Published in Biochim Biophys Acta on July 05, 2004
Controlling natural killer cell responses: integration of signals for activation and inhibition. Annu Rev Immunol (2013) 3.38
Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. J Clin Invest (2009) 2.55
Proline cis-trans isomerization controls autoinhibition of a signaling protein. Mol Cell (2007) 2.44
Inhibitory receptor signaling via tyrosine phosphorylation of the adaptor Crk. Immunity (2008) 2.03
ABL tyrosine kinases: evolution of function, regulation, and specificity. Sci Signal (2010) 1.91
Crk and CrkL adaptor proteins: networks for physiological and pathological signaling. Cell Commun Signal (2009) 1.79
Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1. J Cell Biol (2008) 1.66
Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion. J Exp Med (2005) 1.66
Functional significance of VEGFR-2 on ovarian cancer cells. Int J Cancer (2009) 1.39
Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling. Cancer Res (2007) 1.33
The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways. J Cell Biol (2007) 1.32
Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src. Mol Cell Biol (2005) 1.30
Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]. Proc Natl Acad Sci U S A (2010) 1.27
RNAi screen reveals an Abl kinase-dependent host cell pathway involved in Pseudomonas aeruginosa internalization. PLoS Pathog (2008) 1.20
GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover. EMBO J (2006) 1.18
Abl silencing inhibits CAS-mediated process and constriction in resistance arteries. Circ Res (2007) 1.18
P130Cas Src-binding and substrate domains have distinct roles in sustaining focal adhesion disassembly and promoting cell migration. PLoS One (2010) 1.14
Src SH2 arginine 175 is required for cell motility: specific focal adhesion kinase targeting and focal adhesion assembly function. Mol Cell Biol (2006) 1.11
Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators. Mol Biol Cell (2012) 1.10
Individual Cas phosphorylation sites are dispensable for processive phosphorylation by Src and anchorage-independent cell growth. J Biol Chem (2006) 1.10
Silencing of p130cas in ovarian carcinoma: a novel mechanism for tumor cell death. J Natl Cancer Inst (2011) 1.08
The adaptor protein Crk controls activation and inhibition of natural killer cells. Immunity (2012) 1.07
Cell biological steps and checkpoints in accessing NK cell cytotoxicity. Immunol Cell Biol (2014) 1.07
p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. EMBO J (2007) 1.06
The integrin-coupled signaling adaptor p130Cas suppresses Smad3 function in transforming growth factor-beta signaling. Mol Biol Cell (2008) 1.05
The rho-specific guanine nucleotide exchange factor Dbs regulates breast cancer cell migration. J Biol Chem (2009) 1.02
p130 Crk-associated substrate (CAS) in vascular smooth muscle. J Cardiovasc Pharmacol Ther (2009) 1.01
Crk adaptor proteins act as key signaling integrators for breast tumorigenesis. Breast Cancer Res (2012) 0.98
BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling. J Biol Chem (2009) 0.96
Roles for crk in cancer metastasis and invasion. Genes Cancer (2012) 0.96
Models of crk adaptor proteins in cancer. Genes Cancer (2012) 0.94
Phosphorylation of Trask by Src kinases inhibits integrin clustering and functions in exclusion with focal adhesion signaling. Mol Cell Biol (2010) 0.94
Actin cytoskeletal mediators of motility and invasion amplified and overexpressed in head and neck cancer. Clin Exp Metastasis (2008) 0.94
Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway. Mol Cancer (2014) 0.94
Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signals. J Cell Sci (2009) 0.93
Abelson tyrosine kinase facilitates Salmonella enterica serovar Typhimurium entry into epithelial cells. Infect Immun (2008) 0.93
p130Cas substrate domain signaling promotes migration, invasion, and survival of estrogen receptor-negative breast cancer cells. Breast Cancer (Dove Med Press) (2009) 0.93
Pressure activates colon cancer cell adhesion via paxillin phosphorylation, Crk, Cas, and Rac1. Cell Mol Life Sci (2008) 0.90
SRC induces podoplanin expression to promote cell migration. J Biol Chem (2010) 0.88
PEAK1, a novel kinase target in the fight against cancer. Oncotarget (2010) 0.88
SRC points the way to biomarkers and chemotherapeutic targets. Genes Cancer (2012) 0.88
A FAK/Src chimera with gain-of-function properties promotes formation of large peripheral adhesions associated with dynamic actin assembly. Cell Motil Cytoskeleton (2008) 0.87
Focal adhesion components are essential for mammalian cell cytokinesis. Cell Cycle (2008) 0.86
BCAR1 protein plays important roles in carcinogenesis and predicts poor prognosis in non-small-cell lung cancer. PLoS One (2012) 0.85
NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer. Genes Cancer (2012) 0.84
Live cell imaging of mechanotransduction. J R Soc Interface (2010) 0.83
The docking protein p130Cas regulates cell sensitivity to proteasome inhibition. BMC Biol (2011) 0.82
Increased BCAR1 predicts poor outcomes of non-small cell lung cancer in multiple-center patients. Ann Surg Oncol (2013) 0.81
The evolutionarily conserved arrangement of domains in SRC family kinases is important for substrate recognition. Biochemistry (2008) 0.81
Podoplanin - a small glycoprotein with many faces. Am J Cancer Res (2016) 0.81
Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem (2011) 0.80
Focal adhesion kinase-related nonkinase inhibits vascular smooth muscle cell invasion by focal adhesion targeting, tyrosine 168 phosphorylation, and competition for p130(Cas) binding. Arterioscler Thromb Vasc Biol (2011) 0.80
A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents. Am J Respir Crit Care Med (2012) 0.79
RhoA and membrane fluidity mediates the spatially polarized Src/FAK activation in response to shear stress. Sci Rep (2014) 0.79
Antroquinonol Targets FAK-Signaling Pathway Suppressed Cell Migration, Invasion, and Tumor Growth of C6 Glioma. PLoS One (2015) 0.79
Helicobacter pylori induces cancer cell motility independent of the c-Met receptor. J Carcinog (2009) 0.78
Protein tyrosine phosphatase PTP1B in cell adhesion and migration. Cell Adh Migr (2013) 0.78
Clinical Significance of SASH1 Expression in Glioma. Dis Markers (2015) 0.78
Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway. Nat Chem Biol (2015) 0.77
The cytoplasmic tyrosine kinase Arg regulates gastrulation via control of actin organization. Dev Biol (2012) 0.76
Cellular and molecular drivers of differential organ growth: insights from the limbs of Monodelphis domestica. Dev Genes Evol (2016) 0.76
Synthesis of functional signaling domains by combinatorial polymerization of phosphorylation motifs. ACS Chem Biol (2009) 0.76
Integrins in the Spotlight of Cancer. Int J Mol Sci (2016) 0.75
Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity. Oncogene (2014) 0.75
Phosphoproteomic Analysis Identifies Focal Adhesion Kinase 2 (FAK2) as a Potential Therapeutic Target for Tamoxifen Resistance in Breast Cancer. Mol Cell Proteomics (2015) 0.75
A pre-metazoan origin of the CRK gene family and co-opted signaling network. Sci Rep (2016) 0.75
PTP1B inhibitor promotes endothelial cell motility by activating the DOCK180/Rac1 pathway. Sci Rep (2016) 0.75
Modeling, signaling and cytoskeleton dynamics: integrated modeling-experimental frameworks in cell migration. Wiley Interdiscip Rev Syst Biol Med (2016) 0.75
Spatiotemporal dynamics of RhoA activity in migrating cells. Nature (2006) 6.84
Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells. Proteomics (2011) 2.44
Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circ Res (2009) 1.89
Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold. J Cell Biol (2002) 1.87
Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization. PLoS One (2009) 1.68
Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A (2010) 1.67
Profiling signaling polarity in chemotactic cells. Proc Natl Acad Sci U S A (2007) 1.40
Regulation of cell migration and survival by focal adhesion targeting of Lasp-1. J Cell Biol (2004) 1.38
R-Ras controls membrane protrusion and cell migration through the spatial regulation of Rac and Rho. Mol Biol Cell (2004) 1.28
Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]. Proc Natl Acad Sci U S A (2010) 1.27
ERK and RhoA differentially regulate pseudopodia growth and retraction during chemotaxis. J Biol Chem (2003) 1.24
KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer. Cancer Res (2012) 1.22
Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network. Proc Natl Acad Sci U S A (2008) 1.20
Role of connexins in metastatic breast cancer and melanoma brain colonization. J Cell Sci (2013) 1.11
The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proc Natl Acad Sci U S A (2008) 1.05
Guiding cell migration through directed extension and stabilization of pseudopodia. Exp Cell Res (2004) 1.03
Cytoplasmic c-Abl provides a molecular 'Rheostat' controlling carcinoma cell survival and invasion. Oncogene (2003) 1.02
Deregulation of proteasome function induces Abl-mediated cell death by uncoupling p130CAS and c-CrkII. J Biol Chem (2005) 1.01
Assay for neurite outgrowth quantification. Biotechniques (2003) 0.93
Methods for pseudopodia purification and proteomic analysis. Sci STKE (2007) 0.92
A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting. Blood (2010) 0.91
Cancer cell migration within 3D layer-by-layer microfabricated photocrosslinked PEG scaffolds with tunable stiffness. Biomaterials (2012) 0.91
PEAK1, a novel kinase target in the fight against cancer. Oncotarget (2010) 0.88
PhosphoBlast, a computational tool for comparing phosphoprotein signatures among large datasets. Mol Cell Proteomics (2007) 0.88
Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover. J Biol Chem (2012) 0.86
Biochemical purification of pseudopodia from migratory cells. Methods Mol Biol (2007) 0.85
Computational methods for comparison of large genomic and proteomic datasets reveal protein markers of metastatic cancer. J Proteome Res (2006) 0.83
Quantitative phosphoproteome analysis of lysophosphatidic acid induced chemotaxis applying dual-step (18)O labeling coupled with immobilized metal-ion affinity chromatography. J Proteome Res (2008) 0.83
Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem (2011) 0.80
Proteomics method for identification of pseudopodium phosphotyrosine proteins. Methods Mol Biol (2012) 0.78
Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1. J Mol Biol (2010) 0.77