Published in J Neurosci on April 15, 2002
Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition. J Neurosci (2008) 1.27
Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice. J Neurochem (2009) 1.08
Acetylcholinesterase-Abeta complexes are more toxic than Abeta fibrils in rat hippocampus: effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss. Am J Pathol (2004) 0.94
Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis. PLoS One (2013) 0.87
Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-beta E22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cells. J Biol Chem (2010) 0.87
Tacrine, Trolox and Tryptoline as Lead Compounds for the Design and Synthesis of Multi-target Agents for Alzheimer's Disease Therapy. Open Med Chem J (2017) 0.75
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients. Clin Sci (Lond) (2004) 2.38
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). J Biol Chem (2002) 1.99
The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress. Hum Mol Genet (2010) 1.83
Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis. J Biol Chem (2005) 1.72
Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension. J Clin Invest (2004) 1.70
TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity. J Cell Biol (2005) 1.68
Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis. J Biol Chem (2007) 1.64
In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model. J Neurosci (2014) 1.63
Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. J Biol Chem (2005) 1.61
Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. J Biol Chem (2007) 1.47
Wnt signaling in neuroprotection and stem cell differentiation. Prog Neurobiol (2008) 1.46
Tungstate activates BK channels in a β subunit- and Mg2+-dependent manner: relevance for arterial vasodilatation. Cardiovasc Res (2012) 1.45
Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses. Proc Natl Acad Sci U S A (2010) 1.39
Wnt-5a/JNK signaling promotes the clustering of PSD-95 in hippocampal neurons. J Biol Chem (2009) 1.38
TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells. Proc Natl Acad Sci U S A (2008) 1.36
Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons. Exp Cell Res (2004) 1.34
Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel. J Gen Physiol (2006) 1.33
Metformin as an adjunctive treatment to control body weight and metabolic dysfunction during olanzapine administration: a multicentric, double-blind, placebo-controlled trial. Schizophr Res (2007) 1.31
Peroxisomal proliferation protects from beta-amyloid neurodegeneration. J Biol Chem (2005) 1.31
STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits. Brain (2008) 1.25
Structure and function of amyloid in Alzheimer's disease. Prog Neurobiol (2004) 1.25
A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia. Proc Natl Acad Sci U S A (2009) 1.25
Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia. J Biol Chem (2004) 1.22
IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid. J Cell Biol (2008) 1.22
Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons. J Neurosci (2010) 1.21
Beta-amyloid causes depletion of synaptic vesicles leading to neurotransmission failure. J Biol Chem (2009) 1.19
Genetic variation in the KCNMA1 potassium channel alpha subunit as risk factor for severe essential hypertension and myocardial infarction. J Hypertens (2008) 1.19
Maxi K+ channel mediates regulatory volume decrease response in a human bronchial epithelial cell line. Am J Physiol Cell Physiol (2002) 1.19
Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: requirement of syndecan-3 for successful fiber formation. J Cell Sci (2003) 1.17
Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease. Brain Res Brain Res Rev (2004) 1.17
Protective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk. Circ Res (2005) 1.16
Prevalence and risk factors associated with the metabolic syndrome and dyslipidemia in White, Black, Amerindian and Mixed Hispanics in Zulia State, Venezuela. Diabetes Res Clin Pract (2005) 1.15
Extended release metformin for metabolic control assistance during prolonged clozapine administration: a 14 week, double-blind, parallel group, placebo-controlled study. Schizophr Res (2009) 1.15
Trolox and 17beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway. J Biol Chem (2005) 1.14
Regulation of NMDA-receptor synaptic transmission by Wnt signaling. J Neurosci (2011) 1.12
ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity. Mol Neurodegener (2007) 1.10
RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration. Hum Mol Genet (2007) 1.10
Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons. J Neurosci (2007) 1.10
Loss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthma. J Biol Chem (2010) 1.08
Structure-function implications in Alzheimer's disease: effect of Abeta oligomers at central synapses. Curr Alzheimer Res (2008) 1.08
Thyroid hormone preconditioning: protection against ischemia-reperfusion liver injury in the rat. Hepatology (2007) 1.08
Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function. Neural Dev (2009) 1.08
ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association. Traffic (2005) 1.07
Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway. FASEB J (2002) 1.06
Coagulation and inflammation markers during atypical or typical antipsychotic treatment in schizophrenia patients and drug-free first-degree relatives. Schizophr Res (2008) 1.05
Oxidative stress-mediated hepatotoxicity of iron and copper: role of Kupffer cells. Biometals (2003) 1.05
Synaptotoxicity of Alzheimer beta amyloid can be explained by its membrane perforating property. PLoS One (2010) 1.05
Wnt-5a occludes Abeta oligomer-induced depression of glutamatergic transmission in hippocampal neurons. Mol Neurodegener (2010) 1.05
Wnt signaling in the regulation of adult hippocampal neurogenesis. Front Cell Neurosci (2013) 1.04
Alzheimer disease beta-amyloid activity mimics cholesterol oxidase. J Clin Invest (2005) 1.04
Screening test for preeclampsia through assessment of uteroplacental blood flow and biochemical markers of oxidative stress and endothelial dysfunction. Am J Obstet Gynecol (2005) 1.04
Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Abeta oligomers. J Cell Physiol (2008) 1.03
Transient receptor potential genes, smoking, occupational exposures and cough in adults. Respir Res (2012) 1.02
Liver NF-kappaB and AP-1 DNA binding in obese patients. Obesity (Silver Spring) (2009) 1.01
WNT signaling in neuronal maturation and synaptogenesis. Front Cell Neurosci (2013) 1.01
Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease. Proc Natl Acad Sci U S A (2012) 1.00
Canonical Wnt3a modulates intracellular calcium and enhances excitatory neurotransmission in hippocampal neurons. J Biol Chem (2010) 1.00
Recent rodent models for Alzheimer's disease: clinical implications and basic research. J Neural Transm (Vienna) (2011) 0.99
Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli. Proc Natl Acad Sci U S A (2013) 0.99
Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans. Aging Cell (2009) 0.98
Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca(2+) in mitochondrial dynamics. Front Cell Neurosci (2013) 0.98
c-Abl modulates AICD dependent cellular responses: transcriptional induction and apoptosis. J Cell Physiol (2009) 0.98
Thyroid hormone-induced oxidative stress triggers nuclear factor-kappaB activation and cytokine gene expression in rat liver. Free Radic Biol Med (2003) 0.97
Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain (2009) 0.96
N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemia-reperfusion injury. PLoS One (2011) 0.96
IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site. J Biol Chem (2008) 0.96
The role of Wnt signaling in neuroprotection. Drug News Perspect (2009) 0.95
PPAR gamma activators induce growth arrest and process extension in B12 oligodendrocyte-like cells and terminal differentiation of cultured oligodendrocytes. J Neurosci Res (2003) 0.95
The TRPV4 channel. Handb Exp Pharmacol (2014) 0.94
Oxidative stress triggers the amyloidogenic pathway in human vascular smooth muscle cells. Neurobiol Aging (2007) 0.94
Acetylcholinesterase-Abeta complexes are more toxic than Abeta fibrils in rat hippocampus: effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss. Am J Pathol (2004) 0.94
Late-onset episodic ataxia type 2 associated with a novel loss-of-function mutation in the CACNA1A gene. J Neurol Sci (2009) 0.93
ORMDL3 modulates store-operated calcium entry and lymphocyte activation. Hum Mol Genet (2012) 0.93
Combined loss of p21(waf1/cip1) and p27(kip1) enhances tumorigenesis in mice. Lab Invest (2011) 0.93
Heparin activates Wnt signaling for neuronal morphogenesis. J Cell Physiol (2008) 0.92
Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines. Pflugers Arch (2008) 0.92
Plasma membrane voltage-dependent anion channel mediates antiestrogen-activated maxi Cl- currents in C1300 neuroblastoma cells. J Biol Chem (2003) 0.92
Highly crosslinked polyethylene does not reduce the wear in total knee arthroplasty: in vivo study of particles in synovial fluid. J Arthroplasty (2013) 0.92
Wnt signaling in skeletal muscle dynamics: myogenesis, neuromuscular synapse and fibrosis. Mol Neurobiol (2013) 0.92
Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation. J Neurosci (2010) 0.92
Thyroid hormone-induced oxidative stress in rodents and humans: a comparative view and relation to redox regulation of gene expression. Comp Biochem Physiol C Toxicol Pharmacol (2005) 0.92
Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway. J Cell Physiol (2009) 0.91
Copper reduction by copper binding proteins and its relation to neurodegenerative diseases. Biometals (2003) 0.91
Protection against in vivo liver ischemia-reperfusion injury by n-3 long-chain polyunsaturated fatty acids in the rat. Free Radic Res (2010) 0.91
Two different heparin-binding domains in the triple-helical domain of ColQ, the collagen tail subunit of synaptic acetylcholinesterase. J Biol Chem (2003) 0.91
Wnt signaling: role in LTP, neural networks and memory. Ageing Res Rev (2013) 0.91
SIRT1 regulates dendritic development in hippocampal neurons. PLoS One (2012) 0.90
Circadian stress tolerance in adult Caenorhabditis elegans. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2008) 0.90
Adult hippocampal neurogenesis in aging and Alzheimer's disease. Birth Defects Res C Embryo Today (2010) 0.90
The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease? Biochemistry (2011) 0.90
Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer's Disease. Front Physiol (2012) 0.89
Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Abeta peptide. Implications for the pathogenesis of Alzheimer's disease. Mol Neurodegener (2010) 0.89
A review of TRP channels splicing. Semin Cell Dev Biol (2006) 0.89
Wnt signaling modulates pre- and postsynaptic maturation: therapeutic considerations. Dev Dyn (2010) 0.89
Wnt-5a is a synaptogenic factor with neuroprotective properties against Aβ toxicity. Neurodegener Dis (2012) 0.89