Published in Blood on March 08, 2005
Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH. Blood (2011) 2.55
The MACPF/CDC family of pore-forming toxins. Cell Microbiol (2008) 2.15
Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis. J Clin Invest (2005) 1.18
Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer. Proc Natl Acad Sci U S A (2009) 1.14
Human NK cell lytic granules and regulation of their exocytosis. Front Immunol (2012) 1.10
Spectrum and clinical implications of syntaxin 11 gene mutations in familial haemophagocytic lymphohistiocytosis: association with disease-free remissions and haematopoietic malignancies. J Med Genet (2006) 1.09
Perforin gene mutations in patients with acquired aplastic anemia. Blood (2007) 1.07
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Human perforin mutations and susceptibility to multiple primary cancers. Oncoimmunology (2013) 0.90
Human immunodeficiency syndromes affecting human natural killer cell cytolytic activity. Front Immunol (2014) 0.88
Analysis of the -398C/T polymorphism in the perforin gene in oncohematological patients. Rev Bras Hematol Hemoter (2011) 0.87
Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals. Immunol Cell Biol (2015) 0.81
Modulatory effects of perforin gene dosage on pathogen-associated blood-brain barrier (BBB) disruption. J Neuroinflammation (2016) 0.76
Variations of the perforin gene in patients with chronic inflammatory demyelinating polyradiculoneuropathy. Genes Immun (2014) 0.75
Molecular study of the perforin gene in familial hematological malignancies. Hered Cancer Clin Pract (2011) 0.75
Immunologic difference between hypersensitivity to mosquito bite and hemophagocytic lymphohistiocytosis associated with Epstein-Barr virus infection. PLoS One (2013) 0.75
A mutation in caspase-9 decreases the expression of BAFFR and ICOS in patients with immunodeficiency and lymphoproliferation. Genes Immun (2015) 0.75
An A91V SNP in the perforin gene is frequently found in NK/T-cell lymphomas. PLoS One (2014) 0.75
Quantification of ATP7B Protein in Dried Blood Spots by Peptide Immuno-SRM as a Potential Screen for Wilson's Disease. J Proteome Res (2016) 0.75
A common fold mediates vertebrate defense and bacterial attack. Science (2007) 3.43
The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy. Blood (2010) 3.23
Perforin-mediated target-cell death and immune homeostasis. Nat Rev Immunol (2006) 3.04
The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature (2010) 2.23
The MACPF/CDC family of pore-forming toxins. Cell Microbiol (2008) 2.15
The molecular basis for perforin oligomerization and transmembrane pore assembly. Immunity (2009) 1.98
Suppression of lymphoma and epithelial malignancies effected by interferon gamma. J Exp Med (2002) 1.85
Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors. Blood (2002) 1.83
Novel mechanisms of apoptosis induced by histone deacetylase inhibitors. Cancer Res (2003) 1.73
Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes. Immunity (2011) 1.73
Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack. Blood (2013) 1.53
The major human and mouse granzymes are structurally and functionally divergent. J Cell Biol (2006) 1.48
Functional crosstalk between type I and II interferon through the regulated expression of STAT1. PLoS Biol (2010) 1.40
Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. Immunity (2002) 1.39
Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin. J Biol Chem (2005) 1.39
Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia. Mol Ther (2013) 1.33
Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2. Biochem Biophys Res Commun (2005) 1.32
Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation. J Immunol (2002) 1.31
Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491. J Biol Chem (2004) 1.31
Perforin: structure, function, and role in human immunopathology. Immunol Rev (2010) 1.30
Apoptosis induced by the lymphocyte effector molecule perforin. Curr Opin Immunol (2007) 1.29
Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer. J Immunol (2004) 1.24
Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors. Immunity (2003) 1.23
Perforin and granzymes: function, dysfunction and human pathology. Nat Rev Immunol (2015) 1.23
The battlefield of perforin/granzyme cell death pathways. J Leukoc Biol (2009) 1.18
hScrib is a functional homologue of the Drosophila tumour suppressor Scribble. Oncogene (2003) 1.15
Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice. Proc Natl Acad Sci U S A (2005) 1.14
Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer. Proc Natl Acad Sci U S A (2009) 1.14
Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells. J Biol Chem (2006) 1.13
A role for granzyme M in TLR4-driven inflammation and endotoxicosis. J Immunol (2010) 1.13
Functional dissection of the granzyme family: cell death and inflammation. Immunol Rev (2010) 1.12
Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways. Diabetes (2006) 1.12
Endolysosomal proteases and their inhibitors in immunity. Nat Rev Immunol (2009) 1.10
Adoptive transfer of gene-engineered CD4+ helper T cells induces potent primary and secondary tumor rejection. Blood (2005) 1.10
A central role for Bid in granzyme B-induced apoptosis. J Biol Chem (2004) 1.10
Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function. Blood (2007) 1.10
Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death. Trends Immunol (2012) 1.09
Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse. J Immunol (2013) 1.08
Perforin and Fas induced by IFNgamma and TNFalpha mediate beta cell death by OT-I CTL. Int Immunol (2006) 1.08
Granzyme B encoded by the commonly occurring human RAH allele retains pro-apoptotic activity. J Biol Chem (2004) 1.07
Sustained antigen-specific antitumor recall response mediated by gene-modified CD4+ T helper-1 and CD8+ T cells. Cancer Res (2007) 1.06
The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene. J Exp Med (2004) 1.05
Assaying cytochrome C translocation during apoptosis. Methods Mol Biol (2004) 1.05
Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells. Mol Cell Biol (2005) 1.04
Tumor ablation by gene-modified T cells in the absence of autoimmunity. Cancer Res (2010) 1.04
A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells. Cancer Gene Ther (2004) 1.03
Discordant regulation of granzyme H and granzyme B expression in human lymphocytes. J Biol Chem (2004) 1.03
Granzyme M mediates a novel form of perforin-dependent cell death. J Biol Chem (2004) 1.01
Cathepsin H is an additional convertase of pro-granzyme B. J Biol Chem (2010) 0.99
Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation. Proc Natl Acad Sci U S A (2006) 0.99
Cutting edge: rapid and efficient in vivo cytotoxicity by cytotoxic T cells is independent of granzymes A and B. J Immunol (2009) 0.98
Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis. J Cell Biol (2007) 0.97
Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid. Diabetes (2006) 0.96
Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis. J Cell Biol (2006) 0.95
Purification of natural killer cell cytotoxic granules for assaying target cell apoptosis. J Immunol Methods (2003) 0.95
Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection. J Immunol (2003) 0.94
Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice. Viral Immunol (2008) 0.94
Perforin-mediated suppression of B-cell lymphoma. Proc Natl Acad Sci U S A (2009) 0.94
A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes. J Biol Chem (2006) 0.94
Cytotoxic activity of the lymphocyte toxin granzyme B. Microbes Infect (2004) 0.94
A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells. J Immunol (2011) 0.92
Expression of IFI 16 in epithelial cells and lymphoid tissues. Histochem Cell Biol (2002) 0.91
Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi. BMC Evol Biol (2012) 0.91
The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serum. J Immunother (2009) 0.90
Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin. J Med Chem (2013) 0.90
Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones. Bioorg Med Chem (2011) 0.90
Homeostatic defects in interleukin 18-deficient mice contribute to protection against the lethal effects of endotoxin. Immunol Cell Biol (2011) 0.88
Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis. Immunol Cell Biol (2006) 0.87
Addressing the mysteries of perforin function. Immunol Cell Biol (2006) 0.87
A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death. Transplantation (2006) 0.86
Cytotoxic lymphocytes; instigators of dramatic target cell death. Biochem Pharmacol (2004) 0.86
Defining the interaction of perforin with calcium and the phospholipid membrane. Biochem J (2013) 0.85
Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology (2010) 0.85
Inhibition of the cellular function of perforin by 1-amino-2,4-dicyanopyrido[1,2-a]benzimidazoles. Bioorg Med Chem (2011) 0.83
Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules. Methods (2008) 0.83
Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice. PLoS One (2012) 0.82
Activated mouse B cells lack expression of granzyme B. J Immunol (2012) 0.82
Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin. J Med Chem (2008) 0.81
Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: modulation by the serpin inhibitor PI-9. J Cell Biochem (2005) 0.81
Proteolytic activation of the cytotoxic phenotype during human NK cell development. J Immunol (2009) 0.81
The role of p202 in regulating hematopoietic cell proliferation and differentiation. J Interferon Cytokine Res (2008) 0.80
The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains. Tissue Antigens (2007) 0.79
The perforin pore facilitates the delivery of cationic cargos. J Biol Chem (2014) 0.79
Fatal immune dysregulation due to a gain of glycosylation mutation in lymphocyte perforin. Blood (2011) 0.78
Cloning and characterisation of Ifi206: a new murine HIN-200 family member. J Cell Biochem (2008) 0.78
H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells. Trends Immunol (2007) 0.77
Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy. J Clin Invest (2017) 0.76
Cathepsin C limits acute viral infection independently of NK cell and CD8+ T-cell cytolytic function. Immunol Cell Biol (2010) 0.76
Functional role of phosphatidylinositol 3-kinase in direct tumor lysis by human natural killer cells. Immunobiology (2002) 0.76
A novel role for granzymes in anti-tumor immunity. Oncoimmunology (2012) 0.75
Incentives: encouraging adventurous ideas. Science (2010) 0.75
Granzyme H is a novel protease expressed by human mast cells. Int Arch Allergy Immunol (2014) 0.75
Proteases in lymphocyte killer function: redundancy, polymorphism and questions remaining. Biol Chem (2010) 0.75
Immunotherapy of cancer. Aust Fam Physician (2017) 0.75
Cloning and characterising an unusual perforin from chicken (Gallus gallus). Dev Comp Immunol (2013) 0.75