 0.83
Zinc transporters, mechanisms of action and therapeutic utility: implications for type 2 diabetes mellitus. J Nutr Metab (2012) 0.83
Zinc regulates the acute phase response and serum amyloid A production in response to sepsis through JAK-STAT3 signaling. PLoS One (2014) 0.82
Extracellular zinc and ATP-gated P2X receptor calcium entry channels: New zinc receptors as physiological sensors and therapeutic targets. Purinergic Signal (2005) 0.82
Cellular transport and homeostasis of essential and nonessential metals. Metallomics (2012) 0.82
Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells. Diabetologia (2014) 0.82
Zinc and diabetic retinopathy. J Diabetes Res (2013) 0.81
ZIP4, a novel determinant of tumor invasion in hepatocellular carcinoma, contributes to tumor recurrence after liver transplantation. Int J Biol Sci (2014) 0.81
Immunological orchestration of zinc homeostasis: The battle between host mechanisms and pathogen defenses. Arch Biochem Biophys (2016) 0.80
X-ray fluorescence imaging of the hippocampal formation after manganese exposure. Metallomics (2013) 0.80
ZIPCO, a putative metal ion transporter, is crucial for Plasmodium liver-stage development. EMBO Mol Med (2014) 0.80
Gene expression of the zinc transporter ZIP14 (SLC39a14) is affected by weight loss and metabolic status and associates with PPARγ in human adipose tissue and 3T3-L1 pre-adipocytes. BMC Obes (2015) 0.80
Transepithelial transport of zinc and L-histidine across perfused intestine of American lobster, Homarus americanus. J Comp Physiol B (2006) 0.80
Identification of putative interactions between swine and human influenza A virus nucleoprotein and human host proteins. Virol J (2014) 0.79
The critical role of intracellular zinc in adenosine A(2) receptor activation induced cardioprotection against reperfusion injury. J Mol Cell Cardiol (2010) 0.79
Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity. Cell Rep (2015) 0.79
Functional role of intracellular labile zinc in pulmonary endothelium. Pulm Circ (2012) 0.79
The zinc transporter, Slc39a7 (Zip7) is implicated in glycaemic control in skeletal muscle cells. PLoS One (2013) 0.78
ZIP4 confers resistance to zinc deficiency-induced apoptosis in pancreatic cancer. Cell Cycle (2014) 0.78
Widespread expression of zinc transporter ZnT (SLC30) family members in mouse endocrine cells. Histochem Cell Biol (2012) 0.78
Co-expression of zinc binding motif and GFP as a cellular indicator of metal ions mobility. Int J Biol Sci (2005) 0.78
Mammalian zinc transporters: nutritional and physiologic regulation. Annu Rev Nutr (2009) 2.91
Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci U S A (2005) 2.60
Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells. Proc Natl Acad Sci U S A (2006) 2.35
Responsive transporter genes within the murine intestinal-pancreatic axis form a basis of zinc homeostasis. Proc Natl Acad Sci U S A (2004) 1.82
Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression. Proc Natl Acad Sci U S A (2007) 1.81
Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-gamma expression in activated human T cells. J Leukoc Biol (2009) 1.50
Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. Am J Physiol Cell Physiol (2011) 1.32
Zinc supplementation of young men alters metallothionein, zinc transporter, and cytokine gene expression in leukocyte populations. Proc Natl Acad Sci U S A (2006) 1.21
Zinc transporters 1, 2 and 4 are differentially expressed and localized in rats during pregnancy and lactation. J Nutr (2003) 1.19
Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia). PLoS One (2012) 1.17
Interleukin-1beta contributes via nitric oxide to the upregulation and functional activity of the zinc transporter Zip14 (Slc39a14) in murine hepatocytes. Am J Physiol Gastrointest Liver Physiol (2009) 1.11
STAT5-glucocorticoid receptor interaction and MTF-1 regulate the expression of ZnT2 (Slc30a2) in pancreatic acinar cells. Proc Natl Acad Sci U S A (2010) 1.09
Genomic analysis, cytokine expression, and microRNA profiling reveal biomarkers of human dietary zinc depletion and homeostasis. Proc Natl Acad Sci U S A (2011) 1.06
MTF-1-mediated repression of the zinc transporter Zip10 is alleviated by zinc restriction. PLoS One (2011) 1.06
Krüppel-like factor 4 regulates adaptive expression of the zinc transporter Zip4 in mouse small intestine. Am J Physiol Gastrointest Liver Physiol (2009) 1.05
The zinc transporter Zip14 influences c-Met phosphorylation and hepatocyte proliferation during liver regeneration in mice. Gastroenterology (2012) 0.97
Overexpression of CRIP in transgenic mice alters cytokine patterns and the immune response. Am J Physiol Endocrinol Metab (2002) 0.92
Dietary zinc modulates gene expression in murine thymus: results from a comprehensive differential display screening. Proc Natl Acad Sci U S A (2003) 0.91
Proteomic analysis shows the upregulation of erythrocyte dematin in zinc-restricted human subjects. Am J Clin Nutr (2012) 0.84
Gastric and colonic zinc transporter ZIP11 (Slc39a11) in mice responds to dietary zinc and exhibits nuclear localization. J Nutr (2013) 0.78