Published in CMAJ on July 06, 2004
Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec. CMAJ (2005) 5.59
First, the bad news... CMAJ (2004) 1.96
Effect of a fermented milk combining Lactobacillus acidophilus Cl1285 and Lactobacillus casei in the prevention of antibiotic-associated diarrhea: a randomized, double-blind, placebo-controlled trial. Can J Gastroenterol (2007) 1.76
Distinctive profiles of infection and pathology in hamsters infected with Clostridium difficile strains 630 and B1. Infect Immun (2009) 1.35
Probiotic therapy for the prevention and treatment of Clostridium difficile-associated diarrhea: a systematic review. CMAJ (2005) 1.31
Analysis of proline reduction in the nosocomial pathogen Clostridium difficile. J Bacteriol (2006) 1.09
A DNA vaccine targeting the receptor-binding domain of Clostridium difficile toxin A. Vaccine (2009) 1.08
Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile infection among hospitalized patients: systematic review and meta-analysis. Open Med (2013) 0.91
Tolevamer, an anionic polymer, neutralizes toxins produced by the BI/027 strains of Clostridium difficile. Antimicrob Agents Chemother (2008) 0.86
Clostridium difficile infection after allogeneic hematopoietic stem cell transplant: strain diversity and outcomes associated with NAP1/027. Biol Blood Marrow Transplant (2014) 0.85
Do admissions and discharges to long-term care facilities influence hospital burden of Clostridium difficile infection? J Hosp Infect (2011) 0.77
Effect of Lactobacillus acidophilus & epidermal growth factor on experimentally induced Clostridium difficile infection. Indian J Med Res (2011) 0.76
Current advances related to Clostridium difficile infection. Indian J Med Res (2015) 0.75
Key research issues in Clostridium difficile. Can J Infect Dis Med Microbiol (2005) 0.75
A new formulation of tolevamer, a novel nonantibiotic polymer, is safe and well-tolerated in healthy volunteers: a randomized phase I trial. Br J Clin Pharmacol (2008) 0.75
SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcus. Infect Control Hosp Epidemiol (2003) 10.16
Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile. Clin Infect Dis (2001) 6.92
Fulminant Clostridium difficile: an underappreciated and increasing cause of death and complications. Ann Surg (2002) 4.91
Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors: cohort and case-control studies. CMAJ (2004) 4.88
Secular trends in hospital-acquired Clostridium difficile disease in the United States, 1987-2001. J Infect Dis (2004) 3.42
Ten years of prospective Clostridium difficile-associated disease surveillance and treatment at the Minneapolis VA Medical Center, 1982-1991. Infect Control Hosp Epidemiol (1994) 3.06
Hospitals battling outbreaks of C. difficile. CMAJ (2004) 2.76
Reduction in the incidence of Clostridium difficile-associated diarrhea in an acute care hospital and a skilled nursing facility following replacement of electronic thermometers with single-use disposables. Infect Control Hosp Epidemiol (1992) 2.37
Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years. Infect Control Hosp Epidemiol (2003) 1.97
Clostridium difficile colitis: an increasingly aggressive iatrogenic disease? Arch Surg (2002) 1.94
Survey of incidence of Clostridium difficile infection in Canadian hospitals and diagnostic approaches. J Clin Microbiol (1998) 1.89
A prospective nationwide study of Clostridium difficile-associated diarrhea in Sweden. The Swedish C. difficile Study Group. Clin Infect Dis (1998) 1.84
National Clostridium difficile Standards Group: Report to the Department of Health. J Hosp Infect (2004) 1.15
N-CDAD in Canada: results of the Canadian Nosocomial Infection Surveillance Program 1997 N-CDAD Prevalence Surveillance Project. Can J Infect Dis (2001) 1.10
Identification of severe acute respiratory syndrome in Canada. N Engl J Med (2003) 14.29
Hospital outbreak of Middle East respiratory syndrome coronavirus. N Engl J Med (2013) 11.85
Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. CMAJ (2004) 9.93
Outpatient gatifloxacin therapy and dysglycemia in older adults. N Engl J Med (2006) 7.01
Resistance to levofloxacin and failure of treatment of pneumococcal pneumonia. N Engl J Med (2002) 6.22
Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec. CMAJ (2005) 5.59
Antiviral therapy and outcomes of influenza requiring hospitalization in Ontario, Canada. Clin Infect Dis (2007) 5.39
Increasing risk of relapse after treatment of Clostridium difficile colitis in Quebec, Canada. Clin Infect Dis (2005) 4.89
Neisseria gonorrhoeae treatment failure and susceptibility to cefixime in Toronto, Canada. JAMA (2013) 4.69
Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum beta-lactamase involved in an outbreak in long-term-care facilities in Toronto, Canada. Antimicrob Agents Chemother (2004) 4.46
Investigation of a nosocomial outbreak of severe acute respiratory syndrome (SARS) in Toronto, Canada. CMAJ (2003) 3.96
Transactional sex is the driving force in the dynamics of HIV in Accra, Ghana. AIDS (2004) 3.87
Health care-associated Clostridium difficile infection in adults admitted to acute care hospitals in Canada: a Canadian Nosocomial Infection Surveillance Program Study. Clin Infect Dis (2009) 3.86
Randomized controlled trial of chlorhexidine gluconate for washing, intranasal mupirocin, and rifampin and doxycycline versus no treatment for the eradication of methicillin-resistant Staphylococcus aureus colonization. Clin Infect Dis (2006) 3.80
Health care-associated Clostridium difficile infection in Canada: patient age and infecting strain type are highly predictive of severe outcome and mortality. Clin Infect Dis (2010) 3.42
An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections. Nat Med (2002) 3.39
Empirical validation of guidelines for the management of pharyngitis in children and adults. JAMA (2004) 3.14
Impact of emergency colectomy on survival of patients with fulminant Clostridium difficile colitis during an epidemic caused by a hypervirulent strain. Ann Surg (2007) 3.08
Triple reassortant H3N2 influenza A viruses, Canada, 2005. Emerg Infect Dis (2006) 3.05
West Nile virus infection in 2002: morbidity and mortality among patients admitted to hospital in southcentral Ontario. CMAJ (2003) 3.03
Outcomes of Clostridium difficile-associated disease treated with metronidazole or vancomycin before and after the emergence of NAP1/027. Am J Gastroenterol (2007) 2.83
At the threshold: defining clinically meaningful resistance thresholds for antibiotic choice in community-acquired pneumonia. Clin Infect Dis (2008) 2.71
Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences. Proc Natl Acad Sci U S A (2014) 2.63
Predicting antimicrobial resistance in invasive pneumococcal infections. Clin Infect Dis (2005) 2.59
Laboratory characterization of methicillin-resistant Staphylococcus aureus in Canadian hospitals: results of 5 years of National Surveillance, 1995-1999. J Infect Dis (2002) 2.57
Molecular complexity of successive bacterial epidemics deconvoluted by comparative pathogenomics. Proc Natl Acad Sci U S A (2010) 2.43
Managing skin and soft tissue infections: expert panel recommendations on key decision points. J Antimicrob Chemother (2003) 2.41
Reducing antimicrobial therapy for asymptomatic bacteriuria among noncatheterized inpatients: a proof-of-concept study. Clin Infect Dis (2014) 2.37
Increasing risk of infectious complications after transrectal ultrasound-guided prostate biopsies: time to reassess antimicrobial prophylaxis? Eur Urol (2012) 2.37
Genome-wide molecular dissection of serotype M3 group A Streptococcus strains causing two epidemics of invasive infections. Proc Natl Acad Sci U S A (2004) 2.32
Genetic variability of human respiratory syncytial virus A strains circulating in Ontario: a novel genotype with a 72 nucleotide G gene duplication. PLoS One (2012) 2.21
SARS among critical care nurses, Toronto. Emerg Infect Dis (2004) 2.10
Healthcare-associated influenza in Canadian hospitals from 2006 to 2012. Infect Control Hosp Epidemiol (2014) 2.06
Detection of airborne severe acute respiratory syndrome (SARS) coronavirus and environmental contamination in SARS outbreak units. J Infect Dis (2005) 2.03
Invasive M1T1 group A Streptococcus undergoes a phase-shift in vivo to prevent proteolytic degradation of multiple virulence factors by SpeB. Mol Microbiol (2004) 1.99
Outcomes assessment of the surgical management of esophageal cancer in younger and older patients. Ann Thorac Surg (2012) 1.96
SARS in healthcare facilities, Toronto and Taiwan. Emerg Infect Dis (2004) 1.95
Severe group a streptococcal soft-tissue infections in Ontario: 1992-1996. Clin Infect Dis (2002) 1.93
Is a mass immunization program for pandemic (H1N1) 2009 good value for money? Evidence from the Canadian Experience. Vaccine (2010) 1.91
Mosaic prophages with horizontally acquired genes account for the emergence and diversification of the globally disseminated M1T1 clone of Streptococcus pyogenes. J Bacteriol (2005) 1.90
Impact of a reduction in the use of high-risk antibiotics on the course of an epidemic of Clostridium difficile-associated disease caused by the hypervirulent NAP1/027 strain. Clin Infect Dis (2007) 1.87
Risk of infection following a visit to the emergency department: a cohort study. CMAJ (2012) 1.83
New Delhi metallo-beta-lactamase, Ontario, Canada. Emerg Infect Dis (2011) 1.81
Phylogenetic analysis reveals a cryptic species Blastomyces gilchristii, sp. nov. within the human pathogenic fungus Blastomyces dermatitidis. PLoS One (2013) 1.79
Integrated analysis of FOCUS 1 and FOCUS 2: randomized, doubled-blinded, multicenter phase 3 trials of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in patients with community-acquired pneumonia. Clin Infect Dis (2010) 1.78
Pneumococcal pneumonia: potential for diagnosis through a urinary metabolic profile. J Proteome Res (2009) 1.78
Successful management of severe group A streptococcal soft tissue infections using an aggressive medical regimen including intravenous polyspecific immunoglobulin together with a conservative surgical approach. Scand J Infect Dis (2005) 1.75
Update on herpes zoster vaccination: a family practitioner's guide. Can Fam Physician (2011) 1.74
New Delhi metallo-β-lactamase-1: local acquisition in Ontario, Canada, and challenges in detection. CMAJ (2011) 1.73
Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals. Antimicrob Agents Chemother (2007) 1.72
Clostridium difficile infections in a Canadian tertiary care hospital before and during a regional epidemic associated with the BI/NAP1/027 strain. Antimicrob Agents Chemother (2008) 1.71
Alternative methods of estimating an incubation distribution: examples from severe acute respiratory syndrome. Epidemiology (2007) 1.70
Modulation of bacterial growth by tumor necrosis factor-alpha in vitro and in vivo. Am J Respir Crit Care Med (2003) 1.70
Treatment of Barrett's esophagus with early neoplasia: a comparison of endoscopic therapy and esophagectomy. Gastrointest Endosc (2008) 1.69
Clinical and epidemiologic features of group a streptococcal pneumonia in Ontario, Canada. Arch Intern Med (2003) 1.67
FOCUS 1: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia. J Antimicrob Chemother (2011) 1.66
Risk factors for resistance to antimicrobial agents among nursing home residents. Am J Epidemiol (2003) 1.62
Modeling transmission of methicillin-resistant Staphylococcus aureus among patients admitted to a hospital. Infect Control Hosp Epidemiol (2005) 1.61
Use of a selective enrichment broth to recover Clostridium difficile from stool swabs stored under different conditions. J Clin Microbiol (2005) 1.61
Canadian guidelines for the management of acute exacerbations of chronic bronchitis: executive summary. Can Respir J (2003) 1.58
Guillain-Barré syndrome after influenza vaccination in adults: a population-based study. Arch Intern Med (2006) 1.57
Volume-outcome relationship in surgery for esophageal malignancy: systematic review and meta-analysis 2000-2011. J Gastrointest Surg (2011) 1.57
The society of thoracic surgeons guidelines on the diagnosis and staging of patients with esophageal cancer. Ann Thorac Surg (2013) 1.56
Severe acute respiratory syndrome (SARS): a year in review. Annu Rev Med (2005) 1.55
Identification of a streptolysin S-associated gene cluster and its role in the pathogenesis of Streptococcus iniae disease. Infect Immun (2002) 1.52
Effect of multivitamin and mineral supplementation on episodes of infection in nursing home residents: a randomized, placebo-controlled study. J Am Geriatr Soc (2007) 1.52
Interpretation of diagnostic laboratory tests for severe acute respiratory syndrome: the Toronto experience. CMAJ (2004) 1.50
High prevalence of ST131 isolates producing CTX-M-15 and CTX-M-14 among extended-spectrum-beta-lactamase-producing Escherichia coli isolates from Canada. Antimicrob Agents Chemother (2010) 1.50
Identification of a progenitor of the CTX-M-9 group of extended-spectrum beta-lactamases from Kluyvera georgiana isolated in Guyana. Antimicrob Agents Chemother (2005) 1.50
A review of Streptococcus pneumoniae infection treatment failures associated with fluoroquinolone resistance. Clin Infect Dis (2005) 1.49
Use of, effectiveness of, and attitudes regarding influenza vaccine among house staff. Infect Control Hosp Epidemiol (2003) 1.48
Proton pump inhibitors and hospitalization for Clostridium difficile-associated disease: a population-based study. Clin Infect Dis (2006) 1.48
Invasive group A streptococcal disease: risk factors for adults. Emerg Infect Dis (2003) 1.48
Genome-wide dissection of globally emergent multi-drug resistant serotype 19A Streptococcus pneumoniae. BMC Genomics (2009) 1.47
Decreased necrotizing fasciitis capacity caused by a single nucleotide mutation that alters a multiple gene virulence axis. Proc Natl Acad Sci U S A (2010) 1.47
Methicillin-resistant Staphylococcus aureus colonization in veterinary personnel. Emerg Infect Dis (2006) 1.46
Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. Antimicrob Agents Chemother (2010) 1.45
Possible SARS coronavirus transmission during cardiopulmonary resuscitation. Emerg Infect Dis (2004) 1.45
Viable group A streptococci in macrophages during acute soft tissue infection. PLoS Med (2006) 1.43
Pulmonary pathology of severe acute respiratory syndrome in Toronto. Mod Pathol (2005) 1.41
Distinct signatures of diversifying selection revealed by genome analysis of respiratory tract and invasive bacterial populations. Proc Natl Acad Sci U S A (2011) 1.39
Risk of Clostridium difficile infection after perioperative antibacterial prophylaxis before and during an outbreak of infection due to a hypervirulent strain. Clin Infect Dis (2008) 1.38