Published in Curr Opin Neurobiol on June 01, 2004
Organelles and trafficking machinery for postsynaptic plasticity. Annu Rev Neurosci (2006) 2.82
The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting. Mol Cancer Res (2008) 2.21
A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression. Arch Gen Psychiatry (2009) 2.15
EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1. Nat Cell Biol (2005) 2.02
The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development. Proc Natl Acad Sci U S A (2007) 1.88
Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors. J Biol Chem (2008) 1.80
Control of synapse development and plasticity by Rho GTPase regulatory proteins. Prog Neurobiol (2011) 1.77
Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor. J Biol Chem (2007) 1.44
Eph receptor signaling and ephrins. Cold Spring Harb Perspect Biol (2013) 1.33
The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways. J Cell Biol (2007) 1.32
Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor. J Biol Chem (2008) 1.30
Bidirectional ephrin/Eph signaling in synaptic functions. Brain Res (2006) 1.22
Eph receptors and ephrin signaling pathways: a role in bone homeostasis. Int J Med Sci (2008) 1.17
Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis. Thromb Haemost (2007) 1.10
Synaptic plasticity, a symphony in GEF. ACS Chem Neurosci (2010) 1.06
Endocytosis of EphA receptors is essential for the proper development of the retinocollicular topographic map. EMBO J (2011) 1.03
Distribution of EphB receptors and ephrin-B1 in the developing vertebrate spinal cord. J Comp Neurol (2006) 0.99
Eph/ephrin interactions modulate muscle satellite cell motility and patterning. Development (2011) 0.95
Proteomic and bioinformatic analysis of epithelial tight junction reveals an unexpected cluster of synaptic molecules. Biol Direct (2006) 0.94
Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer's disease. Neurobiol Aging (2014) 0.91
EphrinB2 induces tyrosine phosphorylation of NR2B via Src-family kinases during inflammatory hyperalgesia. Neuroscience (2008) 0.91
Role of Eph/ephrin tyrosine kinase in malignant glioma. Neuro Oncol (2011) 0.90
Dopaminergic axon guidance: which makes what? Front Cell Neurosci (2012) 0.88
Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain. Mol Pain (2010) 0.85
EphA2 is a functional receptor for the growth factor progranulin. J Cell Biol (2016) 0.84
Protein Kinase Activity Decreases with Higher Braak Stages of Alzheimer's Disease Pathology. J Alzheimers Dis (2015) 0.83
Eph receptors are involved in the activity-dependent synaptic wiring in the mouse cerebellar cortex. PLoS One (2011) 0.82
EphB receptors co-distribute with a nicotinic receptor subtype and regulate nicotinic downstream signaling in neurons. Mol Cell Neurosci (2008) 0.82
Looking forward to EphB signaling in synapses. Semin Cell Dev Biol (2011) 0.82
Repetitive grooming and sensorimotor abnormalities in an ephrin-A knockout model for Autism Spectrum Disorders. Behav Brain Res (2014) 0.82
PI3K contributed to modulation of spinal nociceptive information related to ephrinBs/EphBs. PLoS One (2012) 0.82
Complementary expression and repulsive signaling suggest that EphB receptors and ephrin-B ligands control cell positioning in the gastric epithelium. Histochem Cell Biol (2011) 0.80
The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function. BMC Immunol (2011) 0.79
Expression of Eph receptor A10 is correlated with lymph node metastasis and stage progression in breast cancer patients. Cancer Med (2013) 0.79
Steady-state increase of cAMP-response element binding protein, Rac, and PAK signaling in presenilin-deficient neurons. J Neurochem (2007) 0.79
Altered distribution of the EphA4 kinase in hippocampal brain tissue of patients with Alzheimer's disease correlates with pathology. Acta Neuropathol Commun (2014) 0.78
Modeling presenilin-dependent familial Alzheimer's disease: emphasis on presenilin substrate-mediated signaling and synaptic function. Int J Alzheimers Dis (2010) 0.78
Effect of task-specific training on Eph/ephrin expression after stroke. BMB Rep (2016) 0.77
Amygdala EphB2 Signaling Regulates Glutamatergic Neuron Maturation and Innate Fear. J Neurosci (2016) 0.76
Ephs and Ephrins in malignant gliomas. Growth Factors (2014) 0.76
A Modified Adenovirus Vector-Mediated Antibody Screening Method Identifies EphA2 as a Cancer Target. Transl Oncol (2017) 0.76
Multipotent adult hippocampal progenitor cells maintained as neurospheres favor differentiation toward glial lineages. Biotechnol J (2014) 0.75
The magic of synaptogenesis. Meeting on spinogenesis and synaptic plasticity. EMBO Rep (2004) 0.75
Receptor tyrosine kinase EphA7 is required for interneuron connectivity at specific subcellular compartments of granule cells. Sci Rep (2016) 0.75
Role of amyloid β protein receptors in mediating synaptic plasticity. Biomed Rep (2017) 0.75
Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nat Neurosci (2003) 3.34
The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. Nat Cell Biol (2006) 2.87
Molecular mechanisms of dendritic spine development and remodeling. Prog Neurobiol (2005) 2.54
'Eph'ective signaling: forward, reverse and crosstalk. J Cell Sci (2003) 2.17
Tsc2-Rheb signaling regulates EphA-mediated axon guidance. Nat Neurosci (2010) 2.17
EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1. Nat Cell Biol (2005) 2.02
Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth. Proc Natl Acad Sci U S A (2004) 2.01
Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity. Structure (2006) 1.97
Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors. J Biol Chem (2008) 1.80
An ephrin mimetic peptide that selectively targets the EphA2 receptor. J Biol Chem (2002) 1.74
Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport. Nat Neurosci (2009) 1.70
Paradoxes of the EphB4 receptor in cancer. Cancer Res (2007) 1.58
Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. J Biol Chem (2004) 1.52
Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins. Cell Signal (2004) 1.51
The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas. Cancer Cell (2012) 1.50
Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport. Proc Natl Acad Sci U S A (2009) 1.49
The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord. J Neurosci (2009) 1.48
EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity. J Biol Chem (2005) 1.46
Eph-ephrin promiscuity is now crystal clear. Nat Neurosci (2004) 1.44
Eph/ephrins and N-cadherin coordinate to control the pattern of sympathetic ganglia. Development (2006) 1.38
Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus. J Comp Neurol (2007) 1.34
Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain. J Neurochem (2008) 1.34
Pericyte deficiencies lead to aberrant tumor vascularizaton in the brain of the NG2 null mouse. Dev Biol (2010) 1.34
Eph receptor signaling and ephrins. Cold Spring Harb Perspect Biol (2013) 1.33
The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways. J Cell Biol (2007) 1.32
Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor. J Biol Chem (2008) 1.30
Eph receptors, ephrins, and synaptic function. Neuroscientist (2004) 1.29
Targeting the EphA4 receptor in the nervous system with biologically active peptides. Mol Cell Neurosci (2003) 1.24
Eph receptors inactivate R-Ras through different mechanisms to achieve cell repulsion. J Cell Sci (2006) 1.20
Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity. J Biol Chem (2009) 1.19
The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases. J Neurosci (2007) 1.18
The EphB4 receptor-tyrosine kinase promotes the migration of melanoma cells through Rho-mediated actin cytoskeleton reorganization. J Biol Chem (2006) 1.12
Targeting Eph receptors with peptides and small molecules: progress and challenges. Semin Cell Dev Biol (2011) 1.11
Developmental course of EphA4 cellular and subcellular localization in the postnatal rat hippocampus. J Comp Neurol (2009) 1.11
Protein kinase D is a positive regulator of Bit1 apoptotic function. J Biol Chem (2008) 1.11
Ephrin-A5 exerts positive or inhibitory effects on distinct subsets of EphA4-positive motor neurons. J Neurosci (2004) 1.08
Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells. Cell Signal (2010) 1.08
EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain. J Neurochem (2010) 1.07
Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor. Biochem J (2009) 1.06
Eph receptors and ephrins: therapeutic opportunities. Annu Rev Pharmacol Toxicol (2014) 1.04
Profiling Eph receptor expression in cells and tissues: a targeted mass spectrometry approach. Cell Adh Migr (2012) 1.02
A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors. Chem Biol Drug Des (2011) 1.01
Cancer somatic mutations disrupt functions of the EphA3 receptor tyrosine kinase through multiple mechanisms. Biochemistry (2012) 1.01
HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery. Chem Biol (2013) 1.00
Novel targeted system to deliver chemotherapeutic drugs to EphA2-expressing cancer cells. J Med Chem (2012) 1.00
SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases. J Biol Chem (2004) 0.98
Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition. J Biol Chem (2007) 0.98
Structure-activity relationship analysis of peptides targeting the EphA2 receptor. Biochemistry (2010) 0.97
NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nat Struct Mol Biol (2011) 0.97
Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. Nat Commun (2013) 0.96
Targeted delivery of paclitaxel to EphA2-expressing cancer cells. Clin Cancer Res (2012) 0.96
PEGylation potentiates the effectiveness of an antagonistic peptide that targets the EphB4 receptor with nanomolar affinity. PLoS One (2011) 0.96
EphB2 and ephrin-B1 expressed in the adult kidney regulate the cytoarchitecture of medullary tubule cells through Rho family GTPases. J Cell Sci (2006) 0.96
Heparan sulfate regulates ephrin-A3/EphA receptor signaling. Proc Natl Acad Sci U S A (2008) 0.94
Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem J (2012) 0.93
Eph receptors and ephrins in neuron-astrocyte communication at synapses. Glia (2011) 0.92
Association of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistance. J Biol Chem (2014) 0.91
Tonotopic gradients of Eph family proteins in the chick nucleus laminaris during synaptogenesis. J Neurobiol (2004) 0.90
EphA receptors and ephrin-A ligands exhibit highly regulated spatial and temporal expression patterns in the developing olfactory system. Brain Res Dev Brain Res (2002) 0.90
Engineered fibrin matrices for functional display of cell membrane-bound growth factor-like activities: study of angiogenic signaling by ephrin-B2. Biomaterials (2004) 0.88
Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling. Gene (2007) 0.88
Can Eph receptors stimulate the mind? Neuron (2002) 0.87
Proliferation and tumor suppression: not mutually exclusive for Eph receptors. Cancer Cell (2009) 0.86
Activated SRC oncogene phosphorylates R-ras and suppresses integrin activity. J Biol Chem (2001) 0.86
Structure-activity relationships and mechanism of action of Eph-ephrin antagonists: interaction of cholanic acid with the EphA2 receptor. ChemMedChem (2012) 0.86
New exchanges in eph-dependent growth cone dynamics. Neuron (2005) 0.85
Expression of EphB receptors and EphrinB ligands in the developing chick auditory brainstem. J Comp Neurol (2002) 0.85
The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas. Cell Signal (2010) 0.85
Design, synthesis and bioevaluation of an EphA2 receptor-based targeted delivery system. ChemMedChem (2014) 0.85
Molecular determinants for interaction of SHEP1 with Cas localize to a highly solvent-protected region in the complex. FEBS Lett (2005) 0.84
NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer. Genes Cancer (2012) 0.84
Design and Synthesis of Potent Bivalent Peptide Agonists Targeting the EphA2 Receptor. ACS Med Chem Lett (2013) 0.83
Characterization of a novel angiogenic model based on stable, fluorescently labelled endothelial cell lines amenable to scale-up for high content screening. Biol Cell (2011) 0.83
Eph receptors are involved in the activity-dependent synaptic wiring in the mouse cerebellar cortex. PLoS One (2011) 0.82
The EphB4 receptor promotes the growth of melanoma cells expressing the ephrin-B2 ligand. Pigment Cell Melanoma Res (2010) 0.81
The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain. J Neurosci (2010) 0.81
Ephrin-A1/EphA4-mediated adhesion of monocytes to endothelial cells. Biochim Biophys Acta (2013) 0.81
Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor. ACS Chem Biol (2014) 0.81
SHEP1 partners with CasL to promote marginal zone B-cell maturation. Proc Natl Acad Sci U S A (2010) 0.80
EphA4 is not required for Purkinje cell compartmentation. Brain Res Dev Brain Res (2002) 0.80
Inhibition of Eph receptor-ephrin ligand interaction by tea polyphenols. Pharmacol Res (2012) 0.80
Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem (2013) 0.80
Complementary expression and repulsive signaling suggest that EphB receptors and ephrin-B ligands control cell positioning in the gastric epithelium. Histochem Cell Biol (2011) 0.80
EphB signaling inhibits gap junctional intercellular communication and synchronized contraction in cultured cardiomyocytes. Basic Res Cardiol (2011) 0.79
Unique structure and dynamics of the EphA5 ligand binding domain mediate its binding specificity as revealed by X-ray crystallography, NMR and MD simulations. PLoS One (2013) 0.79
The PTB domain of tensin: NMR solution structure and phosphoinositides binding studies. Biopolymers (2008) 0.79
Restraining stem cell niche plasticity: a new talent of Eph receptors. Cell Stem Cell (2010) 0.79
Design, synthesis and characterization of novel small molecular inhibitors of ephrin-B2 binding to EphB4. Biochem Pharmacol (2012) 0.77
A novel Flk1-TVA transgenic mouse model for gene delivery to angiogenic vasculature. Transgenic Res (2007) 0.76
Neuroscience. Axons seek neighborly advice. Science (2008) 0.75