Published in Tuberculosis (Edinb) on January 01, 2004
A multistage tuberculosis vaccine that confers efficient protection before and after exposure. Nat Med (2011) 4.09
Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum. PLoS Med (2008) 3.01
The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2008) 2.92
Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution. PLoS Genet (2009) 2.89
Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. Antimicrob Agents Chemother (2007) 2.80
A novel in vitro multiple-stress dormancy model for Mycobacterium tuberculosis generates a lipid-loaded, drug-tolerant, dormant pathogen. PLoS One (2009) 2.15
Bacterial growth and cell division: a mycobacterial perspective. Microbiol Mol Biol Rev (2008) 2.01
Mouse model of necrotic tuberculosis granulomas develops hypoxic lesions. J Infect Dis (2011) 1.96
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst Biol (2008) 1.84
A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis. ACS Chem Biol (2012) 1.59
Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. PLoS Comput Biol (2006) 1.53
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc Natl Acad Sci U S A (2013) 1.51
DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis. Protein Sci (2007) 1.51
The multistage vaccine H56 boosts the effects of BCG to protect cynomolgus macaques against active tuberculosis and reactivation of latent Mycobacterium tuberculosis infection. J Clin Invest (2011) 1.50
Differential gene expression in response to exposure to antimycobacterial agents and other stress conditions among seven Mycobacterium tuberculosis whiB-like genes. Antimicrob Agents Chemother (2006) 1.48
Sensitive detection of gene expression in mycobacteria under replicating and non-replicating conditions using optimized far-red reporters. PLoS One (2010) 1.44
Metronidazole lacks activity against Mycobacterium tuberculosis in an in vivo hypoxic granuloma model of latency. J Infect Dis (2008) 1.40
Portrait of a pathogen: the Mycobacterium tuberculosis proteome in vivo. PLoS One (2010) 1.35
Lipidomic analyses of Mycobacterium tuberculosis based on accurate mass measurements and the novel "Mtb LipidDB". J Lipid Res (2011) 1.34
Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. BMC Infect Dis (2007) 1.32
Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target. J Bacteriol (2011) 1.25
Genome sequence of the Fleming strain of Micrococcus luteus, a simple free-living actinobacterium. J Bacteriol (2009) 1.25
Physiology of mycobacteria. Adv Microb Physiol (2009) 1.23
Microarray analysis of whole genome expression of intracellular Mycobacterium tuberculosis. Curr Mol Med (2007) 1.19
VapC toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins. PLoS One (2011) 1.13
Noncognate Mycobacterium tuberculosis toxin-antitoxins can physically and functionally interact. J Biol Chem (2010) 1.11
Transcriptomic analysis identifies growth rate modulation as a component of the adaptation of mycobacteria to survival inside the macrophage. J Bacteriol (2007) 1.06
Characterization of [4Fe-4S]-containing and cluster-free forms of Streptomyces WhiD. Biochemistry (2009) 1.04
Functional analysis of molybdopterin biosynthesis in mycobacteria identifies a fused molybdopterin synthase in Mycobacterium tuberculosis. J Bacteriol (2010) 1.02
Modeling phenotypic metabolic adaptations of Mycobacterium tuberculosis H37Rv under hypoxia. PLoS Comput Biol (2012) 0.99
Transcriptional Adaptation of Drug-tolerant Mycobacterium tuberculosis During Treatment of Human Tuberculosis. J Infect Dis (2015) 0.99
Mycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities. PLoS One (2013) 0.98
Functional and genetic characterization of the tap efflux pump in Mycobacterium bovis BCG. Antimicrob Agents Chemother (2012) 0.95
Spotlight on Mycobacteria and dendritic cells: will novel targets to fight tuberculosis emerge? EMBO Mol Med (2009) 0.93
In vivo adaptation of the Wayne model of latent tuberculosis. Infect Immun (2007) 0.92
Central metabolism in Mycobacterium smegmatis during the transition from O2-rich to O2-poor conditions as studied by isotopomer-assisted metabolite analysis. Biotechnol Lett (2009) 0.91
New agents for the treatment of drug-resistant Mycobacterium tuberculosis. Adv Drug Deliv Rev (2016) 0.90
DevR-mediated adaptive response in Mycobacterium tuberculosis H37Ra: links to asparagine metabolism. Tuberculosis (Edinb) (2009) 0.89
Control of CydB and GltA1 expression by the SenX3 RegX3 two component regulatory system of Mycobacterium tuberculosis. PLoS One (2011) 0.88
A Bayesian Change point model for differential gene expression patterns of the DosR regulon of Mycobacterium tuberculosis. BMC Genomics (2008) 0.88
Association of strong immune responses to PPE protein Rv1168c with active tuberculosis. Clin Vaccine Immunol (2008) 0.87
The role of transport mechanisms in mycobacterium tuberculosis drug resistance and tolerance. Pharmaceuticals (Basel) (2012) 0.85
mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J Bacteriol (2009) 0.85
Different roles of DosS and DosT in the hypoxic adaptation of Mycobacteria. J Bacteriol (2010) 0.85
A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis. Mol Cell Proteomics (2013) 0.85
Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis. BMC Microbiol (2010) 0.84
Mycobacterium Lysine ε-aminotransferase is a novel alarmone metabolism related persister gene via dysregulating the intracellular amino acid level. Sci Rep (2016) 0.83
Proline-proline-glutamic acid (PPE) protein Rv1168c of Mycobacterium tuberculosis augments transcription from HIV-1 long terminal repeat promoter. J Biol Chem (2012) 0.83
Potassium availability triggers Mycobacterium tuberculosis transition to, and resuscitation from, non-culturable (dormant) states. Open Biol (2014) 0.81
Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Sci (2007) 0.81
Characterization of two in vivo-expressed methyltransferases of the Mycobacterium tuberculosis complex: antigenicity and genetic regulation. Microbiology (2008) 0.81
The DosS-DosT/DosR Mycobacterial Sensor System. Biosensors (Basel) (2013) 0.80
Detrimental effects of hypoxia-specific expression of uracil DNA glycosylase (Ung) in Mycobacterium smegmatis. J Bacteriol (2010) 0.79
TuberQ: a Mycobacterium tuberculosis protein druggability database. Database (Oxford) (2014) 0.79
Targeting lipid esterases in mycobacteria grown under different physiological conditions using activity-based profiling with tetrahydrolipstatin (THL). Mol Cell Proteomics (2013) 0.79
Mycobacterium tuberculosis DosR is required for activity of the PmbtB and PmbtI promoters under hypoxia. PLoS One (2014) 0.78
M. tuberculosis Gene Expression during Transition to the "Non-Culturable" State. Acta Naturae (2009) 0.78
Understanding communication signals during mycobacterial latency through predicted genome-wide protein interactions and boolean modeling. PLoS One (2012) 0.78
Rv1894c is a novel hypoxia-induced nitronate monooxygenase required for Mycobacterium tuberculosis virulence. J Infect Dis (2013) 0.78
Genomic and transcriptomic analysis of the streptomycin-dependent Mycobacterium tuberculosis strain 18b. BMC Genomics (2016) 0.77
Protein array identification of protein markers for serodiagnosis of Mycobacterium tuberculosis infection. Sci Rep (2015) 0.77
Host cell-induced components of the sulfate assimilation pathway are major protective antigens of Mycobacterium tuberculosis. J Infect Dis (2012) 0.77
A rhodanine agent active against non-replicating intracellular Mycobacterium avium subspecies paratuberculosis. Gut Pathog (2009) 0.76
Sputum is a surrogate for bronchoalveolar lavage for monitoring Mycobacterium tuberculosis transcriptional profiles in TB patients. Tuberculosis (Edinb) (2016) 0.75
Targeting Phenotypically Tolerant Mycobacterium tuberculosis. Microbiol Spectr (2017) 0.75
Crystallization of a protein using dehydration without a precipitant. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.75
Proteomics Analysis of Three Different Strains of Mycobacterium tuberculosis under In vitro Hypoxia and Evaluation of Hypoxia Associated Antigen's Specific Memory T Cells in Healthy Household Contacts. Front Microbiol (2016) 0.75
Transcriptional Profiling of Mycobacterium tuberculosis Exposed to In Vitro Lysosomal Stress. Infect Immun (2016) 0.75
Mycobacterium tuberculosis P-type ATPases: possible targets for drug or vaccine development. Biomed Res Int (2014) 0.75
A Proteomic Signature of Dormancy in an Actinobacterium: Micrococcus luteus. J Bacteriol (2017) 0.75
Crystal structure of a hypothetical protein, TTHA0829 from Thermus thermophilus HB8, composed of cystathionine-β-synthase (CBS) and aspartate-kinase chorismate-mutase tyrA (ACT) domains. Extremophiles (2016) 0.75
Dissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays. Microbiology (2002) 3.40
Microarrays reveal that each of the ten dominant lineages of Staphylococcus aureus has a unique combination of surface-associated and regulatory genes. J Bacteriol (2006) 3.37
Antibiotic treatment of clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts. Infect Immun (2009) 3.36
Evolutionary dynamics of Clostridium difficile over short and long time scales. Proc Natl Acad Sci U S A (2010) 3.18
Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum. PLoS Med (2008) 3.01
Construction and analysis of chromosomal Clostridium difficile mutants. Mol Microbiol (2006) 2.65
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect Immun (2006) 2.56
Application of DNA microarrays to study the evolutionary genomics of Yersinia pestis and Yersinia pseudotuberculosis. Genome Res (2003) 2.51
Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories. J Bacteriol (2010) 2.36
A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor. Mol Microbiol (2005) 2.08
Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source. Proc Natl Acad Sci U S A (2005) 2.04
Stationary phase gene expression of Mycobacterium tuberculosis following a progressive nutrient depletion: a model for persistent organisms? Tuberculosis (Edinb) (2004) 1.92
Identification of pathogen-specific genes through microarray analysis of pathogenic and commensal Neisseria species. Microbiology (2005) 1.88
Improved detection of nasopharyngeal cocolonization by multiple pneumococcal serotypes by use of latex agglutination or molecular serotyping by microarray. J Clin Microbiol (2011) 1.82
Evolutionary genomics of Staphylococcus aureus reveals insights into the origin and molecular basis of ruminant host adaptation. Genome Biol Evol (2010) 1.81
Optimisation of bioluminescent reporters for use with mycobacteria. PLoS One (2010) 1.75
Design, validation, and application of a seven-strain Staphylococcus aureus PCR product microarray for comparative genomics. Appl Environ Microbiol (2005) 1.73
Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis. Tuberculosis (Edinb) (2005) 1.73
Analysis of whole-genome microarray replicates using mixed models. Bioinformatics (2003) 1.73
A dual read-out assay to evaluate the potency of compounds active against Mycobacterium tuberculosis. PLoS One (2013) 1.71
Efficient switching of mycobacteriophage L5-based integrating plasmids in Mycobacterium tuberculosis. FEMS Microbiol Lett (2003) 1.66
The majority of inducible DNA repair genes in Mycobacterium tuberculosis are induced independently of RecA. Mol Microbiol (2003) 1.63
The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (2003) 1.62
Variation in Salmonella enterica serovar typhi IncHI1 plasmids during the global spread of resistant typhoid fever. Antimicrob Agents Chemother (2008) 1.58
The influence of reduced oxygen availability on pathogenicity and gene expression in Mycobacterium tuberculosis. Tuberculosis (Edinb) (2004) 1.58
Multiple colonization with S. pneumoniae before and after introduction of the seven-valent conjugated pneumococcal polysaccharide vaccine. PLoS One (2010) 1.56
The distribution of mobile genetic elements (MGEs) in MRSA CC398 is associated with both host and country. Genome Biol Evol (2011) 1.53
Effect of chicken meat environment on gene expression of Campylobacter jejuni and its relevance to survival in food. Int J Food Microbiol (2010) 1.49
The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2007) 1.49
Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection. PLoS Pathog (2011) 1.46
Use of a tetracycline-inducible system for conditional expression in Mycobacterium tuberculosis and Mycobacterium smegmatis. Appl Environ Microbiol (2005) 1.45
Sensitive detection of gene expression in mycobacteria under replicating and non-replicating conditions using optimized far-red reporters. PLoS One (2010) 1.44
Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake. BMC Microbiol (2008) 1.38
Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv. J Biol Chem (2008) 1.37
The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds. Tuberculosis (Edinb) (2004) 1.33
NssR, a member of the Crp-Fnr superfamily from Campylobacter jejuni, regulates a nitrosative stress-responsive regulon that includes both a single-domain and a truncated haemoglobin. Mol Microbiol (2005) 1.32
Detection of large numbers of pneumococcal virulence genes in streptococci of the mitis group. J Clin Microbiol (2010) 1.32
Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis. PLoS One (2013) 1.31
Empirical Bayesian models for analysing molecular serotyping microarrays. BMC Bioinformatics (2011) 1.30
Application of comparative phylogenomics to study the evolution of Yersinia enterocolitica and to identify genetic differences relating to pathogenicity. J Bacteriol (2006) 1.29
Genomic diversity between strains of the same serotype and multilocus sequence type among pneumococcal clinical isolates. Infect Immun (2006) 1.27
Functional complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium smegmatis fabG but not Escherichia coli fabG. J Bacteriol (2007) 1.26
Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target. J Bacteriol (2011) 1.25
Two distinct clones of methicillin-resistant Staphylococcus aureus (MRSA) with the same USA300 pulsed-field gel electrophoresis profile: a potential pitfall for identification of USA300 community-associated MRSA. J Clin Microbiol (2009) 1.25
Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development. J Bacteriol (2007) 1.23
Conditional expression of Mycobacterium smegmatis dnaA, an essential DNA replication gene. Microbiology (2002) 1.21
Microarray analysis of the transcriptional responses of Clostridium difficile to environmental and antibiotic stress. J Med Microbiol (2008) 1.20
Explorative multifactor approach for investigating global survival mechanisms of Campylobacter jejuni under environmental conditions. Appl Environ Microbiol (2005) 1.20
The Staphylococcus aureus response to unsaturated long chain free fatty acids: survival mechanisms and virulence implications. PLoS One (2009) 1.19
Mycobacterial cells have dual nickel-cobalt sensors: sequence relationships and metal sites of metal-responsive repressors are not congruent. J Biol Chem (2007) 1.17
Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection. PLoS Genet (2013) 1.17
Emergence of new PCR ribotypes from the hypervirulent Clostridium difficile 027 lineage. J Med Microbiol (2011) 1.16
Discovery of stable and variable differences in the Mycobacterium avium subsp. paratuberculosis type I, II, and III genomes by pan-genome microarray analysis. Appl Environ Microbiol (2008) 1.15
Comparative transcriptomics reveals key gene expression differences between the human and bovine pathogens of the Mycobacterium tuberculosis complex. Microbiology (2007) 1.14
Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target. J Exp Med (2004) 1.14
Identifying vulnerable pathways in Mycobacterium tuberculosis by using a knockdown approach. Appl Environ Microbiol (2011) 1.11
Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2. J Biol Chem (2010) 1.09
Advancement of Imidazo[1,2-a]pyridines with Improved Pharmacokinetics and Nanomolar Activity Against Mycobacterium tuberculosis. ACS Med Chem Lett (2013) 1.09
Functional analysis of GlnE, an essential adenylyl transferase in Mycobacterium tuberculosis. J Bacteriol (2008) 1.06
EmbA is an essential arabinosyltransferase in Mycobacterium tuberculosis. Microbiology (2008) 1.06
Genome structure in the vole bacillus, Mycobacterium microti, a member of the Mycobacterium tuberculosis complex with a low virulence for humans. Microbiology (2004) 1.06
DNA microarrays for virus detection in cases of central nervous system infection. J Clin Microbiol (2004) 1.06
Use of genome level-informed PCR as a new investigational approach for analysis of outbreak-associated Mycobacterium tuberculosis isolates. J Clin Microbiol (2004) 1.05
Influence of tigecycline on expression of virulence factors in biofilm-associated cells of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2009) 1.04
Genomic variations define divergence of water/wildlife-associated Campylobacter jejuni niche specialists from common clonal complexes. Environ Microbiol (2011) 1.04
The pneumococcal response to oxidative stress includes a role for Rgg. Microbiology (2009) 1.02
The nonmevalonate pathway of isoprenoid biosynthesis in Mycobacterium tuberculosis is essential and transcriptionally regulated by Dxs. J Bacteriol (2010) 1.02
A new in vivo model to test anti-tuberculosis drugs using fluorescence imaging. J Antimicrob Chemother (2012) 1.02
Mycobacterium tuberculosis responds to chloride and pH as synergistic cues to the immune status of its host cell. PLoS Pathog (2013) 1.01
The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery. BMC Struct Biol (2007) 1.01
Defective pneumococcal-specific Th1 responses in HIV-infected adults precedes a loss of control of pneumococcal colonization. Clin Infect Dis (2012) 1.00
Expression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens. Chem Biol (2009) 1.00
Using a DNA microarray to investigate the distribution of insect virulence factors in strains of photorhabdus bacteria. J Bacteriol (2003) 1.00
Quantification of global transcription patterns in prokaryotes using spotted microarrays. Genome Biol (2007) 0.99
Mycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities. PLoS One (2013) 0.98
Microarray analysis of Mycobacterium microti reveals deletion of genes encoding PE-PPE proteins and ESAT-6 family antigens. Tuberculosis (Edinb) (2004) 0.98
Contrasting transcriptional responses of a virulent and an attenuated strain of Mycobacterium tuberculosis infecting macrophages. PLoS One (2010) 0.98
The critical role of embC in Mycobacterium tuberculosis. J Bacteriol (2008) 0.97
Genomic diversity among Beijing and non-Beijing Mycobacterium tuberculosis isolates from Myanmar. PLoS One (2008) 0.97
A point mutation in cpsE renders Streptococcus pneumoniae nonencapsulated and enhances its growth, adherence and competence. BMC Microbiol (2014) 0.97
The promoter of Rv0560c is induced by salicylate and structurally-related compounds in Mycobacterium tuberculosis. PLoS One (2012) 0.96
Functional demonstration of reverse transsulfuration in the Mycobacterium tuberculosis complex reveals that methionine is the preferred sulfur source for pathogenic Mycobacteria. J Biol Chem (2004) 0.96
Expression of Mycobacterium tuberculosis Rv1991c using an arabinose-inducible promoter demonstrates its role as a toxin. FEMS Microbiol Lett (2007) 0.96
Deletion of a previously uncharacterized flagellar-hook-length control gene fliK modulates the sigma54-dependent regulon in Campylobacter jejuni. Microbiology (2007) 0.96
Nontypeable pneumococcal isolates among navajo and white mountain apache communities: are these really a cause of invasive disease? J Infect Dis (2012) 0.95
Global transcriptional profiling of Burkholderia pseudomallei under salt stress reveals differential effects on the Bsa type III secretion system. BMC Microbiol (2010) 0.94
HemZ is essential for heme biosynthesis in Mycobacterium tuberculosis. Tuberculosis (Edinb) (2005) 0.94
Control of the acetamidase gene of Mycobacterium smegmatis by multiple regulators. FEMS Microbiol Lett (2003) 0.93
Identification of the Mycobacterium tuberculosis GlnE promoter and its response to nitrogen availability. Microbiology (2006) 0.93
Transcriptional analysis of temporal gene expression in germinating Clostridium difficile 630 endospores. PLoS One (2013) 0.92
Posttranscriptional regulation of flagellin synthesis in Helicobacter pylori by the RpoN chaperone HP0958. J Bacteriol (2008) 0.92
Altered innate defenses in the neonatal gastrointestinal tract in response to colonization by neuropathogenic Escherichia coli. Infect Immun (2013) 0.92
Mutations in the CCGTTCACA DnaA box of Mycobacterium tuberculosis oriC that abolish replication of oriC plasmids are tolerated on the chromosome. J Bacteriol (2002) 0.91