Published in Nat Struct Mol Biol on November 13, 2011
The structure of cell-matrix adhesions: the new frontier. Curr Opin Cell Biol (2011) 0.99
Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. J Am Chem Soc (2014) 0.92
Association of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistance. J Biol Chem (2014) 0.91
Breast cancer antiestrogen resistance 3 (BCAR3) promotes cell motility by regulating actin cytoskeletal and adhesion remodeling in invasive breast cancer cells. PLoS One (2013) 0.89
NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer. Genes Cancer (2012) 0.84
Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease. Oncoscience (2014) 0.82
CAS proteins in health and disease: an update. IUBMB Life (2014) 0.82
Breast cancer anti-estrogen resistance 3 (BCAR3) protein augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas). J Biol Chem (2012) 0.82
Tyrosine Y189 in the substrate domain of the adhesion docking protein NEDD9 is conserved with p130Cas Y253 and regulates NEDD9-mediated migration and focal adhesion dynamics. PLoS One (2013) 0.79
Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity. Angew Chem Int Ed Engl (2015) 0.75
Breast cancer antiestrogen resistance 3-p130(Cas) interactions promote adhesion disassembly and invasion in breast cancer cells. Oncogene (2016) 0.75
The role of focal adhesion anchoring domains of CAS in mechanotransduction. Sci Rep (2017) 0.75
A novel spontaneous mutation of BCAR3 results in extrusion cataracts in CF#1 mouse strain. Mamm Genome (2016) 0.75
LKB1 modulates lung cancer differentiation and metastasis. Nature (2007) 7.80
Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell (2006) 4.68
The structural basis of the activation of Ras by Sos. Nature (1998) 4.50
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell (2003) 3.66
Paxillin comes of age. J Cell Sci (2008) 3.57
Rap1 signalling: adhering to new models. Nat Rev Mol Cell Biol (2001) 3.36
Integrin signalling adaptors: not only figurants in the cancer story. Nat Rev Cancer (2010) 2.94
Structural analysis of autoinhibition in the Ras activator Son of sevenless. Cell (2004) 2.38
BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells. J Natl Cancer Inst (2000) 2.29
Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain. Structure (2003) 2.15
Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state. Nature (2006) 1.88
Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. Nature (2008) 1.66
A Ras-induced conformational switch in the Ras activator Son of sevenless. Proc Natl Acad Sci U S A (2006) 1.57
The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin. J Biol Chem (1999) 1.44
Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N). Oncogene (1997) 1.36
Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling. Cancer Res (2007) 1.33
p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor. J Biol Chem (2000) 1.31
Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. EMBO J (1998) 1.27
A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A. J Biol Chem (1999) 1.26
Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3. J Biol Chem (2003) 1.24
Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation. J Cell Sci (2002) 1.14
AND-34, a novel p130Cas-binding thymic stromal cell protein regulated by adhesion and inflammatory cytokines. J Immunol (1999) 1.11
Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways. J Biol Chem (2000) 1.09
Functional identification of genes causing estrogen independence of human breast cancer cells. Breast Cancer Res Treat (2008) 1.07
NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway. J Biol Chem (1999) 1.07
The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42. J Immunol (2003) 1.06
Structural features of the focal adhesion kinase-paxillin complex give insight into the dynamics of focal adhesion assembly. Protein Sci (2005) 1.06
Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2. Biochem Biophys Res Commun (2009) 0.98
SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases. J Biol Chem (2004) 0.98
BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling. J Biol Chem (2009) 0.96
BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas. Cell Signal (2011) 0.91
Structural insights into the association between BCAR3 and Cas family members, an atypical complex implicated in anti-oestrogen resistance. J Mol Biol (2008) 0.88
Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1. Structure (2009) 0.88
Regulation of T-lymphocyte physiology by the Chat-H/CasL adapter complex. Immunol Rev (2009) 0.86
Characterization of AND-34 function and signaling. Methods Enzymol (2006) 0.85
The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas. Cell Signal (2010) 0.85
The adaptor protein Sh2d3c is critical for marginal zone B cell development and function. J Immunol (2010) 0.82
The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain. J Neurosci (2010) 0.81
SHEP1 partners with CasL to promote marginal zone B-cell maturation. Proc Natl Acad Sci U S A (2010) 0.80
Mechanism of XIAP-mediated inhibition of caspase-9. Mol Cell (2003) 4.07
Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nat Neurosci (2003) 3.34
Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding. Cell (2007) 3.06
The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. Nat Cell Biol (2006) 2.87
The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions. Mol Cell (2005) 2.68
Molecular mechanisms of dendritic spine development and remodeling. Prog Neurobiol (2005) 2.54
XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs. EMBO J (2005) 2.27
The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing. EMBO J (2010) 2.25
Structure and ubiquitin binding of the ubiquitin-interacting motif. J Biol Chem (2003) 2.19
'Eph'ective signaling: forward, reverse and crosstalk. J Cell Sci (2003) 2.17
Whole-exome-sequencing-based discovery of human FADD deficiency. Am J Hum Genet (2010) 2.17
Tsc2-Rheb signaling regulates EphA-mediated axon guidance. Nat Neurosci (2010) 2.17
The Fas-FADD death domain complex structure unravels signalling by receptor clustering. Nature (2008) 2.11
EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1. Nat Cell Biol (2005) 2.02
Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth. Proc Natl Acad Sci U S A (2004) 2.01
The Nod-like receptor (NLR) family: a tale of similarities and differences. PLoS One (2008) 1.99
Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity. Structure (2006) 1.97
AlgK is a TPR-containing protein and the periplasmic component of a novel exopolysaccharide secretin. Structure (2010) 1.97
Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors. J Biol Chem (2008) 1.80
Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein. J Mol Biol (2007) 1.78
Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme. Nat Nanotechnol (2011) 1.77
Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J Am Chem Soc (2009) 1.75
An ephrin mimetic peptide that selectively targets the EphA2 receptor. J Biol Chem (2002) 1.74
Crystal structure of DJ-1/RS and implication on familial Parkinson's disease. FEBS Lett (2003) 1.73
Structure of the mid-region of tropomyosin: bending and binding sites for actin. Proc Natl Acad Sci U S A (2005) 1.72
Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport. Nat Neurosci (2009) 1.70
Rationally tuning the reduction potential of a single cupredoxin beyond the natural range. Nature (2009) 1.68
Caspase mechanisms. Adv Exp Med Biol (2008) 1.64
Rational design of a structural and functional nitric oxide reductase. Nature (2009) 1.60
Paradoxes of the EphB4 receptor in cancer. Cancer Res (2007) 1.58
Structural studies of a bacterial condensin complex reveal ATP-dependent disruption of intersubunit interactions. Cell (2009) 1.58
A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform. Structure (2005) 1.53
Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. J Biol Chem (2004) 1.52
Structural and kinetic determinants of protease substrates. Nat Struct Mol Biol (2009) 1.52
Eph receptors in the adult brain. Curr Opin Neurobiol (2004) 1.51
Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins. Cell Signal (2004) 1.51
The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas. Cancer Cell (2012) 1.50
Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport. Proc Natl Acad Sci U S A (2009) 1.49
A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition. Mol Cell (2004) 1.48
The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord. J Neurosci (2009) 1.48
EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity. J Biol Chem (2005) 1.46
Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis. Cell (2013) 1.44
Eph-ephrin promiscuity is now crystal clear. Nat Neurosci (2004) 1.44
Implications for viral capsid assembly from crystal structures of HIV-1 Gag(1-278) and CA(N)(133-278). Biochemistry (2006) 1.41
Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain. Nat Struct Mol Biol (2006) 1.41
Eph/ephrins and N-cadherin coordinate to control the pattern of sympathetic ganglia. Development (2006) 1.38
The refined crystal structure of an eel pout type III antifreeze protein RD1 at 0.62-A resolution reveals structural microheterogeneity of protein and solvation. Biophys J (2003) 1.36
Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening. Mol Cell (2010) 1.36
Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus. J Comp Neurol (2007) 1.34
Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain. J Neurochem (2008) 1.34
Pericyte deficiencies lead to aberrant tumor vascularizaton in the brain of the NG2 null mouse. Dev Biol (2010) 1.34
Eph receptor signaling and ephrins. Cold Spring Harb Perspect Biol (2013) 1.33
The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways. J Cell Biol (2007) 1.32
Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor. J Biol Chem (2008) 1.30
Roles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobin. Proc Natl Acad Sci U S A (2010) 1.29
Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development. J Biol Chem (2006) 1.29
Eph receptors, ephrins, and synaptic function. Neuroscientist (2004) 1.29
Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7. J Biol Chem (2005) 1.25
Targeting the EphA4 receptor in the nervous system with biologically active peptides. Mol Cell Neurosci (2003) 1.24
Structural insight into substrate specificity of phosphodiesterase 10. Proc Natl Acad Sci U S A (2007) 1.22
Eph receptors inactivate R-Ras through different mechanisms to achieve cell repulsion. J Cell Sci (2006) 1.20
Molecular cell death platforms and assemblies. Curr Opin Cell Biol (2010) 1.20
Vascular endothelial-cadherin tyrosine phosphorylation in angiogenic and quiescent adult tissues. Circ Res (2005) 1.20
Crystal structures of the BlaI repressor from Staphylococcus aureus and its complex with DNA: insights into transcriptional regulation of the bla and mec operons. J Bacteriol (2005) 1.19
Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity. J Biol Chem (2009) 1.19
The CARD plays a critical role in ASC foci formation and inflammasome signalling. Biochem J (2013) 1.18
The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases. J Neurosci (2007) 1.18
Structural models for interactions between the 20S proteasome and its PAN/19S activators. J Biol Chem (2009) 1.17
Crystal structure and RNA binding of the Tex protein from Pseudomonas aeruginosa. J Mol Biol (2008) 1.15
Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding. Proc Natl Acad Sci U S A (2004) 1.14
The EphB4 receptor-tyrosine kinase promotes the migration of melanoma cells through Rho-mediated actin cytoskeleton reorganization. J Biol Chem (2006) 1.12
Structure of the cytoplasmic region of PelD, a degenerate diguanylate cyclase receptor that regulates exopolysaccharide production in Pseudomonas aeruginosa. J Biol Chem (2012) 1.11
Structural basis for alginate secretion across the bacterial outer membrane. Proc Natl Acad Sci U S A (2011) 1.11
Targeting Eph receptors with peptides and small molecules: progress and challenges. Semin Cell Dev Biol (2011) 1.11
Developmental course of EphA4 cellular and subcellular localization in the postnatal rat hippocampus. J Comp Neurol (2009) 1.11
Protein kinase D is a positive regulator of Bit1 apoptotic function. J Biol Chem (2008) 1.11
Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity. Biochemistry (2008) 1.09
Ephrin-A5 exerts positive or inhibitory effects on distinct subsets of EphA4-positive motor neurons. J Neurosci (2004) 1.08
Crystal structure of the pyocyanin biosynthetic protein PhzS. Biochemistry (2008) 1.08
Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells. Cell Signal (2010) 1.08
Crystal structure of the [Mg2+-(chromomycin A3)2]-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by a metal ion. Nucleic Acids Res (2004) 1.08
Crystal structure of Haemophilus influenzae NadR protein. A bifunctional enzyme endowed with NMN adenyltransferase and ribosylnicotinimide kinase activities. J Biol Chem (2002) 1.07
EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain. J Neurochem (2010) 1.07
Identification and structural characterization of the ALIX-binding late domains of simian immunodeficiency virus SIVmac239 and SIVagmTan-1. J Virol (2010) 1.06
Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor. Biochem J (2009) 1.06
The peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics. J Immunol (2012) 1.05
Characterization of two potentially universal turn motifs that shape the repeated five-residues fold--crystal structure of a lumenal pentapeptide repeat protein from Cyanothece 51142. Protein Sci (2006) 1.05
Eph receptors and ephrins: therapeutic opportunities. Annu Rev Pharmacol Toxicol (2014) 1.04
Structural and functional analysis of the pyocyanin biosynthetic protein PhzM from Pseudomonas aeruginosa. Biochemistry (2007) 1.04
Profiling Eph receptor expression in cells and tissues: a targeted mass spectrometry approach. Cell Adh Migr (2012) 1.02
Structural insights into membrane targeting by the flagellar calcium-binding protein (FCaBP), a myristoylated and palmitoylated calcium sensor in Trypanosoma cruzi. J Biol Chem (2008) 1.02
Alternative conformations of the archaeal Nop56/58-fibrillarin complex imply flexibility in box C/D RNPs. J Mol Biol (2007) 1.02
A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors. Chem Biol Drug Des (2011) 1.01
Profound asymmetry in the structure of the cAMP-free cAMP Receptor Protein (CRP) from Mycobacterium tuberculosis. J Biol Chem (2009) 1.01
Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. J Am Chem Soc (2009) 1.01
Cancer somatic mutations disrupt functions of the EphA3 receptor tyrosine kinase through multiple mechanisms. Biochemistry (2012) 1.01
HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery. Chem Biol (2013) 1.00
Crystal structure of human kynurenine aminotransferase II. J Biol Chem (2007) 1.00