Published in Nutrients on July 30, 2012
Extreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa. PLoS Genet (2014) 0.84
A Review of the Current Status and Concept of the Emerging Implications of Zinc and Zinc Transporters in the Development of Pancreatic Cancer. Pancreat Disord Ther (2013) 0.83
Zinc and gastrointestinal disease. World J Gastrointest Pathophysiol (2014) 0.82
Zinc at sub-cytotoxic concentrations induces heme oxygenase-1 expression in human cancer cells. Cell Physiol Biochem (2013) 0.81
A moderate increase in dietary zinc reduces DNA strand breaks in leukocytes and alters plasma proteins without changing plasma zinc concentrations. Am J Clin Nutr (2016) 0.80
The New Role for an Old Kinase: Protein Kinase CK2 Regulates Metal Ion Transport. Pharmaceuticals (Basel) (2016) 0.78
A simplicial complex-based approach to unmixing tumor progression data. BMC Bioinformatics (2015) 0.76
PT93, a novel caffeic acid amide derivative, suppresses glioblastoma cells migration, proliferation and MMP-2/-9 expression. Oncol Lett (2017) 0.75
Zinc transporters and dysregulated channels in cancers. Front Biosci (Landmark Ed) (2017) 0.75
Potential Coagulation Factor-Driven Pro-Inflammatory Responses in Ovarian Cancer Tissues Associated with Insufficient O₂ and Plasma Supply. Int J Mol Sci (2017) 0.75
Zinc and Oxidative Stress: Current Mechanisms. Antioxidants (Basel) (2017) 0.75
Global cancer statistics. CA Cancer J Clin (2011) 185.92
The hallmarks of cancer. Cell (2000) 113.05
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A (2001) 71.82
Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet (2005) 29.45
New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer (2002) 24.71
Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol (2006) 23.04
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol (2000) 21.15
How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol (2001) 14.05
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science (1994) 13.51
Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell (2002) 9.61
Matrix metalloproteinases: a review. Crit Rev Oral Biol Med (1993) 9.03
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24
International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control. Food Nutr Bull (2004) 5.76
ATM activation by oxidative stress. Science (2010) 5.22
Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci U S A (1997) 4.38
Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials. Am J Clin Nutr (2002) 3.88
Mammalian zinc transport, trafficking, and signals. J Biol Chem (2006) 3.05
Mammalian zinc transporters: nutritional and physiologic regulation. Annu Rev Nutr (2009) 2.91
Mammalian zinc transporters. Annu Rev Nutr (2004) 2.82
The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots. Mol Cancer (2006) 2.70
Gene expression profiling of breast cancer: a new tumor marker. J Clin Oncol (2005) 2.69
Pathways governing G1/S transition and their response to DNA damage. FEBS Lett (2001) 2.58
Zinc is a novel intracellular second messenger. J Cell Biol (2007) 2.46
Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites. Mol Biotechnol (2002) 2.40
Counting the zinc-proteins encoded in the human genome. J Proteome Res (2006) 2.38
Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer. Nature (2004) 2.36
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proc Natl Acad Sci U S A (1996) 2.31
Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal-like transitions. Clin Exp Metastasis (2008) 2.30
Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies. Int J Dev Biol (2004) 2.23
Functions of zinc in signaling, proliferation and differentiation of mammalian cells. Biometals (2002) 2.21
hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer. Mol Cancer (2005) 2.21
ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks. Oncogene (2007) 2.12
Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium. Am J Pathol (2003) 2.12
Zinc and human health: an update. Arch Toxicol (2011) 2.08
Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer. J Mammary Gland Biol Neoplasia (2010) 2.07
Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II). Biochem J (1993) 2.02
Redox regulation in cancer: a double-edged sword with therapeutic potential. Oxid Med Cell Longev (2010) 1.99
Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies. J Natl Cancer Inst (1996) 1.99
Identification of novel genes that co-cluster with estrogen receptor alpha in breast tumor biopsy specimens, using a large-scale real-time reverse transcription-PCR approach. Endocr Relat Cancer (2006) 1.96
The p53 pathway in breast cancer. Breast Cancer Res (2002) 1.94
New insights of epithelial-mesenchymal transition in cancer metastasis. Acta Biochim Biophys Sin (Shanghai) (2008) 1.94
The role of zinc in growth and cell proliferation. J Nutr (2000) 1.89
Zinc homeostasis and signaling in health and diseases: Zinc signaling. J Biol Inorg Chem (2011) 1.89
Regulation of matrix metalloproteinase activity in health and disease. FEBS J (2010) 1.88
Evidence for a zinc uptake transporter in human prostate cancer cells which is regulated by prolactin and testosterone. J Biol Chem (1999) 1.86
Oxidative metal release from metallothionein via zinc-thiol/disulfide interchange. Proc Natl Acad Sci U S A (1994) 1.84
Oxygen free radicals and metallothionein. Free Radic Biol Med (1993) 1.84
Physiology and pathophysiology of matrix metalloproteases. Amino Acids (2010) 1.83
Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression. Proc Natl Acad Sci U S A (2007) 1.81
The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim Biophys Acta (2003) 1.81
Apoptosis plays a distinct role in the loss of precursor lymphocytes during zinc deficiency in mice. J Nutr (2002) 1.76
Mitochondrial function, zinc, and intermediary metabolism relationships in normal prostate and prostate cancer. Mitochondrion (2005) 1.74
Mitochondrial free radical production and cell signaling. Mol Aspects Med (2004) 1.70
Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development. Clin Exp Metastasis (2008) 1.69
Zinc deficiency, DNA damage and cancer risk. J Nutr Biochem (2004) 1.68
Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells. J Inorg Biochem (2003) 1.66
Zinc as an anti-tumor agent in prostate cancer and in other cancers. Arch Biochem Biophys (2007) 1.65
Zinc: an overview. Nutrition (1995) 1.64
'Why do tumour cells glycolyse?': from glycolysis through citrate to lipogenesis. Mol Cell Biochem (2005) 1.61
Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP. Curr Opin Cell Biol (2005) 1.61
Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues. Mol Cancer (2006) 1.57
Wnt, hedgehog and snail: sister pathways that control by GSK-3beta and beta-Trcp in the regulation of metastasis. Cell Cycle (2005) 1.57
STAT3 as a central regulator of tumor metastases. Curr Mol Med (2009) 1.57
Zinc deficiency affects cell cycle and deoxythymidine kinase gene expression in HUT-78 cells. J Lab Clin Med (1996) 1.57
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J Cell Biol (2009) 1.55
Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line. Proc Natl Acad Sci U S A (2002) 1.54
Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. Am J Clin Nutr (2007) 1.52
Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. J Biol Chem (2006) 1.52
The emerging role of the LIV-1 subfamily of zinc transporters in breast cancer. Mol Med (2007) 1.51
Zinc induces mitochondria apoptogenesis in prostate cells. Mol Urol (2000) 1.51
Zinc and zinc transporters in normal prostate and the pathogenesis of prostate cancer. Front Biosci (2005) 1.50
Zinc transfer from transcription factor IIIA fingers to thionein clusters. Proc Natl Acad Sci U S A (1991) 1.50
Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Sp1. FEBS Lett (1991) 1.50
Copper and zinc levels in normal and malignant tissues. Cancer (1983) 1.48
Zinc metallothionein imported into liver mitochondria modulates respiration. Proc Natl Acad Sci U S A (2001) 1.46
Direct effect of zinc on mitochondrial apoptogenesis in prostate cells. Prostate (2002) 1.46
Zinc coordination environments in proteins as redox sensors and signal transducers. Antioxid Redox Signal (2006) 1.43
Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling. Exp Cell Res (2003) 1.42
Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation. Trends Mol Med (2009) 1.40
ZIP7-mediated intracellular zinc transport contributes to aberrant growth factor signaling in antihormone-resistant breast cancer Cells. Endocrinology (2008) 1.38
Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation. J Biol Chem (2002) 1.37
A zinc-sensing receptor triggers the release of intracellular Ca2+ and regulates ion transport. Proc Natl Acad Sci U S A (2001) 1.37
Role of zinc in the pathogenesis and treatment of prostate cancer: critical issues to resolve. Prostate Cancer Prostatic Dis (2004) 1.37
Interaction between estradiol and growth factors in the regulation of specific gene expression in MCF-7 human breast cancer cells. J Steroid Biochem Mol Biol (1997) 1.36
Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality. Epidemiology (2006) 1.36
Zinc and the immune system. Proc Nutr Soc (2000) 1.35
Zinc in specialized secretory tissues: roles in the pancreas, prostate, and mammary gland. Adv Nutr (2011) 1.35
Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells. Cancer Sci (2007) 1.35
Diverse effects of zinc on NF-kappaB and AP-1 transcription factors: implications for prostate cancer progression. Carcinogenesis (2006) 1.33
A structural role for metal ions in the "wild-type" conformation of the tumor suppressor protein p53. Cancer Res (1993) 1.33
Zinc deficiency. BMJ (2003) 1.33
hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands. Mol Cancer (2007) 1.33
Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts. J Nutr (2003) 1.25
Zn transporter levels and localization change throughout lactation in rat mammary gland and are regulated by Zn in mammary cells. J Nutr (2003) 1.25
Aminopeptidase N regulated by zinc in human prostate participates in tumor cell invasion. Int J Cancer (2001) 1.24
Escherichia coli deoxyribonucleic acid polymerase I, a zinc metalloenzyme. Nuclear quadrupolar relaxation studies of the role of bound zinc. J Biol Chem (1973) 1.24
Zinc deficiency causes oxidative damage to proteins, lipids and DNA in rat testes. J Nutr (1995) 1.24
Associations between drug metabolism genotype, chemotherapy pharmacokinetics, and overall survival in patients with breast cancer. J Clin Oncol (2005) 1.23
Damage of zinc fingers in DNA repair proteins, a novel molecular mechanism in carcinogenesis. Toxicol Lett (2005) 1.23
Serum and tissue trace elements in patients with breast cancer in Taiwan. Biol Trace Elem Res (2002) 1.23
Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. J Biol Chem (2006) 1.52
Zinc transporter-2 (ZnT2) variants are localized to distinct subcellular compartments and functionally transport zinc. Biochem J (2009) 1.12
X-ray fluorescence microscopy reveals accumulation and secretion of discrete intracellular zinc pools in the lactating mouse mammary gland. PLoS One (2010) 1.09
Prolactin regulates ZNT2 expression through the JAK2/STAT5 signaling pathway in mammary cells. Am J Physiol Cell Physiol (2009) 1.01
Zinc deficiency is associated with increased brain zinc import and LIV-1 expression and decreased ZnT-1 expression in neonatal rats. J Nutr (2005) 1.01
Maternal zinc deficiency reduces NMDA receptor expression in neonatal rat brain, which persists into early adulthood. J Neurochem (2005) 0.99
Zip6-attenuation promotes epithelial-to-mesenchymal transition in ductal breast tumor (T47D) cells. Exp Cell Res (2009) 0.97
Functional analysis of two single nucleotide polymorphisms in SLC30A2 (ZnT2): implications for mammary gland function and breast disease in women. Physiol Genomics (2010) 0.97
A dominant negative heterozygous G87R mutation in the zinc transporter, ZnT-2 (SLC30A2), results in transient neonatal zinc deficiency. J Biol Chem (2012) 0.94
ZnT4 provides zinc to zinc-dependent proteins in the trans-Golgi network critical for cell function and Zn export in mammary epithelial cells. Am J Physiol Cell Physiol (2012) 0.93
Prevalence of systemic inflammation and micronutrient imbalance in patients with complex abdominal hernias. J Gastrointest Surg (2013) 0.93
Functional and molecular responses of suckling rat pups and human intestinal Caco-2 cells to copper treatment. J Nutr Biochem (2004) 0.91
Effects of copper supplementation on copper absorption, tissue distribution, and copper transporter expression in an infant rat model. Am J Physiol Gastrointest Liver Physiol (2004) 0.91
Apo- and holo-lactoferrin are both internalized by lactoferrin receptor via clathrin-mediated endocytosis but differentially affect ERK-signaling and cell proliferation in Caco-2 cells. J Cell Physiol (2011) 0.91
Expression of functional recombinant human lysozyme in transgenic rice cell culture. Transgenic Res (2002) 0.89
Zinc-dependent lysosomal enlargement in TRPML1-deficient cells involves MTF-1 transcription factor and ZnT4 (Slc30a4) transporter. Biochem J (2013) 0.89
Moderate zinc deficiency reduces testicular Zip6 and Zip10 abundance and impairs spermatogenesis in mice. J Nutr (2011) 0.89
Marginal maternal zinc deficiency in lactating mice reduces secretory capacity and alters milk composition. J Nutr (2012) 0.89
Zip6 (LIV-1) regulates zinc uptake in neuroblastoma cells under resting but not depolarizing conditions. Brain Res (2008) 0.88
A histidine-rich motif mediates mitochondrial localization of ZnT2 to modulate mitochondrial function. Am J Physiol Cell Physiol (2011) 0.87
Iron metabolism in infants and children. Food Nutr Bull (2007) 0.87
ZnT2-overexpression represses the cytotoxic effects of zinc hyper-accumulation in malignant metallothionein-null T47D breast tumor cells. Cancer Lett (2011) 0.87
Zinc networks: the cell-specific compartmentalization of zinc for specialized functions. Biol Chem (2012) 0.86
rRNA probes used to quantify the effects of glycomacropeptide and alpha-lactalbumin supplementation on the predominant groups of intestinal bacteria of infant rhesus monkeys challenged with enteropathogenic Escherichia coli. J Pediatr Gastroenterol Nutr (2003) 0.86
Expression, characterization, and biologic activity of recombinant human lactoferrin in rice. J Pediatr Gastroenterol Nutr (2003) 0.86
Participation of mammary gland in long-chain polyunsaturated fatty acid synthesis during pregnancy and lactation in rats. Biochim Biophys Acta (2011) 0.84
The biology of zinc transport in mammary epithelial cells: implications for mammary gland development, lactation, and involution. J Mammary Gland Biol Neoplasia (2013) 0.82
A graded model of dietary zinc deficiency: effects on growth, insulin-like growth factor-I, and the glucose/insulin axis in weanling rats. J Pediatr Gastroenterol Nutr (2005) 0.80
Maternal iron and zinc supplementation during pregnancy affects body weight and iron status in rat pups at weaning. J Nutr (2011) 0.80
The effects of alpha-lactalbumin and glycomacropeptide on the association of CaCo-2 cells by enteropathogenic Escherichia coli, Salmonella typhimurium and Shigella flexneri. FEMS Microbiol Lett (2006) 0.79
Effects of zinc exposure on zinc transporter expression in human intestinal cells of varying maturity. J Pediatr Gastroenterol Nutr (2010) 0.79
Detection of a single nucleotide polymorphism in the human alpha-lactalbumin gene: implications for human milk proteins. J Nutr Biochem (2005) 0.79
Maternal zinc deficiency raises plasma prolactin levels in lactating rats. J Nutr (2004) 0.78
Lactoferrin receptor mediates apo- but not holo-lactoferrin internalization via clathrin-mediated endocytosis in trophoblasts. Biochem J (2008) 0.78
Effects of chronic copper exposure during early life in rhesus monkeys. Am J Clin Nutr (2005) 0.77
Zinc supplementation of pregnant rats with adequate zinc nutriture suppresses immune functions in their offspring. J Nutr (2007) 0.76