Published in Methods Mol Biol on January 01, 2004
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell (2006) 10.19
Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax. Diabetes (2009) 1.37
Mitochondria-targeted drugs enhance Nlrp3 inflammasome-dependent IL-1β secretion in association with alterations in cellular redox and energy status. Free Radic Biol Med (2013) 0.92
Neisseria gonorrhoeae-mediated inhibition of apoptotic signalling in polymorphonuclear leukocytes. Infect Immun (2011) 0.91
Reovirus infection or ectopic expression of outer capsid protein micro1 induces apoptosis independently of the cellular proapoptotic proteins Bax and Bak. J Virol (2010) 0.88
The Makes Caterpillars Floppy (MCF)-Like Domain of Vibrio vulnificus Induces Mitochondrion-Mediated Apoptosis. Infect Immun (2015) 0.82
Induced autoprocessing of the cytopathic Makes caterpillars floppy-like effector domain of the Vibrio vulnificus MARTX toxin. Cell Microbiol (2015) 0.81
Proximal events in 7,12-dimethylbenz[a]anthracene-induced, stromal cell-dependent bone marrow B cell apoptosis: stromal cell-B cell communication and apoptosis signaling. J Immunol (2010) 0.80
Hsp27 binding to the 3'UTR of bim mRNA prevents neuronal death during oxidative stress-induced injury: a novel cytoprotective mechanism. Mol Biol Cell (2014) 0.78
Francisella tularensis Modulates a Distinct Subset of Regulatory Factors and Sustains Mitochondrial Integrity to Impair Human Neutrophil Apoptosis. J Innate Immun (2016) 0.77
c-FLIP protects T lymphocytes from apoptosis in the intrinsic pathway. J Immunol (2015) 0.76
Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization. Autophagy (2016) 0.75
AMPK is a direct adenylate charge-regulated protein kinase. Science (2011) 3.58
A common fold mediates vertebrate defense and bacterial attack. Science (2007) 3.43
The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy. Blood (2010) 3.23
Perforin-mediated target-cell death and immune homeostasis. Nat Rev Immunol (2006) 3.04
β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK). Proc Natl Acad Sci U S A (2010) 2.28
The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature (2010) 2.23
The MACPF/CDC family of pore-forming toxins. Cell Microbiol (2008) 2.15
The molecular basis for perforin oligomerization and transmembrane pore assembly. Immunity (2009) 1.98
Suppression of lymphoma and epithelial malignancies effected by interferon gamma. J Exp Med (2002) 1.85
Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors. Blood (2002) 1.83
Novel mechanisms of apoptosis induced by histone deacetylase inhibitors. Cancer Res (2003) 1.73
Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes. Immunity (2011) 1.73
Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack. Blood (2013) 1.53
The major human and mouse granzymes are structurally and functionally divergent. J Cell Biol (2006) 1.48
Functional crosstalk between type I and II interferon through the regulated expression of STAT1. PLoS Biol (2010) 1.40
Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. Immunity (2002) 1.39
Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin. J Biol Chem (2005) 1.39
Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia. Mol Ther (2013) 1.33
Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2. Biochem Biophys Res Commun (2005) 1.32
Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation. J Immunol (2002) 1.31
Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491. J Biol Chem (2004) 1.31
Perforin: structure, function, and role in human immunopathology. Immunol Rev (2010) 1.30
Apoptosis induced by the lymphocyte effector molecule perforin. Curr Opin Immunol (2007) 1.29
Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer. J Immunol (2004) 1.24
AMPK-independent pathways regulate skeletal muscle fatty acid oxidation. J Physiol (2008) 1.23
Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors. Immunity (2003) 1.23
Perforin and granzymes: function, dysfunction and human pathology. Nat Rev Immunol (2015) 1.23
A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis. Blood (2005) 1.22
The battlefield of perforin/granzyme cell death pathways. J Leukoc Biol (2009) 1.18
hScrib is a functional homologue of the Drosophila tumour suppressor Scribble. Oncogene (2003) 1.15
Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice. Proc Natl Acad Sci U S A (2005) 1.14
Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer. Proc Natl Acad Sci U S A (2009) 1.14
A role for granzyme M in TLR4-driven inflammation and endotoxicosis. J Immunol (2010) 1.13
Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells. J Biol Chem (2006) 1.13
Functional dissection of the granzyme family: cell death and inflammation. Immunol Rev (2010) 1.12
Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways. Diabetes (2006) 1.12
Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function. Blood (2007) 1.10
A central role for Bid in granzyme B-induced apoptosis. J Biol Chem (2004) 1.10
Adoptive transfer of gene-engineered CD4+ helper T cells induces potent primary and secondary tumor rejection. Blood (2005) 1.10
Endolysosomal proteases and their inhibitors in immunity. Nat Rev Immunol (2009) 1.10
Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death. Trends Immunol (2012) 1.09
Perforin and Fas induced by IFNgamma and TNFalpha mediate beta cell death by OT-I CTL. Int Immunol (2006) 1.08
Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse. J Immunol (2013) 1.08
Granzyme B encoded by the commonly occurring human RAH allele retains pro-apoptotic activity. J Biol Chem (2004) 1.07
Sustained antigen-specific antitumor recall response mediated by gene-modified CD4+ T helper-1 and CD8+ T cells. Cancer Res (2007) 1.06
The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene. J Exp Med (2004) 1.05
Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells. Mol Cell Biol (2005) 1.04
Tumor ablation by gene-modified T cells in the absence of autoimmunity. Cancer Res (2010) 1.04
A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells. Cancer Gene Ther (2004) 1.03
Discordant regulation of granzyme H and granzyme B expression in human lymphocytes. J Biol Chem (2004) 1.03
Granzyme M mediates a novel form of perforin-dependent cell death. J Biol Chem (2004) 1.01
Cathepsin H is an additional convertase of pro-granzyme B. J Biol Chem (2010) 0.99
Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation. Proc Natl Acad Sci U S A (2006) 0.99
Cutting edge: rapid and efficient in vivo cytotoxicity by cytotoxic T cells is independent of granzymes A and B. J Immunol (2009) 0.98
Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis. J Cell Biol (2007) 0.97
Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid. Diabetes (2006) 0.96
Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis. J Cell Biol (2006) 0.95
Rho-associated coiled-coil kinase (ROCK) protein controls microtubule dynamics in a novel signaling pathway that regulates cell migration. J Biol Chem (2012) 0.95
Purification of natural killer cell cytotoxic granules for assaying target cell apoptosis. J Immunol Methods (2003) 0.95
Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice. Viral Immunol (2008) 0.94
Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection. J Immunol (2003) 0.94
A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes. J Biol Chem (2006) 0.94
Perforin-mediated suppression of B-cell lymphoma. Proc Natl Acad Sci U S A (2009) 0.94
Cytotoxic activity of the lymphocyte toxin granzyme B. Microbes Infect (2004) 0.94
A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells. J Immunol (2011) 0.92
Expression of IFI 16 in epithelial cells and lymphoid tissues. Histochem Cell Biol (2002) 0.91
Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi. BMC Evol Biol (2012) 0.91
Hsp72 inhibits Fas-mediated apoptosis upstream of the mitochondria in type II cells. J Biol Chem (2005) 0.90
The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serum. J Immunother (2009) 0.90
Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones. Bioorg Med Chem (2011) 0.90
Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin. J Med Chem (2013) 0.90
Hsp72 chaperone function is dispensable for protection against stress-induced apoptosis. Cell Stress Chaperones (2008) 0.89
Homeostatic defects in interleukin 18-deficient mice contribute to protection against the lethal effects of endotoxin. Immunol Cell Biol (2011) 0.88
Ca2+/Calmodulin-dependent protein kinase kinase beta is regulated by multisite phosphorylation. J Biol Chem (2011) 0.88
Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis. Immunol Cell Biol (2006) 0.87
Addressing the mysteries of perforin function. Immunol Cell Biol (2006) 0.87
Cytotoxic lymphocytes; instigators of dramatic target cell death. Biochem Pharmacol (2004) 0.86
A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death. Transplantation (2006) 0.86
Defining the interaction of perforin with calcium and the phospholipid membrane. Biochem J (2013) 0.85
Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology (2010) 0.85
Cyclin-dependent kinase-mediated phosphorylation of RBP1 and pRb promotes their dissociation to mediate release of the SAP30·mSin3·HDAC transcriptional repressor complex. J Biol Chem (2010) 0.83
Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules. Methods (2008) 0.83
Inhibition of the cellular function of perforin by 1-amino-2,4-dicyanopyrido[1,2-a]benzimidazoles. Bioorg Med Chem (2011) 0.83
Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice. PLoS One (2012) 0.82
Activated mouse B cells lack expression of granzyme B. J Immunol (2012) 0.82
Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin. J Med Chem (2008) 0.81
Proteolytic activation of the cytotoxic phenotype during human NK cell development. J Immunol (2009) 0.81
Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: modulation by the serpin inhibitor PI-9. J Cell Biochem (2005) 0.81
The role of p202 in regulating hematopoietic cell proliferation and differentiation. J Interferon Cytokine Res (2008) 0.80
The perforin pore facilitates the delivery of cationic cargos. J Biol Chem (2014) 0.79
The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains. Tissue Antigens (2007) 0.79
Fatal immune dysregulation due to a gain of glycosylation mutation in lymphocyte perforin. Blood (2011) 0.78
Cloning and characterisation of Ifi206: a new murine HIN-200 family member. J Cell Biochem (2008) 0.78
A high-throughput LC-MS/MS screen for GHRP in equine and human urine, featuring peptide derivatization for improved chromatography. Drug Test Anal (2014) 0.78
Pro-GRP-derived peptides are expressed in colorectal cancer cells and tumors and are biologically active in vivo. Endocrinology (2011) 0.77
H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells. Trends Immunol (2007) 0.77
Functional role of phosphatidylinositol 3-kinase in direct tumor lysis by human natural killer cells. Immunobiology (2002) 0.76
Cathepsin C limits acute viral infection independently of NK cell and CD8+ T-cell cytolytic function. Immunol Cell Biol (2010) 0.76
Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy. J Clin Invest (2017) 0.76
Activation of AMPK reduces the co-transporter activity of NKCC1. Mol Membr Biol (2014) 0.76