Published in Science on June 11, 2004
Thermochemistry of proton-coupled electron transfer reagents and its implications. Chem Rev (2010) 2.64
Axial ligand tuning of a nonheme iron(IV)-oxo unit for hydrogen atom abstraction. Proc Natl Acad Sci U S A (2007) 1.70
Heme enzyme structure and function. Chem Rev (2014) 1.58
X-ray emission spectroscopy to study ligand valence orbitals in Mn coordination complexes. J Am Chem Soc (2009) 1.55
Iron(IV)hydroxide pK(a) and the role of thiolate ligation in C-H bond activation by cytochrome P450. Science (2013) 1.46
Significantly shorter Fe-S bond in cytochrome P450-I is consistent with greater reactivity relative to chloroperoxidase. Nat Chem (2015) 1.44
Role of the secondary coordination sphere in metal-mediated dioxygen activation. Inorg Chem (2010) 1.42
Axial ligand effects on the geometric and electronic structures of nonheme oxoiron(IV) complexes. J Am Chem Soc (2008) 1.32
Crystallographic and single-crystal spectral analysis of the peroxidase ferryl intermediate. Biochemistry (2010) 1.23
Resonance Raman spectroscopy of chloroperoxidase compound II provides direct evidence for the existence of an iron(IV)-hydroxide. Proc Natl Acad Sci U S A (2006) 1.21
C-H bond cleavage with reductants: re-investigating the reactivity of monomeric Mn(III/IV)-oxo complexes and the role of oxo ligand basicity. J Am Chem Soc (2009) 1.20
Kinetics of two-electron oxidations by the compound I derivative of chloroperoxidase, a model for cytochrome P450 oxidants. Org Lett (2006) 1.18
X-ray absorption spectroscopy of chloroperoxidase compound I: Insight into the reactive intermediate of P450 chemistry. Proc Natl Acad Sci U S A (2005) 1.17
Mechanism of and exquisite selectivity for O-O bond formation by the heme-dependent chlorite dismutase. Proc Natl Acad Sci U S A (2008) 1.16
X-ray absorption spectroscopic characterization of a cytochrome P450 compound II derivative. Proc Natl Acad Sci U S A (2008) 1.13
Reactive intermediates in cytochrome p450 catalysis. J Biol Chem (2013) 1.13
Detection and kinetic characterization of a highly reactive heme-thiolate peroxygenase compound I. J Am Chem Soc (2012) 1.12
Structure and quantum chemical characterization of chloroperoxidase compound 0, a common reaction intermediate of diverse heme enzymes. Proc Natl Acad Sci U S A (2006) 1.11
Transition metal spin state energetics and noninnocent systems: challenges for DFT in the bioinorganic arena. J Biol Inorg Chem (2006) 1.05
Insight into the mechanism of an iron dioxygenase by resolution of steps following the FeIV=HO species. Proc Natl Acad Sci U S A (2010) 1.05
Photooxidation of cytochrome P450-BM3. Proc Natl Acad Sci U S A (2010) 1.05
Understanding how the thiolate sulfur contributes to the function of the non-heme iron enzyme superoxide reductase. Acc Chem Res (2007) 1.03
Steric and electronic control over the reactivity of a thiolate-ligated Fe(II) complex with dioxygen and superoxide: reversible mu-oxo dimer formation. Inorg Chem (2004) 1.01
Role of metal-oxo complexes in the cleavage of C-H bonds. Chem Soc Rev (2011) 1.01
Nature of the ferryl heme in compounds I and II. J Biol Chem (2010) 0.99
Prediction of high-valent iron K-edge absorption spectra by time-dependent density functional theory. Dalton Trans (2011) 0.99
Spectroscopic features of cytochrome P450 reaction intermediates. Arch Biochem Biophys (2010) 0.98
Facile concerted proton-electron transfers in a ruthenium terpyridine-4'-carboxylate complex with a long distance between the redox and basic sites. J Am Chem Soc (2008) 0.97
Thirty years of heme peroxidase structural biology. Arch Biochem Biophys (2010) 0.97
Laser flash photolysis generation of high-valent transition metal-oxo species: insights from kinetic studies in real time. Acc Chem Res (2008) 0.95
Ferryl haem protonation gates peroxidatic reactivity in globins. Biochem J (2007) 0.94
Lessons from nature: unraveling biological CH bond activation. Curr Opin Chem Biol (2009) 0.94
Mechanisms of peroxynitrite interactions with heme proteins. Inorg Chem (2010) 0.93
Replacement of tyrosine residues by phenylalanine in cytochrome P450cam alters the formation of Cpd II-like species in reactions with artificial oxidants. J Biol Inorg Chem (2008) 0.93
Polarized X-ray absorption spectroscopy of single-crystal Mn(V) complexes relevant to the oxygen-evolving complex of photosystem II. J Am Chem Soc (2007) 0.93
Dramatic influence of an anionic donor on the oxygen-atom transfer reactivity of a Mn(V) -oxo complex. Chemistry (2014) 0.92
Hydrogen atom abstraction from hydrocarbons by a copper(III)-hydroxide complex. J Am Chem Soc (2015) 0.92
Enzymatic C-H bond activation: Using push to get pull. Nat Chem (2014) 0.92
Driving force for oxygen-atom transfer by heme-thiolate enzymes. Angew Chem Int Ed Engl (2013) 0.92
S K-edge XAS and DFT calculations on cytochrome P450: covalent and ionic contributions to the cysteine-Fe bond and their contribution to reactivity. J Am Chem Soc (2009) 0.92
Activation of a high-valent manganese-oxo complex by a nonmetallic Lewis acid. Inorg Chem (2014) 0.92
The protonation status of compound II in myoglobin, studied by a combination of experimental data and quantum chemical calculations: quantum refinement. Biophys J (2004) 0.91
Replacement of the axial histidine heme ligand with cysteine in nitrophorin 1: spectroscopic and crystallographic characterization. J Biol Inorg Chem (2008) 0.89
Enzyme reactivation by hydrogen peroxide in heme-based tryptophan dioxygenase. J Biol Chem (2011) 0.88
Setting an upper limit on the myoglobin iron(IV)hydroxide pK(a): insight into axial ligand tuning in heme protein catalysis. J Am Chem Soc (2014) 0.88
Discovery of a reaction intermediate of aliphatic aldoxime dehydratase involving heme as an active center. Proc Natl Acad Sci U S A (2006) 0.86
A new look at the role of thiolate ligation in cytochrome P450. J Biol Inorg Chem (2017) 0.85
Fenton chemistry at aqueous interfaces. Proc Natl Acad Sci U S A (2013) 0.85
X-ray structure analysis of a metalloprotein with enhanced active-site resolution using in situ x-ray absorption near edge structure spectroscopy. Proc Natl Acad Sci U S A (2007) 0.84
Ferryl protonation in oxoiron(IV) porphyrins and its role in oxygen transfer. J Am Chem Soc (2015) 0.84
Characterization and dioxygen reactivity of a new series of coordinatively unsaturated thiolate-ligated manganese(II) complexes. Inorg Chem (2012) 0.83
Ru(II)-diimine functionalized metalloproteins: From electron transfer studies to light-driven biocatalysis. Biochim Biophys Acta (2015) 0.83
Crystal structure of aldoxime dehydratase and its catalytic mechanism involved in carbon-nitrogen triple-bond synthesis. Proc Natl Acad Sci U S A (2013) 0.83
Metal-Templated Ligand Architectures for Trinuclear Chemistry: Tricopper Complexes and Their O2 Reactivity. Chem Sci (2012) 0.83
Heme-thiolate ferryl of aromatic peroxygenase is basic and reactive. Proc Natl Acad Sci U S A (2015) 0.83
Probing the heme-thiolate oxygenase domain of inducible nitric oxide synthase with Ru(II) and Re(I) electron tunneling wires. J Porphyr Phthalocyanines (2008) 0.82
Moving protons and electrons in biomimetic systems. Biochemistry (2015) 0.82
Spectroscopic description of an unusual protonated ferryl species in the catalase from Proteus mirabilis and density functional theory calculations on related models. Consequences for the ferryl protonation state in catalase, peroxidase and chloroperoxidase. J Biol Inorg Chem (2007) 0.81
Axial and equatorial ligand effects on biomimetic cysteine dioxygenase model complexes. Org Biomol Chem (2012) 0.81
Synthetic Applications of Proton-Coupled Electron Transfer. Acc Chem Res (2016) 0.80
Highly Enantioselective Oxidation of Nonactivated Aliphatic C-H Bonds with Hydrogen Peroxide Catalyzed by Manganese Complexes. ACS Cent Sci (2017) 0.80
Spectroscopic and theoretical investigation of a complex with an [O═Fe(IV)-O-Fe(IV)═O] core related to methane monooxygenase intermediate Q. J Am Chem Soc (2014) 0.79
Characterization of a selenocysteine-ligated P450 compound I reveals direct link between electron donation and reactivity. Nat Chem (2017) 0.78
Direct visualization of a Fe(IV)-OH intermediate in a heme enzyme. Nat Commun (2016) 0.78
Paramagnetic nuclear magnetic resonance relaxation and molecular mechanics studies of the chloroperoxidase-indole complex: insights into the mechanism of chloroperoxidase-catalyzed regioselective oxidation of indole. Biochemistry (2013) 0.78
Water oxidation by a cytochrome p450: mechanism and function of the reaction. PLoS One (2013) 0.78
Synthesis and structural characterization of a series of Mn(III)OR complexes, including a water-soluble Mn(III)OH that promotes aerobic hydrogen-atom transfer. Inorg Chem (2013) 0.78
Low temperature photo-oxidation of chloroperoxidase Compound II. J Inorg Biochem (2010) 0.76
Electrochemistry of mammalian cytochrome P450 2B4 indicates tunable thermodynamic parameters in surfactant films. J Inorg Biochem (2013) 0.76
Proton-Coupled Electron Transfer in Organic Synthesis: Fundamentals, Applications, and Opportunities. Top Curr Chem (J) (2016) 0.75
Ab initio dynamics of the cytochrome P450 hydroxylation reaction. J Chem Phys (2015) 0.75
Reactivity of an Fe(IV)-Oxo Complex with Protons and Oxidants. J Am Chem Soc (2016) 0.75
Applications of density functional theory to iron-containing molecules of bioinorganic interest. Front Chem (2014) 0.75
Water-soluble Fe(II)-H2O complex with a weak O-H bond transfers a hydrogen atom via an observable monomeric Fe(III)-OH. J Am Chem Soc (2015) 0.75
Beyond ferryl-mediated hydroxylation: 40 years of the rebound mechanism and C-H activation. J Biol Inorg Chem (2016) 0.75
New function of aldoxime dehydratase: Redox catalysis and the formation of an expected product. PLoS One (2017) 0.75
Hole Hopping through Tryptophan in Cytochrome P450. Biochemistry (2017) 0.75
Spectroscopic studies of the cytochrome P450 reaction mechanisms. Biochim Biophys Acta (2017) 0.75
Tryptophan-accelerated electron flow through proteins. Science (2008) 3.29
Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex. Science (2008) 1.79
Alpha-synuclein structures from fluorescence energy-transfer kinetics: implications for the role of the protein in Parkinson's disease. Proc Natl Acad Sci U S A (2004) 1.60
The protein-folding speed limit: intrachain diffusion times set by electron-transfer rates in denatured Ru(NH3)5(His-33)-Zn-cytochrome c. Proc Natl Acad Sci U S A (2003) 1.43
Tumor detection and elimination by a targeted gallium corrole. Proc Natl Acad Sci U S A (2009) 1.34
Hydrogen evolution catalyzed by cobaloximes. Acc Chem Res (2009) 1.33
Characterization of the periplasmic heme-binding protein shut from the heme uptake system of Shigella dysenteriae. Biochemistry (2005) 1.31
Mapping the cytochrome C folding landscape. J Am Chem Soc (2002) 1.31
Reaction of ferric cytochrome P450cam with peracids: kinetic characterization of intermediates on the reaction pathway. J Biol Chem (2005) 1.30
Stability and folding kinetics of structurally characterized cytochrome c-b562. Biochemistry (2006) 1.29
Electron tunneling through organic molecules in frozen glasses. Science (2005) 1.27
Specific delivery of corroles to cells via noncovalent conjugates with viral proteins. Pharm Res (2006) 1.26
Many faces of the unfolded state: conformational heterogeneity in denatured yeast cytochrome C. J Mol Biol (2005) 1.26
Electron transfer and electronic conduction through an intervening medium. Angew Chem Int Ed Engl (2008) 1.23
Neutral thiol as a proximal ligand to ferrous heme iron: implications for heme proteins that lose cysteine thiolate ligation on reduction. Proc Natl Acad Sci U S A (2003) 1.20
Electrostatic effects on funneled landscapes and structural diversity in denatured protein ensembles. Proc Natl Acad Sci U S A (2009) 1.19
Tertiary contact formation in alpha-synuclein probed by electron transfer. J Am Chem Soc (2005) 1.19
Alpha-synuclein: stable compact and extended monomeric structures and pH dependence of dimer formation. J Am Soc Mass Spectrom (2004) 1.17
Type-zero copper proteins. Nat Chem (2009) 1.17
Electron hopping through proteins. Coord Chem Rev (2012) 1.16
Proton-coupled electron flow in protein redox machines. Chem Rev (2010) 1.16
Long-range electron tunneling. J Am Chem Soc (2014) 1.16
Substrate modulation of the properties and reactivity of the oxy-ferrous and hydroperoxo-ferric intermediates of cytochrome P450cam as shown by cryoreduction-EPR/ENDOR spectroscopy. J Am Chem Soc (2005) 1.15
Epoxidation of olefins by hydroperoxo-ferric cytochrome P450. J Am Chem Soc (2003) 1.14
EPR and ENDOR characterization of intermediates in the cryoreduced oxy-nitric oxide synthase heme domain with bound L-arginine or N(G)-hydroxyarginine. Biochemistry (2002) 1.14
Snapshots of cytochrome c folding. Proc Natl Acad Sci U S A (2005) 1.13
Multimodal wide-field two-photon excitation imaging: characterization of the technique for in vivo applications. Biomed Opt Express (2011) 1.13
Preface on making oxygen. Inorg Chem (2008) 1.13
Structural model for an alkaline form of ferricytochrome C. J Am Chem Soc (2003) 1.11
High-potential C112D/M121X (X = M, E, H, L) Pseudomonas aeruginosa azurins. Inorg Chem (2009) 1.11
Alpha-synuclein tertiary contact dynamics. J Phys Chem B (2007) 1.09
Rapid freeze-quench ENDOR study of chloroperoxidase compound I: the site of the radical. J Am Chem Soc (2006) 1.08
Copper(II) binding to alpha-synuclein, the Parkinson's protein. J Am Chem Soc (2008) 1.05
Photooxidation of cytochrome P450-BM3. Proc Natl Acad Sci U S A (2010) 1.05
EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme. Biochemistry (2004) 1.04
Highly active mixed-metal nanosheet water oxidation catalysts made by pulsed-laser ablation in liquids. J Am Chem Soc (2014) 1.04
Conformational states of cytochrome P450cam revealed by trapping of synthetic molecular wires. J Mol Biol (2004) 1.04
Mechanism of H(2) evolution from a photogenerated hydridocobaloxime. J Am Chem Soc (2010) 1.03
Structural features of cytochrome c' folding intermediates revealed by fluorescence energy-transfer kinetics. Proc Natl Acad Sci U S A (2002) 1.02
Redox properties of tyrosine and related molecules. FEBS Lett (2011) 1.00
Mimicking protein-protein electron transfer: voltammetry of Pseudomonas aeruginosa azurin and the Thermus thermophilus Cu(A) domain at omega-derivatized self-assembled-monolayer gold electrodes. J Am Chem Soc (2004) 0.99
Nature of the cytochrome c molten globule. J Am Chem Soc (2005) 0.99
Electron transfer reactivity of type zero Pseudomonas aeruginosa azurin. J Am Chem Soc (2011) 0.99
Spectroscopic investigations of intermediates in the reaction of cytochrome P450(BM3)-F87G with surrogate oxygen atom donors. J Inorg Biochem (2006) 0.98
Kinetics of electron transfer reactions of H2-evolving cobalt diglyoxime catalysts. J Am Chem Soc (2010) 0.98
The cytochrome c folding landscape revealed by electron-transfer kinetics. J Mol Biol (2002) 0.97
Electron flow through metalloproteins. Chem Rev (2013) 0.97
Nanosecond photoreduction of cytochrome p450cam by channel-specific Ru-diimine electron tunneling wires. J Am Chem Soc (2003) 0.97
Characterization of heme ligation properties of Rv0203, a secreted heme binding protein involved in Mycobacterium tuberculosis heme uptake. Biochemistry (2012) 0.96
Structural features of the cytochrome C molten globule revealed by fluorescence energy transfer kinetics. J Am Chem Soc (2002) 0.96
Differential cytostatic and cytotoxic action of Metallocorroles against human cancer cells: potential platforms for anticancer drug development. Chem Res Toxicol (2012) 0.96
An outer-sphere hydrogen-bond network constrains copper coordination in blue proteins. J Inorg Biochem (2002) 0.96
A mechanistic study of tumor-targeted corrole toxicity. Mol Pharm (2011) 0.96
Hydroperoxoferric heme intermediate as a second electrophilic oxidant in cytochrome P450-catalyzed reactions. J Biol Inorg Chem (2004) 0.95
Probing folded and unfolded states of outer membrane protein a with steady-state and time-resolved tryptophan fluorescence. J Phys Chem B (2006) 0.95
Excited-state dynamics of structurally characterized [ReI(CO)3(phen)(HisX)]+ (X = 83, 109) Pseudomonas aeruginosa azurins in aqueous solution. J Am Chem Soc (2006) 0.95
Bacterial spore detection by [Tb3+(macrocycle)(dipicolinate)] luminescence. J Am Chem Soc (2007) 0.95
Spectroscopy and reactivity of a photogenerated tryptophan radical in a structurally defined protein environment. J Am Chem Soc (2003) 0.95
Amphiphilic corroles bind tightly to human serum albumin. Bioconjug Chem (2004) 0.95
Picosecond photoreduction of inducible nitric oxide synthase by rhenium(I)-diimine wires. J Am Chem Soc (2005) 0.94
Protein-surfactant film voltammetry of wild-type and mutant cytochrome P450 BM3. Inorg Chem (2005) 0.94
Direct observation of a novel perturbed oxyferrous catalytic intermediate during reduced putidaredoxin-initiated turnover of cytochrome P-450-CAM: probing the effector role of putidaredoxin in catalysis. J Biol Chem (2005) 0.93
Spermine binding to Parkinson's protein alpha-synuclein and its disease-related A30P and A53T mutants. J Phys Chem B (2008) 0.93
Replacement of tyrosine residues by phenylalanine in cytochrome P450cam alters the formation of Cpd II-like species in reactions with artificial oxidants. J Biol Inorg Chem (2008) 0.93
Site-specific collapse dynamics guide the formation of the cytochrome c' four-helix bundle. Proc Natl Acad Sci U S A (2006) 0.93
Noninnocence in metal complexes: a dithiolene dawn. Inorg Chem (2011) 0.93
A multimode optical imaging system for preclinical applications in vivo: technology development, multiscale imaging, and chemotherapy assessment. Mol Imaging Biol (2012) 0.93
Alpha-synuclein structures probed by 5-fluorotryptophan fluorescence and 19F NMR spectroscopy. J Phys Chem B (2006) 0.92
Luminescent ruthenium(II)- and rhenium(I)-diimine wires bind nitric oxide synthase. J Am Chem Soc (2005) 0.92
Fluorescent probes for cytochrome p450 structural characterization and inhibitor screening. J Am Chem Soc (2002) 0.92
Phototriggering electron flow through Re(I)-modified Pseudomonas aeruginosa azurins. Chemistry (2011) 0.92
Probing the oxyferrous and catalytically active ferryl states of Amphitrite ornata dehaloperoxidase by cryoreduction and EPR/ENDOR spectroscopy. Detection of compound I. J Am Chem Soc (2010) 0.92
Characterization of SiaA, a streptococcal heme-binding protein associated with a heme ABC transport system. Biochemistry (2008) 0.92
Inner- and outer-sphere metal coordination in blue copper proteins. J Inorg Biochem (2012) 0.91
Near-IR phosphorescence of iridium(III) corroles at ambient temperature. J Am Chem Soc (2010) 0.91
Molecular basis for the inability of an oxygen atom donor ligand to replace the natural sulfur donor heme axial ligand in cytochrome P450 catalysis. Spectroscopic characterization of the Cys436Ser CYP2B4 mutant. Arch Biochem Biophys (2010) 0.91
Rapid kinetics investigations of peracid oxidation of ferric cytochrome P450cam: nature and possible function of compound ES. J Inorg Biochem (2006) 0.91
15N-1H Residual dipolar coupling analysis of native and alkaline-K79A Saccharomyces cerevisiae cytochrome c. Biophys J (2003) 0.90
Electron tunneling in rhenium-modified Pseudomonas aeruginosa azurins. Biochim Biophys Acta (2004) 0.90
Structures of thiolate- and carboxylate-ligated ferric H93G myoglobin: models for cytochrome P450 and for oxyanion-bound heme proteins. Biochemistry (2006) 0.90
Cryoreduction EPR and 13C, 19F ENDOR study of substrate-bound substates and solvent kinetic isotope effects in the catalytic cycle of cytochrome P450cam and its T252A mutant. Dalton Trans (2005) 0.90
EPR and ENDOR studies of cryoreduced compounds II of peroxidases and myoglobin. Proton-coupled electron transfer and protonation status of ferryl hemes. Biochemistry (2008) 0.90
Replacement of the axial histidine heme ligand with cysteine in nitrophorin 1: spectroscopic and crystallographic characterization. J Biol Inorg Chem (2008) 0.89
Using deeply trapped intermediates to map the cytochrome c folding landscape. Proc Natl Acad Sci U S A (2002) 0.89
The influence of substrate on the spectral properties of oxyferrous wild-type and T252A cytochrome P450-CAM. Arch Biochem Biophys (2005) 0.89
Cloning, heterologous expression, and characterization of recombinant class II cytochromes c from Rhodopseudomonas palustris. Biochim Biophys Acta (2003) 0.89
Gold electrodes wired for coupling with the deeply buried active site of Arthrobacter globiformis amine oxidase. J Am Chem Soc (2003) 0.89
Electron flow through nitrotyrosinate in Pseudomonas aeruginosa azurin. J Am Chem Soc (2013) 0.89
Electron Tunneling through Pseudomonas aeruginosa Azurins on SAM Gold Electrodes. Inorganica Chim Acta (2008) 0.89
Geometrical Analysis of Cytochrome c Unfolding. Mol Phys (2011) 0.89
Early events in the folding of four-helix-bundle heme proteins. Proc Natl Acad Sci U S A (2005) 0.88
Reduction of dioxygen catalyzed by pyrene-wired heme domain cytochrome P450 BM3 electrodes. J Am Chem Soc (2004) 0.88
Heme binding to the Mammalian circadian clock protein period 2 is nonspecific. Biochemistry (2010) 0.88
Cobaltocene-mediated catalytic monooxygenation using holo and heme domain cytochrome P450 BM3. J Inorg Biochem (2004) 0.88
Folding energy landscape of cytochrome cb562. Proc Natl Acad Sci U S A (2009) 0.87
Ratiometric spectral imaging for fast tumor detection and chemotherapy monitoring in vivo. J Biomed Opt (2011) 0.87
A Euclidean Perspective on the Unfolding of Azurin: Spatial Correlations. Mol Phys (2013) 0.87
Iridium corroles. J Am Chem Soc (2008) 0.87
Molecular mechanisms of cobalt-catalyzed hydrogen evolution. Proc Natl Acad Sci U S A (2012) 0.87