Published in Nat Immunol on December 13, 2009
CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance. Cancer Cell (2015) 2.20
HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes. Blood (2012) 1.76
Decision checkpoints in the thymus. Nat Immunol (2010) 1.75
Signal integration and crosstalk during thymocyte migration and emigration. Nat Rev Immunol (2011) 1.45
Regeneration of the aged thymus by a single transcription factor. Development (2014) 1.23
Gα13 and Rho mediate endosomal trafficking of CXCR4 into Rab11+ vesicles upon stromal cell-derived factor-1 stimulation. J Immunol (2010) 1.10
Determining γδ versus αß T cell development. Nat Rev Immunol (2010) 1.09
Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus. Proc Natl Acad Sci U S A (2011) 1.03
αβ versus γδ fate choice: counting the T-cell lineages at the branch point. Immunol Rev (2010) 1.00
CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis. Arthritis Res Ther (2010) 0.99
Regulation of thymocyte positive selection and motility by GIT2. Nat Immunol (2010) 0.96
Opposing chemokine gradients control human thymocyte migration in situ. J Clin Invest (2013) 0.94
How to find your way through the thymus: a practical guide for aspiring T cells. Cell Mol Life Sci (2011) 0.94
Life and death in the thymus--cell death signaling during T cell development. Curr Opin Cell Biol (2010) 0.93
Thymus atrophy and double-positive escape are common features in infectious diseases. J Parasitol Res (2012) 0.87
SDF-1 activates papillary label-retaining cells during kidney repair from injury. Am J Physiol Renal Physiol (2012) 0.84
G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1-induced T cell functions. J Immunol (2011) 0.83
HIV-1 Nef down-modulates C-C and C-X-C chemokine receptors via ubiquitin and ubiquitin-independent mechanism. PLoS One (2014) 0.82
Cutting edge: CXCR4 is critical for CD8+ memory T cell homeostatic self-renewal but not rechallenge self-renewal. J Immunol (2014) 0.81
Pharmacological inhibition of glycogen synthase kinase 3 regulates T cell development in vitro. PLoS One (2013) 0.81
The Contribution of Chemokines and Migration to the Induction of Central Tolerance in the Thymus. Front Immunol (2015) 0.81
Self-renewal of thymocytes in the absence of competitive precursor replenishment. J Exp Med (2012) 0.80
Interaction of Ras with p110γ is required for thymic β-selection in the mouse. J Immunol (2011) 0.80
A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors. Nat Cell Biol (2016) 0.80
Pre-T Cell Receptors (Pre-TCRs) Leverage Vβ Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands. J Biol Chem (2016) 0.79
Human Peripheral CD4(+) Vδ1(+) γδT Cells Can Develop into αβT Cells. Front Immunol (2014) 0.79
Interleukin-7 supports survival of T-cell receptor-β-expressing CD4(-) CD8(-) double-negative thymocytes. Immunology (2013) 0.79
RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4. PLoS One (2013) 0.78
Impairment of T cell development and acute inflammatory response in HIV-1 Tat transgenic mice. Sci Rep (2015) 0.78
HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination. J Biol Chem (2012) 0.77
Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation. Proc Natl Acad Sci U S A (2010) 0.77
ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers. J Immunol (2015) 0.76
Asymmetric cell division during T cell development controls downstream fate. J Cell Biol (2015) 0.76
Analysis of the N-terminal positively charged residues of the simian immunodeficiency virus Vif reveals a critical amino acid required for the antagonism of rhesus APOBEC3D, G, and H. Virology (2013) 0.76
T-cell selection in the thymus: a spatial and temporal perspective. Immunol Rev (2016) 0.76
ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis. Mol Cell Biol (2015) 0.76
Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent. Elife (2016) 0.75
Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum. Sci Rep (2017) 0.75
Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation. PLoS One (2014) 0.75
Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms. Retrovirology (2013) 0.75
CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling. Cell Death Dis (2014) 0.75
Lymphoid differentiation of hematopoietic stem cells requires efficient Cxcr4 desensitization. J Exp Med (2017) 0.75
Targeting primary acute myeloid leukemia with a new CXCR4 antagonist IgG1 antibody (PF-06747143). Sci Rep (2017) 0.75
Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation. JCI Insight (2017) 0.75
TCR-CXCR4 signaling stabilizes cytokine mRNA transcripts via a PREX1-Rac1 pathway: implications for CTCL. Blood (2017) 0.75
Progressive Changes in CXCR4 Expression That Define Thymocyte Positive Selection Are Dispensable For Both Innate and Conventional αβT-cell Development. Sci Rep (2017) 0.75
HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science (1996) 26.19
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell (1992) 17.50
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med (2004) 11.71
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature (1998) 11.41
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature (1996) 10.67
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity (2001) 9.45
Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity (2002) 8.17
The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature (1998) 7.38
Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4. J Exp Med (1997) 3.62
Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci U S A (2007) 3.61
Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. J Clin Invest (2006) 3.34
Apoptosis in the development and maintenance of the immune system. Nat Immunol (2003) 3.02
T cell costimulation by chemokine receptors. Nat Immunol (2005) 3.00
Journey through the thymus: stromal guides for T-cell development and selection. Nat Rev Immunol (2006) 3.00
Zoned out: functional mapping of stromal signaling microenvironments in the thymus. Annu Rev Immunol (2007) 2.98
Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science (1993) 2.93
Generation of HIV latency during thymopoiesis. Nat Med (2001) 2.91
Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma. Blood (2007) 2.76
Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J Exp Med (2002) 2.68
Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate. Nat Rev Immunol (2005) 2.63
HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells. Cell (2008) 2.46
Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. J Immunol (2004) 2.18
The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity. J Exp Med (2004) 2.14
CXCR4 physically associates with the T cell receptor to signal in T cells. Immunity (2006) 2.01
NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development. Immunity (2000) 1.91
Active movement of T cells away from a chemokine. Nat Med (2000) 1.87
The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes. J Immunol (1999) 1.81
Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development. J Exp Med (2001) 1.80
Diverse transcriptional response of CD4+ T cells to stromal cell-derived factor SDF-1: cell survival promotion and priming effects of SDF-1 on CD4+ T cells. J Immunol (2001) 1.70
A nonredundant role for the adapter protein Shc in thymic T cell development. Nat Immunol (2002) 1.70
The thymus as an inductive site for T lymphopoiesis. Annu Rev Cell Dev Biol (2007) 1.64
Critical role for CXCR4 signaling in progenitor localization and T cell differentiation in the postnatal thymus. J Immunol (2003) 1.63
Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kappaB and NFAT. Nat Immunol (2001) 1.59
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med (2005) 1.46
Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells. Immunity (1999) 1.45
Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor. Immunol Rev (2006) 1.45
Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res (2007) 1.44
Branching out to gain control: how the pre-TCR is linked to multiple functions. Immunol Today (2000) 1.28
A survival guide to early T cell development. Immunol Res (2006) 1.24
Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment. Immunol Rev (1998) 1.19
Cellular and molecular events during early thymus development. Immunol Rev (2006) 1.19
Selective in vivo inhibition of mitogen-activated protein kinase activation using cell-permeable peptides. J Biol Chem (2001) 1.17
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells. Blood (2007) 1.09
CXCR4 engagement promotes dendritic cell survival and maturation. Biochem Biophys Res Commun (2007) 1.04
Control of early thymocyte development by the pre-T cell receptor complex: A receptor without a ligand? Semin Immunol (1999) 0.97
Chemorepulsion and thymocyte emigration. J Clin Invest (2002) 0.86
Chemokines as immunotransmitters? Nat Immunol (2005) 0.86
ShcA mediates the dominant pathway to extracellular signal-regulated kinase activation during early thymic development. Mol Cell Biol (2006) 0.81
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 33.94
Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity (2003) 21.56
Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell (2009) 20.29
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol (2007) 16.21
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity (2002) 14.57
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature (2008) 14.26
ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci (2005) 11.55
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe (2008) 11.08
Interactions between the microbiota and the immune system. Science (2012) 10.45
The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol (2008) 9.64
MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell (2007) 9.33
CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (2005) 8.97
Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity (2010) 8.90
Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci (2006) 8.25
An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol (2003) 8.23
Plasticity of CD4+ T cell lineage differentiation. Immunity (2009) 8.08
A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med (2006) 6.86
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature (2010) 6.44
A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science (2005) 5.88
Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells. Science (2004) 5.66
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife (2013) 5.49
A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature (2010) 5.45
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell (2002) 5.07
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. Nature (2009) 4.98
Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med (2008) 4.95
A validated regulatory network for Th17 cell specification. Cell (2012) 4.82
Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin. Nat Immunol (2008) 4.78
DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. Immunity (2002) 4.62
BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature (2007) 4.36
Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat Cell Biol (2002) 4.29
Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature (2010) 4.10
Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci U S A (2009) 4.10
Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med (2002) 4.02
Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol (2005) 4.01
Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse. Cell (2007) 3.92
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature (2011) 3.90
Transcriptional regulation of Th17 cell differentiation. Semin Immunol (2007) 3.86
PKC-theta knockout mice are protected from fat-induced insulin resistance. J Clin Invest (2004) 3.86
The microbiome in infectious disease and inflammation. Annu Rev Immunol (2012) 3.76
Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut. Immunity (2008) 3.64
Clearance of apoptotic cells: implications in health and disease. J Cell Biol (2010) 3.55
The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med (2008) 3.45
Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. Nature (2011) 3.37
RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology (2008) 3.13
Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells. J Virol (2004) 3.12
Flexible use of nuclear import pathways by HIV-1. Cell Host Microbe (2010) 3.08
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97
Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells. Nature (2013) 2.95
Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone. Nat Immunol (2008) 2.93
The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med (2007) 2.84
Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity (2005) 2.72
Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J Exp Med (2002) 2.68
Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein. Nature (2011) 2.63
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma. J Exp Med (2008) 2.60
CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors. Science (2004) 2.54
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity (2012) 2.54
Phagosome maturation: going through the acid test. Nat Rev Mol Cell Biol (2008) 2.53
Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol (2003) 2.51
Nuclear hormone receptors in T lymphocytes. Cell (2002) 2.51
RUNX proteins in transcription factor networks that regulate T-cell lineage choice. Nat Rev Immunol (2009) 2.49
Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes. Nat Immunol (2002) 2.46
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature (2002) 2.41
Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J Exp Med (2007) 2.39
The chemokine SDF1 regulates migration of dentate granule cells. Development (2002) 2.34
A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science (2012) 2.30
Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthritis Rheumatol (2015) 2.26
Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum (2012) 2.24
A pathway for phagosome maturation during engulfment of apoptotic cells. Nat Cell Biol (2008) 2.20
ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat Immunol (2008) 2.19
Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation. Nature (2012) 2.18
How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets. Immunity (2009) 2.15
The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity. J Exp Med (2004) 2.14
Transcriptional regulatory networks in Th17 cell differentiation. Curr Opin Immunol (2009) 2.12
Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration. J Biol Chem (2003) 2.04
Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2. Circ Res (2010) 2.04
The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. FASEB J (2006) 2.04
Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis. Science (2013) 2.03
Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat Immunol (2009) 2.02
Clearing the dead: apoptotic cell sensing, recognition, engulfment, and digestion. Cold Spring Harb Perspect Biol (2013) 2.00
The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment. Cell Host Microbe (2011) 1.97
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. Blood (2012) 1.95
Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology (2010) 1.92
Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses. J Exp Med (2004) 1.88
Compositional and structural requirements for laminin and basement membranes during mouse embryo implantation and gastrulation. Development (2004) 1.88
c-Myb is critical for B cell development and maintenance of follicular B cells. Immunity (2005) 1.87
Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO. Curr Biol (2004) 1.87
Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells. Nature (2010) 1.87
Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). J Biol Chem (2001) 1.86
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). J Biol Chem (2004) 1.85
The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1. Curr Biol (2005) 1.82
The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy. Kidney Int (2011) 1.82
The role of the nuclear hormone receptor RORgammat in the development of lymph nodes and Peyer's patches. Immunol Rev (2003) 1.82
CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity. J Exp Med (2011) 1.82
ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion. Cancer Res (2007) 1.77