Published in J Biol Chem on April 30, 2013
Significantly shorter Fe-S bond in cytochrome P450-I is consistent with greater reactivity relative to chloroperoxidase. Nat Chem (2015) 1.44
Unusual cytochrome p450 enzymes and reactions. J Biol Chem (2013) 1.24
Expanding P450 catalytic reaction space through evolution and engineering. Curr Opin Chem Biol (2014) 1.00
Mechanism of the third oxidative step in the conversion of androgens to estrogens by cytochrome P450 19A1 steroid aromatase. J Am Chem Soc (2014) 0.90
Structure and biochemical properties of the alkene producing cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 bacterium. J Biol Chem (2014) 0.89
The diverse chemistry of cytochrome P450 17A1 (P450c17, CYP17A1). J Steroid Biochem Mol Biol (2014) 0.87
Enzymatic oxidative biodegradation of nanoparticles: Mechanisms, significance and applications. Toxicol Appl Pharmacol (2016) 0.86
Divergent mechanisms of iron-containing enzymes for hydrocarbon biosynthesis. J Biol Inorg Chem (2016) 0.86
Heme-thiolate ferryl of aromatic peroxygenase is basic and reactive. Proc Natl Acad Sci U S A (2015) 0.83
Regio- and stereoselective hydroxylation of 10-undecenoic acid with a light-driven P450 BM3 biocatalyst yielding a valuable synthon for natural product synthesis. Bioorg Med Chem (2014) 0.82
Methane-Oxidizing Enzymes: An Upstream Problem in Biological Gas-to-Liquids Conversion. J Am Chem Soc (2016) 0.82
Mechanisms of superoxide signaling in epigenetic processes: relation to aging and cancer. Aging Dis (2015) 0.82
A multiscale approach to modelling drug metabolism by membrane-bound cytochrome P450 enzymes. PLoS Comput Biol (2014) 0.80
Insights into an efficient light-driven hybrid P450 BM3 enzyme from crystallographic, spectroscopic and biochemical studies. Biochim Biophys Acta (2016) 0.80
Regio- and stereospecific hydroxylation of various steroids at the 16α position of the D ring by the Streptomyces griseus cytochrome P450 CYP154C3. Appl Environ Microbiol (2013) 0.79
Mechanism of 17α,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1: 18O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN. J Biol Chem (2016) 0.78
Spin equilibrium and O₂-binding kinetics of Mycobacterium tuberculosis CYP51 with mutations in the histidine-threonine dyad. J Inorg Biochem (2014) 0.76
Synthesis and reactivity of a mononuclear non-haem cobalt(IV)-oxo complex. Nat Commun (2017) 0.75
New trends in cytochrome p450 research at the half-century mark. J Biol Chem (2013) 0.75
Reactivity of an Fe(IV)-Oxo Complex with Protons and Oxidants. J Am Chem Soc (2016) 0.75
Transition metal-free intramolecular regioselective couplings of aliphatic and aromatic C-H bonds. Sci Rep (2016) 0.75
Metal-Assisted Oxo Atom Addition to an Fe(III) Thiolate. J Am Chem Soc (2016) 0.75
Reaction Intermediates and Molecular Mechanism of Peroxynitrite Activation by NO Synthases. Biophys J (2016) 0.75
Spectroscopic studies of the cytochrome P450 reaction mechanisms. Biochim Biophys Acta (2017) 0.75
Hole Hopping through Tryptophan in Cytochrome P450. Biochemistry (2017) 0.75
Structure and chemistry of cytochrome P450. Chem Rev (2005) 5.85
The catalytic pathway of cytochrome p450cam at atomic resolution. Science (2000) 5.42
Cytochrome P450 compound I: capture, characterization, and C-H bond activation kinetics. Science (2010) 3.61
Proton-coupled electron transfer: a reaction chemist's view. Annu Rev Phys Chem (2004) 3.01
Oxoiron(IV) in chloroperoxidase compound II is basic: implications for P450 chemistry. Science (2004) 2.38
Hydrocarbon hydroxylation by cytochrome P450 enzymes. Chem Rev (2010) 2.34
Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site. J Biol Chem (2003) 2.09
Aliphatic hydroxylation by highly purified liver microsomal cytochrome P-450. Evidence for a carbon radical intermediate. Biochem Biophys Res Commun (1978) 1.68
Interaction of peroxidases with aromatic peracids and alkyl peroxides. Product analysis. J Biol Chem (1972) 1.68
Application of Badger's rule to heme and non-heme iron-oxygen bonds: an examination of ferryl protonation states. J Am Chem Soc (2006) 1.61
Kinetic characterization of compound I formation in the thermostable cytochrome P450 CYP119. J Biol Chem (2002) 1.54
Evidence for compound I formation in the reaction of cytochrome P450cam with m-chloroperbenzoic acid. Biochem Biophys Res Commun (1994) 1.52
C-H bond activation in heme proteins: the role of thiolate ligation in cytochrome P450. Curr Opin Chem Biol (2009) 1.48
Cytochrome p450 compound I. J Am Chem Soc (2006) 1.37
On the status of ferryl protonation. J Inorg Biochem (2006) 1.30
Reaction of ferric cytochrome P450cam with peracids: kinetic characterization of intermediates on the reaction pathway. J Biol Chem (2005) 1.30
Microsecond freeze-hyperquenching: development of a new ultrafast micro-mixing and sampling technology and application to enzyme catalysis. Biochim Biophys Acta (2004) 1.23
Substrate recognition and molecular mechanism of fatty acid hydroxylation by cytochrome P450 from Bacillus subtilis. Crystallographic, spectroscopic, and mutational studies. J Biol Chem (2003) 1.22
Mössbauer spectroscopic evidence for the electronic configuration of iron in horseradish peroxidase and its peroxide derivatives. Biochemistry (1969) 1.21
Resonance Raman spectroscopy of chloroperoxidase compound II provides direct evidence for the existence of an iron(IV)-hydroxide. Proc Natl Acad Sci U S A (2006) 1.21
Substrate modulation of the properties and reactivity of the oxy-ferrous and hydroperoxo-ferric intermediates of cytochrome P450cam as shown by cryoreduction-EPR/ENDOR spectroscopy. J Am Chem Soc (2005) 1.15
Evidence for basic ferryls in cytochromes P450. J Am Chem Soc (2006) 1.14
Cryotrapped reaction intermediates of cytochrome p450 studied by radiolytic reduction with phosphorus-32. J Biol Chem (2001) 1.14
Evidence for two ferryl species in chloroperoxidase compound II. J Am Chem Soc (2006) 1.11
Spectrum of chloroperoxidase compound I. Biochem Biophys Res Commun (1980) 1.10
Characterization of the microsomal cytochrome P450 2B4 O2 activation intermediates by cryoreduction and electron paramagnetic resonance. Biochemistry (2008) 1.09
Cytochrome P450: the active oxidant and its spectrum. Inorg Chem (2010) 1.09
Characterization of a cytochrome P450 from the acidothermophilic archaea Sulfolobus solfataricus. Biochem Biophys Res Commun (1998) 1.09
Spectra and kinetic studies of the compound I derivative of cytochrome P450 119. J Am Chem Soc (2008) 1.09
Photooxidation of cytochrome P450-BM3. Proc Natl Acad Sci U S A (2010) 1.05
Nitration and inactivation of cytochrome P450BM-3 by peroxynitrite. Stopped-flow measurements prove ferryl intermediates. Eur J Biochem (2000) 1.03
Quantitative production of compound I from a cytochrome P450 enzyme at low temperatures. Kinetics, activation parameters, and kinetic isotope effects for oxidation of benzyl alcohol. J Am Chem Soc (2009) 0.98
Reaction of cytochrome P450BM3 and peroxynitrite yields nitrosyl complex. J Am Chem Soc (2007) 0.95
Kinetics of oxidation of benzphetamine by compounds I of cytochrome P450 2B4 and its mutants. J Am Chem Soc (2009) 0.94
Crystal structure of H2O2-dependent cytochrome P450SPalpha with its bound fatty acid substrate: insight into the regioselective hydroxylation of fatty acids at the alpha position. J Biol Chem (2011) 0.93
Characterization of the peroxidase activity of CYP119, a thermostable P450 from Sulfolobus acidocaldarius. Chembiochem (2008) 0.93
Cloning of a potential cytochrome P450 from the archaeon Sulfolobus solfataricus. FEBS Lett (1996) 0.90
The mystery of cytochrome P450 Compound I: a mini-review dedicated to Klaus Ruckpaul. Biochim Biophys Acta (2010) 0.90
Kinetic isotope effects in hydroxylation reactions effected by cytochrome P450 compounds I implicate multiple electrophilic oxidants for P450-catalyzed oxidations. Biochemistry (2009) 0.87
Uncoupling oxygen transfer and electron transfer in the oxygenation of camphor analogues by cytochrome P450-CAM. Direct observation of an intermolecular isotope effect for substrate C-H activation. J Biol Chem (1995) 0.86
Kinetics and activation parameters for oxidations of styrene by Compounds I from the cytochrome P450(BM-3) (CYP102A1) heme domain and from CYP119. Biochemistry (2009) 0.85
Oxidation of 10-undecenoic acid by cytochrome P450(BM-3) and its Compound I transient. Org Biomol Chem (2011) 0.84
Kinetics of the oxidation of ascorbic acid, ferrocyanide and p-phenolsulfonic acid by chloroperoxidase compounds I and II. Eur J Biochem (1987) 0.83
Structure, electronic properties and catalytic behaviour of an activity-enhancing CYP102A1 (P450(BM3)) variant. Dalton Trans (2011) 0.82
Structure and direct electrochemistry of cytochrome P450 from the thermoacidophilic crenarchaeon, Sulfolobus tokodaii strain 7. J Inorg Biochem (2004) 0.81
Cytochrome P450 119 Compounds I Formed by Chemical Oxidation and Photooxidation Are the Same Species. Chemistry (2012) 0.79
Novel reactivity of cytochrome P-450-CAM. Methyl hydroxylation of 5,5-difluorocamphor. J Biol Chem (1984) 0.78
Cytochrome P450 compound I: capture, characterization, and C-H bond activation kinetics. Science (2010) 3.61
Substrate-triggered formation and remarkable stability of the C-H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2. Biochemistry (2009) 1.69
Iron(IV)hydroxide pK(a) and the role of thiolate ligation in C-H bond activation by cytochrome P450. Science (2013) 1.46
Rapid freeze-quench 57Fe Mössbauer spectroscopy: monitoring changes of an iron-containing active site during a biochemical reaction. Inorg Chem (2005) 1.45
On the feasibility of N2 fixation via a single-site FeI/FeIV cycle: Spectroscopic studies of FeI(N2)FeI, FeIV[triple bond]N, and related species. Proc Natl Acad Sci U S A (2006) 1.40
Catalytic conversion of nitrogen to ammonia by an iron model complex. Nature (2013) 1.38
On the status of ferryl protonation. J Inorg Biochem (2006) 1.30
Preparation and properties of a monomeric Mn(IV)-oxo complex. J Am Chem Soc (2006) 1.29
Resonance Raman spectroscopy of chloroperoxidase compound II provides direct evidence for the existence of an iron(IV)-hydroxide. Proc Natl Acad Sci U S A (2006) 1.21
X-ray absorption spectroscopy of chloroperoxidase compound I: Insight into the reactive intermediate of P450 chemistry. Proc Natl Acad Sci U S A (2005) 1.17
Structural analysis of the Mn(IV)/Fe(III) cofactor of Chlamydia trachomatis ribonucleotide reductase by extended X-ray absorption fine structure spectroscopy and density functional theory calculations. J Am Chem Soc (2008) 1.16
Evidence for basic ferryls in cytochromes P450. J Am Chem Soc (2006) 1.14
The manganese(IV)/iron(III) cofactor of Chlamydia trachomatis ribonucleotide reductase: structure, assembly, radical initiation, and evolution. Curr Opin Struct Biol (2008) 1.11
Evidence for two ferryl species in chloroperoxidase compound II. J Am Chem Soc (2006) 1.11
Cytochrome P450: the active oxidant and its spectrum. Inorg Chem (2010) 1.09
Rational tuning of the thiolate donor in model complexes of superoxide reductase: direct evidence for a trans influence in Fe(III)-OOR complexes. J Am Chem Soc (2008) 0.99
Cryoreduction of the NO-adduct of taurine:alpha-ketoglutarate dioxygenase (TauD) yields an elusive {FeNO}(8) species. J Am Chem Soc (2010) 0.96
Heterometallic triiron-oxo/hydroxo clusters: effect of redox-inactive metals. J Am Chem Soc (2013) 0.95
Reaction of cytochrome P450BM3 and peroxynitrite yields nitrosyl complex. J Am Chem Soc (2007) 0.95
O(2)-evolving chlorite dismutase as a tool for studying O(2)-utilizing enzymes. Biochemistry (2012) 0.95
Function of the diiron cluster of Escherichia coli class Ia ribonucleotide reductase in proton-coupled electron transfer. J Am Chem Soc (2013) 0.94
A substrate radical intermediate in catalysis by the antibiotic resistance protein Cfr. Nat Chem Biol (2013) 0.93
Electron tunneling in rhenium-modified Pseudomonas aeruginosa azurins. Biochim Biophys Acta (2004) 0.90
Oxygen-atom transfer reactivity of axially ligated Mn(V)-oxo complexes: evidence for enhanced electrophilic and nucleophilic pathways. J Am Chem Soc (2014) 0.89
Setting an upper limit on the myoglobin iron(IV)hydroxide pK(a): insight into axial ligand tuning in heme protein catalysis. J Am Chem Soc (2014) 0.88
A 2.8 Å Fe-Fe separation in the Fe2(III/IV) intermediate, X, from Escherichia coli ribonucleotide reductase. J Am Chem Soc (2013) 0.87
Two-coordinate Fe⁰ and Co⁰ complexes supported by cyclic (alkyl)(amino)carbenes. Angew Chem Int Ed Engl (2014) 0.87
Sensitizer-linked substrates and ligands: ruthenium probes of cytochrome P450 structure and mechanism. Methods Enzymol (2002) 0.85
Characterization of a cross-linked protein-nucleic acid substrate radical in the reaction catalyzed by RlmN. J Am Chem Soc (2014) 0.83
X-ray absorption spectroscopy and reactivity of thiolate-ligated Fe(III)-OOR complexes. Inorg Chem (2010) 0.82
Do hydroxyl radical-water clusters, OH(H2O)n, n = 1-5, exist in the atmosphere? J Phys Chem A (2006) 0.75