Published in Nat Med on July 04, 2004
Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer (2008) 15.20
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell (2008) 8.01
Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest (2007) 6.31
Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med (2006) 6.04
Trophic macrophages in development and disease. Nat Rev Immunol (2009) 5.37
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nat Med (2006) 5.22
Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc Natl Acad Sci U S A (2007) 4.81
A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood (2007) 4.49
The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ (2008) 4.31
Unchain my heart: the scientific foundations of cardiac repair. J Clin Invest (2005) 4.25
G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood (2005) 3.76
Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J Clin Invest (2010) 3.74
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. Blood (2008) 3.67
Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha. J Clin Invest (2007) 3.63
Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells. Cancer Cell (2008) 3.56
Acute liver failure: Summary of a workshop. Hepatology (2008) 3.49
Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair. Cell Stem Cell (2011) 3.49
The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis. Trends Immunol (2007) 3.25
CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression. Cancer Metastasis Rev (2010) 3.24
Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells. Stem Cells (2008) 3.12
Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis (2013) 3.07
Endothelial progenitor cells: identity defined? J Cell Mol Med (2009) 2.96
Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression. Circ Res (2009) 2.82
Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration. Proc Natl Acad Sci U S A (2008) 2.65
Leukemia stem cells and microenvironment: biology and therapeutic targeting. J Clin Oncol (2011) 2.52
Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance. J Clin Oncol (2009) 2.52
Aging and disease as modifiers of efficacy of cell therapy. Circ Res (2008) 2.51
Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3. J Cell Biol (2006) 2.50
Cardiovascular biology of the incretin system. Endocr Rev (2012) 2.42
Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis. Circulation (2007) 2.35
Biomarker system for studying muscle, stem cells, and cancer in vivo. FASEB J (2009) 2.31
Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling. Cardiovasc Res (2010) 2.30
The biology of fracture healing. Injury (2011) 2.26
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev (2012) 2.24
Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature (2014) 2.21
The role of oxygen during fracture healing. Bone (2012) 2.21
Multiple roles of chemokine CXCL12 in the central nervous system: a migration from immunology to neurobiology. Prog Neurobiol (2007) 2.18
Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities. Blood (2011) 2.08
Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice. Proc Natl Acad Sci U S A (2008) 2.07
The bone marrow at the crossroads of blood and immunity. Nat Rev Immunol (2011) 2.07
Formation of large coronary arteries by cardiac progenitor cells. Proc Natl Acad Sci U S A (2008) 2.05
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues. Proc Natl Acad Sci U S A (2009) 2.05
Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence. Blood (2011) 2.02
Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nat Rev Cancer (2014) 2.00
Endothelial progenitor cell transplantation improves long-term stroke outcome in mice. Ann Neurol (2010) 1.96
Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc Natl Acad Sci U S A (2009) 1.95
Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension. Am J Pathol (2008) 1.90
Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis. Int J Biochem Cell Biol (2009) 1.90
Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue. Curr Opin Hematol (2006) 1.86
SDF-1 is both necessary and sufficient to promote proliferative retinopathy. J Clin Invest (2005) 1.84
Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall. Am J Physiol Lung Cell Mol Physiol (2009) 1.81
Oxidative stress promotes myofibroblast differentiation and tumour spreading. EMBO Mol Med (2010) 1.81
A sex-specific role for androgens in angiogenesis. J Exp Med (2010) 1.78
Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages. J Clin Invest (2009) 1.78
Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice. J Orthop Res (2009) 1.76
Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice. J Biol Chem (2008) 1.76
The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis. J Leukoc Biol (2009) 1.76
Tumor-associated macrophages as major players in the tumor microenvironment. Cancers (Basel) (2014) 1.74
Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment. Mol Biol Cell (2007) 1.72
Chemokines as mediators of neovascularization. Arterioscler Thromb Vasc Biol (2008) 1.71
Surgical approaches to create murine models of human wound healing. J Biomed Biotechnol (2010) 1.71
Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and neurogenesis after cerebral ischemia in rats. Neurobiol Dis (2012) 1.70
Prevalence of endogenous CD34+ adipose stem cells predicts human fat graft retention in a xenograft model. Plast Reconstr Surg (2013) 1.70
Chemokines in health and disease. Exp Cell Res (2011) 1.69
Monocytes/macrophages cooperate with progenitor cells during neovascularization and tissue repair: conversion of cell columns into fibrovascular bundles. Am J Pathol (2006) 1.68
Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones. EMBO J (2009) 1.68
Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury. J Am Soc Nephrol (2008) 1.68
VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting. Proc Natl Acad Sci U S A (2011) 1.67
TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice. J Clin Invest (2011) 1.66
Hyperoxia, endothelial progenitor cell mobilization, and diabetic wound healing. Antioxid Redox Signal (2008) 1.66
Role for circulating osteogenic precursor cells in aortic valvular disease. Arterioscler Thromb Vasc Biol (2011) 1.61
Resistance and escape from antiangiogenesis therapy: clinical implications and future strategies. J Clin Oncol (2012) 1.61
Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis. Am J Respir Cell Mol Biol (2007) 1.61
Diabetes irreversibly depletes bone marrow-derived mesenchymal progenitor cell subpopulations. Diabetes (2014) 1.61
The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha. Diabetes Care (2010) 1.60
Mobilized human hematopoietic stem/progenitor cells promote kidney repair after ischemia/reperfusion injury. Circulation (2010) 1.58
Hypoxia inducible factor-2alpha: a critical mediator of aggressive tumor phenotypes. Curr Opin Genet Dev (2009) 1.57
Hematopoietic microRNA-126 protects against renal ischemia/reperfusion injury by promoting vascular integrity. J Am Soc Nephrol (2014) 1.57
The role of SDF-1-CXCR4/CXCR7 axis in the therapeutic effects of hypoxia-preconditioned mesenchymal stem cells for renal ischemia/reperfusion injury. PLoS One (2012) 1.56
Culturing of human mesenchymal stem cells as three-dimensional aggregates induces functional expression of CXCR4 that regulates adhesion to endothelial cells. J Biol Chem (2008) 1.56
Long-term administration of AMD3100, an antagonist of SDF-1/CXCR4 signaling, alters fracture repair. J Orthop Res (2012) 1.56
Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice. J Clin Invest (2008) 1.56
A functional heteromeric MIF receptor formed by CD74 and CXCR4. FEBS Lett (2009) 1.54
The inflammatory microenvironment in hepatocellular carcinoma: a pivotal role for tumor-associated macrophages. Biomed Res Int (2012) 1.53
Hypoxia-induced angiogenesis: good and evil. Genes Cancer (2011) 1.52
Hypoxia-inducible factor 1 and cardiovascular disease. Annu Rev Physiol (2013) 1.52
Use of MR cell tracking to evaluate targeting of glial precursor cells to inflammatory tissue by exploiting the very late antigen-4 docking receptor. Radiology (2012) 1.51
Molecular imaging of bone marrow mononuclear cell survival and homing in murine peripheral artery disease. JACC Cardiovasc Imaging (2012) 1.49
Neoangiogenesis contributes to the development of hemophilic synovitis. Blood (2010) 1.48
A new role of substance P as an injury-inducible messenger for mobilization of CD29(+) stromal-like cells. Nat Med (2009) 1.47
SDF-1 promotes endochondral bone repair during fracture healing at the traumatic brain injury condition. PLoS One (2013) 1.47
Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages. Stem Cells (2008) 1.46
Haematopoietic stem cell migration to the ischemic damaged kidney is not altered by manipulating the SDF-1/CXCR4-axis. Nephrol Dial Transplant (2009) 1.45
Emerging targets in cancer management: role of the CXCL12/CXCR4 axis. Onco Targets Ther (2013) 1.44
Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proc Natl Acad Sci U S A (2009) 1.43
CXCR4 acts as a costimulator during thymic beta-selection. Nat Immunol (2009) 1.42
Heme oxygenase in the regulation of vascular biology: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal (2010) 1.41
Stromal cell-derived factor-1 promoted angiogenesis and inflammatory cell infiltration in aneurysm walls. J Neurosurg (2013) 1.41
Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity. Blood (2009) 1.40
The neuroblast and angioblast chemotaxic factor SDF-1 (CXCL12) expression is briefly up regulated by reactive astrocytes in brain following neonatal hypoxic-ischemic injury. BMC Neurosci (2005) 1.38
Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen (2009) 7.29
Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation (2002) 5.82
Corneal avascularity is due to soluble VEGF receptor-1. Nature (2006) 4.77
Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med (2008) 4.46
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature (2011) 3.90
Quantitative and reproducible murine model of excisional wound healing. Wound Repair Regen (2004) 3.60
Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. Am J Pathol (2004) 3.13
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell (2012) 2.81
The embrace device significantly decreases scarring following scar revision surgery in a randomized controlled trial. Plast Reconstr Surg (2014) 2.66
A novel technique for vacuum assisted closure device application in noncontiguous wounds. J Plast Reconstr Aesthet Surg (2006) 2.61
A Novel Approach to Keloid Reconstruction with Bilaminar Dermal Substitute and Epidermal Skin Grafting. Plast Reconstr Surg (2016) 2.59
Melanoma Extirpation with Immediate Reconstruction: The Oncologic Safety and Cost Savings of Single-Stage Treatment. Plast Reconstr Surg (2016) 2.54
Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. Nat Med (2009) 2.39
CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature (2009) 2.39
Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing. Am J Pathol (2005) 2.21
Adult vasculogenesis occurs through in situ recruitment, proliferation, and tubulization of circulating bone marrow-derived cells. Blood (2004) 2.21
Studies in Fat Grafting: Part V. Cell-Assisted Lipotransfer to Enhance Fat Graft Retention Is Dose Dependent. Plast Reconstr Surg (2015) 2.09
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues. Proc Natl Acad Sci U S A (2009) 2.05
Outcomes of immediate tissue expander breast reconstruction followed by reconstruction of choice in the setting of postmastectomy radiation therapy. Ann Plast Surg (2014) 2.01
Cellular dysfunction in the diabetic fibroblast: impairment in migration, vascular endothelial growth factor production, and response to hypoxia. Am J Pathol (2003) 1.99
The use of acellular dermal matrix in immediate two-stage tissue expander breast reconstruction. Plast Reconstr Surg (2012) 1.98
Homing to hypoxia: HIF-1 as a mediator of progenitor cell recruitment to injured tissue. Trends Cardiovasc Med (2005) 1.97
Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. FASEB J (2007) 1.87
Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling. Nat Med (2011) 1.86
HIF-1alpha dysfunction in diabetes. Cell Cycle (2010) 1.77
Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice. J Biol Chem (2008) 1.76
Surgical approaches to create murine models of human wound healing. J Biomed Biotechnol (2010) 1.71
Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia. Circulation (2007) 1.71
Intraoperative perfusion mapping with laser-assisted indocyanine green imaging can predict and prevent complications in immediate breast reconstruction. Plast Reconstr Surg (2010) 1.63
Topical lineage-negative progenitor-cell therapy for diabetic wounds. Plast Reconstr Surg (2008) 1.60
A murine model for studying diffusely injected human fat. Plast Reconstr Surg (2009) 1.59
Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold. Biomaterials (2011) 1.58
The role of stem cells in aesthetic surgery: fact or fiction? Plast Reconstr Surg (2014) 1.55
Comparative healing of human cutaneous surgical incisions created by the PEAK PlasmaBlade, conventional electrosurgery, and a standard scalpel. Plast Reconstr Surg (2011) 1.55
Staphylococcal biofilms impair wound healing by delaying reepithelialization in a murine cutaneous wound model. Wound Repair Regen (2009) 1.54
db/db mice exhibit severe wound-healing impairments compared with other murine diabetic strains in a silicone-splinted excisional wound model. Wound Repair Regen (2007) 1.54
Determination of bone marrow-derived endothelial progenitor cell significance in angiogenic growth factor-induced neovascularization in vivo. Exp Hematol (2002) 1.49
An information theoretic, microfluidic-based single cell analysis permits identification of subpopulations among putatively homogeneous stem cells. PLoS One (2011) 1.47
Studies in fat grafting: Part II. Effects of injection mechanics on material properties of fat. Plast Reconstr Surg (2014) 1.46
CD105 protein depletion enhances human adipose-derived stromal cell osteogenesis through reduction of transforming growth factor β1 (TGF-β1) signaling. J Biol Chem (2011) 1.46
The TallyHo polygenic mouse model of diabetes: implications in wound healing. Plast Reconstr Surg (2011) 1.45
A Multicenter Experience With Image-Guided Surgical Navigation: Broadening Clinical Indications in Complex Craniomaxillofacial Surgery. J Craniofac Surg (2015) 1.42
Hypertrophic scar formation following burns and trauma: new approaches to treatment. PLoS Med (2007) 1.42
Use of computer-aided design and computer-aided manufacturing to produce orthognathically ideal surgical outcomes: a paradigm shift in head and neck reconstruction. J Oral Maxillofac Surg (2009) 1.42
The SNaP system: biomechanical and animal model testing of a novel ultraportable negative-pressure wound therapy system. Plast Reconstr Surg (2010) 1.41
Studies in fat grafting: Part I. Effects of injection technique on in vitro fat viability and in vivo volume retention. Plast Reconstr Surg (2014) 1.40
The temporal sequence of periosteal attachment after elevation. Plast Reconstr Surg (2003) 1.39
Nipple-sparing mastectomy in patients with prior breast irradiation: are patients at higher risk for reconstructive complications? Plast Reconstr Surg (2014) 1.39
Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth. Proc Natl Acad Sci U S A (2009) 1.36
Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth. Cancer Res (2009) 1.34
Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma. Arterioscler Thromb Vasc Biol (2007) 1.33
IFATS collection: Adipose stromal cells adopt a proangiogenic phenotype under the influence of hypoxia. Stem Cells (2009) 1.30
Decreased circulating progenitor cell number and failed mechanisms of stromal cell-derived factor-1alpha mediated bone marrow mobilization impair diabetic tissue repair. Diabetes (2010) 1.28
Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2. FASEB J (2004) 1.26
The mechanisms of action of vacuum assisted closure: more to learn. Surgery (2009) 1.25
Vascular anastomosis using controlled phase transitions in poloxamer gels. Nat Med (2011) 1.24
Diabetes impairs the angiogenic potential of adipose-derived stem cells by selectively depleting cellular subpopulations. Stem Cell Res Ther (2014) 1.24
Development of a novel, highly quantitative in vivo model for the study of biofilm-impaired cutaneous wound healing. Wound Repair Regen (2011) 1.23
SDF-1 alpha expression during wound healing in the aged is HIF dependent. Plast Reconstr Surg (2009) 1.21
Diabetes impairs endothelial progenitor cell-mediated blood vessel formation in response to hypoxia. Plast Reconstr Surg (2007) 1.20
Sterile "ready-to-use" AlloDerm decreases postoperative infectious complications in patients undergoing immediate implant-based breast reconstruction with acellular dermal matrix. Plast Reconstr Surg (2013) 1.20
Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing. Stem Cells (2014) 1.19
Aging and diabetes impair the neovascular potential of adipose-derived stromal cells. Plast Reconstr Surg (2009) 1.18
Pushing back: wound mechanotransduction in repair and regeneration. J Invest Dermatol (2011) 1.17
Stem cell recruitment after injury: lessons for regenerative medicine. Regen Med (2012) 1.14
In vivo directed differentiation of pluripotent stem cells for skeletal regeneration. Proc Natl Acad Sci U S A (2012) 1.14
Mesenchymal stem cells can participate in ischemic neovascularization. Plast Reconstr Surg (2009) 1.12
Nonintegrating knockdown and customized scaffold design enhances human adipose-derived stem cells in skeletal repair. Stem Cells (2011) 1.11
An evidence-based approach to the surgical management of pressure ulcers. Ann Plast Surg (2012) 1.11
Outcomes of tissue expander/implant breast reconstruction in the setting of prereconstruction radiation. Plast Reconstr Surg (2012) 1.09
Current thoughts for the prevention and treatment of pressure ulcers: using the evidence to determine fact or fiction. Ann Surg (2013) 1.08
Skin graft vascularization involves precisely regulated regression and replacement of endothelial cells through both angiogenesis and vasculogenesis. Plast Reconstr Surg (2006) 1.08