Published in Exp Cell Res on July 01, 2004
The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog Neurobiol (2006) 3.17
Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease. Proc Natl Acad Sci U S A (2007) 1.84
Interruption of beta-catenin signaling reduces neurogenesis in Alzheimer's disease. J Neurosci (2009) 1.72
Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease. PLoS One (2010) 1.41
A common biological mechanism in cancer and Alzheimer's disease? Curr Alzheimer Res (2009) 1.36
The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease. Mol Neurodegener (2008) 1.20
Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling. J Biol Chem (2008) 1.20
GSK-3β, a pivotal kinase in Alzheimer disease. Front Mol Neurosci (2014) 1.18
Wnt transmembrane signaling and long-term spatial memory. Hippocampus (2011) 1.14
Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death. Free Radic Biol Med (2010) 1.13
Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol Psychiatry (2012) 1.11
Involvment of cytosolic and mitochondrial GSK-3beta in mitochondrial dysfunction and neuronal cell death of MPTP/MPP-treated neurons. PLoS One (2009) 1.09
Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function. Neural Dev (2009) 1.08
WNT signaling in activated microglia is proinflammatory. Glia (2010) 1.07
Analysis of Dickkopf3 interactions with Wnt signaling receptors. Growth Factors (2010) 1.05
Wnt-5a occludes Abeta oligomer-induced depression of glutamatergic transmission in hippocampal neurons. Mol Neurodegener (2010) 1.05
WNT signaling in neuronal maturation and synaptogenesis. Front Cell Neurosci (2013) 1.01
Focal adhesions regulate Abeta signaling and cell death in Alzheimer's disease. Biochim Biophys Acta (2006) 0.98
Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca(2+) in mitochondrial dynamics. Front Cell Neurosci (2013) 0.98
Characterization of Wnt signaling during photoreceptor degeneration. Invest Ophthalmol Vis Sci (2007) 0.97
Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease. Neuron (2014) 0.97
WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity. PLoS One (2011) 0.96
Association of glycogen synthase kinase-3β with Parkinson's disease (review). Mol Med Rep (2014) 0.94
Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation. J Neurosci (2010) 0.92
Wnt-5a-regulated miR-101b controls COX2 expression in hippocampal neurons. Biol Res (2016) 0.90
Signaling pathway cross talk in Alzheimer's disease. Cell Commun Signal (2014) 0.89
Wnts in adult brain: from synaptic plasticity to cognitive deficiencies. Front Cell Neurosci (2013) 0.88
Genome-wide identification of new Wnt/beta-catenin target genes in the human genome using CART method. BMC Genomics (2010) 0.87
Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model. Neuropsychopharmacology (2011) 0.86
Computation as the mechanistic bridge between precision medicine and systems therapeutics. Clin Pharmacol Ther (2012) 0.85
Regulation of cell survival mechanisms in Alzheimer's disease by glycogen synthase kinase-3. Int J Alzheimers Dis (2011) 0.85
Wnt signaling in neuropsychiatric disorders: ties with adult hippocampal neurogenesis and behavior. Neurosci Biobehav Rev (2014) 0.83
N-butylidenephthalide attenuates Alzheimer's disease-like cytopathy in Down syndrome induced pluripotent stem cell-derived neurons. Sci Rep (2015) 0.82
Effect of activation of canonical Wnt signaling by the Wnt-3a protein on the susceptibility of PC12 cells to oxidative and apoptotic insults. Braz J Med Biol Res (2011) 0.81
Amyloid beta: multiple mechanisms of toxicity and only some protective effects? Oxid Med Cell Longev (2014) 0.81
Spatio-temporal expression pattern of frizzled receptors after contusive spinal cord injury in adult rats. PLoS One (2012) 0.81
The role of Wnt signaling in the development of Alzheimer's disease: a potential therapeutic target? Biomed Res Int (2014) 0.80
Evaluation of acute antiapoptotic effects of Li+ in neuronal cell cultures. J Neural Transm (Vienna) (2006) 0.80
How the Wnt signaling pathway protects from neurodegeneration: the mitochondrial scenario. Front Cell Neurosci (2015) 0.80
Characterization of Wnt/β-catenin and BMP/Smad signaling pathways in an in vitro model of amyotrophic lateral sclerosis. Front Cell Neurosci (2013) 0.80
Frizzled-5 receptor is involved in neuronal polarity and morphogenesis of hippocampal neurons. PLoS One (2013) 0.79
Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice. Mol Neurodegener (2015) 0.79
Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma. Front Neurosci (2016) 0.79
The Gα o Activator Mastoparan-7 Promotes Dendritic Spine Formation in Hippocampal Neurons. Neural Plast (2015) 0.78
Role of wnt signaling in the control of adult hippocampal functioning in health and disease: therapeutic implications. Curr Neuropharmacol (2013) 0.78
Wnt-related SynGAP1 is a neuroprotective factor of glutamatergic synapses against Aβ oligomers. Front Cell Neurosci (2015) 0.77
Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology. Neuropathol Appl Neurobiol (2015) 0.76
Wnt-5a/Frizzled9 Receptor Signaling through the Gαo-Gβγ Complex Regulates Dendritic Spine Formation. J Biol Chem (2016) 0.76
The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model. Mol Brain (2017) 0.75
Wnt Signaling Prevents the Aβ Oligomer-Induced Mitochondrial Permeability Transition Pore Opening Preserving Mitochondrial Structure in Hippocampal Neurons. PLoS One (2017) 0.75
Lack of evidence of the interaction of the Aβ peptide with the Wnt signaling cascade in Drosophila models of Alzheimer's disease. Mol Brain (2014) 0.75
Wnt/TLR Dialog in Neuroinflammation, Relevance in Alzheimer's Disease. Front Immunol (2017) 0.75
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). J Biol Chem (2002) 1.99
Loss of AKAP150 perturbs distinct neuronal processes in mice. Proc Natl Acad Sci U S A (2008) 1.96
Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis. J Biol Chem (2007) 1.64
In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model. J Neurosci (2014) 1.63
Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. J Biol Chem (2007) 1.47
Wnt signaling in neuroprotection and stem cell differentiation. Prog Neurobiol (2008) 1.46
Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses. Proc Natl Acad Sci U S A (2010) 1.39
Wnt-5a/JNK signaling promotes the clustering of PSD-95 in hippocampal neurons. J Biol Chem (2009) 1.38
Peroxisomal proliferation protects from beta-amyloid neurodegeneration. J Biol Chem (2005) 1.31
Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling. Exp Cell Res (2004) 1.31
STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits. Brain (2008) 1.25
Structure and function of amyloid in Alzheimer's disease. Prog Neurobiol (2004) 1.25
Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons. J Neurosci (2010) 1.21
Beta-amyloid causes depletion of synaptic vesicles leading to neurotransmission failure. J Biol Chem (2009) 1.19
Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: requirement of syndecan-3 for successful fiber formation. J Cell Sci (2003) 1.17
Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease. Brain Res Brain Res Rev (2004) 1.17
Trolox and 17beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway. J Biol Chem (2005) 1.14
Regulation of NMDA-receptor synaptic transmission by Wnt signaling. J Neurosci (2011) 1.12
ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity. Mol Neurodegener (2007) 1.10
Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons. J Neurosci (2007) 1.10
Structure-function implications in Alzheimer's disease: effect of Abeta oligomers at central synapses. Curr Alzheimer Res (2008) 1.08
Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function. Neural Dev (2009) 1.08
Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease. J Biol Chem (2003) 1.08
ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association. Traffic (2005) 1.07
Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway. FASEB J (2002) 1.06
Wnt-5a occludes Abeta oligomer-induced depression of glutamatergic transmission in hippocampal neurons. Mol Neurodegener (2010) 1.05
Wnt signaling in the regulation of adult hippocampal neurogenesis. Front Cell Neurosci (2013) 1.04
Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Abeta oligomers. J Cell Physiol (2008) 1.03
A self-limiting switch based on translational control regulates the transition from proliferation to differentiation in an adult stem cell lineage. Cell Stem Cell (2012) 1.02
WNT signaling in neuronal maturation and synaptogenesis. Front Cell Neurosci (2013) 1.01
Inhibition of nuclear factor-kappa B enhances the capacity of immature dendritic cells to induce antigen-specific tolerance in experimental autoimmune encephalomyelitis. J Pharmacol Exp Ther (2006) 1.01
Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease. Proc Natl Acad Sci U S A (2012) 1.00
Recent rodent models for Alzheimer's disease: clinical implications and basic research. J Neural Transm (Vienna) (2011) 0.99
Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans. Aging Cell (2009) 0.98
Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca(2+) in mitochondrial dynamics. Front Cell Neurosci (2013) 0.98
c-Abl modulates AICD dependent cellular responses: transcriptional induction and apoptosis. J Cell Physiol (2009) 0.98
Megalin/LRP2 expression is induced by peroxisome proliferator-activated receptor -alpha and -gamma: implications for PPARs' roles in renal function. PLoS One (2011) 0.96
The role of Wnt signaling in neuroprotection. Drug News Perspect (2009) 0.95
PPAR gamma activators induce growth arrest and process extension in B12 oligodendrocyte-like cells and terminal differentiation of cultured oligodendrocytes. J Neurosci Res (2003) 0.95
Acetylcholinesterase-Abeta complexes are more toxic than Abeta fibrils in rat hippocampus: effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss. Am J Pathol (2004) 0.94
Heparin activates Wnt signaling for neuronal morphogenesis. J Cell Physiol (2008) 0.92
Wnt signaling in skeletal muscle dynamics: myogenesis, neuromuscular synapse and fibrosis. Mol Neurobiol (2013) 0.92
Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation. J Neurosci (2010) 0.92
Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway. J Cell Physiol (2009) 0.91
Copper reduction by copper binding proteins and its relation to neurodegenerative diseases. Biometals (2003) 0.91
Wnt signaling involvement in beta-amyloid-dependent neurodegeneration. Neurochem Int (2002) 0.91
Two different heparin-binding domains in the triple-helical domain of ColQ, the collagen tail subunit of synaptic acetylcholinesterase. J Biol Chem (2003) 0.91
Wnt signaling: role in LTP, neural networks and memory. Ageing Res Rev (2013) 0.91
SIRT1 regulates dendritic development in hippocampal neurons. PLoS One (2012) 0.90
Circadian stress tolerance in adult Caenorhabditis elegans. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2008) 0.90
The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease? Biochemistry (2011) 0.90
Adult hippocampal neurogenesis in aging and Alzheimer's disease. Birth Defects Res C Embryo Today (2010) 0.90
Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer's Disease. Front Physiol (2012) 0.89
Wnt signaling modulates pre- and postsynaptic maturation: therapeutic considerations. Dev Dyn (2010) 0.89
Wnt-5a is a synaptogenic factor with neuroprotective properties against Aβ toxicity. Neurodegener Dis (2012) 0.89
Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Abeta peptide. Implications for the pathogenesis of Alzheimer's disease. Mol Neurodegener (2010) 0.89
Signaling pathway cross talk in Alzheimer's disease. Cell Commun Signal (2014) 0.89
The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer's mouse model. Curr Alzheimer Res (2010) 0.88
Heparan sulfate proteoglycans exert positive and negative effects in Shh activity. J Cell Biochem (2005) 0.88
Induction of cellular prion protein gene expression by copper in neurons. Am J Physiol Cell Physiol (2005) 0.87
M1 muscarinic receptor activation protects neurons from beta-amyloid toxicity. A role for Wnt signaling pathway. Neurobiol Dis (2004) 0.87
Genome-wide identification of new Wnt/beta-catenin target genes in the human genome using CART method. BMC Genomics (2010) 0.87
The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from beta-amyloid neurotoxicity by acting on Wnt signaling components. Neurobiol Dis (2005) 0.86
Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification. Mol Neurodegener (2009) 0.86
Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706. Front Mol Neurosci (2011) 0.86
Peroxisome proliferator-activated receptor gamma is a novel target of the nerve growth factor signaling pathway in PC12 cells. J Biol Chem (2005) 0.86
Role of Sirt1 during the ageing process: relevance to protection of synapses in the brain. Mol Neurobiol (2014) 0.85
Tetrahydrohyperforin increases adult hippocampal neurogenesis in wild-type and APPswe/PS1ΔE9 mice. J Alzheimers Dis (2013) 0.85
The GABA(A)ρ receptors in hippocampal spontaneous activity and their distribution in hippocampus, amygdala and visual cortex. Neurosci Lett (2011) 0.85
Laminin affects polymerization, depolymerization and neurotoxicity of Abeta peptide. Peptides (2002) 0.84
Vitamin E but not 17beta-estradiol protects against vascular toxicity induced by beta-amyloid wild type and the Dutch amyloid variant. J Neurosci (2002) 0.83
Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons. Mol Neurodegener (2010) 0.83
Anti-ribosomal P protein autoantibodies from patients with neuropsychiatric lupus impair memory in mice. Arthritis Rheumatol (2015) 0.83
Tetrahydrohyperforin induces mitochondrial dynamics and prevents mitochondrial Ca2+ overload after Aβ and Aβ-AChE complex challenge in rat hippocampal neurons. J Alzheimers Dis (2013) 0.82
Cholinergic abnormalities, endosomal alterations and up-regulation of nerve growth factor signaling in Niemann-Pick type C disease. Mol Neurodegener (2012) 0.82
The hypolipidemic drug metabolites nafenopin-CoA and ciprofibroyl-CoA are competitive P2Y1 receptor antagonists. FEBS Lett (2003) 0.82
The functional links between prion protein and copper. Biol Res (2006) 0.82