Published in PLoS One on April 01, 2013
Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase. Mol Microbiol (2014) 1.62
The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1. PLoS One (2015) 1.55
Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery. Proc Natl Acad Sci U S A (2014) 1.07
The Mycobacterium tuberculosis Rv2745c plays an important role in responding to redox stress. PLoS One (2014) 0.89
Antibacterial activity of and resistance to small molecule inhibitors of the ClpP peptidase. ACS Chem Biol (2013) 0.86
Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2. PLoS Pathog (2014) 0.84
The Mycobacterium tuberculosis Clp gene regulator is required for in vitro reactivation from hypoxia-induced dormancy. J Biol Chem (2014) 0.82
Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease. Mol Microbiol (2016) 0.81
Rv2744c Is a PspA Ortholog That Regulates Lipid Droplet Homeostasis and Nonreplicating Persistence in Mycobacterium tuberculosis. J Bacteriol (2016) 0.78
Dual stoichiometry and subunit organization in the ClpP1/P2 protease from the cyanobacterium Synechococcus elongatus. J Struct Biol (2015) 0.76
Cloning and characterization of Clp protease proteolytic subunit 2 and its implication in clinical diagnosis of tuberculosis. Int J Clin Exp Pathol (2014) 0.75
AAA+ Machines of Protein Destruction in Mycobacteria. Front Mol Biosci (2017) 0.75
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature (1998) 60.62
An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect Immun (1996) 9.21
New unstable variants of green fluorescent protein for studies of transient gene expression in bacteria. Appl Environ Microbiol (1998) 6.61
MEROPS: the peptidase database. Nucleic Acids Res (2009) 5.33
The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action. J Biol Chem (2004) 4.75
Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis. Mol Microbiol (1999) 4.27
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics. Nat Med (2005) 3.40
Dissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays. Microbiology (2002) 3.40
A specificity-enhancing factor for the ClpXP degradation machine. Science (2000) 3.31
The tmRNA website: reductive evolution of tmRNA in plastids and other endosymbionts. Nucleic Acids Res (2004) 2.88
Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis. Proc Natl Acad Sci U S A (2001) 2.59
Gene expression profile of Mycobacterium tuberculosis in a non-replicating state. Tuberculosis (Edinb) (2004) 2.33
ClpP of Bacillus subtilis is required for competence development, motility, degradative enzyme synthesis, growth at high temperature and sporulation. Mol Microbiol (1998) 2.20
New insights into the ATP-dependent Clp protease: Escherichia coli and beyond. Mol Microbiol (1999) 2.13
Site-directed mutagenesis using double-stranded plasmid DNA templates. Methods Mol Biol (1996) 2.12
RseA, the SigE specific anti-sigma factor of Mycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis. Mol Microbiol (2009) 2.04
Dissecting virulence pathways of Mycobacterium tuberculosis through protein-protein association. Proc Natl Acad Sci U S A (2006) 1.95
Regulation of the inducible acetamidase gene of Mycobacterium smegmatis. Microbiology (1997) 1.86
The clp proteases of Bacillus subtilis are directly involved in degradation of misfolded proteins. J Bacteriol (2000) 1.74
Transcriptional control of the iron-responsive fxbA gene by the mycobacterial regulator IdeR. J Bacteriol (1999) 1.65
Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection. PLoS Pathog (2012) 1.60
clpC and clpP1P2 gene expression in Corynebacterium glutamicum is controlled by a regulatory network involving the transcriptional regulators ClgR and HspR as well as the ECF sigma factor sigmaH. Mol Microbiol (2004) 1.54
The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease. EMBO Mol Med (2009) 1.53
The Clp ATPases define a novel class of molecular chaperones. Mol Microbiol (1996) 1.40
sigA is an essential gene in Mycobacterium smegmatis. Mol Microbiol (1998) 1.36
The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring. EMBO J (2012) 1.31
Global role for ClpP-containing proteases in stationary-phase adaptation of Escherichia coli. J Bacteriol (2003) 1.31
Functional genomics reveals extended roles of the Mycobacterium tuberculosis stress response factor sigmaH. J Bacteriol (2009) 1.29
Characterization of a Clp protease gene regulator and the reaeration response in Mycobacterium tuberculosis. PLoS One (2010) 1.28
Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target. J Bacteriol (2011) 1.25
Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1. Acta Crystallogr D Biol Crystallogr (2007) 1.17
Transcriptional regulation of furA and katG upon oxidative stress in Mycobacterium smegmatis. J Bacteriol (2001) 1.15
ClgR regulation of chaperone and protease systems is essential for Mycobacterium tuberculosis parasitism of the macrophage. Microbiology (2010) 1.15
Identifying vulnerable pathways in Mycobacterium tuberculosis by using a knockdown approach. Appl Environ Microbiol (2011) 1.11
In Vitro Model of Hypoxically Induced Nonreplicating Persistence of Mycobacterium tuberculosis. Methods Mol Med (2001) 1.08
The transcriptional activator ClgR controls transcription of genes involved in proteolysis and DNA repair in Corynebacterium glutamicum. Mol Microbiol (2005) 1.06
ClgR, a novel regulator of clp and lon expression in Streptomyces. J Bacteriol (2004) 1.06
Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase. Nucleic Acids Res (2010) 1.03
ClpP is involved in the stress response and degradation of misfolded proteins in Salmonella enterica serovar Typhimurium. Microbiology (2002) 1.03
Diversity-oriented synthesis of cyclic acyldepsipeptides leads to the discovery of a potent antibacterial agent. Bioorg Med Chem (2010) 1.01
Development and application of unstable GFP variants to kinetic studies of mycobacterial gene expression. J Microbiol Methods (2003) 1.00
Assaying promoter activity using LacZ and GFP as reporters. Methods Mol Biol (2009) 0.98
The promoter of Rv0560c is induced by salicylate and structurally-related compounds in Mycobacterium tuberculosis. PLoS One (2012) 0.96
Identification of the Mycobacterium tuberculosis GlnE promoter and its response to nitrogen availability. Microbiology (2006) 0.93
Crystal structure of the caseinolytic protease gene regulator, a transcriptional activator in actinomycetes. J Biol Chem (2008) 0.85
ClpXP degrades SsrA-tagged proteins in Streptococcus pneumoniae. J Bacteriol (2009) 0.84
Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories. J Bacteriol (2010) 2.36
Gene expression profile of Mycobacterium tuberculosis in a non-replicating state. Tuberculosis (Edinb) (2004) 2.33
Optimisation of bioluminescent reporters for use with mycobacteria. PLoS One (2010) 1.75
Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis. Tuberculosis (Edinb) (2005) 1.73
Analysis of whole-genome microarray replicates using mixed models. Bioinformatics (2003) 1.73
A dual read-out assay to evaluate the potency of compounds active against Mycobacterium tuberculosis. PLoS One (2013) 1.71
Efficient switching of mycobacteriophage L5-based integrating plasmids in Mycobacterium tuberculosis. FEMS Microbiol Lett (2003) 1.66
The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2007) 1.49
Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection. PLoS Pathog (2011) 1.46
Use of a tetracycline-inducible system for conditional expression in Mycobacterium tuberculosis and Mycobacterium smegmatis. Appl Environ Microbiol (2005) 1.45
Sensitive detection of gene expression in mycobacteria under replicating and non-replicating conditions using optimized far-red reporters. PLoS One (2010) 1.44
Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake. BMC Microbiol (2008) 1.38
Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv. J Biol Chem (2008) 1.37
Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis. PLoS One (2013) 1.31
Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target. J Bacteriol (2011) 1.25
Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development. J Bacteriol (2007) 1.23
Conditional expression of Mycobacterium smegmatis dnaA, an essential DNA replication gene. Microbiology (2002) 1.21
Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target. J Exp Med (2004) 1.14
Identifying vulnerable pathways in Mycobacterium tuberculosis by using a knockdown approach. Appl Environ Microbiol (2011) 1.11
Advancement of Imidazo[1,2-a]pyridines with Improved Pharmacokinetics and Nanomolar Activity Against Mycobacterium tuberculosis. ACS Med Chem Lett (2013) 1.09
EmbA is an essential arabinosyltransferase in Mycobacterium tuberculosis. Microbiology (2008) 1.06
Functional analysis of GlnE, an essential adenylyl transferase in Mycobacterium tuberculosis. J Bacteriol (2008) 1.06
A new in vivo model to test anti-tuberculosis drugs using fluorescence imaging. J Antimicrob Chemother (2012) 1.02
The nonmevalonate pathway of isoprenoid biosynthesis in Mycobacterium tuberculosis is essential and transcriptionally regulated by Dxs. J Bacteriol (2010) 1.02
Mycobacterium tuberculosis responds to chloride and pH as synergistic cues to the immune status of its host cell. PLoS Pathog (2013) 1.01
The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery. BMC Struct Biol (2007) 1.01
Expression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens. Chem Biol (2009) 1.00
The critical role of embC in Mycobacterium tuberculosis. J Bacteriol (2008) 0.97
The promoter of Rv0560c is induced by salicylate and structurally-related compounds in Mycobacterium tuberculosis. PLoS One (2012) 0.96
Functional demonstration of reverse transsulfuration in the Mycobacterium tuberculosis complex reveals that methionine is the preferred sulfur source for pathogenic Mycobacteria. J Biol Chem (2004) 0.96
Expression of Mycobacterium tuberculosis Rv1991c using an arabinose-inducible promoter demonstrates its role as a toxin. FEMS Microbiol Lett (2007) 0.96
Identification of the Mycobacterium tuberculosis GlnE promoter and its response to nitrogen availability. Microbiology (2006) 0.93
Control of the acetamidase gene of Mycobacterium smegmatis by multiple regulators. FEMS Microbiol Lett (2003) 0.93
Mutations in the CCGTTCACA DnaA box of Mycobacterium tuberculosis oriC that abolish replication of oriC plasmids are tolerated on the chromosome. J Bacteriol (2002) 0.91
Proteases in Mycobacterium tuberculosis pathogenesis: potential as drug targets. Future Microbiol (2013) 0.90
Control of CydB and GltA1 expression by the SenX3 RegX3 two component regulatory system of Mycobacterium tuberculosis. PLoS One (2011) 0.88
The role of GlnD in ammonia assimilation in Mycobacterium tuberculosis. Tuberculosis (Edinb) (2007) 0.88
Electroporation of mycobacteria. Methods Mol Biol (2009) 0.88
The dUTPase enzyme is essential in Mycobacterium smegmatis. PLoS One (2012) 0.86
The two chorismate mutases from both Mycobacterium tuberculosis and Mycobacterium smegmatis: biochemical analysis and limited regulation of promoter activity by aromatic amino acids. J Bacteriol (2007) 0.86
Rapid recombination screening to test gene essentiality demonstrates that pyrH is essential in Mycobacterium tuberculosis. Tuberculosis (Edinb) (2007) 0.86
Instability of the acetamide-inducible expression vector pJAM2 in Mycobacterium tuberculosis. Plasmid (2005) 0.86
Electroporation of mycobacteria. J Vis Exp (2008) 0.86
Modeling the Qo site of crop pathogens in Saccharomyces cerevisiae cytochrome b. Eur J Biochem (2004) 0.85
Expression and characterization of Mycobacterium tuberculosis CYP144: common themes and lessons learned in the M. tuberculosis P450 enzyme family. Biochim Biophys Acta (2010) 0.84
The genetics of cell wall biosynthesis in Mycobacterium tuberculosis. Future Microbiol (2008) 0.84
Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis. BMC Microbiol (2010) 0.84
The future for early-stage tuberculosis drug discovery. Future Microbiol (2015) 0.84
Mycobacterium tuberculosis Rv0198c, a putative matrix metalloprotease is involved in pathogenicity. Tuberculosis (Edinb) (2011) 0.83
Gene replacement in mycobacteria by using incompatible plasmids. Appl Environ Microbiol (2003) 0.83
The molecular biology of recombination in Mycobacteria: what do we know and how can we use it? Curr Issues Mol Biol (2004) 0.82
Structural, biochemical, and in vivo investigations of the threonine synthase from Mycobacterium tuberculosis. J Mol Biol (2008) 0.81
Deletion of SenX3-RegX3, a key two-component regulatory system of Mycobacterium smegmatis, results in growth defects under phosphate-limiting conditions. Microbiology (2012) 0.81
Two-Component Regulatory Systems of Mycobacteria. Microbiol Spectr (2014) 0.80
Characterisation of target-site resistance to ACCase-inhibiting herbicides in the weed Alopecurus myosuroides (black-grass). Pest Manag Sci (2003) 0.80
Future target-based drug discovery for tuberculosis? Tuberculosis (Edinb) (2014) 0.79
Antimycobacterial activity evaluation, time-kill kinetic and 3D-QSAR study of C-(3-aminomethyl-cyclohexyl)-methylamine derivatives. Bioorg Med Chem Lett (2013) 0.78
Electroporation of mycobacteria. Methods Mol Biol (2015) 0.78
Construction of a severely attenuated mutant of Mycobacterium tuberculosis for reducing risk to laboratory workers. Tuberculosis (Edinb) (2008) 0.78
Revisiting the assignment of Rv0241c to fatty acid synthase type II of Mycobacterium tuberculosis. J Bacteriol (2010) 0.77
Methionine sulfoximine resistance in Mycobacterium tuberculosis is due to a single nucleotide deletion resulting in increased expression of the major glutamine synthetase, GlnA1. Microb Drug Resist (2011) 0.77
Identification of the likely translational start of Mycobacterium tuberculosis GyrB. BMC Res Notes (2013) 0.76
Improved phenoxyalkylbenzimidazoles with activity against Mycobacterium tuberculosis appear to target QcrB. ACS Infect Dis (2017) 0.75
Welcome from Tanya Parish, new Editor-in-Chief. Microbiology (2015) 0.75