Published in Cancer Res on July 01, 2007
Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. Cell (2010) 2.38
CAS proteins in normal and pathological cell growth control. Cell Mol Life Sci (2009) 1.84
Crk and CrkL adaptor proteins: networks for physiological and pathological signaling. Cell Commun Signal (2009) 1.79
Differential dependency network analysis to identify condition-specific topological changes in biological networks. Bioinformatics (2008) 1.56
PTMScout, a Web resource for analysis of high throughput post-translational proteomics studies. Mol Cell Proteomics (2010) 1.13
A novel association between p130Cas and resistance to the chemotherapeutic drug adriamycin in human breast cancer cells. Cancer Res (2008) 1.10
Shiga toxin 2 targets the murine renal collecting duct epithelium. Infect Immun (2009) 1.07
The Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression. Reprod Biol Endocrinol (2008) 1.06
Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lens. Mol Vis (2009) 0.97
NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nat Struct Mol Biol (2011) 0.97
Estrogen stimulation of cell migration involves multiple signaling pathway interactions. Endocrinology (2010) 0.96
BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling. J Biol Chem (2009) 0.96
AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern. Cell Signal (2009) 0.92
Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions. Mol Cell Biol (2012) 0.92
Association of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistance. J Biol Chem (2014) 0.91
BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas. Cell Signal (2011) 0.91
Breast cancer antiestrogen resistance 3 (BCAR3) promotes cell motility by regulating actin cytoskeletal and adhesion remodeling in invasive breast cancer cells. PLoS One (2013) 0.89
The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas. Cell Signal (2010) 0.85
LPA Stimulates the Phosphorylation of p130Cas via Gαi2 in Ovarian Cancer Cells. Genes Cancer (2012) 0.85
NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer. Genes Cancer (2012) 0.84
Long noncoding RNA are aberrantly expressed in human papillary thyroid carcinoma. Oncol Lett (2016) 0.82
Strategies and challenges in eliciting immunity to melanoma. Immunol Rev (2008) 0.82
Breast cancer anti-estrogen resistance 3 (BCAR3) protein augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas). J Biol Chem (2012) 0.82
The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain. J Neurosci (2010) 0.81
Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation. J Cell Sci (2013) 0.79
Breast cancer anti-estrogen resistance 3 inhibits transforming growth factor β/Smad signaling and associates with favorable breast cancer disease outcomes. Breast Cancer Res (2014) 0.78
Expression pattern of bcar3, a downstream target of Gata2, and its binding partner, bcar1, during Xenopus development. Gene Expr Patterns (2015) 0.77
Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia. PLoS One (2016) 0.75
CRKL mediates EML4-ALK signaling and is a potential therapeutic target for ALK-rearranged lung adenocarcinoma. Oncotarget (2016) 0.75
Breast cancer antiestrogen resistance 3-p130(Cas) interactions promote adhesion disassembly and invasion in breast cancer cells. Oncogene (2016) 0.75
A novel spontaneous mutation of BCAR3 results in extrusion cataracts in CF#1 mouse strain. Mamm Genome (2016) 0.75
Relevance of breast cancer cell lines as models for breast tumours: an update. Breast Cancer Res Treat (2004) 4.89
Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature (1997) 4.66
Endocrine-responsive breast cancer and strategies for combating resistance. Nat Rev Cancer (2002) 4.57
CAS/Crk coupling serves as a "molecular switch" for induction of cell migration. J Cell Biol (1998) 4.22
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J (1994) 3.88
Oncogenic PI3K and its role in cancer. Curr Opin Oncol (2006) 3.61
JNK phosphorylates paxillin and regulates cell migration. Nature (2003) 3.60
Rap1 signalling: adhering to new models. Nat Rev Mol Cell Biol (2001) 3.36
Crk family adaptors-signalling complex formation and biological roles. Oncogene (2001) 3.11
Mechanisms of tamoxifen resistance. Endocr Relat Cancer (2004) 2.92
p130Cas: a versatile scaffold in signaling networks. Trends Cell Biol (2006) 2.84
BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells. J Natl Cancer Inst (2000) 2.29
Functions of the adapter protein Cas: signal convergence and the determination of cellular responses. Oncogene (2001) 2.04
Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold. J Cell Biol (2002) 1.87
Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold. Biochim Biophys Acta (2004) 1.84
Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells. Mol Cancer Res (2005) 1.77
The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs). Int J Biochem Cell Biol (2001) 1.62
Bcar1/p130Cas protein and primary breast cancer: prognosis and response to tamoxifen treatment. J Natl Cancer Inst (2000) 1.54
Regulation and localization of CAS substrate domain tyrosine phosphorylation. Cell Signal (2004) 1.47
The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway. Proc Natl Acad Sci U S A (1998) 1.46
Phosphatidylinositol 3-kinases in tumor progression. Eur J Biochem (2001) 1.38
R-Ras signals through specific integrin alpha cytoplasmic domains to promote migration and invasion of breast epithelial cells. J Cell Biol (1999) 1.38
Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: inhibition by gefitinib ('Iressa', ZD1839). Clin Exp Metastasis (2004) 1.33
p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor. J Biol Chem (2000) 1.31
Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. EMBO J (1998) 1.27
Epidermal growth factor modulates tyrosine phosphorylation of p130Cas. Involvement of phosphatidylinositol 3'-kinase and actin cytoskeleton. J Biol Chem (1997) 1.24
Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3. J Biol Chem (2003) 1.24
The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility- and invasiveness-inhibitory activity. Cancer Res (2004) 1.22
Molecular signaling mechanisms of cell migration and invasion. Immunol Res (2000) 1.19
AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter. Cancer Res (2003) 1.18
R-Ras promotes focal adhesion formation through focal adhesion kinase and p130(Cas) by a novel mechanism that differs from integrins. Mol Cell Biol (2003) 1.15
AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner. Mol Cancer Res (2005) 1.14
Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation. J Cell Sci (2002) 1.14
Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways. J Biol Chem (2000) 1.09
NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway. J Biol Chem (1999) 1.07
c-Raf-mediated inhibition of epidermal growth factor-stimulated cell migration. J Biol Chem (1999) 1.03
Cytoplasmic c-Abl provides a molecular 'Rheostat' controlling carcinoma cell survival and invasion. Oncogene (2003) 1.02
Involvement of R-Ras and Ral GTPases in estrogen-independent proliferation of breast cancer cells. Oncogene (2002) 0.99
SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases. J Biol Chem (2004) 0.98
Detection of distinct pools of the adapter protein p130CAS using a panel of monoclonal antibodies. Hybridoma (1997) 0.98
BCAR1/p130Cas expression in untreated and acquired tamoxifen-resistant human breast carcinomas. Int J Cancer (2000) 0.97
Src-dependent association of Cas and p85 phosphatidylinositol 3'-kinase in v-crk-transformed cells. Mol Cancer Res (2003) 0.91
The R-Ras GTPase mediates cross talk between estrogen and insulin signaling in breast cancer cells. Mol Cell Biol (2006) 0.86
CrkII associates with BCAR3 in response to endothelin-1 in human glomerular mesangial cells. Exp Biol Med (Maywood) (2006) 0.82
Pathways to tamoxifen resistance. Cancer Lett (2007) 2.12
Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase. J Cell Biol (2007) 1.93
Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines. FASEB J (2007) 1.82
Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. Mol Cancer Ther (2011) 1.61
Differential dependency network analysis to identify condition-specific topological changes in biological networks. Bioinformatics (2008) 1.56
Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor. J Biol Chem (2002) 1.50
Regulation of Rac1 activation by the low density lipoprotein receptor-related protein. J Cell Biol (2002) 1.35
Antiestrogens, aromatase inhibitors, and apoptosis in breast cancer. Vitam Horm (2005) 1.33
Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis. Carcinogenesis (2005) 1.30
Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator. J Biol Chem (2005) 1.29
Alpha5beta1-integrin controls ebolavirus entry by regulating endosomal cathepsins. Proc Natl Acad Sci U S A (2009) 1.26
Gene network signaling in hormone responsiveness modifies apoptosis and autophagy in breast cancer cells. J Steroid Biochem Mol Biol (2009) 1.26
Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3. J Biol Chem (2003) 1.24
Co-inhibition of BCL-W and BCL2 restores antiestrogen sensitivity through BECN1 and promotes an autophagy-associated necrosis. PLoS One (2010) 1.22
G-DOC: a systems medicine platform for personalized oncology. Neoplasia (2011) 1.18
Cooperativity between the Ras-ERK and Rho-Rho kinase pathways in urokinase-type plasminogen activator-stimulated cell migration. J Biol Chem (2002) 1.17
Identifying cancer biomarkers by network-constrained support vector machines. BMC Syst Biol (2011) 1.14
BCL2 and CASP8 regulation by NF-kappaB differentially affect mitochondrial function and cell fate in antiestrogen-sensitive and -resistant breast cancer cells. FASEB J (2010) 1.14
Soluble urokinase-type plasminogen activator receptor inhibits cancer cell growth and invasion by direct urokinase-independent effects on cell signaling. J Biol Chem (2003) 1.12
interferon regulatory factor-1 mediates the proapoptotic but not cell cycle arrest effects of the steroidal antiestrogen ICI 182,780 (faslodex, fulvestrant). Cancer Res (2004) 1.11
A novel association between p130Cas and resistance to the chemotherapeutic drug adriamycin in human breast cancer cells. Cancer Res (2008) 1.10
The role of X-box binding protein-1 in tumorigenicity. Drug News Perspect (2009) 1.09
Identifying protein interaction subnetworks by a bagging Markov random field-based method. Nucleic Acids Res (2012) 1.07
Cell adhesion promotes Ebola virus envelope glycoprotein-mediated binding and infection. J Virol (2008) 1.05
FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing. PLoS One (2011) 1.04
IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis. Mol Cancer Ther (2010) 1.04
Helicobacter pylori induces interleukin-8 secretion by Toll-like receptor 2- and Toll-like receptor 5-dependent and -independent pathways. Infect Immun (2005) 1.03
Endoplasmic reticulum stress, the unfolded protein response, and gene network modeling in antiestrogen resistant breast cancer. Horm Mol Biol Clin Investig (2011) 0.97
BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling. J Biol Chem (2009) 0.96
Frequent loss of heterozygosity at the interferon regulatory factor-1 gene locus in breast cancer. Breast Cancer Res Treat (2009) 0.95
Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake. J Cell Sci (2002) 0.94
Multilevel support vector regression analysis to identify condition-specific regulatory networks. Bioinformatics (2010) 0.93
The differential expression of Yersinia pseudotuberculosis adhesins determines the requirement for FAK and/or Pyk2 during bacterial phagocytosis by macrophages. Cell Microbiol (2006) 0.91
Src-dependent association of Cas and p85 phosphatidylinositol 3'-kinase in v-crk-transformed cells. Mol Cancer Res (2003) 0.91
Macrophage motility requires distinct α5β1/FAK and α4β1/paxillin signaling events. J Leukoc Biol (2010) 0.90
Breast cancer antiestrogen resistance 3 (BCAR3) promotes cell motility by regulating actin cytoskeletal and adhesion remodeling in invasive breast cancer cells. PLoS One (2013) 0.89
Distinct mechanisms of integrin binding by Yersinia pseudotuberculosis adhesins determine the phagocytic response of host macrophages. Cell Microbiol (2005) 0.88
ERRβ splice variants differentially regulate cell cycle progression. Cell Cycle (2015) 0.88
Regulation of osteoclast structure and function by FAK family kinases. J Leukoc Biol (2012) 0.85
Motif-guided sparse decomposition of gene expression data for regulatory module identification. BMC Bioinformatics (2011) 0.85
In silico discovery of mitosis regulation networks associated with early distant metastases in estrogen receptor positive breast cancers. Cancer Inform (2013) 0.84
ERK/MAPK regulates ERRγ expression, transcriptional activity and receptor-mediated tamoxifen resistance in ER+ breast cancer. FEBS J (2014) 0.84
Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton. Genes Cancer (2012) 0.83
Yersinia pseudotuberculosis adhesins regulate tissue-specific colonization and immune cell localization in a mouse model of systemic infection. Infect Immun (2006) 0.81
Expression of a phosphorylated substrate domain of p130Cas promotes PyMT-induced c-Src-dependent murine breast cancer progression. Carcinogenesis (2013) 0.81
The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines. Cancer Genet Cytogenet (2007) 0.80
Robust identification of transcriptional regulatory networks using a Gibbs sampler on outlier sum statistic. Bioinformatics (2012) 0.79
Trans-resveratrol boronic acid exhibits enhanced anti-proliferative activity on estrogen-dependent MCF-7 breast cancer cells. Cancer Biol Ther (2012) 0.75
Identification of condition-specific regulatory modules through multi-level motif and mRNA expression analysis. Int J Comput Biol Drug Des (2009) 0.75