Published in Microbes Infect on July 01, 2004
B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation. Blood (2006) 1.25
Simian immunodeficiency virus (SIV)-specific CD8+ T-cell responses in vervet African green monkeys chronically infected with SIVagm. J Virol (2008) 1.11
Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia. Proc Natl Acad Sci U S A (2013) 0.96
Immune-mediated changes in actinic keratosis following topical treatment with imiquimod 5% cream. J Transl Med (2007) 0.96
Granzymes drive a rapid listeriolysin O-induced T cell apoptosis. J Immunol (2008) 0.89
Targeted apoptosis activation with GrB/scFvMEL modulates melanoma growth, metastatic spread, chemosensitivity, and radiosensitivity. Neoplasia (2006) 0.88
Altered NK cell function in obese healthy humans. BMC Obes (2015) 0.81
Targeting granzyme B to tumor cells using a yoked human chorionic gonadotropin. Cancer Chemother Pharmacol (2011) 0.80
Granzyme B; the chalk-mark of a cytotoxic lymphocyte. J Transl Med (2004) 0.77
Ectopically expressed perforin-1 is proapoptotic in tumor cell lines by increasing caspase-3 activity and the nuclear translocation of cytochrome C. PLoS One (2012) 0.75
A common fold mediates vertebrate defense and bacterial attack. Science (2007) 3.43
The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy. Blood (2010) 3.23
Perforin-mediated target-cell death and immune homeostasis. Nat Rev Immunol (2006) 3.04
The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature (2010) 2.23
The MACPF/CDC family of pore-forming toxins. Cell Microbiol (2008) 2.15
The molecular basis for perforin oligomerization and transmembrane pore assembly. Immunity (2009) 1.98
Suppression of lymphoma and epithelial malignancies effected by interferon gamma. J Exp Med (2002) 1.85
Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors. Blood (2002) 1.83
Novel mechanisms of apoptosis induced by histone deacetylase inhibitors. Cancer Res (2003) 1.73
Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes. Immunity (2011) 1.73
Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack. Blood (2013) 1.53
The major human and mouse granzymes are structurally and functionally divergent. J Cell Biol (2006) 1.48
Functional crosstalk between type I and II interferon through the regulated expression of STAT1. PLoS Biol (2010) 1.40
Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. Immunity (2002) 1.39
Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin. J Biol Chem (2005) 1.39
Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia. Mol Ther (2013) 1.33
Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2. Biochem Biophys Res Commun (2005) 1.32
Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation. J Immunol (2002) 1.31
Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491. J Biol Chem (2004) 1.31
Perforin: structure, function, and role in human immunopathology. Immunol Rev (2010) 1.30
Apoptosis induced by the lymphocyte effector molecule perforin. Curr Opin Immunol (2007) 1.29
Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer. J Immunol (2004) 1.24
Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors. Immunity (2003) 1.23
Perforin and granzymes: function, dysfunction and human pathology. Nat Rev Immunol (2015) 1.23
A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis. Blood (2005) 1.22
The battlefield of perforin/granzyme cell death pathways. J Leukoc Biol (2009) 1.18
hScrib is a functional homologue of the Drosophila tumour suppressor Scribble. Oncogene (2003) 1.15
Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice. Proc Natl Acad Sci U S A (2005) 1.14
Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer. Proc Natl Acad Sci U S A (2009) 1.14
Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells. J Biol Chem (2006) 1.13
A role for granzyme M in TLR4-driven inflammation and endotoxicosis. J Immunol (2010) 1.13
Functional dissection of the granzyme family: cell death and inflammation. Immunol Rev (2010) 1.12
Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways. Diabetes (2006) 1.12
Adoptive transfer of gene-engineered CD4+ helper T cells induces potent primary and secondary tumor rejection. Blood (2005) 1.10
Endolysosomal proteases and their inhibitors in immunity. Nat Rev Immunol (2009) 1.10
Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function. Blood (2007) 1.10
A central role for Bid in granzyme B-induced apoptosis. J Biol Chem (2004) 1.10
Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death. Trends Immunol (2012) 1.09
Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse. J Immunol (2013) 1.08
Perforin and Fas induced by IFNgamma and TNFalpha mediate beta cell death by OT-I CTL. Int Immunol (2006) 1.08
Granzyme B encoded by the commonly occurring human RAH allele retains pro-apoptotic activity. J Biol Chem (2004) 1.07
Sustained antigen-specific antitumor recall response mediated by gene-modified CD4+ T helper-1 and CD8+ T cells. Cancer Res (2007) 1.06
The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene. J Exp Med (2004) 1.05
Assaying cytochrome C translocation during apoptosis. Methods Mol Biol (2004) 1.05
Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells. Mol Cell Biol (2005) 1.04
Tumor ablation by gene-modified T cells in the absence of autoimmunity. Cancer Res (2010) 1.04
A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells. Cancer Gene Ther (2004) 1.03
Discordant regulation of granzyme H and granzyme B expression in human lymphocytes. J Biol Chem (2004) 1.03
Granzyme M mediates a novel form of perforin-dependent cell death. J Biol Chem (2004) 1.01
Cathepsin H is an additional convertase of pro-granzyme B. J Biol Chem (2010) 0.99
Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation. Proc Natl Acad Sci U S A (2006) 0.99
Cutting edge: rapid and efficient in vivo cytotoxicity by cytotoxic T cells is independent of granzymes A and B. J Immunol (2009) 0.98
Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis. J Cell Biol (2007) 0.97
Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid. Diabetes (2006) 0.96
Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis. J Cell Biol (2006) 0.95
Purification of natural killer cell cytotoxic granules for assaying target cell apoptosis. J Immunol Methods (2003) 0.95
Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection. J Immunol (2003) 0.94
A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes. J Biol Chem (2006) 0.94
Perforin-mediated suppression of B-cell lymphoma. Proc Natl Acad Sci U S A (2009) 0.94
Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice. Viral Immunol (2008) 0.94
A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells. J Immunol (2011) 0.92
Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi. BMC Evol Biol (2012) 0.91
Expression of IFI 16 in epithelial cells and lymphoid tissues. Histochem Cell Biol (2002) 0.91
The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serum. J Immunother (2009) 0.90
Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones. Bioorg Med Chem (2011) 0.90
Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin. J Med Chem (2013) 0.90
Homeostatic defects in interleukin 18-deficient mice contribute to protection against the lethal effects of endotoxin. Immunol Cell Biol (2011) 0.88
Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis. Immunol Cell Biol (2006) 0.87
Addressing the mysteries of perforin function. Immunol Cell Biol (2006) 0.87
Cytotoxic lymphocytes; instigators of dramatic target cell death. Biochem Pharmacol (2004) 0.86
A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death. Transplantation (2006) 0.86
Defining the interaction of perforin with calcium and the phospholipid membrane. Biochem J (2013) 0.85
Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology (2010) 0.85
Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules. Methods (2008) 0.83
Inhibition of the cellular function of perforin by 1-amino-2,4-dicyanopyrido[1,2-a]benzimidazoles. Bioorg Med Chem (2011) 0.83
Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice. PLoS One (2012) 0.82
Activated mouse B cells lack expression of granzyme B. J Immunol (2012) 0.82
Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin. J Med Chem (2008) 0.81
Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: modulation by the serpin inhibitor PI-9. J Cell Biochem (2005) 0.81
Proteolytic activation of the cytotoxic phenotype during human NK cell development. J Immunol (2009) 0.81
The role of p202 in regulating hematopoietic cell proliferation and differentiation. J Interferon Cytokine Res (2008) 0.80
The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains. Tissue Antigens (2007) 0.79
The perforin pore facilitates the delivery of cationic cargos. J Biol Chem (2014) 0.79
Cloning and characterisation of Ifi206: a new murine HIN-200 family member. J Cell Biochem (2008) 0.78
Fatal immune dysregulation due to a gain of glycosylation mutation in lymphocyte perforin. Blood (2011) 0.78
H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells. Trends Immunol (2007) 0.77
Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy. J Clin Invest (2017) 0.76
Cathepsin C limits acute viral infection independently of NK cell and CD8+ T-cell cytolytic function. Immunol Cell Biol (2010) 0.76
Functional role of phosphatidylinositol 3-kinase in direct tumor lysis by human natural killer cells. Immunobiology (2002) 0.76
Incentives: encouraging adventurous ideas. Science (2010) 0.75
A novel role for granzymes in anti-tumor immunity. Oncoimmunology (2012) 0.75
Granzyme H is a novel protease expressed by human mast cells. Int Arch Allergy Immunol (2014) 0.75
Cloning and characterising an unusual perforin from chicken (Gallus gallus). Dev Comp Immunol (2013) 0.75
Proteases in lymphocyte killer function: redundancy, polymorphism and questions remaining. Biol Chem (2010) 0.75
Immunotherapy of cancer. Aust Fam Physician (2017) 0.75