B-RAF is a therapeutic target in melanoma.

PubWeight™: 3.61‹?› | Rank: Top 1%

🔗 View Article (PMID 15208680)

Published in Oncogene on August 19, 2004

Authors

Maria Karasarides1, Antonio Chiloeches, Robert Hayward, Dan Niculescu-Duvaz, Ian Scanlon, Frank Friedlos, Lesley Ogilvie, Douglas Hedley, Jan Martin, Christopher J Marshall, Caroline J Springer, Richard Marais

Author Affiliations

1: Signal Transduction Team, The Cancer Research UK Centre for Cell and Molecular Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.

Articles citing this

BRAF mutation predicts sensitivity to MEK inhibition. Nature (2005) 17.14

Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. Lancet (2012) 6.21

Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis. Br J Cancer (2006) 4.93

Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF. Cancer Cell (2013) 3.63

Vemurafenib: the first drug approved for BRAF-mutant cancer. Nat Rev Drug Discov (2012) 3.09

Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy. Br J Cancer (2010) 2.83

Melanoma: from mutations to medicine. Genes Dev (2012) 2.59

From genes to drugs: targeted strategies for melanoma. Nat Rev Cancer (2012) 2.46

Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells. Cancer Res (2010) 2.42

Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development. Cancer Res (2008) 2.18

Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action? Angiogenesis (2009) 2.15

Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF. PLoS One (2008) 2.15

The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress. Mol Cell Biol (2007) 2.07

PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas. Pigment Cell Melanoma Res (2010) 2.02

Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts. Cancer Res (2005) 1.93

Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation. J Cell Biol (2005) 1.66

Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells. Am J Physiol Renal Physiol (2010) 1.58

Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels. Br J Cancer (2007) 1.57

Targeting BRAF for patients with melanoma. Br J Cancer (2010) 1.56

NF-kappaB activation in melanoma. Pigment Cell Res (2006) 1.55

Melanoma: new insights and new therapies. J Invest Dermatol (2012) 1.54

Melanoma genetics and the development of rational therapeutics. J Clin Invest (2005) 1.50

Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM. Oncogene (2008) 1.38

V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a. EMBO Mol Med (2010) 1.36

Targeting the MAPK pathway in melanoma: why some approaches succeed and other fail. Biochem Pharmacol (2010) 1.36

Analysis of the genome to personalize therapy for melanoma. Oncogene (2010) 1.33

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the (V600E)BRAF oncogene. Oncotarget (2013) 1.32

The use of COLD-PCR and high-resolution melting analysis improves the limit of detection of KRAS and BRAF mutations in colorectal cancer. J Mol Diagn (2010) 1.26

BH3-only protein silencing contributes to acquired resistance to PLX4720 in human melanoma. Cell Death Differ (2012) 1.24

Targeting mutant BRAF in melanoma: current status and future development of combination therapy strategies. Cancer J (2012) 1.18

Detection of mutant BRAF alleles in the plasma of patients with metastatic melanoma. J Mol Diagn (2007) 1.18

A phase II trial of sorafenib in metastatic melanoma with tissue correlates. PLoS One (2010) 1.17

NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma. Br J Cancer (2009) 1.13

Phosphoproteomics in cancer. Mol Oncol (2010) 1.12

Phase I study of the combination of sorafenib and temsirolimus in patients with metastatic melanoma. Clin Cancer Res (2012) 1.11

Emerging targeted therapies for melanoma treatment (review). Int J Oncol (2014) 1.10

Understanding signaling cascades in melanoma. Photochem Photobiol (2007) 1.10

Network-guided analysis of genes with altered somatic copy number and gene expression reveals pathways commonly perturbed in metastatic melanoma. PLoS One (2011) 1.09

RAF265 inhibits the growth of advanced human melanoma tumors. Clin Cancer Res (2012) 1.09

A selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyADP-ribose polymerase inhibitors. Breast Cancer Res (2009) 1.08

Clinical implementation of comprehensive strategies to characterize cancer genomes: opportunities and challenges. Cancer Discov (2011) 1.07

Genotype-dependent sensitivity of uveal melanoma cell lines to inhibition of B-Raf, MEK, and Akt kinases: rationale for personalized therapy. Invest Ophthalmol Vis Sci (2011) 1.07

The roles of microphthalmia-associated transcription factor and pigmentation in melanoma. Arch Biochem Biophys (2014) 1.05

Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor. Mol Cell Biol (2005) 1.04

The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway. Genes Dev (2012) 1.04

Melanoma-restricted genes. J Transl Med (2004) 1.03

Dabrafenib; preclinical characterization, increased efficacy when combined with trametinib, while BRAF/MEK tool combination reduced skin lesions. PLoS One (2013) 1.02

SHOC2 and CRAF mediate ERK1/2 reactivation in mutant NRAS-mediated resistance to RAF inhibitor. J Biol Chem (2012) 1.01

Molecular pathways: BRAF induces bioenergetic adaptation by attenuating oxidative phosphorylation. Clin Cancer Res (2014) 0.98

RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma. Oncogene (2011) 0.98

Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. J Biol Chem (2012) 0.97

Melanoma: Stem cells, sun exposure and hallmarks for carcinogenesis, molecular concepts and future clinical implications. J Carcinog (2010) 0.97

C-Raf is associated with disease progression and cell proliferation in a subset of melanomas. Clin Cancer Res (2009) 0.97

G-protein-coupled receptors and melanoma. Pigment Cell Melanoma Res (2008) 0.97

PDGFRα up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation. Oncotarget (2014) 0.94

BRAF inhibitors in clinical oncology. F1000Prime Rep (2013) 0.93

Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives. Cancer Res (2008) 0.92

C-RAF mutations confer resistance to RAF inhibitors. Cancer Res (2013) 0.91

Vemurafenib: a new treatment for BRAF-V600 mutated advanced melanoma. Cancer Manag Res (2012) 0.91

Targeted inhibition of BRAF kinase: opportunities and challenges for therapeutics in melanoma. Biosci Rep (2012) 0.90

Targeted therapy for melanoma: a primer. Surg Oncol Clin N Am (2011) 0.89

Differential regulation of B-raf isoforms by phosphorylation and autoinhibitory mechanisms. Mol Cell Biol (2006) 0.89

Targeting drivers of melanoma with synthetic small molecules and phytochemicals. Cancer Lett (2015) 0.88

Delivery of intracellular-acting biologics in pro-apoptotic therapies. Curr Pharm Des (2011) 0.87

A Combined Pharmacophore Modeling, 3D QSAR and Virtual Screening Studies on Imidazopyridines as B-Raf Inhibitors. Int J Mol Sci (2015) 0.87

Thyroid cancer: current molecular perspectives. J Oncol (2010) 0.87

Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations. BMC Cancer (2009) 0.86

BRAF inhibitor dabrafenib in patients with metastatic BRAF-mutant thyroid cancer. Thyroid (2015) 0.86

The current state of targeted therapy in melanoma: this time it's personal. Semin Oncol (2012) 0.86

Recent discoveries in the genetics of melanoma and their therapeutic implications. Arch Immunol Ther Exp (Warsz) (2007) 0.85

Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf. Eur J Pharmacol (2009) 0.85

Overview of human primary tumorgraft models: comparisons with traditional oncology preclinical models and the clinical relevance and utility of primary tumorgrafts in basic and translational oncology research. Curr Protoc Pharmacol (2012) 0.85

The Complexity of the ERK/MAP-Kinase Pathway and the Treatment of Melanoma Skin Cancer. Front Cell Dev Biol (2016) 0.83

Detection of BRAF V600E activating mutation in papillary thyroid carcinoma using PCR with allele-specific fluorescent probe melting curve analysis. J Clin Pathol (2007) 0.83

Deltex-3-like (DTX3L) stimulates metastasis of melanoma through FAK/PI3K/AKT but not MEK/ERK pathway. Oncotarget (2015) 0.83

A novel, selective, and efficacious nanomolar pyridopyrazinone inhibitor of V600EBRAF. Cancer Res (2010) 0.83

GNAS1 T393C polymorphism and disease progression in patients with malignant melanoma. Eur J Med Res (2010) 0.83

BAD contributes to RAF-mediated proliferation and cooperates with B-RAF-V600E in cancer signaling. J Biol Chem (2011) 0.82

The potential for BRAF V600 inhibitors in advanced cutaneous melanoma: rationale and latest evidence. Ther Adv Med Oncol (2012) 0.82

Sorafenib inhibits tumor growth and vascularization of rhabdomyosarcoma cells by blocking IGF-1R-mediated signaling. Onco Targets Ther (2008) 0.82

Current and future trials of targeted therapies in cutaneous melanoma. Adv Exp Med Biol (2013) 0.81

Epigenetic manipulation of gene expression: a toolkit for cell biologists. J Cell Biol (2005) 0.81

Sorafenib and dacarbazine as first-line therapy for advanced melanoma: phase I and open-label phase II studies. Br J Cancer (2011) 0.80

Raf-1 activation prevents caspase 9 processing downstream of apoptosome formation. J Signal Transduct (2010) 0.79

Novel treatments for metastatic cutaneous melanoma and the management of emergent toxicities. Clin Med Insights Oncol (2012) 0.79

The immune-related role of BRAF in melanoma. Mol Oncol (2014) 0.78

Expression of drug targets in patients treated with sorafenib, carboplatin and paclitaxel. PLoS One (2013) 0.78

Melanoma: oncogenic drivers and the immune system. Ann Transl Med (2015) 0.78

BRAF drives synovial fibroblast transformation in rheumatoid arthritis. J Biol Chem (2010) 0.77

The RAS/mitogen activated protein (MAP) kinase pathway in melanoma biology and therapeutics. Biologics (2007) 0.77

Effect of HIF-1α on biological activation of human tongue squamous cell carcinoma SCC-15 cells in vitro. Int J Oncol (2015) 0.76

Challenges in the delivery of therapies to melanoma brain metastases. Curr Pharmacol Rep (2016) 0.75

Inducible Mouse Models for Cancer Drug Target Validation. J Cancer Prev (2016) 0.75

Immunotherapy in the management of melanoma: current status. Immunotargets Ther (2013) 0.75

Potential therapeutic targets of epithelial-mesenchymal transition in melanoma. Cancer Lett (2017) 0.75

Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Resistance with Combination Therapy for Melanoma Brain Metastases. J Pharmacol Exp Ther (2015) 0.75

An Investigation of Molecular Docking and Molecular Dynamic Simulation on Imidazopyridines as B-Raf Kinase Inhibitors. Int J Mol Sci (2015) 0.75

Modification, biological evaluation and 3D QSAR studies of novel 2-(1,3-diaryl- 4,5-dihydro-1H-pyrazol-5-yl)phenol derivatives as inhibitors of B-Raf kinase. PLoS One (2014) 0.75

Articles by these authors

Mutations of the BRAF gene in human cancer. Nature (2002) 65.42

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell (2004) 19.51

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell (2010) 17.48

Melanoma biology and new targeted therapy. Nature (2007) 10.71

The RAF proteins take centre stage. Nat Rev Mol Cell Biol (2004) 8.04

RHO-GTPases and cancer. Nat Rev Cancer (2002) 8.03

Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol (2003) 7.93

RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N Engl J Med (2012) 6.93

Rac activation and inactivation control plasticity of tumor cell movement. Cell (2008) 6.01

Guilty as charged: B-RAF is a human oncogene. Cancer Cell (2004) 4.97

Oncogenic Braf induces melanocyte senescence and melanoma in mice. Cancer Cell (2009) 4.76

V599EB-RAF is an oncogene in melanocytes. Cancer Res (2004) 4.49

In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling. Cancer Res (2006) 4.29

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization. Mol Cell (2005) 4.24

Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A. Cancer Cell (2011) 4.02

Gatekeeper mutations mediate resistance to BRAF-targeted therapies. Sci Transl Med (2010) 3.98

ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility. Cancer Cell (2003) 3.28

Tips for learning and teaching evidence-based medicine: introduction to the series. CMAJ (2004) 3.23

ROCK and Dia have opposing effects on adherens junctions downstream of Rho. Nat Cell Biol (2002) 3.16

RalGDS is required for tumor formation in a model of skin carcinogenesis. Cancer Cell (2005) 3.09

Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. Nat Cell Biol (2005) 3.02

ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma. Cancer Cell (2011) 2.77

A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Nat Cell Biol (2013) 2.59

Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia. Cancer Cell (2011) 2.57

Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma. Cancer Discov (2012) 2.56

Identification of direct transcriptional targets of (V600E)BRAF/MEK signalling in melanoma. Pigment Cell Melanoma Res (2009) 2.42

New insight into BRAF mutations in cancer. Curr Opin Genet Dev (2007) 2.40

Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin. Cancer Res (2005) 2.34

RAS and RHO GTPases in G1-phase cell-cycle regulation. Nat Rev Mol Cell Biol (2004) 2.24

ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesis. Cancer Cell (2006) 2.20

Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF. PLoS One (2008) 2.15

The plasticity of cytoskeletal dynamics underlying neoplastic cell migration. Curr Opin Cell Biol (2010) 2.13

Wood ingestion by passalid beetles in the presence of xylose-fermenting gut yeasts. Mol Ecol (2003) 2.08

Effect of SMURF2 targeting on susceptibility to MEK inhibitors in melanoma. J Natl Cancer Inst (2012) 2.01

Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead. J Med Chem (2006) 1.94

Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts. Cancer Res (2005) 1.93

Whole genome sequencing of matched primary and metastatic acral melanomas. Genome Res (2011) 1.90

Metagenomic marine nitrogen fixation--feast or famine? Trends Microbiol (2005) 1.89

Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft für Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels. FEBS J (2005) 1.88

Analysis of the efficacy and toxicity of sorafenib in thyroid cancer: a phase II study in a UK based population. Eur J Endocrinol (2011) 1.82

Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice. Proc Natl Acad Sci U S A (2011) 1.82

Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis. Cancer Res (2004) 1.81

DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells. Curr Biol (2008) 1.75

BRAF signaling and targeted therapies in melanoma. Hematol Oncol Clin North Am (2009) 1.74

Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF. Cancer Res (2005) 1.71

Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation. J Cell Biol (2005) 1.66

Pyridoimidazolones as novel potent inhibitors of v-Raf murine sarcoma viral oncogene homologue B1 (BRAF). J Med Chem (2009) 1.65

Intravital imaging reveals transient changes in pigment production and Brn2 expression during metastatic melanoma dissemination. Cancer Res (2009) 1.63

FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2. EMBO J (2006) 1.61

Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras. J Biol Chem (2003) 1.58

Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation. EMBO J (2003) 1.55

Elucidating distinct roles for NF1 in melanomagenesis. Cancer Discov (2012) 1.53

The role of B-RAF in melanoma. Cancer Metastasis Rev (2005) 1.53

Tumor necrosis factor-alpha blocks apoptosis in melanoma cells when BRAF signaling is inhibited. Cancer Res (2007) 1.50

MicroRNA-200 family members differentially regulate morphological plasticity and mode of melanoma cell invasion. PLoS One (2010) 1.50

Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins. Mol Cell Biol (2008) 1.50

Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor. Science (2009) 1.47

Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation. Biochim Biophys Acta (2004) 1.45

BRAF inhibitors induce metastasis in RAS mutant or inhibitor-resistant melanoma cells by reactivating MEK and ERK signaling. Sci Signal (2014) 1.44

uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180. J Cell Biol (2008) 1.43

V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a. EMBO Mol Med (2010) 1.36

Carboxypeptidase-G2-based gene-directed enzyme-prodrug therapy: a new weapon in the GDEPT armoury. Nat Rev Cancer (2007) 1.33

Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A. Cancer Discov (2012) 1.33

Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cells. J Cell Sci (2003) 1.32