Published in Science on April 11, 2008
Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nat Neurosci (2003) 3.34
The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. Nat Cell Biol (2006) 2.87
Molecular mechanisms of dendritic spine development and remodeling. Prog Neurobiol (2005) 2.54
'Eph'ective signaling: forward, reverse and crosstalk. J Cell Sci (2003) 2.17
Tsc2-Rheb signaling regulates EphA-mediated axon guidance. Nat Neurosci (2010) 2.17
EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1. Nat Cell Biol (2005) 2.02
Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth. Proc Natl Acad Sci U S A (2004) 2.01
Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity. Structure (2006) 1.97
Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors. J Biol Chem (2008) 1.80
An ephrin mimetic peptide that selectively targets the EphA2 receptor. J Biol Chem (2002) 1.74
Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport. Nat Neurosci (2009) 1.70
Paradoxes of the EphB4 receptor in cancer. Cancer Res (2007) 1.58
Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. J Biol Chem (2004) 1.52
Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins. Cell Signal (2004) 1.51
Eph receptors in the adult brain. Curr Opin Neurobiol (2004) 1.51
The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas. Cancer Cell (2012) 1.50
Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport. Proc Natl Acad Sci U S A (2009) 1.49
The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord. J Neurosci (2009) 1.48
EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity. J Biol Chem (2005) 1.46
Eph-ephrin promiscuity is now crystal clear. Nat Neurosci (2004) 1.44
Eph/ephrins and N-cadherin coordinate to control the pattern of sympathetic ganglia. Development (2006) 1.38
Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus. J Comp Neurol (2007) 1.34
Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain. J Neurochem (2008) 1.34
Pericyte deficiencies lead to aberrant tumor vascularizaton in the brain of the NG2 null mouse. Dev Biol (2010) 1.34
Eph receptor signaling and ephrins. Cold Spring Harb Perspect Biol (2013) 1.33
The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways. J Cell Biol (2007) 1.32
Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor. J Biol Chem (2008) 1.30
Eph receptors, ephrins, and synaptic function. Neuroscientist (2004) 1.29
Targeting the EphA4 receptor in the nervous system with biologically active peptides. Mol Cell Neurosci (2003) 1.24
Eph receptors inactivate R-Ras through different mechanisms to achieve cell repulsion. J Cell Sci (2006) 1.20
Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity. J Biol Chem (2009) 1.19
The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases. J Neurosci (2007) 1.18
The EphB4 receptor-tyrosine kinase promotes the migration of melanoma cells through Rho-mediated actin cytoskeleton reorganization. J Biol Chem (2006) 1.12
Targeting Eph receptors with peptides and small molecules: progress and challenges. Semin Cell Dev Biol (2011) 1.11
Developmental course of EphA4 cellular and subcellular localization in the postnatal rat hippocampus. J Comp Neurol (2009) 1.11
Protein kinase D is a positive regulator of Bit1 apoptotic function. J Biol Chem (2008) 1.11
Ephrin-A5 exerts positive or inhibitory effects on distinct subsets of EphA4-positive motor neurons. J Neurosci (2004) 1.08
Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells. Cell Signal (2010) 1.08
EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain. J Neurochem (2010) 1.07
Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor. Biochem J (2009) 1.06
Eph receptors and ephrins: therapeutic opportunities. Annu Rev Pharmacol Toxicol (2014) 1.04
Profiling Eph receptor expression in cells and tissues: a targeted mass spectrometry approach. Cell Adh Migr (2012) 1.02
A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors. Chem Biol Drug Des (2011) 1.01
Cancer somatic mutations disrupt functions of the EphA3 receptor tyrosine kinase through multiple mechanisms. Biochemistry (2012) 1.01
HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery. Chem Biol (2013) 1.00
Novel targeted system to deliver chemotherapeutic drugs to EphA2-expressing cancer cells. J Med Chem (2012) 1.00
SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases. J Biol Chem (2004) 0.98
Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition. J Biol Chem (2007) 0.98
Structure-activity relationship analysis of peptides targeting the EphA2 receptor. Biochemistry (2010) 0.97
NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nat Struct Mol Biol (2011) 0.97
Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. Nat Commun (2013) 0.96
PEGylation potentiates the effectiveness of an antagonistic peptide that targets the EphB4 receptor with nanomolar affinity. PLoS One (2011) 0.96
Targeted delivery of paclitaxel to EphA2-expressing cancer cells. Clin Cancer Res (2012) 0.96
EphB2 and ephrin-B1 expressed in the adult kidney regulate the cytoarchitecture of medullary tubule cells through Rho family GTPases. J Cell Sci (2006) 0.96
Heparan sulfate regulates ephrin-A3/EphA receptor signaling. Proc Natl Acad Sci U S A (2008) 0.94
Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem J (2012) 0.93
Eph receptors and ephrins in neuron-astrocyte communication at synapses. Glia (2011) 0.92
Association of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistance. J Biol Chem (2014) 0.91
Tonotopic gradients of Eph family proteins in the chick nucleus laminaris during synaptogenesis. J Neurobiol (2004) 0.90
EphA receptors and ephrin-A ligands exhibit highly regulated spatial and temporal expression patterns in the developing olfactory system. Brain Res Dev Brain Res (2002) 0.90
Engineered fibrin matrices for functional display of cell membrane-bound growth factor-like activities: study of angiogenic signaling by ephrin-B2. Biomaterials (2004) 0.88
Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling. Gene (2007) 0.88
Can Eph receptors stimulate the mind? Neuron (2002) 0.87
Proliferation and tumor suppression: not mutually exclusive for Eph receptors. Cancer Cell (2009) 0.86
Structure-activity relationships and mechanism of action of Eph-ephrin antagonists: interaction of cholanic acid with the EphA2 receptor. ChemMedChem (2012) 0.86
Activated SRC oncogene phosphorylates R-ras and suppresses integrin activity. J Biol Chem (2001) 0.86
Design, synthesis and bioevaluation of an EphA2 receptor-based targeted delivery system. ChemMedChem (2014) 0.85
Expression of EphB receptors and EphrinB ligands in the developing chick auditory brainstem. J Comp Neurol (2002) 0.85
New exchanges in eph-dependent growth cone dynamics. Neuron (2005) 0.85
The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas. Cell Signal (2010) 0.85
Molecular determinants for interaction of SHEP1 with Cas localize to a highly solvent-protected region in the complex. FEBS Lett (2005) 0.84
NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer. Genes Cancer (2012) 0.84
Characterization of a novel angiogenic model based on stable, fluorescently labelled endothelial cell lines amenable to scale-up for high content screening. Biol Cell (2011) 0.83
Design and Synthesis of Potent Bivalent Peptide Agonists Targeting the EphA2 Receptor. ACS Med Chem Lett (2013) 0.83
Eph receptors are involved in the activity-dependent synaptic wiring in the mouse cerebellar cortex. PLoS One (2011) 0.82
Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor. ACS Chem Biol (2014) 0.81
The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain. J Neurosci (2010) 0.81
Ephrin-A1/EphA4-mediated adhesion of monocytes to endothelial cells. Biochim Biophys Acta (2013) 0.81
The EphB4 receptor promotes the growth of melanoma cells expressing the ephrin-B2 ligand. Pigment Cell Melanoma Res (2010) 0.81
EphA4 is not required for Purkinje cell compartmentation. Brain Res Dev Brain Res (2002) 0.80
SHEP1 partners with CasL to promote marginal zone B-cell maturation. Proc Natl Acad Sci U S A (2010) 0.80
Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem (2013) 0.80
Complementary expression and repulsive signaling suggest that EphB receptors and ephrin-B ligands control cell positioning in the gastric epithelium. Histochem Cell Biol (2011) 0.80
Inhibition of Eph receptor-ephrin ligand interaction by tea polyphenols. Pharmacol Res (2012) 0.80
Restraining stem cell niche plasticity: a new talent of Eph receptors. Cell Stem Cell (2010) 0.79
The PTB domain of tensin: NMR solution structure and phosphoinositides binding studies. Biopolymers (2008) 0.79
Unique structure and dynamics of the EphA5 ligand binding domain mediate its binding specificity as revealed by X-ray crystallography, NMR and MD simulations. PLoS One (2013) 0.79
EphB signaling inhibits gap junctional intercellular communication and synchronized contraction in cultured cardiomyocytes. Basic Res Cardiol (2011) 0.79
Design, synthesis and characterization of novel small molecular inhibitors of ephrin-B2 binding to EphB4. Biochem Pharmacol (2012) 0.77
A novel Flk1-TVA transgenic mouse model for gene delivery to angiogenic vasculature. Transgenic Res (2007) 0.76