Published in J Nutr Biochem on September 13, 2012
Zinc homeostasis and neurodegenerative disorders. Front Aging Neurosci (2013) 1.05
The role of intracellular zinc release in aging, oxidative stress, and Alzheimer's disease. Front Aging Neurosci (2014) 0.98
Validation of type 2 diabetes risk variants identified by genome-wide association studies in Han Chinese population: a replication study and meta-analysis. PLoS One (2014) 0.93
Lipid rafts: linking prion protein to zinc transport and amyloid-β toxicity in Alzheimer's disease. Front Cell Dev Biol (2014) 0.83
Confusion about Cadmium Risks: The Unrecognized Limitations of an Extrapolated Paradigm. Environ Health Perspect (2015) 0.83
Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes. BMC Genomics (2013) 0.80
Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation. Mol Nutr Food Res (2015) 0.79
Zinc, aging, and immunosenescence: an overview. Pathobiol Aging Age Relat Dis (2015) 0.79
Influence of +1245 A/G MT1A polymorphism on advanced glycation end-products (AGEs) in elderly: effect of zinc supplementation. Genes Nutr (2014) 0.78
Zinc and the aging brain. Genes Nutr (2013) 0.77
SLC39A6: a potential target for diagnosis and therapy of esophageal carcinoma. J Transl Med (2015) 0.76
The Zinc Concentration in the Diet and the Length of the Feeding Period Affect the Methylation Status of the ZIP4 Zinc Transporter Gene in Piglets. PLoS One (2015) 0.76
Chasing flies because time flies. J Innate Immun (2014) 0.75
Adverse effects of parental zinc deficiency on metal homeostasis and embryonic development in a zebrafish model. J Nutr Biochem (2017) 0.75
Maternal dietary zinc supplementation enhances the epigenetic-activated antioxidant ability of chick embryos from maternal normal and high temperatures. Oncotarget (2017) 0.75
Immune and metabolic responses in early and late sepsis during mild dietary zinc restriction. J Surg Res (2016) 0.75
Aging amplifies multiple phenotypic defects in mice with zinc transporter Zip14 (Slc39a14) deletion. Exp Gerontol (2016) 0.75
Main biomarkers associated with age-related plasma zinc decrease and copper/zinc ratio in healthy elderly from ZincAge study. Eur J Nutr (2016) 0.75
Differential Effects of Low- and High-dose Zinc Supplementation on Synaptic Plasticity and Neurogenesis in the Hippocampus of Control and High-fat Diet-fed Mice. Neurochem Res (2017) 0.75
Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev (2006) 5.61
Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. FASEB J (1998) 4.62
Inflammation and cancer: an ancient link with novel potentials. Int J Cancer (2007) 4.19
Bone Marrow-Derived Macrophages (BMM): Isolation and Applications. CSH Protoc (2008) 4.06
Immunosenescence of ageing. J Pathol (2007) 3.32
Widespread and tissue specific age-related DNA methylation changes in mice. Genome Res (2010) 2.99
Inflammation: gearing the journey to cancer. Mutat Res (2008) 2.89
Mammalian zinc transporters. Annu Rev Nutr (2004) 2.82
The SLC39 family of metal ion transporters. Pflugers Arch (2003) 2.27
Reprogramming of the immune system during zinc deficiency. Annu Rev Nutr (2004) 2.10
Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. Nat Immunol (2006) 1.98
Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis. Crit Care Med (2009) 1.94
Overview of mammalian zinc transporters. Cell Mol Life Sci (2004) 1.90
Zinc homeostasis and signaling in health and diseases: Zinc signaling. J Biol Inorg Chem (2011) 1.89
Zinc and the risk for infectious disease. Annu Rev Nutr (2004) 1.79
Suggested lower cutoffs of serum zinc concentrations for assessing zinc status: reanalysis of the second National Health and Nutrition Examination Survey data (1976-1980). Am J Clin Nutr (2003) 1.77
Regulation of T cell receptor signaling by activation-induced zinc influx. J Exp Med (2011) 1.73
Zinc and copper intakes and their major food sources for older adults in the 1994-96 continuing survey of food intakes by individuals (CSFII). J Nutr (2000) 1.67
Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line. Proc Natl Acad Sci U S A (2002) 1.54
Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. Am J Clin Nutr (2007) 1.52
Intracellular zinc homeostasis and zinc signaling. Cancer Sci (2008) 1.52
Epigenetics: A New Bridge between Nutrition and Health. Adv Nutr (2010) 1.51
Mineral intakes of elderly adult supplement and non-supplement users in the third national health and nutrition examination survey. J Nutr (2002) 1.21
Zinc supplementation of young men alters metallothionein, zinc transporter, and cytokine gene expression in leukocyte populations. Proc Natl Acad Sci U S A (2006) 1.21
Age-associated epigenetic modifications in human DNA increase its immunogenicity. Aging (Albany NY) (2010) 1.15
Blood micronutrient and thyroid hormone concentrations in the oldest-old. J Clin Endocrinol Metab (2000) 1.12
Nutritional influences on epigenetics and age-related disease. Proc Nutr Soc (2011) 1.11
Epigenetics, aging, and autoimmunity. Autoimmunity (2008) 1.11
A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission. Am J Clin Nutr (2011) 1.10
Dysregulation between TH1 and TH2 T cell subpopulations in the elderly. Mech Ageing Dev (1996) 1.08
Zinc fluxes and zinc transporter genes in chronic diseases. Mutat Res (2007) 1.07
Nutrition, epigenetics, and metabolic syndrome. Antioxid Redox Signal (2012) 1.04
The immune system and the impact of zinc during aging. Immun Ageing (2009) 1.03
The role of epigenetics in aging and autoimmunity. Clin Rev Allergy Immunol (2010) 1.03
Determination of standard zinc values in the intact tissues of mice by ICP spectrometry. Biol Trace Elem Res (1997) 1.01
Developmental consequences of trace mineral deficiencies in rodents: acute and long-term effects. J Nutr (2003) 1.01
Zinc deficiency in elderly patients. Nutrition (1993) 0.98
Aging and inflammation: etiological culprits of cancer. Curr Aging Sci (2009) 0.97
Dietary zinc supplementation inhibits NFkappaB activation and protects against chemically induced diabetes in CD1 mice. Exp Biol Med (Maywood) (2001) 0.97
Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9. J Leukoc Biol (2007) 0.92
The role of zinc in genomic stability. Mutat Res (2011) 0.92
Age-related difference of site-specific histone modifications in rat liver. Biogerontology (2008) 0.90
Effect of zinc deficiency on methionine metabolism, methylation reactions and protein synthesis in isolated perfused rat liver. J Nutr (1985) 0.90
Possible roles of zinc nutriture in the fetal origins of disease. Exp Gerontol (2007) 0.88
Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions. Rejuvenation Res (2008) 0.87
Zinc and its role in age-related inflammation and immune dysfunction. Mol Nutr Food Res (2011) 0.86
Micronutrient (Zn, Cu, Fe)-gene interactions in ageing and inflammatory age-related diseases: implications for treatments. Ageing Res Rev (2012) 0.84
Involvement of DNA hypermethylation in down-regulation of the zinc transporter ZIP8 in cadmium-resistant metallothionein-null cells. Toxicol Appl Pharmacol (2009) 0.83
Low serum zinc levels in patients undergoing coronary angiography correlate with immune activation and inflammation. J Trace Elem Med Biol (2012) 0.83
Zinc supplementation increases zinc status and thymopoiesis in aged mice. J Nutr (2009) 0.82
Zinc intake and sources in the US adult population: 1976-1980. J Am Coll Nutr (1995) 0.81
Does promoter methylation of the SLC30A5 (ZnT5) zinc transporter gene contribute to the ageing-related decline in zinc status? Proc Nutr Soc (2009) 0.81
Inflammation, aging, and cancer vaccines. Biogerontology (2010) 0.81
Comparison of intracellular zinc signals in nonadherent lymphocytes from young-adult and elderly donors: role of zinc transporters (Zip family) and proinflammatory cytokines. J Nutr Biochem (2011) 0.81
Intracellular free zinc up-regulates IFN-γ and T-bet essential for Th1 differentiation in Con-A stimulated HUT-78 cells. Biochem Biophys Res Commun (2011) 0.78
Epigenetic control in immune function. Adv Exp Med Biol (2011) 0.77
Isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats. Anesthesiology (2009) 2.65
Human hippocampal theta activity during virtual navigation. Hippocampus (2005) 2.37
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis (2005) 2.05
Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects. Exp Biol Med (Maywood) (2007) 1.98
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. FASEB J (2006) 1.98
Multi-targeted prevention of cancer by sulforaphane. Cancer Lett (2008) 1.98
Dietary histone deacetylase inhibitors: from cells to mice to man. Semin Cancer Biol (2007) 1.93
Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention? Carcinogenesis (2005) 1.46
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clin Epigenetics (2011) 1.31
Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Mol Nutr Food Res (2011) 1.22
Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in rats. J Nutr (2009) 1.21
Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. Pharm Res (2011) 1.21
Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Cancer Lett (2006) 1.15
Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells. Clin Epigenetics (2011) 1.12
Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. Mol Cancer (2011) 1.11
Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds. Environ Mol Mutagen (2009) 1.11
The natural history of dementia. Psychogeriatrics (2014) 1.04
MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals. Mol Carcinog (2011) 1.04
Can selective ligands for glutamate binding proteins be rationally designed? Curr Top Med Chem (2006) 1.02
Aging is associated with altered dendritic cells subset distribution and impaired proinflammatory cytokine production. Exp Gerontol (2009) 1.00
Induction of regulatory T cells by green tea polyphenol EGCG. Immunol Lett (2011) 0.99
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics (2013) 0.98
Induction of proinflammatory response in prostate cancer epithelial cells by activated macrophages. Cancer Lett (2008) 0.97
Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design. Pharmacol Res (2011) 0.96
Zinc deficiency alters DNA damage response genes in normal human prostate epithelial cells. J Nutr (2008) 0.96
3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. Toxicol Appl Pharmacol (2012) 0.96
Dietary agents as histone deacetylase inhibitors. Mol Carcinog (2006) 0.95
Alpha-tocopherol modulates genes involved in hepatic xenobiotic pathways in mice. J Nutr Biochem (2008) 0.95
Metabolism as a key to histone deacetylase inhibition. Crit Rev Biochem Mol Biol (2011) 0.95
Comparison of isothiocyanate metabolite levels and histone deacetylase activity in human subjects consuming broccoli sprouts or broccoli supplement. J Agric Food Chem (2011) 0.94
Reliability and validity of food frequency questionnaire and nutrient biomarkers in elders with and without mild cognitive impairment. Alzheimer Dis Assoc Disord (2011) 0.93
Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells. Exp Biol Med (Maywood) (2010) 0.93
Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates. Nutr Rev (2008) 0.93
Changes in the expression of the NR2B subunit during aging in macaque monkeys. Neurobiol Aging (2004) 0.93
Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract. Mol Nutr Food Res (2015) 0.92
Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFκB pathway in the Noble rat model. J Nutr Biochem (2011) 0.92
A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis. Clin Epigenetics (2012) 0.92
Dietary zinc restriction in rats alters antioxidant status and increases plasma F2 isoprostanes. J Nutr Biochem (2006) 0.91
3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One (2012) 0.89
A simple assay for frequency of chromosome breaks and loss (micronuclei) by flow cytometry of human reticulocytes. FASEB J (2004) 0.89
Abiotrophia defectiva endocarditis and associated hemophagocytic syndrome--a first case report and review of the literature. Int J Infect Dis (2008) 0.88
Dietary zinc restriction and repletion affects DNA integrity in healthy men. Am J Clin Nutr (2009) 0.88
Marginal zinc deficiency increases oxidative DNA damage in the prostate after chronic exercise. Free Radic Biol Med (2009) 0.88
Anti-inflammatory activity of soy and tea in prostate cancer prevention. Exp Biol Med (Maywood) (2010) 0.87
MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Mol Nutr Food Res (2012) 0.87
Zinc and its role in age-related inflammation and immune dysfunction. Mol Nutr Food Res (2011) 0.86
Protection by dietary zinc in ALS mutant G93A SOD transgenic mice. Neurosci Lett (2005) 0.85
Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer. Int J Cancer (2012) 0.85
Consumption of green tea extract results in osteopenia in growing male mice. J Nutr (2009) 0.85
An increase in the association of GluN2B containing NMDA receptors with membrane scaffolding proteins was related to memory declines during aging. J Neurosci (2013) 0.85
Catalytic asymmetric synthesis of glutamate analogues. Org Lett (2004) 0.85
Sulforaphane induces SLPI secretion in the nasal mucosa. Respir Med (2012) 0.84
Reducing expression of GluN1(0XX) subunit splice variants of the NMDA receptor interferes with spatial reference memory. Behav Brain Res (2012) 0.83
Relationship between mRNA expression of splice forms of the zeta1 subunit of the N-methyl-D-aspartate receptor and spatial memory in aged mice. Brain Res (2008) 0.83
Zinc supplementation increases zinc status and thymopoiesis in aged mice. J Nutr (2009) 0.82
Zinc transporter expression profiles in the rat prostate following alterations in dietary zinc. Biometals (2009) 0.81
Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention. Mol Nutr Food Res (2014) 0.81
Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention. AAPS J (2013) 0.81
Restoration of Trigeminal Cutaneous Sensation with Cross-Face Sural Nerve Grafts: A Novel Approach to Facial Sensory Rehabilitation. Plast Reconstr Surg (2015) 0.81
Acute dissociation for analyses of NMDA receptor function in cortical neurons during aging. J Neurosci Methods (2003) 0.80
Changes in expression of splice cassettes of NMDA receptor GluN1 subunits within the frontal lobe and memory in mice during aging. Behav Brain Res (2011) 0.80
Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation. Mol Nutr Food Res (2015) 0.79
Phytase supplementation increases bone mineral density, lean body mass and voluntary physical activity in rats fed a low-zinc diet. J Nutr Biochem (2009) 0.79
The epigenome as a potential mediator of cancer and disease prevention in prenatal development. Nutr Rev (2013) 0.78
Comparison of opioid and alpha-2 adrenergic receptor binding in horse and dog brain using radioligand autoradiography. Vet Anaesth Analg (2003) 0.78
Troponin T elevation after coronary bypass surgery: clinical relevance and correlation with perioperative variables. J Cardiovasc Med (Hagerstown) (2006) 0.77
Differential response to zinc-induced apoptosis in benign prostate hyperplasia and prostate cancer cells. J Nutr Biochem (2009) 0.77
Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors. Curr Top Med Chem (2016) 0.77
Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane. Toxicol Appl Pharmacol (2013) 0.76
Regulation of hepatic suppressor of cytokine signaling 3 by zinc. J Nutr Biochem (2012) 0.76
Dietary zinc depletion and repletion affects plasma proteins: an analysis of the plasma proteome. Biometals (2012) 0.75
The association of night-time systolic blood pressure with ultrasound markers of subclinical cardiac and vascular disease. Blood Press Monit (2016) 0.75
Timing of Presentation of Pediatric Compartment Syndrome and its Microsurgical Implication: A Retrospective Review. Plast Reconstr Surg (2016) 0.75
Effects of developmental exposure to lead, magnesium and zinc mixtures on spatial learning and expression of NMDA receptor subunit mRNA in Fischer 344 rats. Toxicol Lett (2002) 0.75