Published in Clin Infect Dis on March 01, 2009
The changing epidemiology of Clostridium difficile infections. Clin Microbiol Rev (2010) 4.48
Proton pump inhibitors and risk for recurrent Clostridium difficile infection among inpatients. Am J Gastroenterol (2013) 4.10
The epidemiology of community-acquired Clostridium difficile infection: a population-based study. Am J Gastroenterol (2011) 3.92
Current status of Clostridium difficile infection epidemiology. Clin Infect Dis (2012) 3.14
Binary toxin and death after Clostridium difficile infection. Emerg Infect Dis (2011) 1.79
Multicenter study of Clostridium difficile infection rates from 2000 to 2006. Infect Control Hosp Epidemiol (2010) 1.73
Enhancing patient safety by reducing healthcare-associated infections: the role of discovery and dissemination. Infect Control Hosp Epidemiol (2010) 1.55
A Canadian Working Group report on fecal microbial therapy: microbial ecosystems therapeutics. Can J Gastroenterol (2012) 1.25
Incidence and Costs of Clostridium difficile Infections in Canada. Open Forum Infect Dis (2015) 1.22
Procalcitonin levels associate with severity of Clostridium difficile infection. PLoS One (2013) 1.22
Mortality and Clostridium difficile infection: a review. Antimicrob Resist Infect Control (2012) 1.15
Hypervirulent Clostridium difficile strains in hospitalized patients, Canada. Emerg Infect Dis (2010) 1.13
Prophage-stimulated toxin production in Clostridium difficile NAP1/027 lysogens. J Bacteriol (2011) 1.10
Epidemiology of Clostridium difficile infection. J Pharm Pract (2013) 1.10
Does doxycycline protect against development of Clostridium difficile infection? Clin Infect Dis (2012) 1.06
Poor functional status as a risk factor for severe Clostridium difficile infection in hospitalized older adults. J Am Geriatr Soc (2013) 1.05
Characterization of a stable, metronidazole-resistant Clostridium difficile clinical isolate. PLoS One (2013) 1.04
Risk factors for Clostridium difficile toxin-positive diarrhea: a population-based prospective case-control study. Eur J Clin Microbiol Infect Dis (2012) 1.01
Reduction in Clostridium difficile infection rates after mandatory hospital public reporting: findings from a longitudinal cohort study in Canada. PLoS Med (2012) 1.01
Epidemiology of Clostridium difficile infection in two tertiary-care hospitals in Perth, Western Australia: a cross-sectional study. New Microbes New Infect (2014) 1.00
Defining Appropriate Use of Proton-Pump Inhibitors Among Medical Inpatients. J Gen Intern Med (2015) 0.98
Reducing the risk of severe complications among patients with Clostridium difficile infection. Can J Gastroenterol (2011) 0.96
Recent advances in the understanding of antibiotic resistance in Clostridium difficile infection. Ther Adv Infect Dis (2016) 0.95
Clostridium difficile infection in Italian urban hospitals: data from 2006 through 2011. BMC Infect Dis (2013) 0.95
The ecology and pathobiology of Clostridium difficile infections: an interdisciplinary challenge. Zoonoses Public Health (2010) 0.93
Physician attitudes toward the use of fecal microbiota transplantation for the treatment of recurrent Clostridium difficile infection. Can J Gastroenterol Hepatol (2014) 0.91
Epidemiology and clinical characteristics of Clostridium difficile infection in a Korean tertiary hospital. J Korean Med Sci (2011) 0.89
Determinants of Clostridium difficile Infection Incidence Across Diverse United States Geographic Locations. Open Forum Infect Dis (2014) 0.89
Susceptibility of Clostridium difficile isolates from a Phase 2 clinical trial of cadazolid and vancomycin in C. difficile infection. J Antimicrob Chemother (2015) 0.88
Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections. World J Gastroenterol (2016) 0.86
Antimicrobial activity of bismuth subsalicylate on Clostridium difficile, Escherichia coli O157:H7, norovirus, and other common enteric pathogens. Gut Microbes (2015) 0.86
Evaluation of an algorithmic approach in comparison with the Illumigene assay for laboratory diagnosis of Clostridium difficile infection. J Clin Microbiol (2013) 0.86
The identification and epidemiology of meticillin-resistant Staphylococcus aureus and Clostridium difficile in patient rooms and the ward environment. BMC Infect Dis (2013) 0.86
Cost-Effectiveness Analysis of Six Strategies to Treat Recurrent Clostridium difficile Infection. PLoS One (2016) 0.85
Severe clinical outcome is uncommon in Clostridium difficile infection in children: a retrospective cohort study. BMC Pediatr (2014) 0.84
Risk of Clostridium difficile Infection with the Use of a Proton Pump Inhibitor for Stress Ulcer Prophylaxis in Critically Ill Patients. Gut Liver (2016) 0.83
Outbreak of Clostridium difficile PCR ribotype 027--the recent experience of a regional hospital. BMC Infect Dis (2014) 0.82
Impact of Surotomycin on the Gut Microbiota of Healthy Volunteers in a Phase 1 Clinical Trial. Antimicrob Agents Chemother (2016) 0.82
Clostridium difficile associated risk of death score (CARDS): a novel severity score to predict mortality among hospitalised patients with C. difficile infection. Aliment Pharmacol Ther (2016) 0.81
A prospective study to examine the epidemiology of methicillin-resistant Staphylococcus aureus and Clostridium difficile contamination in the general environment of three community hospitals in southern Ontario, Canada. BMC Infect Dis (2012) 0.81
Predictors of Clostridium difficile infection severity in patients hospitalised in medical intensive care. World J Gastroenterol (2013) 0.81
Incidence and Clinical Outcomes of Clostridium difficile Infection after Treatment with Tuberculosis Medication. Gut Liver (2016) 0.81
Mortality in hospitalized older adults associated with Clostridium difficile infection at a district hospital. Infect Dis Rep (2010) 0.80
A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitors. BMC Syst Biol (2014) 0.80
Surgical Management of Clostridium difficile Colitis. Clin Colon Rectal Surg (2012) 0.80
High Mortality Risk in Chronic Kidney Disease and End Stage Kidney Disease Patients with Clostridium Difficile Infection: A Systematic Review and Meta-analysis. J Nat Sci (2015) 0.80
Association Between Use of Proton Pump Inhibitors and a Clostridium difficile-Associated Disease Outbreak: Case-Control Study. Can J Hosp Pharm (2010) 0.80
Clinical and economic consequences of vancomycin and fidaxomicin for the treatment of Clostridium difficile infection in Canada. Can J Infect Dis Med Microbiol (2014) 0.80
Acid suppression and the risk of Clostridium difficile infection. J Pediatr (2013) 0.79
A cost-effectiveness and budget impact analysis of first-line fidaxomicin for patients with Clostridium difficile infection (CDI) in Germany. Infection (2016) 0.79
Surveillance of infection severity: a registry study of laboratory diagnosed Clostridium difficile. PLoS Med (2012) 0.78
A Review of Management of Clostridium difficile Infection: Primary and Recurrence. Antibiotics (Basel) (2015) 0.78
Epidemiological and economic burden of Clostridium difficile in the United States: estimates from a modeling approach. BMC Infect Dis (2016) 0.78
Clostridium difficile infection: same incidence and worse prognosis? Clin Infect Dis (2009) 0.78
The traditional antidiarrheal remedy, Garcinia buchananii stem bark extract, inhibits propulsive motility and fast synaptic potentials in the guinea pig distal colon. Neurogastroenterol Motil (2010) 0.78
Clostridium difficile infection in patients with liver disease: a review. Eur J Clin Microbiol Infect Dis (2015) 0.77
Clostridium difficile infection in the community: are proton pump inhibitors to blame? World J Gastroenterol (2013) 0.77
Prevalence of antimicrobial use in a network of Canadian hospitals in 2002 and 2009. Can J Infect Dis Med Microbiol (2015) 0.77
Upregulation of the host SLC11A1 gene by Clostridium difficile toxin B facilitates glucosylation of Rho GTPases and enhances toxin lethality. Infect Immun (2013) 0.77
Chronic kidney disease and end-stage renal disease are risk factors for poor outcomes of Clostridium difficile infection: a systematic review and meta-analysis. Int J Clin Pract (2015) 0.76
Management and prevention of recurrent clostridium difficile infection in patients after total joint arthroplasty: a review. Geriatr Orthop Surg Rehabil (2012) 0.76
Appendicectomy and clostridium difficile infection: is there a link? J Clin Med Res (2014) 0.76
Importance of culture for detection of Clostridium difficile toxin from stool samples to report true incidence and mortality related to C. difficile in hospitals. Clin Infect Dis (2009) 0.76
Diagnostic test accuracy of glutamate dehydrogenase for Clostridium difficile: Systematic review and meta-analysis. Sci Rep (2016) 0.76
Risk factors for recurrent hospital-acquired Clostridium difficile infection in a Japanese university hospital. Clin Exp Gastroenterol (2015) 0.75
Epidemiology and outcome of Clostridium difficile infections in patients hospitalized in Internal Medicine: findings from the nationwide FADOI-PRACTICE study. BMC Infect Dis (2016) 0.75
Assessing the magnitude and trends in hospital acquired infections in Canadian hospitals through sequential point prevalence surveys. Antimicrob Resist Infect Control (2016) 0.75
An Economic Analysis of Strategies to Control Clostridium Difficile Transmission and Infection Using an Agent-Based Simulation Model. PLoS One (2016) 0.75
A Comparison of Current Guidelines of Five International Societies on Clostridium difficile Infection Management. Infect Dis Ther (2016) 0.75
Impact of malignancy on Clostridium difficile infection. Eur J Clin Microbiol Infect Dis (2016) 0.75
Use of culture- and ELISA-based toxin assay for detecting Clostridium Difficile, a neglected pathogen: A single-center study from a tertiary care setting. J Lab Physicians (2017) 0.75
Hospital outbreak of Middle East respiratory syndrome coronavirus. N Engl J Med (2013) 11.85
Transmission of influenza A in human beings. Lancet Infect Dis (2007) 8.34
Front-line ownership: generating a cure mindset for patient safety. Healthc Pap (2013) 7.42
Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum beta-lactamase involved in an outbreak in long-term-care facilities in Toronto, Canada. Antimicrob Agents Chemother (2004) 4.46
Investigation of a nosocomial outbreak of severe acute respiratory syndrome (SARS) in Toronto, Canada. CMAJ (2003) 3.96
Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. Proc Natl Acad Sci U S A (2011) 3.87
Effect of a clinical pathway to reduce hospitalizations in nursing home residents with pneumonia: a randomized controlled trial. JAMA (2006) 3.83
Spread of a novel influenza A (H1N1) virus via global airline transportation. N Engl J Med (2009) 3.80
Randomized controlled trial of chlorhexidine gluconate for washing, intranasal mupirocin, and rifampin and doxycycline versus no treatment for the eradication of methicillin-resistant Staphylococcus aureus colonization. Clin Infect Dis (2006) 3.80
Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med (2004) 3.61
Rescue of DeltaF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules. Am J Physiol Lung Cell Mol Physiol (2006) 3.59
Vancomycin-associated nephrotoxicity in the critically ill: a retrospective multivariate regression analysis*. Crit Care Med (2014) 3.45
Health care-associated Clostridium difficile infection in Canada: patient age and infecting strain type are highly predictive of severe outcome and mortality. Clin Infect Dis (2010) 3.42
An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections. Nat Med (2002) 3.39
Enteric infections, diarrhea, and their impact on function and development. J Clin Invest (2008) 3.23
Cutting edge: TREM-2 attenuates macrophage activation. J Immunol (2006) 3.07
West Nile virus infection in 2002: morbidity and mortality among patients admitted to hospital in southcentral Ontario. CMAJ (2003) 3.03
Rapid detection of the O25b-ST131 clone of Escherichia coli encompassing the CTX-M-15-producing strains. J Antimicrob Chemother (2009) 2.85
Preliminary Estimates of Mortality and Years of Life Lost Associated with the 2009 A/H1N1 Pandemic in the US and Comparison with Past Influenza Seasons. PLoS Curr (2010) 2.77
Per capita antibiotic consumption: how does a North American jurisdiction compare with Europe? Clin Infect Dis (2004) 2.73
Evaluation of the Carba NP test for rapid detection of carbapenemase-producing Enterobacteriaceae and Pseudomonas aeruginosa. Antimicrob Agents Chemother (2013) 2.73
Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences. Proc Natl Acad Sci U S A (2014) 2.63
Predicting antimicrobial resistance in invasive pneumococcal infections. Clin Infect Dis (2005) 2.59
Laboratory characterization of methicillin-resistant Staphylococcus aureus in Canadian hospitals: results of 5 years of National Surveillance, 1995-1999. J Infect Dis (2002) 2.57
Molecular complexity of successive bacterial epidemics deconvoluted by comparative pathogenomics. Proc Natl Acad Sci U S A (2010) 2.43
Predictors of death in infants hospitalized with pertussis: a case-control study of 16 pertussis deaths in Canada. J Pediatr (2003) 2.42
Impact of antimicrobial stewardship in critical care: a systematic review. J Antimicrob Chemother (2011) 2.40
Reducing antimicrobial therapy for asymptomatic bacteriuria among noncatheterized inpatients: a proof-of-concept study. Clin Infect Dis (2014) 2.37
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals. Antimicrob Agents Chemother (2004) 2.36
Diagnosing streptococcal sore throat in adults: randomized controlled trial of in-office aids. Can Fam Physician (2007) 2.35
Genome-wide molecular dissection of serotype M3 group A Streptococcus strains causing two epidemics of invasive infections. Proc Natl Acad Sci U S A (2004) 2.32
The Salmonella genomic island 1 is an integrative mobilizable element. Mol Microbiol (2005) 2.29
In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance. J Exp Med (2005) 2.21
SARS among critical care nurses, Toronto. Emerg Infect Dis (2004) 2.10
Healthcare-associated influenza in Canadian hospitals from 2006 to 2012. Infect Control Hosp Epidemiol (2014) 2.06
Detection of airborne severe acute respiratory syndrome (SARS) coronavirus and environmental contamination in SARS outbreak units. J Infect Dis (2005) 2.03
Global public health implications of a mass gathering in Mecca, Saudi Arabia during the midst of an influenza pandemic. J Travel Med (2010) 2.00
SARS in healthcare facilities, Toronto and Taiwan. Emerg Infect Dis (2004) 1.95
Severe group a streptococcal soft-tissue infections in Ontario: 1992-1996. Clin Infect Dis (2002) 1.93
Is a mass immunization program for pandemic (H1N1) 2009 good value for money? Evidence from the Canadian Experience. Vaccine (2010) 1.91
Mosaic prophages with horizontally acquired genes account for the emergence and diversification of the globally disseminated M1T1 clone of Streptococcus pyogenes. J Bacteriol (2005) 1.90
Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin. Nat Immunol (2009) 1.88
Pandemic influenza in Canadian children: a summary of hospitalized pediatric cases. Vaccine (2010) 1.86
Variant Salmonella genomic island 1 antibiotic resistance gene cluster in Salmonella enterica serovar Albany. Emerg Infect Dis (2003) 1.84
Fecal markers of intestinal inflammation and permeability associated with the subsequent acquisition of linear growth deficits in infants. Am J Trop Med Hyg (2012) 1.83
Risk of infection following a visit to the emergency department: a cohort study. CMAJ (2012) 1.83
Guidelines for the prevention and management of community-associated methicillin-resistant Staphylococcus aureus: A perspective for Canadian health care practitioners. Can J Infect Dis Med Microbiol (2006) 1.81
Pneumococcal pneumonia: potential for diagnosis through a urinary metabolic profile. J Proteome Res (2009) 1.78
Vaccinating to protect a vulnerable subpopulation. PLoS Med (2007) 1.76
Clostridium difficile infection in hospitals: a brewing storm. CMAJ (2004) 1.74
Update on herpes zoster vaccination: a family practitioner's guide. Can Fam Physician (2011) 1.74
New Delhi metallo-β-lactamase-1: local acquisition in Ontario, Canada, and challenges in detection. CMAJ (2011) 1.73
AcrAB-TolC directs efflux-mediated multidrug resistance in Salmonella enterica serovar typhimurium DT104. Antimicrob Agents Chemother (2004) 1.73
Salmonella enterica serotype Typhimurium DT 104 antibiotic resistance genomic island I in serotype paratyphi B. Emerg Infect Dis (2002) 1.73
Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals. Antimicrob Agents Chemother (2007) 1.72
Alternative methods of estimating an incubation distribution: examples from severe acute respiratory syndrome. Epidemiology (2007) 1.70
Characterization of the first extended-spectrum beta-lactamase-producing Salmonella isolate identified in Canada. J Clin Microbiol (2003) 1.69
Adverse events with 4 months of rifampin therapy or 9 months of isoniazid therapy for latent tuberculosis infection: a randomized trial. Ann Intern Med (2008) 1.69
Adequacy of early empiric antibiotic treatment and survival in severe sepsis: experience from the MONARCS trial. Clin Infect Dis (2003) 1.67
Clinical and epidemiologic features of group a streptococcal pneumonia in Ontario, Canada. Arch Intern Med (2003) 1.67
Burden of seasonal influenza in children with neurodevelopmental conditions. Pediatr Infect Dis J (2014) 1.63
Elevated influenza-related excess mortality in South African elderly individuals, 1998-2005. Clin Infect Dis (2010) 1.62
Modeling transmission of methicillin-resistant Staphylococcus aureus among patients admitted to a hospital. Infect Control Hosp Epidemiol (2005) 1.61
Use of a selective enrichment broth to recover Clostridium difficile from stool swabs stored under different conditions. J Clin Microbiol (2005) 1.61
The state of infection surveillance and control in Canadian acute care hospitals. Am J Infect Control (2003) 1.58
Guillain-Barré syndrome after influenza vaccination in adults: a population-based study. Arch Intern Med (2006) 1.57
Long-term therapy with aerosolized ribavirin for parainfluenza 3 virus respiratory tract infection in an infant with severe combined immunodeficiency. Pediatr Transplant (2007) 1.54
Effect of multivitamin and mineral supplementation on episodes of infection in nursing home residents: a randomized, placebo-controlled study. J Am Geriatr Soc (2007) 1.52
Base deficit from the first peripheral venous sample: a surrogate for arterial base deficit in the trauma bay. J Trauma (2011) 1.52
Pediatric injuries from needles discarded in the community: epidemiology and risk of seroconversion. Pediatrics (2008) 1.51
Project TENDR: Targeting Environmental Neuro-Developmental Risks The TENDR Consensus Statement. Environ Health Perspect (2016) 1.50
Interpretation of diagnostic laboratory tests for severe acute respiratory syndrome: the Toronto experience. CMAJ (2004) 1.50
High prevalence of ST131 isolates producing CTX-M-15 and CTX-M-14 among extended-spectrum-beta-lactamase-producing Escherichia coli isolates from Canada. Antimicrob Agents Chemother (2010) 1.50
Identification of a progenitor of the CTX-M-9 group of extended-spectrum beta-lactamases from Kluyvera georgiana isolated in Guyana. Antimicrob Agents Chemother (2005) 1.50
Comparative genomics of Canadian epidemic lineages of methicillin-resistant Staphylococcus aureus. J Clin Microbiol (2007) 1.49
Emergence of drug resistance: implications for antiviral control of pandemic influenza. Proc Biol Sci (2007) 1.49
Audit and feedback to reduce broad-spectrum antibiotic use among intensive care unit patients: a controlled interrupted time series analysis. Infect Control Hosp Epidemiol (2012) 1.49
Use of, effectiveness of, and attitudes regarding influenza vaccine among house staff. Infect Control Hosp Epidemiol (2003) 1.48
Invasive group A streptococcal disease: risk factors for adults. Emerg Infect Dis (2003) 1.48
Genome-wide dissection of globally emergent multi-drug resistant serotype 19A Streptococcus pneumoniae. BMC Genomics (2009) 1.47
Decreased necrotizing fasciitis capacity caused by a single nucleotide mutation that alters a multiple gene virulence axis. Proc Natl Acad Sci U S A (2010) 1.47